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Statistical and computational Statistical and computational challenges in genetics and evolution challenges in genetics and evolution Ziheng Yang Professor of Statistical Genetics, FRS Galton Laboratory GEE UCL speciation speciation H G C speciation speciation G
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Statistical and computationalStatistical and computational ... · Statistical and computationalStatistical and computational challenges in genetics and evolutionchallenges in genetics

Sep 30, 2018

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Page 1: Statistical and computationalStatistical and computational ... · Statistical and computationalStatistical and computational challenges in genetics and evolutionchallenges in genetics

Statistical and computationalStatistical and computational

challenges in genetics and evolutionchallenges in genetics and evolution

Ziheng Yang

Professor of Statistical Genetics, FRS

Galton Laboratory

GEE

UCL

speciation

speciation

H GC

speciation

speciation

G

Page 2: Statistical and computationalStatistical and computational ... · Statistical and computationalStatistical and computational challenges in genetics and evolutionchallenges in genetics

Firstattempt:20K genesfor 36species,200GB RAM

Bayesian dating of divergences of mammalsBayesian dating of divergences of mammals

Page 3: Statistical and computationalStatistical and computational ... · Statistical and computationalStatistical and computational challenges in genetics and evolutionchallenges in genetics

biological networks (Andrewbiological networks (Andrew PomiakowskiPomiakowski))

Page 4: Statistical and computationalStatistical and computational ... · Statistical and computationalStatistical and computational challenges in genetics and evolutionchallenges in genetics

Mapping disease genes through genomeMapping disease genes through genome--widewideassociation studies (David Balding, Vincentassociation studies (David Balding, Vincent PlagnolPlagnol))

Page 5: Statistical and computationalStatistical and computational ... · Statistical and computationalStatistical and computational challenges in genetics and evolutionchallenges in genetics

Origin of milk drinking in Europe &persistence of lactose: Co-evolutionof genes and culture revealed by ABC

Mark Thomas

Page 6: Statistical and computationalStatistical and computational ... · Statistical and computationalStatistical and computational challenges in genetics and evolutionchallenges in genetics

Research driven by biological questions and data.

Involves statistical/mathematical modelling &

computation-intensive inference (ML, Bayesian, MC, MCMC, MC3)

Computational Biology in GEE/UGI/CoMPLEX

David BaldingJulia DayJim Mallet

Nikolas ManiatisDavid Murrell

Vincent PlagnolAndew Pomiankowski

Max TelfordMax Reuter

Mark ThomasZiheng Yang

EvolutionPopulation genetics

Molecular phylogeneticsComparative genomics

Biological NetworksMedical genetics

DevelopmentBiodiversity

Ecology

Stats &Maths Computation