Dr. D. Y. Patil Unitech Society's, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune – 411018 RECOMMENDATIONS/ SUGGESTIONS COMMUNICATED TO AFFILIATING UNIVERSITY (SPPU) AND ACTION TAKEN FOR B. PHARM & M. PHARM 2018 – 2019
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Dr. D. Y. Patil Unitech Society's,
Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research,
Pimpri, Pune – 411018
RECOMMENDATIONS/ SUGGESTIONS
COMMUNICATED TO AFFILIATING
UNIVERSITY (SPPU) AND ACTION TAKEN
FOR B. PHARM & M. PHARM
2018 – 2019
Sr. No. Particulars of document
1. Communication of subject teacher with HODs and
recommendations/suggestions for subject redesigning (Department of
Pharmaceutical Chemistry) 2018 - 2019
Communication of subject teacher with HODs
(Subject – Pharmaceutical Inorganic Chemistry, B. Pharm)
Recommendations - (Subject – Pharmaceutical Inorganic Chemistry, B. Pharm)
Communication of subject teacher with HODs
(Subject – Pharmaceutical Organic Chemistry, B. Pharm)
Recommendations (Subject – Pharmaceutical Organic Chemistry, B. Pharm)
Communication of subject teacher with HODs
(Subject – Pharmaceutical Analysis I & Biochemistry, B. Pharm)
Recommendations (Subject – Pharmaceutical Analysis I, B. Pharm)
Recommendations (Subject –Biochemistry, B. Pharm)
Recommendations (Subject – Pharmaceutical Organic Chemistry - II, B. Pharm)
Recommendations (Subject – Pharmaceutical Organic Chemistry III, B. Pharm)
2. Communication of HOD with BOS Chairman (Department of Pharmaceutical
Chemistry) 2018 - 2019
Communication (B. Pharm & M. Pharm)
3. Communication of BOS chairman with Academic board, SPPU (Department of
Pharmaceutical Chemistry) 2018 – 2019
FY B. Pharm
SY B. Pharm
M. Pharm
4. Action taken by University (Department of Pharmaceutical Chemistry) 2018 –
2019
Revised syllabus copy (Subject – Pharmaceutical Inorganic Chemistry, B. Pharm)
Revised syllabus copy (Subject – Pharmaceutical Organic Chemistry, B. Pharm)
Revised syllabus copy (Subject – Pharmaceutical Analysis I, B. Pharm)
Revised syllabus copy (Subject –Biochemistry, B. Pharm)
Revised syllabus copy (Subject – Pharmaceutical Organic Chemistry - II, B. Pharm)
Revised syllabus copy (Subject – Pharmaceutical Organic Chemistry - III, B. Pharm)
5. Recommendations/suggestions from HODs for subject redesigning (Department
of Pharmaceutics) 2018 - 2019
M. Pharm (Subject – Modern Pharmaceutics)
M. Pharm (Subject – Pharmaceutics Practical Sem II)
6. Communication of HOD with BOS Chairman (Department of Pharmaceutics)
2018 - 2019
M. Pharm
7. Action taken by University (Department of Pharmaceutics) 2018 – 2019
Revised syllabus copy (Subject – Modern Pharmaceutics)
Revised syllabus copy (Subject – Pharmaceutics Practical Sem II)
8. Recommendations in Pharm D syllabus 2018- 2019
2310512022,13:39 Dr. D.Y. Patil Unitech Society Mail - Syllabus modification points
BP104T PHARMACEUTIcAL I NoRGAN tC CH EM tsTRy(Theory)
Suggestions:
o waters in Pharmacy may be included the syllabus. (They will read-preparation of purified waterand water for injection BP by distillation in Pharm Engineering Theory and perform
Bacteriological analysis of water in Microbiology practicar)
r (Unit lll) Antimicrobials is a separate chapter so may be bulleted separatelyo (Unit lll) Cathartics- Kaolin and Bentonite are not used as cathartics but protectives, separate
tab may be created for these two.o (Unit lV)Typographical error- Remove 333 after sodium nitrite
BP110P. PHARMACEUTTcAL I NORGAN rc cH EMrsrRy (practica t)
Suggestions:
Determination of potassium iodate and iodine in potassium lodide
BP202T . PHARMACE UTt cAL O RGAN I c CH E M tSTRy _t (Th eory)
concept of binary mixture.separation may be introduced ( t or 2 exercises)
Construction of stereomodel may be shifted to second year as stereochemistry in a part of 2no yearsyllabus. ( The excercises related to D/L, R/S, conformational isomers is not possible if kept in first year)
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5114122, 12 50 PM Dr U Y Patrl Unitech Socrety Marl - Fw Fwd tlegardrnq PCI Syllabrrs 2018 Pattern Sublect POCI
FKOM IUE] X,I IACAEry.rs. Asha Thomas Pharmacy <asha'thomas@dypvp'edu'in>
1. Pharmacopoeia, sources of impurities in medicinal agent and limit test should beremoved from syllabus as it is covered in pIC in detail.
