Page 1
8092
8092
8092
8092
8071
8071
8078
8078
8067
8067
8069
8067
8070
8067
8070
8092
8092
8092
8091
8091
8091
ABS -AMI
8080
8080
8079
8094
8094
8094
8094
8094
8086
8086
8086
8086
8086
8086
8086
8086
8086
8086
8086
8086
8064
8064
8064
8064
8064
8064
8064
8064
8064
8064
8064
8064
8095
8095
8073
8073
8057
8057
8057
8057
8057
8088
8088
8054
8054
8054
8080
8068
8080
8080
8068
8080
SUBJECT INDEX
S-i
ABSORPTION
acetylsalicylic acid
gastrointestinal tract
mephenesin influence
sodium salicylate
ACETAZOLAMIDE
anticonvulsant potency
maximal electroshock seizure
ACETYLCHOLINE
atropine inhibition
8070
heart contractile force
high energy phosphates
intestinal motility
intraarterial injection
8069 8070
mammalian striated muscle
mesenteric reflexes
myotonic goat muscle
reflex apnea
super sensitivity
ACETYLSA.LICYLIC ACID
gastrointestinal absorption
mephene sin
plasma salicylate levels
ACTH
abstinence response
human subjects
morphine addiction
urinary 17-ketosteroid
elevation
ADENINE NUCLEOTIDES
heart contractile force
heart muscle content
isolated guinea pig atrium
ADRENA.LECTOMYblood pressure
cardiac arrhythmia
cigarette smoke
denervated nictitating
membrane
Su-4029
LADRENERGIC BLOCKADE
dibenamine
dichloroi soproterenol
i soproterenol vasodepressor
effect
phentolamine
positive chronotropic effects
positive inotropic effects
Su-4029 antagonism
sympathomimetic amines
ADRENERGIC BLOCKING AGENTS
dichloroi soproterenol
mammalian heart
tetrazotized diorthoanisidine
(TDA)
AJMALINE
atrial fibrillation
A-V transmission
bradycardia
8069 functional refractory period
heart-lung preparation
ALCOHOLabrupt cessation
abstinence eLfects
anticonvulsant properties
anticonvulsant tests
chronic administration
CNS depression
hyperexcitabi lity
MES patterns
neurotoxici ty
physical dependence
protective index
seizure thresholds
ALCOHOL, ALLYL
action mechanism
blood concentration
hemoconcentrat ion
hypot ension
metabolism
8091 microquantitation method
oxygen uptake
8078 pharmacodynamics
8078 plasma histamine
8078 tissue slices
tissue swelling
toxicity
ALPHA-LOBELINK
cross-circulation
ventilatory response
8068 ALPHAPRODINE
8068 intestinal motility
leval lorphan antagonism
8068 ALSEROXYLON
8080 antiarrhythmic effect
atrial flutter
auricular fibrillation
quinidine-like activity
ventricular tachycardia
AMINE OXIDASE
hog kidney cortex
mescaline degradation
Page 2
8088
8088
8088
80938093
8093
8093
8071
8071
8070
8069
8069
8077
8069
8069
8069
8070
8069
8070
8060
3073
8073
8085
8073
8073
8073
8073
8085
8084
8085
8085
8073
8060
8060
8062
8062
8062
8062
8062
8062
8062
8062
8078
8078
8078
8078
8057
8057
8052
8052
8071
8071
8072
8071
8072
8072
8072
8072
8072
8072
8072
8072
8072
8097
8097
8097
8081
8081
8057
8057
8069
8059
8053
8069
8070
8069
AMI-ATR
SUBJECT INDEX
VOL. 124
5-2
rabbit liver microsomes
rabbit liver mitochondria
sheep plasma
2 -AMINO-4-2-CRLOROANILINO-
s-TRIAZINE
diuretic effects
electrolyte excretion
intravenous administration
water excretion
AMMONIUM CHLORIDE
anticonvulsant augmenting
effect
maximal electroshock seizure
ANALGESIC -ANTAGONISTS
analgesics
intestinal motility
ANALGESICS
antagonistic drugs
antagoni St S
denervated intestinal ioops
human subjects
innervated intestinal loops
intestinal loop tone
intestinal motility
intestinal segments
morphine
new morphine derivatives
normorphi ne
postoperative pain
sedative potency
testing method
tremorine
ANAPHYLAXIS
acetylcholine response
antibody-containing cells
histamine response
nonsensitized guinea pigs
nonspecific antigen
organ responses in vitro
sensitized guinea pigs
specific antigen
ANOXIA
heart contractile force
heart muscle
high energy phosphate
isolated guinea pig atria
ANTIARRHYTHMICS
ataraxic agents
quinidine-like activity
ANTIBIOTICS
biological disposition
streptovaricin
ANTICHOLINESTERASES
atropine block
atropine inhibition
DFP
8070
enzymatic production
eserine
8070
intraarterial injection
8070
mammalian striated muscle
myotonia congeni ta
organic thiophosphate
conversion 8077
8073 sarin
8073 skeletal muscle
ANTICONVULSANTS
alcohol 8086
carbonic anhydrase
inhibitors
di phenylhydantoin
8072 8086
initial seizure severity
maximal electroshock seizure
mephobarbi tal
MES test
me santoin
paramethadi one
phenacemi de
phenobarbi tal
recovery time
seizure duration
trimethadione
8086
ANTIHISTAMINICS
chiorpheni ramine
comparative study
optical isomers
ARTERIES, RENAL
renal blood flow
sympathomimetic drug
inj ect ions
ATARAXIC AGENTS
antiarrhythmic effect
quinidine-like activity
ATROPINE
acetylcholine response
dibromopyruvic acid
DMPP vascular responses
extraocular muscle
goat skeletal muscle
intraarterial injection
8070
Page 3
8069
8070
8069
8069
8070
