Sun Q, et al. Circulation 2009;119:538-46

Sun Q, et al. Circulation 2009;119:538-46

Glucose tolerance test and vasomotor response in FA- or PM2.5-exposed C57BL/6 mice fed HFC


PM2.5 exposure impairs insulin signaling via the PI3-kinase/Akt pathway in FA- or PM2.5-

exposed C57BL/6 mice fed HFC


Exposure to ambient PM2.5 increases circulatory adipokines and inflammatory

biomarkers in C57BL/6 mice fed HFC


PM2.5 exposure increases visceral fat mass measured by magnetic resonance imaging in C57BL/6 mice fed HFC


PM2.5 exposure increases ATM infiltration and adipocyte size in C57BL/6 mice fed HFC


Exposure to ambient PM2.5 increases macrophage infiltration in adipose tissue and induces a shift in macrophage phenotype characteristics in C57BL/6 mice fed HFC


Glucose and insulin tolerance tests and YFP cell fluorescence staining of live adipose tissue in c-fmsYFP mice fed HFC


PM2.5 exposure increases YFP cell infiltration in mesenteric tissue and YFP cell adhesion in the

cremasteric vasculature in c-fmsYFP mice fed HFC


CLINICAL PERSPECTIVE


Physical and biological data in C57BL/6 mice exposed to fine particulate matter (PM2.5) or filtered air (FA)

Sun Q, et al. Circulation 2009;119:538-46 Supp Mat

Hypothetical schema illustrating potential interactions between particulate air pollution and over nutrition leading to the

development of type 2 diabetes mellitus and insulin resistance


Representative photomicrographs showing colocalization of PKC-βII and IRS-1 in aortic tissues by immunofluorescent

staining in C57BL/6 mice fed with HFC


Sun Q, et al. Circulation 2009;119:538-46

Documents

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exposed c57bl6 mice

insulin resistancesun

cfmsyfp mice

clinical perspectivesun

filtered air fasun q

ambient pm2

yfp cell infiltration