2. Preparation and standardizationof compound should be clearly stated.3. Assay of compound should be same in theory and practical. Ex. Assay of ephedrine HCL
and magnesium sulphate is not covered in practicals
4. In unit IV, redox titration permanganometry is not mentioned and that is covered inpracticals. .
5. Very less allotted hours for unit V, electrochemical methods of analysis. In 2015 pattemSPPU syllabus same chapters were allotted total 18hrs. Difficult to complete topic instipulated time.
Subject: Biochemistry
Semester - Sem II
Suggpstions:
1. In unit I, biomolecules details should be mentioned as how much needs to be covered inintroduction of carbohydrate, lipid, nucleic acids, amino acid and protein.
2. Strucfures in pathways should not be mandatory.
3. Disorders related to pathways are mentioned in syllabus which is different as comparedto SPPU 2015 pattem. Questions in university question paper should be pathway withdisorders, as only disorders is part ofpathophysiology.
4. In unit III, amino acid metabolism, syllabus says catabolism of tyrosine and its metabolicdisorders. Alongwith degradation of tyrosine, catabolism of tyrosine also results information of melanin and thyroid hormones. Clarification is required.
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6t3t2021i1312021 Dr. D.Y. Patil Unitech Society Mail - Final Syllabus FY SY and M Pharm _MQASyllabus FY SY and M Pharm MQA
Note: The weight age of topics while setting SPPU university Question paper should be
proportionate to the teaching hours allotted.
Recommended Books (Latest Editions)
1.. Beckett, A.H. and Stenlake, J. B. 1970, Practical Pharmaceutical Chemistry,Yoll & lI,4th edn, Stahlone Press of University of London.
2. Jeffery, G. H., Bassett, J., Mendham, J. and Cdenney, R., Vogel's Textbook of QuantitativeChemical Analysis,5th edn, Thames Polyechnic, Longman Grgup, uK Ltd, London.3. Gundu Rao, P. 2008, Pharmaceutical and Medicinal Inorganic Chemistry, VallabhPrakashan.
4. Bentley, A.O., Driver, J.E. and Atherden, L.M. 1969, Bentley and Driver's Textbook ofP har m a c e ut i c al C he mi s try, Oxford University Press, London.
6. Anand, S.K. and Chatwal, G.R. 2017, Inorganic Pharmaceutical Chemistry, HimalayaPublishing House Pvt Ltd.7. Block, J.H., Roche, E.B., Soine, T.o and wilson, C.o. 1974, Inorganic Medicinal andP harmaceuti c al C he mis try, Philadelphia, PA.
8. Indian Pharmacopoeia, Ministry of Health and Family Welfare, Controller of PublicationsEdition. New Delhi.
1. Beckett, A.H. and Stenlake, J. B. 1970, Practical Pharmaceutical Chemistry,Yol I & il,4th edn, Stahlone Press of University of London.