8053
8053
8053
8053
8053
8053
8053
8057
8057
8057
8057
8057
8057
8057
8077
8077
8077
8077
ATR-BRA
8081
8074
8074
8074
8053
8081
8081
8053
8074
8079
8097
8054
8064
8053
8053
8053
8080
8079
8097
8054
8059
8080
8053
8063
8063
8063
8063
8075
8075
8075
8075
8075
8053
8074
8053
8074
8053
8053
8074
8059
8053
8079
8097
8067
8059
8059
8084
8058
8053
8054
8081
8079
8079
8053
8089
8089
8076
8076
SUF,JECT INDEX
S -3
1958
mammalian striated muscle
myotonia congenita
nerve stimulation
neuromuscular transmission
relaxation time
ThA vascular responses
AUTONOMIC BLOCKING AGENTS
DMPP vascular actions
TMA vascular actions
AUTONOMIC NERVOUS SYSTEM
DMPP
ganglionic stimulation
peripheral stimulation
TMA
BENACTYZINE
antiarrhythmic effect
antiveratrinic activity
atrial flutter
auricular fibrillation
quinidine-like activity
toxicity
ventricular tachycardia
BENZOTRIAZINE DITHIOPHOSPHORIC
ACID (GUTHION)
anticholinesterase formation
enzymatic oxidation
methylcholanthrene
pretreatment
rat liver microsomes
toxicity
BIOASSAY
minimum error table
parallel line
percent potency estimate
precision level
BISHYDROXYCOUMARIN
hemorrhagic necrosi s
menadione treatment
myocardial damage
vitamin E treatment
vitamin Kl treatment
BLOOD FLOW
atropine pretreatment
cardiac output fractionation
DMPP
estrogens
femoral artery
hexamethonium pretreatment
intestine
intraarterial injection
isotope tracer technique
kidney
ovariectomized rats
phentolamine pretreatment
renal vascular bed
sympathomimetic amines
TMA
uterus
BLOOD PRESSURE
acetyicholine depressor
response
acetyicholine response
adrenal ectomy
allyl alcohol hypotension
atropine pretreatment
azapetine pretreatment
biphasic response
cardiac sympathetic nerve
stimulation
carotid occlusion
chlorpheniramine optical
isomers
cigarette smoke
dibromopyruvic acid
dichloroi soproterenol
DMPP
8097
epinephrine response 8059
8097
hexamethonium influence
8077 hexamethonium pretreatment
histamine depressor response
histamine response
intraarterial veratridine
levarterenol response
mecamylamine influence
new morphine derivatives
nore thandrol one
phentolamine pretreatment
pressor response
renal blood flow
sympathornimetic amines
8080 8081
TDA adrenergic blockade
TNA
BRAIN
choline retention
DMAE retention
iproniazid administration
iproniazid concentration
Page 4
8076
8083
8083
8089
8061
8061
8061
8061
8061
8061
8061
8098
8098
8098
VOL. 124
8066
8078
8078
8066
8067
8068
8054
8054
8054
8059
8067
8059
8054
8067
8067
8084
8058
8058
8059
8068
8054
8058
8067
8080
8078
8078
8080
force 8080
8095
8095
8095
8087
8087
8087
8087
8087
8087
8087
8087
8087
8087
8087
8087
8087
8087
8087
8082
8082
8082
8082
8082
8097
8059
8050
8059
8059
8097
8087
8087
8087
8068
8068
SUBJECT INDEX
S -4
BRA-CHL
isonicotinic acid
concentration
morphine concentration
morphine tolerance
tracer studies
BRAIN STEM
chl orproma zi ne
evoked potentials
latency
medial reticular formation
pentobarbital
recovery cycle
sciatic nerve stimulation
1 -n-BUTYLAMINO-3 -�-TOLUIDINO-
2-PROPANOL (W-l8l)
convulsion dosage
correlation values
mortality dosage
CALCIUMdichloroi soproterenol
heart contractile force
high energy phosphates
isolated rabbit heart
ventricular contractile
CARBON DIOXIDE
C02 57.-O2 95% inhalation
cross-circulation
ventilatory response
CARBON TETRACHLORIDE
choline oxidation in vitro
DPN
DPN-linked dehydrogenases
enzymatic changes
8 -hydroxyquinoline
inhibitory action
liver function
liver mitochondria
magnesium ATP-ase activation
magnesium- di sodium versene
oxidative activity
oxidative phosphorylation
serum GOT activity
tissue cation concentrations
versene protective action
CARBONIC A.NHYDRASE
anticonvulsant inhibitors
brain inhibitor
concentration
plasma inhibitor
concentration
CARDIAC GLYCOSIDES
di gi toxin
heart contractile force
high energy phosphates
intracellular distribution
CARDIOVASCULAR SYSTEM
acetylcholine
alp�ha receptor substance
blood pressure
8059
cardiac oxygen utilization
cigarette smoke
dibromopyruvic acid
1-epinephrine
heart rate
hemodynami c changes
intraarterial injection
mesenteric reflexes
6-methyl enedihydro-
de soxymorphine
norethandrol one
progesterone
pulse pressure
Su -40 29
TEA pretreatment
testosterone
veratridine
CATECHOL AMINE S
cardiac depletion 8082
ephedrine cardioaccelerator
action
heart-lung preparation
reserpine antiaccelerator
action
reserpine pretreatment
veratramine
CENTRAL NERVOUS SYSTEM
atropine 8059
chlorpheniramine optical
isomers
EEG activation
levorphanol depression
mephene sin
patellar reflex
stimulant effects
CHELATING AGENTS
carbon tetrachloride
8071 enzymatic changes
liver function
8071 CHLORISONDAMINE
ganglionic blockade
8071 Su-4029 pressor response
Page 5
8097
8097
