Sandro C. Esteves, MD., PhD. Director, ANDROFERT Andrology & Human Reproduction C linic C ampinas, BRAZIL S ubc linic al Infec tions and Male Infertility IS O 9001:2008 Reproductive Andrology S urgery Workshop II Reproductive Medicine Unit - J ahra Hospital - Kuwait 2014
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S andro C . Esteves, MD., PhD.Director, ANDROFERT
Andrology & Human Reproduction C linic
C ampinas, BRAZIL
S ubclinical Infections and Male Infertility
IS O 9001:2008
Reproductive Andrology S urgery Workshop IIReproductive Medicine Unit - J ahra Hospital - Kuwait 2014
S ubclinical Male G enital Tract Infection (MAG I)
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ANDROLOGY AND HUMAN REPRODUCTION C LINIC - REFERRAL C ENTER FOR MALE REPRODUCTIONS ESTEVES, 22014 December
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Urethritis, prostatitis
MacrophageNeutrophils
ROS production by leukocytes is 100x higher than defective sperm
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ANDROLOGY AND HUMAN REPRODUCTION C LINIC - REFERRAL C ENTER FOR MALE REPRODUCTIONS ESTEVES, 32014 December
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C hemical species with unpaired electron capable to oxidize lipids, proteins and nucleic acids:
S uperoxide anion (•O-2)Hydroxyl radical (•OH); Hydrogen peroxide(H2O2)Peroxyl radical (ROO•); Hypochlorite ion (OC l-)
G enerated from sperm aerobic metabolism and leukocytes
Reactive Oxygen S pecies (ROS )
S perm and S eminal Plasma Antioxidants:Enzymatic (S OD, catalase, G PX): inactivate ROS by conversion into
other substancesNon-enzymatic (ascorbic acid, alpha-tocopherol, carnitine, etc):
neutralize ROS
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ANDROLOGY AND HUMAN REPRODUCTION C LINIC - REFERRAL C ENTER FOR MALE REPRODUCTIONS ESTEVES, 42014 December
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Yanushpolsky et al 1996, Saleh & Agarwal 2002, Aziz et al 2004
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ANDROLOGY AND HUMAN REPRODUCTION C LINIC - REFERRAL C ENTER FOR MALE REPRODUCTIONS ESTEVES, 52014 APRIL
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25%34% 39%
% DNA Damage (SCSA)
Anti-bacterial properties (Zinc)
S emen C ulture Unreliable
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ANDROLOGY AND HUMAN REPRODUCTION C LINIC - REFERRAL C ENTER FOR MALE REPRODUCTIONS ESTEVES, 62014 December
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Leukocytospermia>1.0 x 106 leukocytes per mL of semen
marker of reproductive tract inflammation
S pontaneous resolution in 50% of cases
Branigan et al 1995, Erel et al 1997, Lackner et al 2008
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ANDROLOGY AND HUMAN REPRODUCTION C LINIC - REFERRAL C ENTER FOR MALE REPRODUCTIONS ESTEVES, 72014 December
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granulocyte macrophage lymphocyte
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ANDROLOGY AND HUMAN REPRODUCTION C LINIC - REFERRAL C ENTER FOR MALE REPRODUCTIONS ESTEVES, 82014 December