Sudden Death and Sickle Cell Trait: How Knowing Your Genes Can Save Your Life Dale Lloyd II, No. 39. (The Rice Football Webletter) 2006 After running 16 consecutive sprints of 100 yards each, he collapsed. He died the next day from acute exertional rhabdomyolysis (ER) associated with a genetic condition called sickle cell trait. Learning Set 4 : Lesson 1 : Slide 1
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Sudden Death and Sickle Cell Trait: How Knowing Your Genes Can Save Your Life Dale Lloyd II, No. 39. (The Rice Football Webletter) 2006 After running 16.
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Sudden Death and Sickle Cell Trait: How Knowing Your Genes Can Save Your Life
Dale Lloyd II, No. 39. (The Rice Football Webletter)
2006
After running 16 consecutive sprints of 100 yards each, he collapsed.He died the next day from acute exertional rhabdomyolysis (ER) associated with a genetic condition called sickle cell trait.
Electrophoresis of Sickling and Non Sickling Hemoglobin
Learning Set 4 : Lesson 2 : Slide 8
Electrophoresis of Sickling and Non Sickling Hemoglobin
Chromosome 11
Learning Set 4 : Lesson 2 : Slide 9
Chromosomal Location of Hemoglobin
Learning Set 4 : Lesson 2 : Slide 10
Mutation found in Hemoglobin
Learning Set 4 : Lesson 2 : Slide 11
Mutation found in Hemoglobin
• Charge– Positive and negative charged amino
acids attract each other– Amino acids with the same kind of charge
repel each other• Hydrophobicity
– Hydrophilic amino acids attract water– Hydrophobic amino acids repel water and
hydrophilic amino acids– Hydrophobic amino acids attract other
hydrophobic amino acids.• Cysteines
– Cysteines are a type of amino acid. When two Cysteines are next to each other they attract and form a strong bond. These strong bonds contribute to protein shape formation.
Red = positive charge (+)K, R, H
Yellow = negative charge (-)D, E
Green = hydrophobicA, V, L, I, P, M, F, W
Blue = hydrophilicG, S, T, N, Q, Y
White = cystine C
Learning Set 4 : Lesson 2 : Slide 12
“Rules” that amino acids follow
Learning Set 4 : Lesson 2 : Slide 13
Sickle Cell Hemoglobins Stick Together
Learning Set 4 : Lesson 2 : Slide 14
Electrophoresis of Sickling and Non Sickling Hemoglobin