-
Biomedicine springer.com/NEWSonline
12
M. Anisimova, ETH Zürich, Switzerland (Ed.)
Evolutionary GenomicsStatistical and Computational Methods,
Volume 1
Together with early theoretical work in population genetics, the
debate on sources of genetic makeup initiated by proponents of the
neutral theory made a solid contribution to the spectacular growth
in statistical methodologies for molecular evolution.
Features 7 Serves as an ideal reference for young and
ex-perienced researchers alike 7 Features practical,
step-by-step guidance to methodologies being used in the field
7 Includes key implementation advice from the experts
Contents Introduction to Genome Biology: Features, Processes,
and Structures.- Diversity of Genome Organization.- Probability,
Statistics, and Com-putational Science.- The Essentials of
Computa-tional Molecular Evolution.- Next-Generation Sequencing
Technologies and Fragment Assem-bly Algorithms.- Gene Prediction.-
Alignment Methods: Strategies, Challenges, Benchmarking, and
Comparative Overview.- Whole-Genome Alignment.- Inferring Orthology
and Paralogy.- Detecting Laterally Transferred Genes.- Genome
Evolution in Outcrossing Vs. Selfing Vs. Asexual Species.-
Transposable Elements And Their Identification.- Evolution of
Genome Content: Population Dynamics of Transposable Elements in
Flies and Humans.- Detection and Phylogenetic Assessment of
Conserved Synteny Derived from Whole Genome Duplications.- Analysis
of Gene Order Evolution Beyond Single-Copy Genes.- Dis-covering
Patterns in Gene Order.
Fields of interestsHuman Genetics; Evolutionary Biology
Target groupsProfessional/practitioner
Product categoryContributed volume
Due February 2012
2012. XX, 354 p. 86 illus., 16 in color.
(Methods in Molecular Biology, Volume 855) Hardcover7 *
€ (D) 117,65 | € (A) 120,95 |
sFr 146,507 € 109,95 | £99.00ISBN
978-1-61779-581-7
9
M. Anisimova, ETH Zürich, Switzerland (Ed.)
Evolutionary GenomicsStatistical and Computational Methods,
Volume 2
Contents Tangled Trees: The Challenge of Inferring Species Trees
from Coalescent and Non-Coalescent Genes.- Modeling Gene Family
Evolution and Reconciling Phylogenetic Discord.- Genome-Wide
Comparative Analysis of Phylogenetic Trees: The Prokaryotic Forest
of Life.- Philosophy and Evolution: Minding the Gap Between
Evolutio-nary Patterns and Tree-Like Patterns.- Selection on the
Protein Coding Genome.- Methods to Detect Selection on Non-Coding
DNA.- The Origin and Evolution of New Genes.- Evolution of Protein
Domain Architectures.- Estimating Recombination Rates from Genetic
Variation in Humans.- Evolution of Viral Genomes: Interplay Between
Selection, Recombination, and Other Forces.- Association Mapping
and Disease: Evolutionary Perspectives.- Ancestral Populati-on
Genomics.- Non-Redundant Representation of Ancestral Recombinations
Graphs.- Using Genomic Tools to Study Regulatory Evolution.-
Characterization and Evolutionary Analysis of Protein-Protein
Interaction Networks.- Statistical Methods in Metabolomics.-
Introduction to the Analysis of Environmental Sequences:
Metageno-mics with MEGAN.- Analyzing Epigenome Data in Context of
Genome Evolution and Human Diseases.- Genetical Genomics for
Evolutionary Studies.- Genomics Data Resources: Frameworks and
Standards.- Sharing Programming Resources Between Bio* Projects
through Remote Procedure Call and Native Call Stack Strategies.-
Scalable Computing for Evolutionary Genomics.
Fields of interestsHuman Genetics; Evolutionary Biology
Target groupsProfessional/practitioner
Product categoryContributed volume
Due February 2012
2012. XVI, 685 p. 113 illus., 64 in color.
(Methods in Molecular Biology, Volume 856) Hardcover7 *
€ (D) 133,70 | € (A) 137,45 |
sFr 166,507 € 124,95 | £112.50ISBN
978-1-61779-584-8
9
T. Balla, National Institutes of Health, Bethesda, MD, USA;
M. Wymann, University of Basel, Switzerland;
J. D. York, Duke University Medical Center, Durham, NC,
USA (Eds)
Phosphoinositides I: Enzymes of Synthesis and
DegradationPhosphoinositides play a major role in cellular
signaling and membrane organization. During the last three decades
we have learned that enzymes turning over phosphoinositides control
vital physiological processes and are involved in the initiation
and progression of cancer, inflammati-on, neurodegenerative,
cardiovascular, metabolic disease and more. In two volumes, this
book elucidates the crucial mechanisms that control the dynamics of
phosphoinositide conversion.
Features 7 In depth discussion of the state of the art of
phosphoinositide research 7 Experts in the field discussing
the 'hot' topics in phosphoinositide research 7 A volume
dedicated to the enzymes involved in the synthesis and degradation
of phosphoinositides
Contents 1. The Phosphatidylinositol 4-kinases: Don’t Call it a
Comeback.- 2. PIP kinases from the cell membrane to the nucleus.-
3. The Phospholipase C Isozymes and Their Regulation.- 4.
Phosphoi-nositide 3-Kinases – A Historical Perspective.- 5. PI
3-kinases – drug targets in inflammation and cancer.- 6.
Phosphoinositide 3-kinases in health and disease.- 7.
Phosphoinositide phosphatases: just as important as the kinases.-
8. The PTEN and myobubularin phosphoinositide 3-phosphatases:
linking lipid signalling to human disease.
Fields of interestsBiomedicine general; Neurosciences; Human
Genetics
Target groupsResearch
Product categoryContributed volume
Due March 2012
2012. X, 280 p. 29 illus., 16 in color.
(Subcellular Biochemistry, Volume 58) Hardcover7 *
€ (D) 149,75 | € (A) 153,94 |
sFr 186,507 € 139,95 | £126.00ISBN
978-94-007-3011-3
9
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News 12/2011 Biomedicine
13
T. Balla, National Institutes of Health, Bethesda, MD, USA;
M. Wymann, University of Basel, Switzerland;
J. D. York, Duke University Medical Center, Durham, NC,
USA (Eds)
Phosphoinositides II: The Diverse Biological
FunctionsPhosphoinositides play a major role in cellular signaling
and membrane organization.