8097
8097
8097
8097
8068
8068
8059
8059
8059
8059
8059
8059
8059
8059
8059
8059
8059
8059
8059
8059
8059
8059
8080
8080
8080
8080
8080
8080
force 8080
8077
8077
8061
8061
8061
8061
8087
8087
8087
8087
8087
8089
8089
8089
8089
8089
8089
8054
8054
8086
8072
8098
8098
8072
8098
8072
8086
8086
8072
8098
8066
8066
8065
8066
8065
8066
8066
8080
8080
8073
8073
1958
SUBJECT INDEX
S-5
CHLORPHENIRAMINE
aerosolized histamine
comparative pharmacology
intravenous histamine
optical isomers
oral antihistamine activity
oral toxicity
therapeutic index
CHLORPROMAZINE
evoked potentials
midbrain reticular formation
recovery cycle
sciatic nerve stimulation
CHOLINE
carbon tetrachloride
chelating agents
liver function
oxidase stimulation
oxidation in vitro
CHOLINE-l,2 �T4comparative distribution
dimethylaminoethanol-l,2 Cl4
radioactivity recovery
CHOLINE -METHYL -C14
comparative distribution
dimethylaminoethanol-l ,2 Cl4
radioactivity recovery
CIGARETTE SMOKE
cardiac oxygen utilization
hemodynatnic changes
CONVULSIONS
alcohol
anti convul sant s
dosage changes
drug-induced
MES test
mortality correlation
postictal recovery time
seizure patterns
seizure thresholds
tonic-clonic seizures
vital functions
CORONARY BLOOD FLOW
cigarette smoke
CROSS -C IRCULATION
succinylcholine
ventilatory response
CYANIDE
intraarterial injection
mesenteric reflexes
CHL-DIH
DIBENAMINE
epinephrine pressor response 8068
dl-norepinephrine pressor
response
Su -4029
DIBROMOPYRUVIC ACID
action sites
8097 analgesia
atropine
blood pressure
cardiovascular system
central actions
cholinergic effects
ECG
EEC
EMG
mephenesin antagonism
nerve muscle preparation
patellar reflex
peripheral actions
smooth muscle
toxicity
DICHLOROISOPROTERENOL (DCI)
blood pressure
cardiac adrenergic blockade
cardiac sympathetic nerve
stimulation
heart rate
isolated rabbit heart
syinpathomimetic amines
ventricular contractile
DIETHYLSTILBE STROL
enzyme activity
rat liver microsomes
thiophosphate oxidation 8077
DIGITOXIN
binding distribution in vitro 8066
blood levels 8066
intracellular distribution
in vivo
met aboli te s
radioactive
radioisotopic tracers
8054 serum protein binding
subcellular localization
8095 tissue slices
8095 DICOXIN
dichloroi soproterenol
8067 positive inotropic effect
8067 DIHYDROCODEINEintestinal motility
levallorphan antagonism
Page 6
VOL. 124
8072
8086
8072
8086
8064
8088
8077
8087
8087
8087
8087
8064
8077
8051
8087
8088
8087
8087
8051
8087
8077
8088
8064
8091
8091
8082
8082
8080
8082
8082
8082
8080
8080
8080
8080
8079
8078
8078
8067
8067
8079
8080
8080
8074
SUBJECT INDEX
S -6
DIM-EST
DIMETHYLAMINOETHANOL-1 ,2 C14
brain fractions
choline precursor
choline-l,2 C14
choline-methyl -C14
comparative tissue
distribution
liver fractions
protein methionine
radioactivity recovery
respiratory carbon dioxide
urinary excretion
1,1 -DIMETHYL-4-PHENYLPIPER-
AZINIUM (DNPP)
atropine pretreatment
autonomic ganglionic
stimulation
comparative study
hexamethonium pretreatment
hind limb denervation
local vasodilatation
peripheral localization
phentolamine pretreatment
TMA
vascular actions
DIPHENYLHYDANTOIN
ammonium chloride
pretreatment
anticonvulsant action
hyponatremia
maximal electroshock seizure
repeated oral administration
reserpine pretreatment
sodium chloride pretreatment
DIURETICS
formoguanami ne
related s-triazines
ELECTROCARDIOGRAM
cigarette smoke
norethandrolone
ELECTROMYOGRAM
atropine inhibition
myotonic goat muscle
ELECTROSHOCK
alcohol
anti convulsant s
carbonic anhydrase inhibitors
diphenylhydantoin
maximal electroshock seizures
maximal seizure pattern
8089 MES patterns
8089 recovery time
8089 seizure threshold
8089 ENZYMES
allyl alcohol
8089 amine oxidases
8089 anticholinesterase formation
8089 ATP-ase activation
8089 carbon tetrachloride
8089 chelating agents
8089 DPN-linked dehydrogenases
liver dehydrogenases
liver microsomal system
8053 liver microsomes
liver mitochondria
8053 mescaline degradation
8053 oxidative activity
8053 oxidative phosphorylation
8053 papaverine metabolism
8053 serum GOT activity
8053 thiophosphate oxidation
8053 tissue preparations
8053 tissue slices
8053 EOSINOPENIA
human subjects
morphine abstinence
8071 EPHEDRINE
8071 cardiac catechol amine
8071 depletion
8071 cardioaccelerator action
8071 dichloroisoproterenol
8071 heart-lung preparation
8071 reserpine antagonism
reserpine pretreatment
8093 sympathomimetic amines
8093 ventricular contractile force
1 -EPINEPHRINE
- dichloro analogue (DCE)
8054 dichloroisoproterenol
8058 epinephrine-reversal
heart contractile force
8070 high energy phosphates
8070 intraarterial injection
mesenteric reflexes
8086 TDA adrenergic blockade
8072 vasopressor effect
