Stem Cells – Canadian Perspective John Laffey Critical Illness and Injury Research Centre, Keenan Research Centre, St Michael’s Hospital. Departments of Anesthesia, Physiology and Interdepartmental Division of Critical Care Medicine, University of Toronto.
35
Embed
Stem Cells Canadian Perspective - Critical Care …...Stem Cells –Canadian Perspective John Laffey Critical Illness and Injury Research Centre, Keenan Research Centre, St Michael’s
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Stem Cells – Canadian Perspective
John LaffeyCritical Illness and Injury Research Centre, Keenan
Research Centre, St Michael’s Hospital.
Departments of Anesthesia, Physiology and Interdepartmental Division of Critical Care Medicine,
• Cost of large scale Clinical Trials for cell therapies
• Need for flexible approaches
• Turning critical care doctors into transplant physicians…
Stem Cells for ARDS – Challenges
Laffey and Matthay, AJRCCM 2017
• Canadian…..contributions to health research and medicine. Two stand out as landmarks: the discovery of insulin in the 1920s and the discovery of stem cells in the 1960s.
• Canada founded the entire field of stem-cell science…….discovering neural stem cells, skin stem cells and cancer stem cells.
• Canada does this for a dime….The “all in” investment in stem-cell research in Canada …..is about $75-million [2012 Figures].
• Funding still seriously lags behind California, which, with roughly the same population as Canada, has committed $3-billion over 10 years for stem-cell research.
Cell therapy trials in Ontario 2015-16
Brain and/or nerves Phase II using MSCs for Multiple
Sclerosis: Toronto*
Phase III using diabetes drug to
stimulate brain repair for malignant
brain tumours: Toronto*
Digestive systemPhase III using MSCs to induce
remission of Crohn’s disease:
London and Toronto
HeartPhase II using genetically modified
stem cells following heart attack:
Ottawa and Toronto*
Phase II using MSCs for advanced
heart failure with left ventricular
assist device: Toronto*
SpinePhase I/II using neural stem
cells for spinal cord trauma:
Toronto*
BloodPhase I using immune cells for
blood cancer relapse after
bone marrow transplantation:
Toronto*
JointsPhase I-II using stem cells mid-
to late-stage knee osteoarthritis;
Toronto*
2015-16
9 trials
11 partners
3 Ontario
cities
655+ patients
Billions of
stem cells
* OIRM researchers leading trial
Critical carePhase I using MSCs for septic
shock: Ottawa*
Hematopoietic stem cell transplantation
First Animal
studies
1954
First Human
studies
1957
First Proof
of efficacy
(in AML)
1977 1982/6
Proof of
efficacy
in CML
Ongoing Discoveries
e.g. MSCs for GVHD
2001-16
Human Allogenic
BM Transplant
1971
• Stem cells offer considerable potential for Critical Illnesses
– Pre-clinical studies highly encouraging
– MSCs now in early phase Clinical Studies for ARDS
• Clinical Translational pathway likely to be lengthy and there
will be setbacks...
• Twin-track strategy of pre-clinical research and early phase
clinical translational studies in progress
• Canada’s role in realizing clinical potential of stem cells