Features 7 In depth discussion of the state of the art of
phosphoinositide research 7 Experts in the field discussing
the 'hot' topics in phosphoinositide research 7 A volume
dedicated to processes regulated by phosphoinositides
Contents 1. Ca2+ signalling by IP3 receptors. - 2.
Phosphoi-nositide signaling during membrane transport in
Saccharomyces cerevisiae. - 3. Phosphoinositides in the mammalian
endo-lysosomal network. - 4. Role of PtdIns(4,5)P2 in vesicle
exocytosis and membrane fusion. - 5. Role of phosphoinositides at
the neuronal synapse. - 6. Phosphatidylinositol 4,5-bisphosphate
and the actin cytoskeleton. - 7. Phosphoinositides in chemotaxis. -
8. Phosphoi-nositides in Golgi complex function. - 9. Sec14 like
PITPs couple lipid metabolism with phosphoi-nositide synthesis to
regulate Golgi functionality. - 10. Phosphoinositide sensitivity of
ion channels, a functional perspective. - 11. Nuclear
phosphoi-nositides: location, regulation and function. - 12.
Phosphoinositides and cellular pathogens. - 13. Defining signal
transduction by inositol phospha-tes. - 14. Cell signalling by
inositol pyrophospha-tes.
Fields of interestsBiomedicine general; Neurosciences; Human
Genetics
Target groupsResearch
Product categoryContributed volume
Due March 2012
2012. X, 390 p. 10 illus. in color. (Subcellular
Biochemistry, Volume 59) Hardcover7 * € (D) 181,85 |
€ (A) 186,94 | sFr 226,507 € 169,95 |
£153.00ISBN 978-94-007-3014-4
9
Y. Bigot, UMR INRA-CNRS, Physiologie de la Reproduction et
des Comportements, France (Ed.)
Mobile Genetic ElementsProtocols and Genomic Applications
Contents Transposable Elements as Tools for Reshaping the
Genome: it‘s a Huge World After All !.-Using and Understanding
RepeatMasker.-Roadmap for Annotating Transposable Elements in
Eukaryote Genomes.-To Detect and to Analyze
Sequence Repeats Whatever their Origin.-Exploring
Bacte-rial Insertion Sequences with ISfinder: Objectives, Uses and
Future Developments.-Methods and Software in NGS for TE
Analysis.-The Application of LTR Retrotransposons As Molecular
Markers in Plants.-Individual Analysis of Transposon Polymorphisms
by AFLP.-Construction of a Library of Random Mutants in the
Spirochete Leptospira Biflexa using a Mariner Transposon.-Ac-Ds
Solutions for Rice Insertion Mutagenesis.-Engineering the
Caenorhabditis elegans Genome by Mos1 Induced Transgene-Instructed
Gene Conversion (MosTIC).-Genome-wide Manipula-tions of Drosophila
Melanogaster with Transpo-sons, Flp Recombinase and FC31
Integrase.-The Sleeping Beauty Transposon Toolbox.-PiggyBac tool
box.-Insertion Site Pattern: Global Approach by Linear
Amplification-mediated PCR (LAM-PCR) and Mass
Sequencing.-Comprehensive DNA Methylation Profiling of Human
Repetitive DNA Elements using a MeDIP-on-RepArray Assay.-Novel
Approach for the Development of New Antibodies Directed Against
Transposase-derived Proteins Encoded by Human Neogenes.
Fields of interestHuman Genetics
Target groupsProfessional/practitioner
Product categoryContributed volume
Due March 2012
2nd ed. 2012. XII, 359 p. 66 illus., 24 in
color. (Methods in Molecular Biology, Volume 859) Hardcover7 *
€ (D) 101,60 | € (A) 104,45 |
sFr 126,507 € 94,95 | £85.50ISBN
978-1-61779-602-9
9
R. G. Dumitrescu, Saba University Medical School,
Netherland Antilles; M. Verma, National Cancer Institute,
Bethesda, MD, USA (Eds)
Cancer EpigeneticsMethods and Protocols
Contents Epigenetic Markers of Early Tumor
Development.-Epigenetics of Solid Cancer Stem Cells.-DNA
Methylation and Histone Modifications in Breast Cancer.-DNA
Methylation Changes in Prostate Cancer.-DNA Methylation in Promoter
Region as Biomarkers in Prostate Cancer.-Epigenetics of Bladder
Cancer.-Epigenetics in Myeloid Malignancies.-The Epigenetics of
Brain Tumors.-DNA Methylation Changes in Cervical
Cancers.-Epigenetics of Colon Cancer.-Promoter Methylati-on in
Head and Neck Tumorigenesis.-Epigenome and DNA Methylation in Oral
Squamous Cell Carcinoma.-Clinical Implications of Epigenetic
Alterations in Human Thoracic Malignancies: Epigenetic Alterations
in Lung Cancer.-The Role of microRNAs in the Management of Liver
Cancer.- Epigenetics in Ovarian Cancer.-DNA Methylation in
Pancreatic Cancer: Protocols for the Isolation of DNA and Bisulfite
Modification.-Detection and Analysis of DNA Methylation by
Pyrosequencing.-Screening for miRNA Expres-sion Changes using
Quantitative PCR (Q-PCR).-Genome-wide Methylation
Analysis.-Microarray for Epigenetic Changes: Gene Expression
Arrays.-Detecting DNA Methylation using the Methyla-ted CpG Island
Amplification and Microarray Technique.- Nutrigenomics –
Implications for Breast and Colon Cancer Prevention.-Dietary and
Lifestyle Factors of DNA Methylation.-Diet, Epigenetics and
Cancer.-Role of Epigenetics in Cancer Health
Disparities.-Multifactorial Etiology of Gastric Cancer.-Epigenetic
Epidemiology for Cancer Risk: Harnessing Germline Epigenetic
Variation. [...]
