Studies in alkaptonuria reveal new roles beyond drug clearance for phase I and II biotransformations in tyrosine metabolism.

1 Title: Studies in alkaptonuria reveal new roles beyond drug clearance for phase I and II biotransformations in tyrosine metabolism. Running title: New roles for phase I and II biotransformations beyond drug clearance Authors: Brendan P Norman 1* , Andrew S Davison 2 , Juliette H Hughes 1 , Hazel Sutherland 1,3 , Peter J Wilson 1 , Neil G Berry 4 , Andrew T Hughes 2 , Anna M Milan 2 , Jonathan C Jarvis 3 , Norman B Roberts 1 , Lakshminarayan R Ranganath 2 , George Bou- Gharios 1 , James A Gallagher 1 1 Department of Musculoskeletal Biology, Institute of Ageing & Chronic Disease, University of Liverpool, William Henry Duncan Building, 6 West Derby Street, Liverpool, L7 8TX, UK. 2 Department of Clinical Biochemistry & Metabolic Medicine, Liverpool Clinical Laboratories, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK. 3 School of Sport & Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool, L3 3AF, UK. 4 Department of Chemistry, University of Liverpool, Crown Street, Liverpool, L69 7ZD, UK. *Corresponding author: BPN, email: [email protected] . CC-BY 4.0 International license available under a was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made The copyright holder for this preprint (which this version posted April 16, 2020. ; https://doi.org/10.1101/2020.04.16.044347 doi: bioRxiv preprint

Studies in alkaptonuria reveal new roles beyond drug clearance for phase I and II biotransformations in tyrosine metabolism.

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