2. Jeffery, G. H., Bassett, J., Mendham, J. and Cdenney, R, Vogel's Textbook of Quantitative
Chemical Analysis,5th edn, Thames Polytechnic, Longman Group, UK Ltd, London.
3. Gundu Rao, P. 2008, Pharmaceutical and Medicinal Inorganic Chemistry, Vallabh
Prakashan.
4. Bentley, A.O., Driver, J.E. and Atherden, L.M. 1969, Bentley and Driver's Textbook ofP harmaceutic al Chemistry, Oxford University Press, London.
6. Anand, S.K. and Chatwal, G.R. 2017, Inorganic Pharmaceutical Chemistry,Himalaya
Publishing House Pvt Ltd.
7. Block, J.H., Roche, E.B., Soine, T.O and Wilson, C.O. 1974, Inorganic Medicinal and
Pharmaceutical Chemi stry, Philadelphia, PA.
8. Indian Pharmacopoeia, Ministry of Health and Family Welfare, Controller of Publications
Edition, New Delhi.
NubD;A B'1vawo"Y
iSoS - M zvY\L'cv
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Dr. D. Y.Fal
Pharmaceuticaf , bciences & ResJarch
Pimpri, pune411 01g.
R"pvrsrl Syuu+Btls Fy
BP202T. Pharmaceutical Organic Chemistry - I (Theory) 45 hours
Scope: This subject deals with classification and nomenclature of simple organiccompounds, isomerism, intermediates formed in reactions, important physical properties,reactions and methods of preparation of these compounds. The syllabus also emphasizeson mechanisms and orientation of reactions.
objectives: upon completion of the course the student shall be able too Write the structure, name and the type of isomerism of the organic compoundo Write the reaction, natne the reaction and orientation of reactionso Account for reactivity/stability of compoundso IdentiVconfirm the identification of organic compounds
Course Content:1. General methods of preparation (any 05) and reactibns of class of compounds
superscripted with asterisk (*) to be explained.
2. To emphasize on definition, types, classification, principles/mechanisms,applications, examples and differences.
TINIT 1
Basic principles of organic chemistry:Hybridization of atomic orbitals of carbon, nitrogen and oxygen to formmolecular orbitals. Types of bonds, bond fission, intermolecular forces,inductive effect, steric effect, electromeric, mesomeric effect and resonance.
hyperconjugation, concept of tautomerism.
04 hours
UNIT IIClassification, nomenclature and isomerism
Al Classification of organic compounds1. Compounds containing carbon and hydrogen atoms only : hydrocarbons
2. Compounds containing carbon, hydrogen and oxygen atoms only(alcohols, phenols, ethers and epoxides, carbonyl compounds, carboxylicacids, esters, anhydrides)
Compounds containing carbon, hydrogen and nitrogen atoms only (amines and imine, nitriles, hydrazines, nitro compounds)
Compounds qontaining carbon, hydrogen, and halogens with oxygen(alkyl halidOs, aryl halides, acyl halides)
5. Compounds containing carbon, hydrogen, oxygen and nitrogen atoms
only (amides, imides, aldoxime and ketoxime)6. compounds containing carbon, hydrogen and sulphur with/without
nitrogen, oxygen and halogen. Sulphonic acids, sulphonylhalides.(At least five mono-functional examples of each class includingaromatic and aliphatic compounds should be covered with their commonnames.) , .,_ -
Bl Common and IUPAC systGhs of nomenclature of organic compoundsIUPAC nomenclature of all classes of compounds: nomenclature of mono-substituted and poly-substituted compounds should be covered.
Cl Structural isomerism in organic compounds, Introduction tostereochemistry, concepts
meso compounds.
of enantiomerism and diastereomerism, I
aJ.
4.