Fields of interestCancer Research
Target groupsProfessional/practitioner
Product categoryContributed volume
Due March 2012
2012. X, 646 p. 42 illus., 32 in color.
(Methods in Molecular Biology, Volume 863) Hardcover7 *
€ (D) 133,70 | € (A) 137,45 |
sFr 166,507 € 124,95 | £112.50ISBN
978-1-61779-611-1
9
www.springer.com/978-94-007-3014-4www.springer.com/978-1-61779-602-9www.springer.com/978-1-61779-611-1
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Biomedicine springer.com/NEWSonline
14
I. D. Duncan, University of Wisconsin-Madison, WI,
USA; R. J. Franklin, University of Cambridge, UK
(Eds)
Myelin Repair and Neuroprotection in Multiple SclerosisMultiple
sclerosis (MS) is the most prevalent de-myelinating disease of the
central nervous system (CNS). It affects over 400,000 people in the
USA alone and is a common disease world wide. This book will cover
a new and emerging field in the development of strategies to treat
MS. Until now, the only therapies available for MS treatment have
been those directed against inflammation and the immune attack on
the CNS. Other treatments are used for symptomatic relief.
Features 7 First book on this topic 7 Authorship from
many of the major players in the field of MS and myelin repair
7 Of equal interest to academic clinical neurologists and
neuroscientists
Contents Myelin and Oligodendrocyte Biology.-Demyeli-nation in
MS.-Remyelination in MS.-The Role of Astrocytes in Inhibiting
Remyelination.-Microglia Promote or Inhibit Remyelination.-Imaging
of
Demyelination/Remyelination.-Remyelination-Endogenous.-Remyelination-Exogenous.-Testing
the Physiologic Response of Remyelination
Therapies.-Immunomodulation and Repair Following Neural Stem
Transplantation.-Phar-macologic Protection of Nerve Fibers in
MS.-Clinical Trials-Measuring Repair Clinically and by
Surrogates.-Biomarkers in Remyelination/Repair.-P. Methods of
Evaluating Neuroprotection in MS Patients.
Fields of interestsNeurosciences; Neurology; Neuroradiology
Target groupsProfessional/practitioner
Product categoryContributed volume
Due April 2012
2012. 350 p. Hardcover7 approx. *
€ (D) 165,80 | € (A) 170,44 |
sFr 206,507 approx. € 154,95 | £139.50ISBN
978-1-4614-2217-4
9
T. W.-M. Fan, A. N. Lane,
R. M. Higashi, University of Louisville, KY, USA
(Eds)
The Handbook of MetabolomicsVital to academic researchers, the
medical field, and especially to biotech and pharmaceutical
sci-entists, metabolomics is a rapidly expanding field that will
provide a key link between functional biology (phenotypes) and the
inner workings of cells in tissues or whole organisms.
Features 7 Examines the rapidly expanding field of
metabolomics with a focus on toxicology and pharmaceutical
applications 7 Integrates metabolomics with transcriptomics
and prote-omics 7 Features extensive bibliographies and
resources
Contents Introduction to Metabolomics.- Considerations of Sample
Preparation for Metabolomics Investigati-on.- Clinical Aspects of
Metabolomics.- Structural Mass Spectrometry for Metabolomics.-
Metabolo-mic Applications of Inductively Coupled Plasma- Mass
Spectrometry (ICP-MS).- Principles of NMR for Applications in
Metabolomics.- Novel NMR and MS Approaches to Metabolomics.-
Metabolic Flux Analysis.- Introduction to Metabolic Control
Analysis (MCA).- Application of Tracer-Based Metabolomics and Flux
Analysis in Targeted Cancer Drug Design.- Non-Invasive Fluxomics in
Mammals by Nuclear Magnetic Resonance Spec-troscopy.- Compositional
Analysis of Phospho-lipids by Mass Spectrometry and Phosphorus-31
Nuclear Magnetic Resonance Spectroscopy.- The HumanCyc
Pathway-Genome Database and Pathway Tools Software as Tools for
Imaging and Analyzing Metabolomics Data.- Metabolomics-Edited
Transcriptomics Analysis (META).
Fields of interestPharmacology/Toxicology
Target groupsProfessional/practitioner
Product categoryContributed volume
Due March 2012
2011 2011. XIV, 569 p. 137 illus., 80 in
color. (Methods in Pharmacology and Toxicology, Volume 17)
Hardcover7 * € (D) 117,65 |
€ (A) 120,95 | sFr 146,507 € 109,95 |
£99.00ISBN 978-1-61779-617-3
9
R. A. Figlin, Samuel Oschin Comprehensive Cancer
Institute, Los Angeles, CA, USA; W. K. Rathmell,
University of North Carolina, Chapel Hill, NC, USA; B. Rini,
Cleveland Clinic Taussig Cancer Institute, OH, USA (Eds)
Renal Cell CarcinomaTranslational Biology, Personalized
Medicine, And Novel Therapeutic Targets
Contents Preface.- The Genetic Basis of Kidney Cancer and
Implications for Targeted Therapies.- Molecular Biology of Clear
Cell Renal Carcinoma.- HIF Biology in RCC: Implications for
Signaling, Disease Progression, and Treatment.- Tissue Biomarkers
in Renal Cell Carcinoma: Intermedi-ate Endpoints in the Selection
of Targeted Agents for RCC.- Molecular Characterization of Renal
Cell Carcinoma.- Targeting The Vegf Pathway In Renal Cell
Carcinoma.- Angiopoetins and Other Non-VEGF Antiangiogenic Targets
In Advanced Renal Cell Carcinoma.- Towards Personalized Cancer
Medicine.- Epigenetic Targeting and Histone Deacetylase Inhibition
in RCC.- C-MET as a Novel Target for the Treatment of Renal Cell
Carcinoma.- Characterizing and Modulating the Tumor
Micro-Environment in Renal Cell Carcino-ma: Potential Therapeutic
Strategies.- Carbonic Anhydrase IX: Its role as a biomarker,
diagnostic, and therapeutic target in Renal Cell Carcinoma.-
Presurgical Therapy for Renal Cell Carcinoma and Implications for
Window of Opportunity Trials.- Mechanisms of Resistance to VEGF
Directed Therapy and Implications for Future Trial Design.- Vaccine
Based Immunotherapy and Targeting the Tumor Microenvironment in
Renal Cell Carcino-ma.- Index.
