ppl. Fig. 1 Marcotte et al. 2008 RRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKG IWIPD RRLLQE ELVEPLTPSG PNQA +RILKETE +K +KVLGSGAFGTVYKG+WIP+ RRLLQERELVEPLTPSGE APNQAL LRILKETEF KKI KVLGSGAFGTVYKGLWIPE ErbB2 EGFR GENVKIPVAIKVLRENTSPKANKEILDEAYVMAG VGSPY VSRLLGICLTSTVQLVT GE VKIPVAIK LRE TSPKANKEILDEAYVMA V +P + V RLLGICLTSTVQL +T GEKVKIPVAIKELREA TSPKANKEILDEAYVMA SVDNPHVCRLLGICLTSTVQL IT ErbB2 EGFR QLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNV QLMP+GCLLD+VRE+ + + GSQ LLNWC +QIAKGM +YLED RLVHRDLAARNV QLMPFGCLLDYVREHKDNI GSQYLLNWC VQIAKGMNYLEDRRLVHRDLAARNV ErbB2 EGFR LVKSPNHVKITDFGLARLLD I DETEYHADGGKVPIKWMALESILRRRFTHQSDVWS LVK+P HVKITDFGLA+LL + E EYHA+GGKVPIKWMALESIL R +THQSDVWS LVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWS ErbB2 EGFR YGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMI YGVTVWELMTFG+KPYDGIPA EI +LEKGERLPQPPICTIDVYMI YGVTVWELMTFGSKPYDGIPA SEIS S ILEKGERLPQPPICTIDVYMI ErbB2 EGFR TK1 TK2 M5 loop * * * 875 907 819 851 766 798 710 742 922 954
Suppl. Fig. 1 Marcotte et al. 2008
Jan 05, 2016
RRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKG IWIPD. RRLLQE ELVEPLTPSG PNQA +RILKETE +K +KVLGSGAFGTVYKG+WIP+. RRLLQERELVEPLTPSGE APNQAL LRILKETEF KKI KVLGSGAFGTVYKGLWIPE. GENVKIPVAIKVLRENTSPKANKEILDEAYVMAG VGSPY VSRLLGICLTSTVQLVT. - PowerPoint PPT Presentation
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Suppl. Fig. 1 Marcotte et al. 2008
RRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKG IWIPD
RRLLQE ELVEPLTPSG PNQA +RILKETE +K +KVLGSGAFGTVYKG+WIP+
RRLLQERELVEPLTPSGE APNQAL LRILKETEF KKI KVLGSGAFGTVYKGLWIPE
ErbB2
EGFR
GENVKIPVAIKVLRENTSPKANKEILDEAYVMAG VGSPY VSRLLGICLTSTVQLVT
GE VKIPVAIK LRE TSPKANKEILDEAYVMA V +P + V RLLGICLTSTVQL +T
GEKVKIPVAIKELREATSPKANKEILDEAYVMA SVDNPHVCRLLGICLTSTVQL IT
ErbB2
EGFR
QLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNV
QLMP+GCLLD+VRE+ + + GSQ LLNWC +QIAKGM +YLED RLVHRDLAARNV
QLMPFGCLLDYVREHKDNI GSQYLLNWC VQIAKGMNYLEDRRLVHRDLAARNV
ErbB2
EGFR
LVKSPNHVKITDFGLARLLD I DETEYHADGGKVPIKWMALESILRRRFTHQSDVWS
LVK+P HVKITDFGLA+LL + E EYHA+GGKVPIKWMALESIL R +THQSDVWS
LVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWS
ErbB2
EGFR
YGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMI
YGVTVWELMTFG+KPYDGIPA EI +LEKGERLPQPPICTIDVYMI
YGVTVWELMTFGSKPYDGIPA SEIS S ILEKGERLPQPPICTIDVYMI
ErbB2
EGFR
TK1
TK2
M5 loop
*
**
875
907
819
851
766
798
710
742
922
954
Suppl. Fig. 2 Marcotte et al. 2008
100 101 102 103 104FL1-H
100
101
102
103
104
FL4-H
100 101 102 103 104FL1-H
100
101
102
103
104
FL4-H
100 101 102 103 104FL1-H
100
101
102
103
104
FL4-H
100 101 102 103 104FL1-H
100
101
102
103
104
FL4-H
A
EGFR
EV EGFR
YHAD TK
Suppl. Fig 3 Marcotte et al. 2008
Suppl. Fig 4 Marcotte et al. 2008
A
B
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