8071 ventricular contractile force
8071 ESTROGENS
8071 ethinyl estradiol
Page 7
EST-HEA
8074
8074
8074
8074
8074
8074
8077
8077
8077
8087
8087
8087
8087
8087
8087
8087
8087
8087
8093
8093
8093
8093
8091
8091
8091
8080
8054
8054
8054
8082
8054
8054
8058
8054
8054
8054
�082
8054
8080
8080
8080
8054
8054
8080
8082
8057
8057
8058
8058
8058
8058
8058
8057
8057
8058
8058
8082
8058
8080
8059
8082
8082
8058
8080
8058
8058
8094
8082
8054
8054
8080
8054
8054
8054
8054
8082
8054
1958SUBJECT INDEX
S-7
intestinal blood flow
isotope tracer technique
ovariectomized rats
renal blood flow
“specific tissue activities”
uterine blood flow
ETHIONINE
liver thiophosphate-oxidizing
enzyme
methylcholanthrene response
thiophosphate susceptibility
ETHYLENEDIAMINE TETRAACETATE
ATP-ase activation
carbon tetrachloride
DPN-linked dehydrogenases
liver mitochondrial function
oxidative activity
oxidative phosphorylation
protective action
serum GOT activity
tissue cation concentrations
FORNOGUANAMINE
diuretic effects
related s-triazines
sodium excretion
water excretion
GONADOTROPIN, CHORIONIC
abstinence response
human subjects
morphine addiction
urinary 17-ketosteroid
elevation
HEART
adrenal denervation
adrenalectomy
adrenergic receptors
arrhythmia
atropine pretreatment
cardiac output
cardiac work
catechol amine depletion
cigarette smoke
coronary A-V oxygen
difference
coronary blood flow
dichloroi soproterenol
dynamics
ECG
ectopic ventricular systoles
negative chronotropic effects
nicotine
nodal rhythm
nore thandrolone
oxygen utilization
piperoxan pretreatment
rate
8058
re serpine
sinus bradycardia
specific adrenergic blockade
sympathetic nerve stimulation
sympathomimetic atnines
“tobacco angina pectoris”
vagotomy
ventricular contractile force
verat rami ne
HEART ARRHYTHMIA
antiarrhythmic effects
ataraxic agents
auricular flutter
coronary ligation
norethandrolone reversion
procaine amide
progesterone reversion
quini dinerefractory period
testosterone reversion
ventricular origin
HEART, ISOLATED
catechol amine depletion
8091 contractile force
8059
DCI adrenergic blockade
dibromopyruvic acid
ephedrine cardioaccelerator
action
heart-lung preparation
8094
nore thandrol one
perfused rabbit heart
progesterone
rate
8059 8094
rauwolfia alkaloids
8054 reserpine antiaccelerator
8054 action
Page 8
8082
8058
VOL. 124
8078
8078
8055
8055
8078
8078
8078
8055
8075
8068
8068
8068
8068
8068
8068
8068
8068
8068
8068
8068
8055
8075
8078
8055
8078
8075
8055
8055
8055
8078
8078
8055
8075
8068
8068
8068
8068
8068
8064
8053
8064
8064
8064
8053
8087
8087
8087
8096
8080
8082
8082
8096
8094
8096
8082
8082
8080
8080
8062
8062
8067
8073
8073
8073
8073
8097
8073
8073
8073
8097
SUBJECT INDEX
S-8
HEA-INT
reserpine pretreatment
rhythm
8059
sympathomimetic amines
testosterone
HEART MUSCLE
adenine nucleotides
anoxia
ATP concentration
calcium concentration
cardiac depressants
cardiac stimulants
contractile force
contraction
dicumarol-induced lesions
ethylenediaminetetraacetic
acid (EDTA)
glycerinated myocardial
fibers
hemorrhagic necrosis
high energy phosphates
ionic strength
isolated guinea pig atria
menadione treatment
pH
potassium ion
sodium ion
spontaneous failure
stimulation frequency
tension generation
vitamin K1 treatment
HEART RATE
cardiac catechol amine
depletion
cardiac norepinephrine
depletion
dichloroi soproterenol
ephedrine accelerator action
heart -lung preparation
8094 8096
hexamethonium influence
rauwolfia alkaloids
reserpine acceleration
reserpine antiaccelerator
potency
reserpine pretreatment
sympathomimetic amines
theophyl line
HEXAHYDRO-l -AZEPINEPROPION-
AMIDOXINE (SU-4029)
action mechanisms
adrenal ect omy
alpha receptor substance
amphetamine pressor response
8080 blocking effects
8058 cardiovascular system
chlori sondamine
C-O pressor response
denervated nictitating
membrane
dibenamine
epinephrine pressor response
iproniazid pretreatment
isopropylarterenol depressor
action 8068
dl-norepinephrine pressor
response
8055 phentolamine
pressor action
sympathomimetic pressor
amine s
tyramine pressor response
HEXAMETHONIUM
allyl alcoholDMPP vascular responses
oxygen uptake
protective action
tissue slices
TMA vascular responses
HYDROCARBONS, HALOGENATED
chelating agents
enzymatic changes
liver function
1-3 -HYDROXY-N-ALLYLMORPHINAN
8082 (LEVALLORPHAN)
metabolic fate 8090
ILEUN
antigen reactions in vitro
sensitized guinea pigs
INTESTINAL MOTILITY
acetylcholine
analgesic -antagoni sts
analgesicsat ropine
barium response
chlorpheniramine optical
isomers
DMPP
hexame thoni urn
8068 histamine response
histamine spasm
Page 9
INT-LEV
8073
8067
8067
8073
8084
8067
8073
8067
8067
8067
8074
8074
8074
8074
8076
8076
8076
8076
8076
8076
8076
8076
8076