Fields of interestsCancer Research; Pharmacology/Toxicology
Target groupsResearch
Product categoryContributed volume
Due March 2012
2012. XV, 270 p. 34 illus., 31 in color.
Hardcover7 * € (D) 149,75 |
€ (A) 153,94 | sFr 186,507 € 139,95 |
£126.00ISBN 978-1-4614-2399-7
9
www.springer.com/978-1-4614-2217-4www.springer.com/978-1-61779-617-3www.springer.com/978-1-4614-2399-7
-
News 12/2011 Biomedicine
15
Forensic Pathology of Infancy and ChildhoodEditors-in-chief:
R. W. Byard, University of Adelaide, SA, Australia;
K. A. Collins, Fulton County Medical Examiner‘s Office,
Atlanta, GA, USA
Contents The History of Pediatric Forensic Pathology and the
Pediatric Autopsy.- Death Scene Investigati-on.- The Autopsy.-
Fetal, Perinatal and Neonatal Death.- Birth Trauma.- Placental and
Maternal Conditions.- Neonaticide.- Fatal Craniocereb-ral and
Spinal Trauma.- Biomechanics of Head Injury.- Ocular Findings in
Inflicted Injury.- Blunt Abdominal and Chest Injuries.- Cutaneous
Fin-dings in the Young.- The Pathological Evaluation of Fractures
at Autopsy.- Dating of Other Injuries.- Homicide in the Older
Child.- Sexual Abuse.- Starvation, Dehydration, Malnutrition, and
Fatal Neglect.- Poisoning and Toxicological Issues.- Fac-titious
Illness by Proxy.- Conditions Simulating Inflicted Injury.
[...]
Fields of interestsForensic Science; Forensic Medicine;
Pharmacolo-gy/Toxicology
Target groupsProfessional/practitioner
Product categoryReference work
Due January 2013
Print
2013. 1000 p. (In 2 volumes, not available separately)
7 approx. * € (D) 544,63 |
€ (A) 559,90 | sFr 780,507 approx.
€ 499,00 | £453.00ISBN 978-1-61779-402-5
9 eReference
2013. 7 approx. ** € (D) 593,81 |
€ (A) 598,80 | sFr 698,007 approx.
€ 499,00 | £449.50ISBN 978-1-61779-403-2
9 Print + eReference
2013. 1000 p. (In 2 volumes, not available separately)
7 approx. * € (D) 667,68 |
€ (A) 686,40 | sFr 831,007 approx.
€ 624,00 | £562.00ISBN 978-1-61779-404-9
9
J. Green, T. Ried, National Cancer Institute,
Bethesda, MD, USA (Eds)
Genetically Engineered Mice for Cancer Researchdesign, analysis,
pathways, validation and pre-clinical testing
Contents Foreword.- Preface.- Overview of Designing
Genetically-Engineered Mouse Models.- The Use of Cre-loxP
Technology and Inducible Systems to Generate Mouse Models of
Cancer.- Using Re-combineering Technology To Create Genetically
Engineered Mouse Models.- Insertional Mutage-nesis for Generating
Mouse Models of Cancer.- The RCAS/TVA Somatic Gene Transfer Method
In Modeling Human Cancer.- Target-selected ENU Mutagenesis to
Develop Cancer Models in the Rat.- The Tumor Pathology of
Genetically Engineered Mice: Genomic Pathology.- Genomic DNA Copy
Number Alterations in Mouse Cancer Models and Human Cancer.-
Characterization of chromosomal translocations in mouse models of
hematological malignancies using spectral karyotyping (SKY), FISH,
and immunocytoche-mistry.- Expression Profiling of Mouse Models of
Human Cancer: model categorization and guidance for preclinical
testing.- Imaging mouse models of human cancer.- Identifying
Mammary Epithelial Stem and Progenitor Cells.- Differentia-tion
Programs in Development and Cancer.- Roles of p53 and PRB Tumor
Suppressor Networks in Human Cancer: Insight from Studies in the
Engineered Mouse.- Mouse Models for Colorectal Cancer.- Src family
tyrosine kinases: Implications for mammary tumor progression.-
Maspin and Suppression of Tumor Metastasis.- Epigenetic Mouse
Models.- Modeling Transforming Growth Factor-ß Signaling in Cancer.
[...]
Fields of interestsCancer Research; Human Genetics; Laboratory
Medicine
Target groupsResearch
Product categoryProfessional book
Due November 2011
2012. XX, 632 p. 75 illus., 47 in color.
Hardcover7 * € (D) 181,85 |
€ (A) 186,94 | sFr 244,007 € 169,95 |
£153.00ISBN 978-0-387-69803-8
9
P. J. Gutiérrez, University of Valladolid, Spain;
I. H. Russo, J. Russo, Fox Chase Cancer Center,
Philadelphia, PA, USA
The Evolution of the Use of Mathematics in Cancer ResearchThe
book will provide an exhaustive and clear explanation of how
Statistics, Mathematics and In-formatics have been used in cancer
research, and seeks to help cancer researchers in achieving their
objectives. To do so, state-of-the-art Biostatistics,
Biomathematics and Bioinformatics methods will be described and
discussed in detail through illustrative and capital examples taken
from cancer research work already published.
Features 7 Provides a clear perspective on how mathema-tics
have been used in cancer research 7 Pro-vides examples of
mathematics to correlate biomathematics, biostatistics, and
bioinformatics to cancer research 7 Thoroughly examines the
procedures of cancer-related biomathematics, biostatistics, and
bioinformatics
Contents Preface.- Historical Introduction.- Descriptive
biostatistics.- Inferential biostatistics I: Estimating values of
biomedical magnitudes.- Inferential biostatistics II: Estimating
biomedical behavi-ors.- Equations: Formulating biomedical laws and
biomedical magnitudes.- Systems of equations: The explanation of
biomedical phenomena(I). Basic questions.- Systems of equations:
The expla-nation of biomedical phenomena(II). Dynamic
interdependencies.- Optimal control theory: From knowledge to
control (I). Basic concepts.- Optimal control theory: From
knowledge to control (II). Biomedical applications.- Game theory.-
Index.