10 hours
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08
Hours
UNIT-IIAlkanes*, Alkenes* and Conjugated dienes*
Halogenation of alkanes, uses of paraffins'
Stabilities of alkengs, it *a E2 reactions - kinetics, order of reactivity
alkyl halides, realrangement of carb
orientation and evidences. El versus
reactions. Chemical Reactions: Ozonol
alkenes, Markownikoff s orientation, free radical addition reactions of alkenes,
Anti Markownikoff s orientation
Stability of conjugated dienes, Diel's-Alder, 1,2 and I,4- electrophilic
addition, free raaicat addition reactions of conjugated dienes, allylic
08
Hours
UNIT-IIIAllryt halides*
SNl and Slr2 reactions - kinetics, order of reactivity of alkyl halides'
,i.rror6.-istry and reaffangement of carbocations. SNl versus Sv2 reactions'
factors affecting SNl and S52 reactions'
Structure and uses of ethylchloride, Chloroform, trichloroethylene,
tetrachloroethylene, dichloromethane, tetrachloromethane and iodoform'
tests, structure and uses of ethyl alcohol,
alcohol, benzyl alcohol, glycerol, and propyleneAlcohols*- Qualitative
Volhard's method, Fajans method, and estimation of Sodium Chloride I.P.
b) Complexometric titration: Classification, metal ion indicators, masking and
demasking reagents, and estimation of Calcium gluconate I'P'
c) Gravimetry: Principle and steps involved in gravimetric analysis. Purity ofthe precipitate: co-precipitation and post precipitation, and estimation of
Barium sulphate I. P.
12 hours
UNIT-IV t
Redox titrationsa) Concepts of oxidation and reduction
b) Preparation and standardization of Potassium Permanganate I. P., Ceric
Ammonium Sulphate I. P.iB. P. and Sodium Thiosulphate I. P.iB. P.
c) Types of redox titrations (Principles and applications) : Permaganometry,
o Conductometry - Introduction, Conductivi Conductometric titrations,
10 hours
*up
R pv: sE| syuta CDP Y
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applications.potentiometry - Electrochemical cell, construction and working of reference
(Standard Hydrogen Electrode, Silver Chloride Electrode and Calomel
Electrode) and Indicator Eectrodes (Metal electrodes and Glass Electrode),
methods to determine end point of potentiometric titration and applications.
Refractometry - Introduction, refractive index, specific and molar refraction,
measurement of RI, Abbe's refractometer and applications.
Polarogaphy - Principle and llkovik Equation.
Note: The weight age of topics while setting SPPU university Question paper should be
proportionate to the teaching hours allotted-
Recommended Books (Latest Editions)
L lndian Pharmacopoeia, Ministry of Health and
Publications Edition, New Delhi'
2. British Pharmacopoeia, British Pharmacopoeia Commission, London' 2015
3. Beckett, A.H. and Stenlake J. B., Practical Pharmaceutical Chemistry, Vol I, Stahlome
Press, University of London.
4. Vogel, A. I., A Textbook of Quantitative Chemical Analysis, Thames Polytechnic,
London, Longman GrouP, UK Ltd'
5. Connors K. A., A Textbook of Pharmaceutical Anal.v'.sis, Third Edition, John Wiley and
. Sons.
6. Christian G.D., Analytical Chemistry, 6/Ed, John Wiley & Sons'
7. Mahadik K.R., Wadodkar S.G., More H.N, Pharmaceutical Analysis, Vol. I and II.
Nirali Prakashan.
8. Kar Ashutosh, Pharmaceutical Drug Analysis, Minerva Press, Nerv Delhi'
9. Day R. A. & Underwood A. L. Quantitative Analysis. slEd., Prentice Hall of India Pvl.Ltd.
New Delhi.
10. skoog, A. D. West, D. M. et al. Fundamentals of Analytical chemistry' 8/ Ed' Thomson
Brookslcole.
11. Willard Merit. Dean Settle, Instrumental Methods of Analysis, 7/Ed, cBS Publisher &
Distributor
12. Sharma, B. K. Instrumental Methods of Chemical Analysis, Goel Publishing House.
Family Welfare, Controller of
BP108P. PHARMACEUTICAL ANALYSIS (Practical)
Preparation and standardization of(1) Aq. Sodium HYdroxide I. P.
