Stem Cell Day Talk Without Videos Zs

8/17/2019 Stem Cell Day Talk Without Videos Zs

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Stem Cells andRegenerative

Medicine

Zach Scheiner,PhD

Science Ofcer


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What are stem cells? What arethe di erent types o stem cells

Why should we study stemcells? What potential therapies

co!ld they provide

What are some o the challengesacing stem cell research


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"ll Stem Cells

Can#$% Sel &Rene'

(% Di erentiate


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Sel &Rene'al )symmetric celldivision*


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S+in Progenitor Cell

S+in Cell

e!ral Progenitor Cell

e!ron )-rain Cell*

Stem CellEmbryonic


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Stem Cell .ypes• /m0ryonic 1 pl!ripotent2 can

ormalmost any cell type in the h!man

0ody

• .iss!e&Speci3c )"d!lt* 1m!ltipotent2 can orm only limitedtypes o cells )0lood, 0rain, liver,

etc%*

•4nd!ced Pl!ripotent

1en ineered


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Conception in a Dish4n 5itro 6ertili7ation


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Day 1

4n 5itro 6ertili7ation


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Day 1

4n 5itro Development


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Day 2



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Day 2



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Day 3



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Day 4



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EmbryonicStemCells

Day 5



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This cell can form all of the

cells in the human body

This cell can formalmost every cell ty e

in the human body

!ully mature

ll


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8!man em0ryonic stem cells inc!lt!re


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6l!orescent imaging oh!man em0ryonic stem cell

colonies


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What Diseases Do StemCells .reat 8ave the

Potential to .reatC!rrently .reat

& -lood Diseases )incl!dingimm!ne system disorders*& 9enetic meta0olicdisorders (verylimited/experimental)

& .iss!e:organ replacement(very limited/experimental)

Potential to .reat

& 8eart Disease& e!rological Diseases)Par+inson;s, "l7heimer;s,8!ntington;s < others*& Stro+e

& .ype $ Dia0etes& Mac!lar Degeneration )acommon ca!se o 0lindness*& Cancer& 845:"4DS& Spinal Cord 4n=!ry& M!ltiple Sclerosis& ;

Potential to .reat

& 8eart Disease& e!rological Diseases)Par+inson;s , "l7heimer;s,8!ntington;s < others*& Stro+e

& .ype $ Dia0etes& Mac!lar Degeneration )acommon ca!se o 0lindness*& Cancer& 845:"4DS& Spinal Cord 4n=!ry& M!ltiple Sclerosis& ;

"andmore#

C!rr ently .reat

& -lood Diseases )incl!dingimm!ne system disorders*& 9enetic meta0olicdisorders (verylimited/experimental)

& .iss!e:organ replacement(very limited/experimental)


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-one Marro' )8ematopoietic Stem Cell* .ransplant

/?ample o a tiss!e&speci3c stem cell therapy


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.rachea transplantation/?ample o tiss!e&speci3c stem cell&0ased tiss!e

replacement

$lic% on Picture to Play &ideo


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.iss!e&speci3c )ad!lt* stem

cells are po'er !l andpromising@Why do researchers study

embryonic stem cells?• .iss!e&speci3c stem cells are limitedin their di erentiation potential )0lood

0lood*•Stem cells rom some tiss!es areinaccessi0le•Some tiss!e&speci3c stem cells don;t


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/m0ryonic Stem&Cell

Derived 8eart M!scleCells

$lic% on Pictures to Play &ideos


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/m0ryonic Stem

Cells

5ideo2 Dia0etes " C4RM Disease .eam

5ideo2"ge&Related Mac!lar Degene

ration )"MD*

http://diabetes_final_1280x720.mov/http://amd_cirm.mov/http://amd_cirm.mov/http://amd_cirm.mov/http://amd_cirm.mov/http://diabetes_final_1280x720.mov/


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5ideo2 C4RM Disease .eam or .ype $Dia0etes


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5ideo2 C4RM Disease .eam or "ge&Related Mac!lar Degeneration )"MD* 1

/ye Disease


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What are some o thechallenges acing

em0ryonic stem cellresearch

• Di erentiation o stem cellsinto

mat!re, !nctional cells

• Potential or t!morormation

4 d! d Pl! i S )iPS*


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4nd!ced Pl!ripotent Stem )iPS*Cells

9enetically engineering ne' stem cells

Skin cells iPS cells

Pros2 o em0ryosreA!ired o imm!nere=ection Disease in a dish

Cons2 May not 0e B to/SCs

9eneticallyen ineered

5ir!sengineeredto e?press o!r+ey

pl!ripotencygenes

5id 2 P +i di &i &


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5ideo2 Par+inson;s disease&in&a&dish


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"c+no'ledgements& .odd D!0nico & "my "dams& >a!rel -archas

www.cirm.ca.gov


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/?tra Slides

! l ll d !


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e!ral stem cells or dr!gdelivery

6oc!sed delivery o chemotherapy or cancer

NSCsinjected

(no tumor)

NSCsinjected(tumor)

Day 0 Day 7 Day 14

Shah et al. Dev Neurosci 2004


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Stem cells or dr!g delivery6oc!sed delivery o chemotherapy or cancer

"nother C4RM Disease .eam

enetically En!ineeredNeural Stem Cells

"ice are !i#en a non$to%ic dru!& 'hich theneural stem cells cancon#ert to an acti#e dru!to shrin tumors


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Milestones in /m0ryonicDevelopment

• Days E&$F2 /m0ryo implants in the !ter!s• Day $F2 .hree distinct layers 0egin to

orm )no more em0ryonic stem cells*

• Days $F&($2 -eginning o !t!re nervo!ssystem

• Days ($&(F2 -eginning o !t!re head,

nec+, mo!th, and nose• Wee+s G&H2 -eginning o organ ormation• Wee+ H2 /m0ryo is called a et!s

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