Fields of interestsCancer Research; Pharmacology/Toxicology
Target groupsResearch
Product categoryMonograph
Due March 2012
2012. IV, 286 p. 67 illus., 33 in color.
Hardcover7 * € (D) 149,75 |
€ (A) 153,94 | sFr 186,507 € 139,95 |
£126.00ISBN 978-1-4614-2396-6
9
www.springer.com/978-1-61779-402-5www.springer.com/978-1-61779-403-2www.springer.com/978-1-61779-404-9www.springer.com/978-0-387-69803-8www.springer.com/978-1-4614-2396-6
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Biomedicine springer.com/NEWSonline
16
M. Hayat, Kean University, Union, NJ, USA (Ed.)
Stem Cells and Cancer Stem Cells, Volume 5Therapeutic
Applications in Disease and Injury
Contents Cancer Stem Cells.- 1 Signaling Pathways In Cancer Stem
Cells Therapeutic Implications.- 2 Inhibition Of Telomerase With
Imetelstat Causes Depletion Of Cancer Stem Cells.- 3 Targeting
Self-Renewal Pathways In Cancer Stem Cells.- 4 Detection Of Cancer
Stem Cells Using Ac133 Antibody.- Tissue Injury.- 5 Peripheral
Nerve Regeneration After Traumatic Injury And Stem Cell Therapy.- 6
Neural Stem Cell Proliferation Surrounding The Area Of Traumatic
Brain Injury Role Of Exercise Therapy.- 7 Mesenchymal Stem Cell
Treatment For Ischemic Brain Injury.- 8 Role Of Neuropeptide Y On
The Maintenance Of Self- Renewal And Proliferation Of Human
Embryonic Stem Cells.- Cardiovascular Applications.- 9
Differentiation Of Human Adipose-Derived Stem Cells Into
Cardiomyocytes.- 10 Cellu-lar Cardiomyoplasty Arterial Cells-Stem
Cells Transplantation.- 11 Cardiac Stem Cells Derived From
Epithelial-Mesenchymal Transition Of The Epicardial Cells Role In
Heart Regeneration (Method).- 12 Allogenic Mesenchymal Stem Cells
In Experimental Ischaemic Stroke Translation To The Clinic?- Bone
Diseases.- 13 Bone Reconst-ruction Utilizing Mesenchymal Stem Cell
Sheets For Cell Delivery.- 14 Dental Implants Application Using
Tissue Engineering Technology.- 15 Dental Stem Cells Regeneration
Of Dentin Upon Tooth Injury.- 16 Scaffolds For Human Dental Stem
Cells To Regenerate Cementum.- Eye Disorders.- 17 Eye Disorders
Caused By Limbal Stem Cell Deficien-cy.- Viral Applications.
[...]
Fields of interestsCancer Research; Gene Expression; Laboratory
Medicine
Target groupsResearch
Product categoryContributed volume
Due February 2012
2012. XIV, 297 p. 45 illus., 38 in color.
(Stem Cells and Cancer Stem Cells, Volume 5) Hardcover7 *
€ (D) 160,45 | € (A) 164,94 |
sFr 200,007 € 149,95 | £135.00ISBN
978-94-007-2899-8
9
M. Hayat, Kean University, Union, NJ, USA (Ed.)
Stem Cells and Cancer Stem Cells, Volume 6Therapeutic
Applications in Disease and Injury
Contents I Embryonic stem cells.-1 Propagation of human
embryonic stem cell: role of tgf β.-2 Self-renewal of embryonic
stem cells: cell cycle regulation.-3 Gene expression and epigenetic
signatures of germ cell-derived pluripotent stem cells and
embryonic stem cells.-4 Human embryonic stem cell bank :
implication of human leukocyte antigens and abo blood group
antigens for cell transplantation.-5 Differentiation of embryonic
stem cells into glu-tamatergic neurons (methods).-6 Differentiation
of embryonic stem cells into endoderm-derived hepatocytes.-7
Differentiation of embryonic stem cells into cardiomyocytes: role
of ouabain.-8 Func-tion of myc for generation of induced
pluripotent stem cells masato nakagawa and shinya yamana-ka.-9
Differentiation of human pluripotent stem cells into retinal
cells.-10 Derivation and invasive function of trophoblast
from human pluripotent stem cells. II Mesenchymal stem cells.-11
Differen-ces between germ-line stem cells and multipotent adult
germ-line stem cells role of micrornas.-12 Molecular and signaling
pathways that modula-te mesenchymal stem cell self-renewal.-13 The
biology and regenerative potential of stem cells and their
mesenchymal progeny.-14 Mesenchymal stem cells: clinical
applications (an overview).-15 Mesenchymal stem cells for the
treatment of cancer.-16 Treatment of neurodegenerative patho-logies
using undifferentiated mesenchymal stem cells.-17 Utility of
mesenchymal stem cell therapry in type 1 diabetes.-18
Differentiation of mesen-chymal stem cells into
adipocyte lineage: role of cytoskeleton-associated
proteins. [...]
Fields of interestsCancer Research; Stem Cells; Pathology
Target groupsResearch
Product categoryContributed volume
Due March 2012
2012. XX, 476 p. 62 illus., 56 in color.
(Stem Cells and Cancer Stem Cells, Volume 6) Hardcover7 *
€ (D) 160,45 | € (A) 164,94 |
sFr 200,007 € 149,95 | £135.00ISBN
978-94-007-2992-6
9
M. Hayat, Kean University, Union, NJ, USA (Ed.)
Teratoid/Rhabdoid, Brain Tumors, and GliomaContents Part I
Teratoid/Rhabdoid.- 1. Pediatric Atypical Teratoid/Rhabdoid
Tumors (An Overview).- 2. Pediatric Atypical
Teratoid/Rhabdoid Tumor .- 3. Pediatric Rhabdomyosarcoma:
Role Of Cell Cycle Regulators Alteration.- 4. Pediatric
Atypical Teratoid/Rhabdoid Tumors: Imaging With Ct And Mri.-
5. Pediatric Atypical Teratoid/Rhabdoid Tumor: Diagnosis Using
Imaging Techniques And Histopathology.- 6. Pediatric Atypical
Teratoid/Rhabdoid Tumors: Differential Diagnosis.- Part II Brain
Tumors (General).- 7. Pediatric Brain Tumors (An
Overview).- 8. Pediatric Cns Primitive Neuroectodermal Tumor:
Role Of The Wnt Pathway.- 9. Neuroblastic Tumors:
Status And Role Of Her Family Recep-tors.- 10. Children
With Neurofibromatosis Type 1: Positron Emission Tomography.-
11. Metabolite Profile Differences In Childhood Brain Tumors: 1h
Magic Angle Spinning Nmr Spectroscopy.- 12. Central Nervous
System Imaging In Childhood Leukemia.- 13.
Immunohistochemistry In The Differential Diagnosis Of Adult And
Pediatric Brain Tumors.- 14. Children With Brain Tumors: Role
Of The Neurosurgeon.- 15. Pediatric Intra-ventricular Brain
Tumors: Endoscopic Neurosur-gical Techniques.- 16.
