To, Date: 17 th Feb.2010 Dr. Anil Dhall, Director & Head of Cardiology, Artemis Health Institute, Sector-51, Gurgaon-122001, Haryana Subject: Approval Letter. Dear Dr. Dhall, This is to inform you that the ARTEMIS HEALTH SCIENCES INSTITUTIONAL REVIEW BOARD in its meeting held on os" Feb. 2010 at 15:00 at conference room, 2nd floor, Artemis Health institute reviewed, discussed and unanimously agreed to approve the conduct of clinical trial entitled "Effects of ivabradine in patients with stable coronary artery disease without clinical heart failure. A randomised double-blind placebo-controlled international multicentre study." The following documents were reviewed. Main Study 1. Investigator's Brochure, version 11, dated 30 January 2009 2. Main study Protocol CL3-16257-083, dated 18 June 2009 3. Main study Protocol Signature Page (copy) 4. Main study Patient Information and Consent Document, dated 18 June 2009, English version 5. Main study Patient Information and Consent Document, (translated from English to Hindi) dated 27 July 2009, Hindi version + translation certificate. 6. Main study Patient Information and Consent Document (back translation Hindi to English), dated 27 July 2009 + translation certificate 7. Patient Cards, dated 24 June 2009, English version 8. Patient Cards, (translated from English to Hindi) dated 25 th July 2009, Hindi version + translation certificate 9. Patient Cards (back translated Hindi to English) dated 25 th July 2009, English version + translation certificate 10. Signed and dated curriculum vitae (CV) of Principal Investigator (Dr. Ani! Dhall) II. QOL Protocol Signature Page (copy) 12. QoL questionnaires(Hindi) + ENGLISH 13. Protocol for QoL study, Final version, dated 30 June 2009 14. Patient Information and Consent document for QoL Study, English Version, dated so" June 2009 15. Patient Information and Consent document for QoL Study, Hindi version, dated 11th August, 2009 + translation certificate 16. Patient Information and Consent document for QoL Study, English Version, (back translated Hindi to English) dated 11 th August 2009+ translation certificate 17. QoL Assistance note dated 9 th October 2009 18. QoL Assistance note dated 9 th October 2009 (translated from English to Hindi)+ Validation Certificate 19. QoL Assistance note dated 9 th October 2009 (back translated from Hindi to English)+ Validation Certificate 20. QoL help note dated 9 th October 2009 21. QoL help note dated 9 th October 2009 (translated from English to Hindi) + Validation Certificate 22. QoL help note dated 9 th October 2009 (back translated from Hindi to English) + Validation Certificate 23. Certificate ofInsurance I Page 1 oE2 Artemis Medicare Services Limited Artemis Health Institute. Sector 51. Gurgaon 122 00 I Haryana Ph.: +91-124-6767999 Fax: +91-124-6767701 Emergency: +91-124-6767000 www.artemishospital.in Registered Office: 414/ I. 4U,Floor. DDA Commercial Complex. District Centre. Janak Purl, New Delhi - I 10 058