Stem cell therapy for spinal cord injuries VISHNU AMBAREESH
Stem cell therapy for spinal cord injuries
Jul 02, 2015
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Stem cell therapy for spinal cord injuries
VISHNU AMBAREESH
japanese scientist Shinya Yamanaka
British scientist John B. Gurdon
Spinal cord injury became the first condition targeted in a human clinical trial using cells made from embryonic stem cells
begun by Geron in 2010
later cancelled for financial reasons.
Doug Brutlag 2011
Geron Stem Cell Therapy
Tom Okarma - Geron
Doug Brutlag 2011
GRNOPC1 Improves Locomotor Behavior
after Spinal Cord Injury
Tom Okarma - Geron
GRNOPC1 – contains oligodendrocyte progenitor cells. Which turn into oligodendrocytes,
If GRNOPC1 works, the progenitor cells will produce new oligodendrocytes in the injured area of the patient's spine, potentially allowing for new movement.
Treatment of chronic spinal cord injured patients with autologous bone marrow-
derived hematopoietic stem cell transplantation
• Cairo University conducted human trial of hematopoietic progenitor stem cells in SCI Patients
• Results: Improved functions
• Not FDA approved
• MRI showed no tumors
• Awaiting 1 year follow up
Doug Brutlag 2011
Human Embryonic Stem Cell (hESC)
Based Therapy
Tom Okarma - Geron
Doug Brutlag 2011
GRNOP1 Phase 1 Multi-Center
Spinal Cord Injury Trial
Tom Okarma - Geron
• injected into the patients' spines 1-2weeks after injury between their third and 10th thoracic vertebrae, or roughly the middle to upper back. Later trials would include patients with less severe spinal injuries and damage to other parts of the spine.
In lab animals, the results were dramatic -paralyzed rodents moved again.
Science is discovering the unknown
• Stem cell field is still in its infancy
• Human embryonic stem cell research is a decade old, adult stem cell research has 30-year head start
• Holds hope for curing or improving treatments for
70+ diseases
SHOULD WE DO IT???
Traditional Chinese herbal medicines
an ancient medicinal practice, called Ji-Sui-Kang (JSK), can improve locomotor function in rats withspinal cord injuries.
“Stay clear of stem cell treatment for Spinal Cord Injury (SCI),” Professor Alan Mackay-Sim
AJIT JOGI
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