Neurosurgical Management Of Pediatric Brain Tumors.- 17.
Pediatric Brain Tumor Biopsy Or Resection: Use Of Postoperative
Nonnarcotic Analgesic Medication.- 18. Clinical Trials In
Pediatric Brain Tumors; Radiotherapy.- 19. Epileptic Seizures
And Supratentorial Brain Tumors In Children.- 20.
Postoperative Pain In Children: Advantage Of Using Nonnarcotic
Analgesic Regimen. [...]
Fields of interestsCancer Research; Pediatric Surgery; Imaging /
Radiology
Target groupsResearch
Product categoryContributed volume
Due March 2012
2012. XIX, 369 p. 57 illus., 27 in color.
(Pediatric Cancer, Volume 2) Hardcover7 *
€ (D) 160,45 | € (A) 164,94 |
sFr 200,007 € 149,95 | £135.00ISBN
978-94-007-2956-8
9
www.springer.com/978-94-007-2899-8www.springer.com/978-94-007-2992-6www.springer.com/978-94-007-2956-8
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News 12/2011 Biomedicine
17
M. Hayat, Kean University, Union, NJ, USA (Ed.)
Tumors of the Central Nervous System, Volume 7Meningiomas and
Schwannomas
Contents MENINGIOMAS.- Molecular Genetics.-
1. Me-ningiomas: Role Of Semaphorin3a Protein In
Antiangiogenesis.- 2. Meningiomas: Role Of Carbonic Ahydrase Ii.-
3. Meningiomas: Role Of Genetic Instabilities Of The E- Cadherin
Gene.- 4. Intracranial Meningiomas: Role Of Exogenous Hormones.- 5.
Meningiomas: Clinical Needs And Molecular Insights.- 6. Meningioma:
Urokinase Plasminogen Activator.- 7. Mir-200a Regulation Of The Wnt
Signaling In Meningioma Tumori-genesis.- Diagnosis.- 8.
Meningiomas: Determi-nation Of Subtypes Using Perfusion Magnetic
Resonance Imaging.- 9. Intracranial Meningioma In Mice: Noninvasive
Bioluminescence Imaging.- 10. Incidentally Discovered Meningiomas:
Growth Rates And Patterns.- 11. Cycstic Papillary Menin-gioma:
Diagnosis.- 12. Meningioma Tumors: De-tection Of Subgroups.-
13. Prognostic Parameters In Atypical And Malignant
Meningiomas.- 14. Sporadic Meningioangiomatosis: Diagnosis With
Computed Tomography And Magnetic Resonance Imaging Therapy.- 15.
Atypical Meningioma: Distinguishing Features And Role Of Adjuvant
Radiation.- 16. Gamma Knife Radiosurgery For Benign Meningioma:
Significance And Therapeu-tic Potential.- 17. Oncocytic Meningioma:
Neuro-surgery.- 18. Intracranial Meningiomas: Treatm-nent And
Quality Of Life.- 19. Cavernous Sinus Meningiomas: Optimal
Treatment.- Recurrence.- 20. Genetic And Clinical Features
Associated With Recurrence In Atypical Meningioma.- 21. Recurrence
And Progression In Meningiomas. [...]
Fields of interestsCancer Research; Laboratory Medicine; Drug
Resistance
Target groupsResearch
Product categoryContributed volume
Due February 2012
2012. XLII, 359 p. 67 illus., 35 in color.
(Tumors of the Central Nervous System, Volume 7) Hardcover7 *
€ (D) 160,45 | € (A) 164,94 |
sFr 200,007 € 149,95 | £135.00ISBN
978-94-007-2893-6
9
M. S. Islam, Karolinska Institutet, Stockholm, Sweden
(Ed.)
Calcium SignalingContents Preface.-1 The regulation of a cell‘s
Ca2+ signaling toolkit: the Ca2+ homeostasome.-2 Methods to detect
Ca2+ in living cells.-3 Development and Optimization of FLIPR High
Throughput Calcium Assays for Ion Channels and GPCRs.-4
Two-photon calcium imaging in the intact brain.-5 Sig-naling
through the Extracellular Calcium-Sensing Receptor (CaSR).-6 Ca2+
signaling: an outlook on the characterization of Ca2+ channels and
their importance in cellular functions.-7 Ryanodine receptor
calcium release channels: an evolutionary perspective.-8 Techniques
and methodologies to study the ryanodine receptor at the
molecu-lar, subcellular and cellular level.-9 Ryanodine Receptor
Physiology and its role in Disease.-10 Phospholipase C.-11 Inositol
1,4,5-trisphosphate and its receptors.-12 Discovery and structural
in-vestigation of the IP3 receptor and the associated IRBIT, a
personal account.-13 Pyridine nucleotide metabolites and calcium
release from intracellular stores.-14 NAADP on target.-15
Store-operated Ca2+ entry.-16 Structure, regulation and biophy-sics
of ICRAC, STIM/Orai1.-17 Mitochondria-associated membranes (MAMs)
as hotspot Ca2+ signalling units.-18 Calcium around the Golgi
apparatus: implications for intracellular memb-rane trafficking.-19
Calcium binding proteins.-20 Cytoplasmic calcium buffering.-21
Elementary calcium release events from the sarcoplasmic reticulum
in the heart.-22 Calcium oscillations and pacemaking.-23 Calcium
Oscillations and Waves in Cells.-24 Calcium signaling: From single
channels to pathways.-25 Simulation strategies for calcium
microdomains and calcium-regulated calcium channels. [...]
Fields of interestsBiomedicine general; Neurosciences;
Receptors
Target groupsGraduate
Product categoryContributed volume
Due February 2012
2012. XX, 1012 p. 199 illus., 143 in color.
(Advances in Experimental Medicine and Biology, Volume 740)
Hardcover7 * € (D) 213,95 |
€ (A) 219,94 | sFr 266,507 € 199,95 |
£180.00ISBN 978-94-007-2887-5
9
JIMD Reports Society for the Study of Inborn Errors o
(Ed.)
Volume 3
Society for the Study of Inborn Errors o, SSIEM, London,
UK (Ed.)