(2) Aq. Sulphuric Acid I. P'/ Aq. Hydrochloric Acid I' P'
(3) Aq. Sodium Thiosulfate I. P.
(4) Aq.Potassium Permanganate I. P'
(5) Aq.Ceric Ammonium Sulphate I. P.
4 h/week
3 turns
Assay of the following compounds along with Standardization of Titrant
(l) Ammonium chloride by acid-base titration
(2) Sodium benzoate I. P. by non-aqueous titration
(3) Sodium chloride I. P. by precipitation titration
(4) Calcium gluconate I' P. by complexometry
(5) Hydrogen peroxide I. P./B. P. by Permanganometry
(6) Fenous sulphate I. P. by cerimetry
(7) Copper sulphate I. P. by iodometr
Determination of Normal ity by electro-analytical methods
(l) Conductometric titrations of strong acid against strong base
iZj Conauctometric titration of strong acid and weak acid against strong bul"- _
ififottntiometric titration of strong acid against strong base (Using Sigmoidal
Measurement of refractive index of so
Rectified Spirit, Castor Oil I. P.)
8 turns
3 turns
I turn
Recommended Books (Latest Editions)
L Indian Pharmacopoeia, Ministry of Health and Family Welfare, Controller of
Publications Edition, New Delhi.
British Pharmacopoeia, British Pharmacopoeia commission,. London, 20 I 5
Beckett, R.U. and Stenlake J. B., Practical Pharmaceutical Chemistry Vol 1,1962,
Stahlome Press, University of London'
4. Vogel, A. I., A Textbook of Quantitative chemical Analysis, Thames Polytechnic'
London, Longman GrouP, UK Ltd.
Connors K. 4., A Textbook of Pharmaceutical Analysis. John Wiley and Sons'
Christian G. D., Analyical Chemistry, John Wiley & Sons'
Mahadik K. R., Wadodkar S.G., Moie H. N, Pharmaceutical Analysis Vol' I and II, Nirali
Prakashan.g. Kar Ashutosh, Pharmaceutical Drug Analysis, Minerva Ptess, New Delhi.
2.a
5.
6.
7.
Dr. D. Y.'Patil lAetitute of
Pimpri, Pune-411 018.
EV'SEDSv *ngus v
8P203 T. BIOCHEMISTRY (Theory) 45 hours
Scope: Biochemistry deals with complete understanding of the molecular levels of the chemical
process associated with living cells. The scope of the subject is to provide biochemical facts and
the principles to understand metabolism of nutrient molecules in physiological and pathological
conditions. It is also emphasizing on genetic organization of mammalian genome, hetero &autocatalytic functions of DNA.Objectives: Upon completion of course the students shall able to
I . Understand the catalyic role of enzymes and importance of enzyme in biochemicalprocess.
2. Understand the metabolism of nutrient molecules in physiological and pathological ,.
conditions.
3. Understand the genetic organization of mammalian genome and functions of DNA in the
synthesis of RNAs and proteins.
UNIT -Ia. Biomolecules
o Introduction, classification, chemical nature and biological role ofcarbohydrates, lipids, nucleic acids, amino acids and proteins.
b. Carbohydrate metabolism. Glycolysis - Pathway, energetics and significance.
o Citric acid cycle- Pathway, energetics and significance.
o HMP shunt and its significance; Glucose-6-Phosphate dehydrogenase. (G6PD) deficiency.
o Glycogen metabolism Pathways and glycogen storage diseases (GSD).
o Gluconeogenesis- Pathway and its significance.
o Hormonal resulation of blood slucose level and Diabetes mellitus.
10 hrs
UNIT-1I
^. Biologicaloxidationo Electron transport chain (ETC) and its mechanism.
o Oxidative phosphorylation & its mechanism and substrate level.
o phosphorylation
o Inhibitors ETC and oxidative phosphorylation / uncouplers.
b. Bioenergetics
o Concept gffree energy, endergonic and exergonic reaction,
relationship between free energy, enthalpy and entropy.