8079
8068
8080
8080
8067
8081
8080
8067
8081
8081
8081
8068
8079
8080
force 8080
8064
8074
8088
8074
8081
8074
8081
8088
8074
8064
8081
8088
8064
8081
8090
8090
8090
8090
8073
8073
8090
8090
8090
8090
8090
8080
8080
8080
8078
8078
8081
8081
8081
8079
8080
8073
8073
8050
8050
8050
8050
8050
8050
8091
8091
8091
8091
8091
8091
8091
1958
SUBJECT INDEX
S-9
“intestinal bio-dialysate”
intraarterial injection
mesenteric reflexes
methacholine response
new morphine derivatives
reflex inhibition
serotonin response
splanchnic nerve section
vagotomy
verat ri dine
INTESTINE
blood flow
estrogens
isotope tracer technique
ovariectomized rats
IPRONIAZID
action mechanism
isonicotinic acid formation
nietaboli sm
monoamine oxidase activity
plasma levels
rat tissue distribution
ISONICOTINIC ACID
iproniazid metabolite
plasma levels
tissue distribution
ISOPROTERENOL
depressor potenUation
depressor response
dichloro analogue (DCI)
dichloroi soproterenol
intraarterial injection
intravenous injection
isolated rabbit heart
mesenteric reflexes
renal artery injection
renal blood flow
renal vasodilator action
Su-4029 augmentation
TDA adrenergic blockade
vasodepressor effect
ventricular contractile
17 -KETOSTEROID
abstinence response
ACTH effect
eosinophil count
gortadotropin effect
human subjects
morphine addiction
urinary excretion
KIDNEY
allyl alcohol
blood flow
diamine oxidase
estrogens
intraarterial injection
isotope tracer technique
local action
mescaline degradation
ovariectomized rats
oxygen uptake
sympathomimetic amines
tissue preparations
tissue slices
vasomotor responses
LEVALLORPHAN
chromatographic fractionation
conjugation
3-hydroxymorphinan formation
infrared absorption spectra
intestinal motility
1 evorphan
metabolic disposition
metabolism in vitro
metabol i te s
tissue slices
urinary excretion
LEVARTERENOL
blood pressure
8081
dichloro analogue (DCNE)
dichloroi soproterenol
blockade
heart contractile force
high energy phosphates
renal artery injection
renal blood flow
renal vasoconstrictor action
TDA adrenergic blockade
ventricular contractile force
LEVORPHAN
intestinal motility
levallorphan antagonism
LEVORPHANOL
biological disposition
CNS depression
C14O2 elimination
conj ugation
distribution
estimation
Page 10
myocardi ti s
absorption
8050
8050
8050
8050
8077
8064
8088
8077
8077
8088
8077
8077
8077
8064
8077
8076
8076
8076
8076
8088
8051
8088
8088
8064
8051
8077
8064
8077
8077
VOL. 124
8075
8075
8092
8057
8057
8057
8057
8088
8088
8088
8088
8088
8071
8071
8071
8071
8071
8071
8071
8071
8071
8071
8077
8077
8077
8077
8084
8084
8084
carbonic anhydrase inhibitor
maximal electroshock seizure
repeated oral administration
reserpine pretreatment
sodium chloride pretreatment
3 -METHYLCHOLANTHRENE
ethione pretreatment
liver thiophosphate-oxidizing
enzyme
protein-free diet
thiophosphate susceptibility
6 -METHYLDIHYDRODESOXYMORPHINE
acute toxicity
analgesia
8064 C-I motility
6 -METHYLENEDIHYDRODESOXYMORPHINE
acute toxicity 8084
8084
8084
8084
8084
8084
8084
8084
8087
8087
8087
8087
8087
8087
8087
8087
8087
8087
8087
8084
8084
SUBJECT INDEX
S-10
LEV -MET
excretion
N-C14 methyl
plasma levels
synthesis
LIVER
age influence
allyl alcohol
amine degradation
carcinogenic hydrocarbons
castrated animals
diamine oxidase
enzyme activity
enzyme synthesis
guthion toxicity
hexamethonium protection
hormone-treated animals
iproniazid administration
iproniazid concentration
isonicotinic acid
concentration
MAO inhibition
mescaline oxidase
microsomal enzyme system
microsomal fractions
mitochondrial fractions
oxygen uptake
papaverine metabolism
partial hepatectorny
phenoxybenzamine protection
protein-free diet
rat liver microsomes
thiophosphate-oxidizing
enzyme
tissue preparations
tissue slices
water content
LIVER DAMAGE
allyl alcohol
LIVER FUNCTION
carbon tetrachloride
inhibition
choline oxidation
DPN
DPN-linked dehydrogenases
fatty infiltration
8 -hydroxyquinoline
magnesium-disodium versene
mi tochondria
oxidative activity
oxidative phosphorylationversene treatment
8077
8088
8064
8064
MENAD lONE
dicumarol -induced
protective action
MEPHENESIN
sodium salicylate
MEPROBAMATE
antiarrhythmic effect
antiveratrinic activity
toxicity
ventricular tachycardia
MESCALINE
amine oxidases
inhibitor pattern
oxidative deamination
tissue preparations
vertebrate species
METHAZOLAMIDE
absorption
ammonium chloride
pretreatment
anticonvulsant action
seizure spread
seizure threshold
anal gesia
cardiovasctilar effect
C-I motility
hypothermia
mi osis
nalorphine reversal
sedation
6 -METHYL -7 -HYDROXYDIHYDRO-
DESOXYMORPHINE
acute toxicity
analgesia
Page 11
8084
8084
8084
8076
8076
8076
8084
8083
8084
8083
8083
8085
8073
8073
8084
8085
8084