JIMD Reports - Case and Research Reports, 2011/3JIMD Reports
publishes case and short re-search reports in the area of inherited
metabolic disorders. Case reports highlight some unusual or
previously unrecorded feature relevant to the disorder, or serve as
an important reminder of clinical or biochemical features of a
Mendelian disorder.
Features 7 Unique collection of case and research reports
on rare metabolic disorders 7 Contains unusual or previously
unrecorded features relevant to me-tabolic disorders 7 All
contributions rigorously peer-reviewed
Contents Different Case Reports.
Fields of interestsHuman Genetics; Metabolic Diseases;
Pediatrics
Target groupsResearch
Product categoryContributed volume
Due December 2011
2012. VII, 139 p. 37 illus., 13 in color.
Softcover7 * € (D) 106,95 |
€ (A) 109,95 | sFr 133,507 € 99,95 |
£90.00ISBN 978-3-642-24935-8
9
www.springer.com/978-94-007-2893-6www.springer.com/978-94-007-2887-5www.springer.com/978-3-642-24935-8
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Biomedicine springer.com/NEWSonline
18
S. Kaul, R. Wadhwa, National Institute of Advanced
Industrial Science & Technology, Ibaraki, Japan (Eds)
Mortalin Biology: Life, Stress and DeathContents Contributors.-
Foreword.- Preface.- Section 1: Structure and Function of
Mortalin.- 1. Birth of Mortalin: Multiple Names, Niches and
Functions Connecting Stress, Senescence and Cancer.- 2.
Mortalin’s Machinery.- 3. The Role of Mortalin in Iron
Homeostasis .- 4. Functional Characteristics of
Mortalin.- Section 2: Mortalin in Evolution2
Deocaris.- 5. Mortalin and Drosophila DmH-sp22: Two
Mitochondrial Chaperones Regulating Aging and Carcinogenesis
.- 6. Mortalin in Invertebrates and The Induction of
Apoptosis by Wild-Type p53 Following Defeat of Mortalin-Based
Cytoplasmic Sequestration in Cancerous Clam Hemocytes
.- 7. Mortalin and Stem Cells: A Study from
Planarians.- Section 3: Morta-lin in Health and
Disease.- 8. Mortalin in Cell Protection from Immune Attack
.- 9. Mortalin in Neurological Diseases.- 10. Loss of
Mortalin Function in Parkinson’s Disease – Supporting the
Mitochondrial Pathway of Neurodegeneration.- 11.
Hsp75/mortalin and Protection from Ischemic Brain Injury.- 12.
Catecholamine Regulated Protein (CRP40), A Splice Variant of
Mortalin-2: Functional Role in CNS Disorders.- 13.
Chapero-nopathies: Diseases in Which Mortalin and Other
Hsp-Chaperones Play a Role in Etiology and Pathogenesis.-
Section 4: Mortalin and Cancer.- 14. The Many Faces of
Mortalin and Tid1.- 15. Mortalin: A Positive Regulator of
Centrosome Duplication and Amplification.- 16. Mortalin
Ex-pression in Normal and Neoplastic Tissues .- 17. Mortalin
- p53 Interaction as A Target for Liver Cancer Therapy.- 18.
Mortalin Targeting Gadgets for Cancer Therapy. [...]
Fields of interestsMolecular Medicine; Gene Function; Cancer
Research
Target groupsResearch
Product categoryContributed volume
Due March 2012
2012. 300 p. 77 illus., 27 in color. Hardcover7 *
€ (D) 149,75 | € (A) 153,94 |
sFr 186,507 € 139,95 | £126.00ISBN
978-94-007-3026-7
9
W. J. Kress, D. L. Erickson, Smithsonian
Institution, Washington, DC, USA (Eds)
DNA BarcodesMethods and Protocols
Features 7 A compendium of the latest information on
generating, applying, and analyzing DNA 7 Pro-vides
step-by-step detail essential for reproducible results
7 Contatins key notes and implementati-on advice from the
experts
Contents Foreword.-Introduction.-Introduction to Animal DNA
Barcoding Protocols.-DNA Barcodes for the Tree of Life – A. Animals
- Insects.-Barcoding Me-thods for Invertebrates.-DNA Barcoding of
Am-phibians and Reptiles.-DNA Barcoding Fishes.-DNA Barcoding
Birds: from Field Collection to Data Analysis.-DNA Barcoding in
Mammals.-Methods for DNA Barcoding of Fungi.-Methods for DNA
Barcoding Photosynthetic Protists Emphasizing the Macroalgae and
Diatoms.-DNA Barcoding Methods for Land Plants.-Field Infor-mation
Management Systems (FIMS) for DNA Barcoding.-Laboratory Information
Manage-ment Systems (LIMS) for DNA Barcoding.-DNA Extraction,
Preservation and Amplification.-DNA Mini-barcodes.-Next Generation
Sequencing: Multiplexing Multiple Barcode Amplicons into Single 454
Run.-The Practical Evaluation of Bar-code Efficacy.-Plant DNA
Barcodes, Taxonomic Management and Species Discovery in Tropical
Forests.-Construction and Analysis of Phyloge-netic Trees using DNA
Barcode Data.- Phyloge-netic Analyses of Ecological
Communities Using Barcode Data.-DNA Barcodes: FISH-BOL, a Case
Study.-Generating Plant DNA Barcodes for Trees in Long-term Forest
Dynamics Plots.- Future Directions.
Fields of interestsHuman Genetics; Animal Genetics and Genomics;
Plant Genetics & Genomics
Target groupsProfessional/practitioner
Product categoryContributed volume
Due April 2012
2012. 435 p. 71 illus., 10 in color. (Methods in
Molecular Biology, Volume 858) Hardcover7 approx. *
€ (D) 112,30 | € (A) 115,45 |
sFr 137,507 approx. € 104,95 | £93.00ISBN
978-1-61779-590-9
9
S. D. Mittleman, University of Southern California,
Los Angeles, CA, USA; N. A. Berger, Case Western Reserve
University, Cleveland, OH, USA (Eds)
Energy Balance and Hematologic MalignanciesThe obesity pandemic
continues to increase on a world-wide basis with over 70% of the
United States population being either overweight or obe-se.
Hematologic malignancies have recently been identified among the
obesity associated malignan-cies spanning the lifespan from
childhood to the elderly and include leukemia, myeloma, lympho-ma
and others.