. Energy rich compounds; classification; biological significances of ATP
and cyclic AMP.
08 hours
UNIT-III
^. Lipid metabolism
o B-Oxidation of saturated fatty acid (Palmitic acid).
o Formation and utilization of ketone bodies; ketoacidosis.
o De novo synth.ri;,if faty acids (Palmitic acid).
. Biological significance of cholesterol and conversion of cholesterol
Scope: This subject deals with general methods of preparation and reactions of some organic
compounds. Reactivity of organic compounds is also studied here. The syllabus emphasizes on
mechanisms & orientation of reactions. Chemistry of fats and oils are also included in the syllabus.
Objectives: Upon completion of the course the student shall be able to
l. write the structure. name and the type of isornerisrrr of the organic compound
2. write the reaction. name the reaction and orientation of reactions
3. account for reactivity/stabitity of compounds
4. prepare small organic compounds
Note:General methods of preparation and reactions of compounds superscripted with asterisk (,*) to be
explairred .
UNIT-IBenzene and its derivativesA. Introduction to benzene, orbital picture, resonance in benzene, Huckel's rule
B. Reactions of benzene - nitration, sulphonation, halogenation- reactivity, Friedel-
Craft' s alky I ation- reactivity, I im itation s, Friede | -Craft' s acyl ation.
C. Substituents, efl'ect of substituents on reactivity and orientation of mono substituted
benzene compounds towards electrophilic substitution reaction
UNIT-IIPhenols* - Acidity of phenols, ef'fect of substituents on acidity, qualitative tests for
phenols, structure and uses of phenol, cresols, resorcinol. naphthols
Aroiratic Amines* - Basicity of amines, effbct of substituents on basicity, Nitrosation
reaction, coupling and Sandmayer's reaction, Hinsberg Test, synthetic uses of aryl
diazonium salts.
UNIT-IIIStereo Isomerism:
a. Optical isomerism
i. Elements of symnretry'. chiral and achiral molecules
ii. Optical activity. enantiomerism. d iastereoisomerism, meso compounds
iii. D & L system of nomenclature of optical isomers, sequence rules, R & S system
of nomenclature of optical isomers
b. Geometrical isomerism
i. Nomenclature of geometrical isomers ((,'is & Truns, E & Z, Syn &.4i?/i systems)
ii. Metlrocls of Seterrnination of confisuration of seometrical isomers.
UNIT-IVPolyn uclear hyd roca rbons:
Synthesis, reactions and structure and medicinal
anthracene, d i phen y I methane, triphen ylmethane and
UNIT-VCycloalkanes*
Stabilities - Baeyer's strain thboilr: limitation of Baeyer's
Moffltt's modiflcation. Sachse Mohr's theorv (Theory ofcyclopropane and cyclobutane only.
uses of naphthalene, phenanthrene,
their derivatives.
strain theory. CoLrlson and
strainless rines)- reactions of
l0 Hours
l0 Hours
l0 Hours
05 H<lurs
UNIT-VIFats and Oils - Hydrolysis, Hydrogenation, Saponiflcation and Rancidity of oils.
02
Hou rs
Note: The weight age of topics while setting SPPU university Question paper should be
proportionate to the teaching hours allotted.
Recommended Books
L Morrison, R. T. & Boyd, R. D., Textbook of Organic Chemistry, VI (ed,) ELBS, London,
1996
2. Pine, S. H, Organic Chemistry, V, Tata McGraw Hill, New Delhi, 2003
3. Finar, I. L., Organic Chemistry Vot. [, V (ed.), ELBS, Pearson Education, New Delhi, 2003
4. Joule and Mills, Heterocyclic Chemistry, IV (ed.), Blackwel Publishing House, Oxford, UK,
5. 2004
6. Li, J. J., Name Reactions, III (ed.), Springer, Berlin, 2006
7. Stereochemistry of Organic Compound Principles and Applications by' Nasipuri. Revised
Edition. New Age International Publishers.