8085
8084
8083
8083
8083
8091
8091
8091
8091
8091
MET-NIC
8070
8056
8059
8059
8059
8069
8056
8059
8070
8069
8056
8056
8059
8059
8059
8059
8059
8059
8084
8073
8084
8073
8052
8069
8069
8069
8054
8054
8054
8098
8098
8054
8067
8067
8067
8098
8067
8068
8068
8068
8084
8084
8084
8070
8069
8070
8059
8070
8069
8059
8069
8070
8069
1958
SUBJECT INDEX
S-ll
C-I motility
6 -METHYLMORPHINE
acute toxicity
analgesia
C-I motility
MONOAMINE OXIDASE
iproniazid
iproniazid metabolism
persistent inhibition
MORPHINE
acute toxicity
analytical method
blood pressure
brain concentration
conj ugat ion
human subjects
intestinal motility
8084
nalorphine antagonism
new derivatives
normorphine comparison
pharmacological studies
postoperative pain
respiratory minute volume
respiratory rate
tissue distribution
tolerance
MORPHINE ADDICTION
abstinence response
ACTH effect
eosinophil count
gonadotropin effect
human subjects
urinary l7-ketosteroid
depression
MORPHINONE
acute toxicity
analgesia
C-I motility
MUSCLE, SKELETAL
acetylcholine
acetyicholine response
action potentials
antagonism
anticholinesterase
potentiation
anticholinesterases
atropine
atropine block
atropine inhibition
cholinergic responses
8084 cholinesterase levels
CO2-bicarbonate medium
denervat ion
dibromopyruvic acid
EMC
intraarterial injection
8070
isolated rat diaphragm
mephene sin
myotonic goat muscle
nerve stimulation
8070
resting potential
tempeure
MUSCLE, SMOOTH
acetylchol me
atropine antagonism
dibromopyruvic acid
intestinal motility
isolated rabbit ileum
neostigmine
NALORPHINE
antagonistic action
intestinal motility
6-methyl enedihydro-
de soxymorphine
morphine
NEPHRECTOMY
streptovaricin elimination
NEUROMUSCULAR JUNCTION
acetylcholine response
atropine inhibition
8091 intraarterial injection
NICOTINE
cardiac arrhythmia
cardiac dynamics
cardiac oxygen utilization
convulsion dosage
correlation values
ECCintestinal motility
intraarterial injection
mesenteric reflexes
mortality dosage
reflex apnea
NICTITATING MEMBRANE
acute denervation
adrenal ectomy
chronic denervation
Page 12
VOL. 124
8061
8061
8061
8086
8098
8098
8098
8086
8086
8086
8086
8086
8086
8064
8064
8064
8064
8053
8068
8068
8068
8053
8078
8078
8078
8088
8092
8076
8076
8076
8092
8088
8092
8078
8078
8058
8058
8058
8058
8077
8077
SUBJECT INDEX
S -12
NIC -PRO
phentolamine
Su -40 29
NOREPINEPHRINE
cardiac depletion
reserpine
dl-NOREPINEPHRINE
dibenamine blockade
phentolamine blockade
pressor action
Su-4029
NORETHANDROLONE
blood pressure
cardiovascular effects
ECG
eurhythmic potency
NORMORPHINE
analgesic potency
human subjects
morphine comparison
postoperative pain
OUABAIN
dichloroi soproterenol
isolated rabbit heart
positive inotropic effect
OXYGEN CONSUMPTION
allyl alcohol
tissue slices
OXYGEN CONSUMPTION, CARDIAC
cardiovascular hemodynamics
cigarette smoke
ECG
nicotine
PAPAVERINE
absorption
enzymatic transformation
estimation
excretion
glucuronide conjugation
human subjects
mammalian species
metabolic fate
phenolic metabolites
physiological disposition
plasma levels
tissue distribution
PENTOBARBITAL
evoked potentials
8068 midbrain reticular formation
8068 recovery cycle
sciatic nerve stimulation
8096 PENTYLENETETRAZOL
8096 alcohol
convulsion dosage
8068 correlation values
8068 mortality dosage
8068 seizure threshold
8068 PHENOBARBITAL
alcohol compari son
8058 anticonvulsant potency
8058 anticonvulsant tests
8058 neurotoxicity
8058 protective index
PHENOXYBENZAMINE
8085 allyl alcohol
8085 oxygen uptake
8085 protective action
8085 tissue slices
PHENTOLAMINE
DMPP vascular responses
epinephrine pressor response
8080 dl-norepinephrine pressor
8080 response
8080 Su-4029 antagonism
TMA vascular responses
8064 PHOSPHATES, ENERGY-RICH
8064 heart contractile force
heart muscle content
8054 isolated guinea pig atria
8054 PLASMA
8054 amine oxidase
8054 gastrointestinal absorption
iproniazid administration
iproniazid concentration
isonicotinic acid
8051 concentrations
8051 mephenesin influence
8051 mescaline degradation
8051 salicylate levels
8051 POTASSIUM
8051 heart contractile force
8051 high energy phosphates
8051 PROCAINE AMIDE
8051 cardiac arrhythmia
8051 coronary occlusion
8051 norethandrolone
8051 PROGESTERONE
cardiovascular effects
8061 enzyme activity
rat liver inicrosomes
Page 13
PRO-RES
8065
8065
8065
8065
8065
8065
8057
8057
8057
8057
8057
8094
8094
8094
8094
8094
8094
8094
8094
8067
8067
8067
8067
8067
8067
8057
8057
8094
8094
8057
8094
8057
8094
8071
8082
8057
8057
8057
8094
8082
8096
8096
8071
8094
8094
8082
8096
8071
8082
8096
8057
8082
8096
8057
8067
8064
8095
8095
8095
8097
8095
8095
8067
8067
8067
8067
8067
8067
SUBJECT INDEX
S-13
1958
thiophosphate oxidation
PROTEIN, DIETARY
3 -methylcholanthrene
protein-free diet
thiophosphate-oxidi zing
enzyme synthesis
PROTEIN, SERUM
component composition
digitoxin binding
lipid content globulin
salt fractionation
serum albumin
zone electrophoresis
QUINIDINE
antiarrhythmic effect
ataraxic agents
atrial flutter
auricular fibrillation
ventricular tachycardia
RAUNESCINE
A-V transmission
functional refractory period
heart rate
heart-lung preparation
reserpine pretreatment
RAUWOLFIA ALKALOIDS
A-V propagation time
A-V transmission
bradycardia
cardiac catechol-amine
depletion
functional refractory period
heart rate
heart-lung preparation
pharmacological groups
reserpine pretreatment
reserpine -type
REFLEXES
dibromopyruvic acid
patellar
REFLEXES, MESENTERIC
acetylcholine
afferent pathway
apnea
1-epinephrine
intestinal motility
intraarterial injection
8077 isoproterenol
mesenteric traction
8077 nicotine
8077 splanchnic nerve section
vagotomy
8077 veratridine
REFRACTORY PERIOD
antiarrhythmic agents
ataraxic agents
A-V propagation time
A-V transmission
cardiac arrhythmia
heart-lung preparation
quinidine
rauwolfia alkaloids
RESERPINE
antagonistic action
antiaccelerator action
antiarrhythmic effect
atrial flutter
auricular fibrillation
A-V transmission
cardiac catechol depletion
cardioaccelerator action
cumulative action
diphenylhydantoin
anticonvulsant action
functional refractory period
heart rate
heart-lung preparation
8094 8096
mammalian heart
methazolamide anticonvulsant
effect
8094 negative chronotropic action
8094 norepinephrine depletion
8094 quinidine-like activity
8094 reserpine pretreatment
8094 8094 8096
8094 right atrial pressure
8094 ventricular tachycardia
RESPIRATION
8059 acetylcholine
8059 allyl alcohol depression
aipha-lobeline
carotid sinus denervation
central mechanisms
chlorpheniramine optical
isomers
CO2-O2 inhalationcross-circulation
Page 14
8067
8067
8084
8083
8083
8084
8067
8083
8095
8067
8067
8095
8097
8095
8067
8078
8078
VOL. 124
8052
8052
8052
8052
8052
8052
8052
8052
8052
8078
8078
8078
8078
8098
8098
8098
8095
8095
8095
8095
8080
8080
8079
8080
8081
8080
8078
8080
8078
8068
8081
8081
8081
8068
8081
8081
8079
8081
8056
8056
8062
8062
8094
8094
8094
8092
8098
8092
8063
8063
8063
8063
SUBJECT INDEX
S-14
RES -TEM
intraarterial injection
mesenteric reflexes
minute volume
morphine administration
morphine tolerance
new morphine derivatives
nicotine
rate changes
rebreathing response
reflex apnea
splanchnic nerve section
succinylcholine
tidal air volume
ventilatory depression
veratridine
RYANODINE
heart contractile force
high energy phosphates
SALICYLATE, SODIUM
gastrointestinal absorption
mephenesin influence
plasma concentration
statistical analysis
SALIVARY GLANDS
dibromopyruvic acid
SEDATIVE AGENTS
6-methyl enedi hydro-
de soxymorphi ne
SEMINAL VESICLES
antigen reactions in vitro
sensitized guinea pigs
SERPENTINE
bradycardia
cardiac arrhythmia
heart -lung preparation
SHOCK
allyl alcohol intoxication
STATISTICAL ANALYSIS
dosage changes
drug-induced convulsions
mephenesin-salicylate
absorption
mortality correlation
plasma salicylate levels
STATISTICAL EVALUATION
minimum error table
parallel line bioassay
percent potency estimate
precision level
STREPTOVARIC IN
absorption
biliary excretion
biological disposition
diffusion rate
enzymatic destruction
nephrec t omy
renal excretion
serum levels
tissue distribution
STROPHANTHIN-K
heart contractile force
high energy phosphates
isolated guinea pig atria
spontaneous heart failure
STRYCHNINE
convulsion dosage
correlation values
mortality dosage
SUCCINYLCHOLINE
cross -circulation
8092 femoral vein injection
8092 intracarotid injection
8092 ventilatory depression
8092 SYMPATHETIC NERVOUS SYSTEM
cardiac nerve stimulation
8059 dichloroisoproterenol
blockade
SYMPATHOMINETIC AMINE S
8084 amine-TDA complexes
cardiac stimulant action
chemical specificity
dichloroi soproterenol
blockade
heart contractile force
heart rate
high energy phosphates
pressor response
8064 renal artery injection
renal blood flow
8098 renal vasomotor responses
8098 Su-4O29
systemic depressor effects
systemic pressor effects
TDA adrenergic blockade
urine flow responses
TEMPERATURE
CO2-bicarbonate medium
diaphragm muscle fibers
Page 15
8058
8077
8077
8077
8069
8069
8069
8060
8060
8060
8060
8060
8060
8060
8093
8093
8093
8093
8093
8093
8086
8086
8086
8086
8086
8068
8068
8062
8074
8074
8074
8074
8062
8062
8062
8053
8053
8053
8053
8053
8053
8053
8053
8053
8053
8053
8053
8053
8053
8079
8079
8079
8079
8079
8079
8079
8079
8079
8079
8079
8080
8080
8080
8080
8098
8098
8098
8077
8077
8077
8077
8077
8077
SUBJECT INDEX
S-iS
1958
resting potential
TESTOSTERONE
cardiovascular effects
enzyme activity