8. Stereochemistrl, 6or'1-ormation and Mechanism by P.S. Kalsi, 718d2008, New Age International
Publishers, Neiv Delhi.
9. Furniss, B. S., Hannaford, A. J. Smith, P. W. G., and Tatchel, A. R., "Vogel's Textbook ofPractical Organic Chemistry", V (ed,), Pearson, London, 1994
10. Finar, L L., Organic Chemistry Vol. I, V (ed.), ELBS, Pearson Education, New Delhi, 2003
11. Mann, F. C. and Saunders, B. C., Practical Organic Chemistry, IV(ed.), Pearson, UK,2009
I am forwarding you the minutes of meeting of BOS held on 8th April.
lam also forwardino vou draft of revised M.Pharm Svllabus (modern Pharmaceutics, andPractical for term ll)'for your kind perusal. I have highlighted ihe changes in yellow. Please shareyour opinion.
lhave mailed Dr. Shilpa chaudhari mam, the examination reforms (Bloom's taxonomy)suggested
byA|CTE and adopted by our institute.
In case of any corrections in the syllabus, please share your opinion.
Thanks and Regards,
Dr. Sanjeevani Deshkar
Asso. Professor
D epartment of Pharmaceutics
Dr. D.Y Patil Institute of Pharmaceutical Sciences & Research,
Pimpri, Pune
Minutes of Meeting BOS Pharmaceutics.docx
17.9k8
MODERN PHARMACEUTICS revised syllabus.docx
1 7.1 kB
PHARMACEUTICS PRACTICALS Sem ll revised syllabus.docx
15.2kB
Dr D .,iglh'[:l+ra'mffi
i;F#HJY[?,.J,"nPfmpri, pune+tid'tb*.a
R.eVrsFL SI/LAR
MODERN PHARMACEUTICS(MPH 103T)
Scope
Course designed to impart advanced knowledge and skills required to learnvarious aspects and concepts at pharmaceutical industries
Objectives
Upon completion of the course, student shall be able to understando The elements ofpreformulation studies.o The Active Pharmaceutical Ingredients and Generic drug Product
development
. Industrial Management and GMp considdrations.
. optimization Techniques & pilot plant Scale Up Techniques
. Stability Testing, steilization process & packaging of dosageforms.
THEORY 60 HRS
1. a. Preformation Concepts - Drug Excipient interactions - different methods,kinetics of stability, Stability testing. Theories of dispersion and pharmaceuticalDispersion (Emulsion and Suspension, SMEDDS| preparation and stability.Latge and small volume parental -physiological and formulation consideration,Manufacturing and evaluation. 12 Hrs
b. Optimization techniques in Pharmaceutical Formulation: Concept andparameters of optimization, Optimization techniques in pharmaceuticalformulation and processing. Statistical design, Response surface method,Contour designs, Factorial designs and application in formulation . l0 Hrs
3 cGMP & Industrial Management: Objectives and policies of current goodmanufacturing practices, layout of buildings, services, equipments and theirmaintenance Prbductitn' management: Production orgini)ation, materialsmanagement, handling and transportation, inventory management and control,production and planning control, Sales forecasting, budget and cost control,industrial and personal relationship. Concept of Total Quality Management.
Hrs
10 Hrs
4 Compression and compaction: Physics of tablet compression, compression,
consolidati_gn,__-effect of friction, distribution of forces, compaction profiles,
s o&W-iA 1o Hrs
5 Diffusion parameters, Dissolution parameters and Pharmacokinetic
parameters, , Similarity factors - fZ and fL, Disol.^
Higuchi, Peppas plot, zero order, first order and Hixson
06 HrsREFERENCES
1. Theory and Practice of Industrial Pharmacy By Lachmann and Libermann2.Pharmaceutical dosage forms: Tablets Vol. 1-3 by Leon Lachmann
3. Pharmaceutical Dosage forms: Disperse systems, Yol,l-2; By LeonLachmann.