rat liver microsomes
thiophosphate oxidation
TETRAETHYLANMONIUM
cardiovascular hemodynamics
cigarette smoke
TETRANETHYLANMONIUM
atropine pretreatment
autonomic ganglionic
stimulation
cholinergic effector
stimulation
comparative study
DNPP
hexamethonium pretreatment
hind limb denervation
local vasodilatation
phentolatnine pretreatment
vascular actions
TETRAZOTIZED DIORTHOANISIDINE
(TDA)
acetylcholine
adrenergic blocking action
asphyxial pressor response
blood pressure
C-O pressor response
epinephrine -reversal
histamine
5 -hydroxytryptamine
isolated arterial strips
related compounds
sympathomimetic amines
T}LEOPHYLLINE
dichloroi soproterenol
heart rate
isolated rabbit heart
positive inotropic effect
THEPHORIN
convulsion dosage
correlation values
mortality dosage
THIOPHOSPHATES, ORGANIC
anticholinesterase formation
cholinesterase inhibition
enzymatic oxidation
guthion susceptibility
rat liver microsomes
SKF 525A
TEM-VAS
8056 susceptibility 8077
TRANSMISSION, NEUROMUSCULAR
atropine block
intraarterial injection
mammalian striated muscle
TREMORINE
analgesic effect
8054 antagonistic drugs
8054 atropine antagonism
hyoscine antagonism
8053 morphine comparison
nalorphine
8053 testing method
s-TRIAZINES
chemical specificity
crystalluria
diuretic effects
formoguanamine
oral administration
side effects
TRIMETHADIONE
alcohol comparison
anticonvulsant potency
anticonvulsant tests
neurotoxici ty
protective index
TYRANINE
pressor response
Su-4029 antagonism
UTERUS
antigen reactions in vitro
blood flow
estrogens
isotope tracer technique
ovariectomized rats
sensitized guinea pigs
VAS DEFERENS
antigen reactions in vitro
sensitized guinea pigs
VASOCONSTRICTION
atropine influence
DNPP
femoral arterial blood flow
hexamethonium influence
VASODILATATION, LOCAL
acetylchol me
atropine pretreatment
Page 16
VOL. 124
8053
8053
8053
8053
8053
8053
8053
8053
8053
8053
8053
8081
8081
8081
8081
8053
8082
8082
8082
8082
8067
8067
8067
8067
8067
8067
8057
8057
8057
8082
8082
8075
8075
8075
8075
8075
8075
SUBJECT INDEX
S-l6
VAS -VIT
denervated leg
DMPP
hexamethonium pretreatment
histamine
intraarterial injection
nitroglycerine
phentolamine pretreatment
TNA
VASOMOTOR RESPONSES
blood pressure
DMPP
femoral blood flow
renal artery injection
renal blood flow
renal vascular bed
sympathomimetic amines
TMA
VERATRANINE
cardiac catechol amine
depletion
heart -lung preparation
negative chronotropic action
reserpine pretreatment
VERATRIDINE
blood pressure
heart rate
intestinal motility
intraarterial injection
mesenteric reflexes
reflex apnea
VERATRINE RESPONSE
antiveratrinic activity
benactyzine pretreatment
meprobamat e
VERATRUM ALKALOIDS
cardiac action
cardiac catechol amine
content
VITAMIN K, DEFICIENCY
dicumarol -induced
hemorrhagic necrosis
myocardial damage
prevention
VITAMIN K1
dicumarol-induced myocarditis
protective action
Page 17
Plummer A J
Povalski H
1958
Abdulian D H
Andersen K S
Arora R B
Aviado D M Jr
Axeirod J
Bain J A
Barsky J
Batterman R C
Beck L
Berman E R
Blum B
Briggs F N
Brody T M
Busch H
Cafruny E J
Calvert D N
Carr J J
Chen C
Cherkas M S
Creese R
Daniel A I
de Beer E �J
de Gubareff T
De Kornfeld T J
DeMaar E W J
Dessau F I
Domino E F
Drill V A
DuBois K P
8059
8050
8057
8081
8051
8089
8088
8092
8079
8088
8098
8055
8087
8059
8079
8087
8092
8060
8088
8056
8068
8081
8078
8085
8061
8075
8079
8058
8077
8093
8074
8095
8062
8054
8095
8051
8075
8064
8096
8086
8090
8068
8050
8080
8092
8077
8056
8072
8075
8076
8052
8052
8076
8053
8081
8050
8098
8088
8086
8088
8091
8078
8097
8073
8071
8089
Perkins M E
Pfeiffer C C
8080 Zacks S
8089 Zeller E A
AUTHOR INDEX
A-l
Eisenman A J
Elliott H W
Fingl E
Fouts J R
Fraser H F
Furchgott R F
Covier W M
Gray C W
Gray W D
Croth D P
Harmel M H
Hendrie K H
Hess S
Hine C H
Innes I R
8082 8094
Inscoe J K
Isbell H
Kagawa C M
Kalman S M
Kao F F
Katsh S
Kien C A
King B D
King W M
Klein S
Kodama J K
Kottegoda S R
Krayer 0
8082 8094 8096
Lasagna L
Lasker N
Lipchuck L
8071 8075
McQuarrie D C
Mannering C J
Martin W R
8059 8061Maxwell R A
8091 Mellett L B
8084 Moran N C
Mouratoff G J
Murphy S D
O’Grady J
Okita G T
8065 8066
Okun R
Osterberg A C
8095
8063
8076
8064
8051
8091
Rauh C E
Redfield B C
Riker W K
Roth F E
Saunders P R
Schanker L S
Schneider F
Scholes N W
Sheps M C
Sherrod T R
Shofer R
Siminoff R
Sjoerdsma A
Sloan J
Spratt J L
8065 8066
Stoufer R M
Swinyard E A
8085 Taylor D B
8054 Tedeschi D H
Tsalikis J
tum-Suden C
8069 8070
Udenfriend S
Unna K R
8059 8061
Van Arman C C
8058 8093
Wagner J C
Wallach D P
8075 Waud D R
8094 8096
Weissbach H
8084 Winbury M M
8071 Wnuck A L
Woods L A
VOL. 124
8068
8068
8071
8076
8067
8097
8083
8090
8068
8056
8063
8054
8051
8083
8051
8091
8070
8072