Features 7 Focuses on the relation of obesity to
hemato-logic malignancies, the epidemiology, potential mechanisms,
and therapeutic considerations on energy balance 7 Adds to the
burgeoning field of information on metabolism and cancer
7 In-cludes effects on pharmacologic and physical approaches
as well as the delayed effects of therapy on energy balance
Contents Preface.- The Epidemiology of Obesity and Hematologic
Malignancies.- Adipocytes, Lipid Metabolism and Hematopoiesis.-
Mechanisms Linking Obesity and Leukemia Prognosis.- Obesi-ty and
Multiple Myeloma.- The Impact of Obesity on Pharmacokinetics and
Dosing of Leukemia Chemotherapy.- The Impact of Obesity on Stem
Cell Transplant.- Obesity Following Childhood Leukemia: Mechanisms
and Consequences.- Phy-sical Activity and Recovery from
Hematological Malignancy.- Index.
Fields of interestsPharmacology/Toxicology; Cancer Research
Target groupsResearch
Product categoryContributed volume
Due March 2012
2012. VI, 144 p. 20 illus., 19 in color.
(Energy Balance and Cancer, Volume 5) Hardcover7 approx. *
€ (D) 149,75 | € (A) 153,94 |
sFr 201,007 approx. € 139,95 | £126.50ISBN
978-1-4614-2402-4
9
www.springer.com/978-94-007-3026-7www.springer.com/978-1-61779-590-9www.springer.com/978-1-4614-2402-4
-
News 12/2011 Biomedicine
19
New SeriesSpringer Series in Translational Stroke ResearchSeries
editor: J. Zhang
The Springer Series in Translational Stroke Re-search will cover
basic, translational and clinical research, emphasizing novel
approaches to help translate scientific discoveries from basic
stroke research into the development of new strategies for the
prevention, assessment, treatment, and en-hancement of central
nervous system repair after stroke and other forms of
neurotrauma.
P. A. Lapchak, Cedars-Sinai Medical Center, Los
Angeles, CA, USA; J. H. Zhang, Loma Linda University, CA,
USA (Eds)
Translational Stroke ResearchFrom Target Selection to Clinical
Trials
Contents Vascular Targets For Ischemic Stroke Treatment.-
Identifying Vascular Targets to Treat Hemorrhagic Stroke.-
Experimental Platforms For Assessing White Matter Pathophysiology
In Stroke.- Neu-roprotection in Stroke.- Protein Aggregation And
Multiple Organelle Damage After Brain Ischemia.- Antioxidants And
Stroke. Success And Pitfalls.- Caspase-Independent Stroke Targets.-
Hypoxia-Inducible Factor: A New Hope To Counteract Stroke.-
Thrombin in Ischemic Stroke Targe-ting.- Toll-Like Receptor
Agonists As Antecedent Therapy For Ischemic Brain Injury:
Advancing Preclinical Studies To The Nonhuman Prima-te.-
Angiogenesis and Arteriogenesis As Stroke Targets.- Hematopoietic
Growth Factor Family For Stroke Drug Development.- Soluble Epoxide
Hydrolase As A Stroke Target.- Membrane Poten-tial As Stroke
Target.- Hypothermia To Identify Therapeutic Targets For Stroke
Treatment.- Stroke Preconditioning To Identify Endogenous
Protec-tive Or Regenerative Mechanisms.- MicroRNAs in Ischemic
Brain: The Fine-tuning Specialists and Novel Therapeutic Targets.-
Neuroglobin: A Novel Target For Endogenous Neuroprotection.-
Characterization Of Novel Neuroprotective Lipid Analogues For The
Treatment Of Stroke.- Na+/H+ Exchangers As Therapeutic Targets For
Cerebral Ischemia.- Iron as a therapeutic target in intracerebral
hemorrhage: Preclinical testing of deferoxamine.- Overcoming
Barriers To Transla-tion From Experimental Stroke Models. Animal
Models Of Stroke For Preclinical Drug Develop-ment: A Comparative
Study Of Flavonols For Cytoprotection. [...]
Fields of interestsNeurosciences; Neurobiology
Target groupsUpper undergraduate
Product categoryContributed volume
Due February 2012
2012. XXX, 974 p. 162 illus., 107 in color.
(Springer Series in Translational Stroke Research) Hardcover7 *
€ (D) 160,45 | € (A) 164,94 |
sFr 200,007 € 149,95 | £135.00ISBN
978-1-4419-9529-2
9
S. Markowitz, N. A. Berger, Case Western Reserve
University, Cleveland, OH, USA (Eds)
Energy Balance and Gastrointestinal CancerThe gastrointestinal
track provides one of the distinct systems where multiple
malignancies, including adenocarcinoma of the pancreas, eso-phagus
and colon are each associated with obesity. This unique association
is covered in this volume of Energy Balance and Cancer from the
epidemio-logic, biologic and potential etiologic viewpoint. The
focus on possible dietary contribution as well as the role of
exercise in prevention and therapy is presented in both animal
model and patient based studies.
Features 7 Explores relation between obesity and
gastrointestinal cancer 7 Features up-to-date re-search
7 Examines the effects of physical activity on colon cancer
prognosis
Contents Preface.- Obesity and Gastrointestinal Cancers:
Epidemiology.- Genetics of Colon Cancer
Suscep-tibility.- Dietary Modulation of Colon Cancer: Effects
on Intermediary Metabolism, Mucosal Cell Differentiation and
Inflammation.- The ApcMin/+ Mouse Model to Study the Effects of
Exercise on Gastrointestinal Malignancy.- Obesity and the
Pathogenesis of Barrett’s Esophagus.- Obesity and Pancreatic
Cancer.- Obesity, Insulin Resistance Pathway Factors and Colon
Cancer.- Ras/Raf and their Influence in Glycolysis in Colon
Cancer.- Energy Balance and Other Modifiable Host Fac-tors on
Colorectal Cancer Prognosis.- Cyclooxy-genase-2 and Chronic
Inflammation: Drivers of Colorectal Tumorigenesis.-
Index.
Fields of interestsCancer Research; Human Physiology
Target groupsResearch
Product categoryContributed volume
Due March 2012
2012. V, 158 p. 15 illus., 9 in color.
(Energy Balance and Cancer, Volume 4) Hardcover7 *
€ (D) 149,75 | € (A) 153,94 |
sFr 186,507 € 139,95 | £126.00ISBN
978-1-4614-2366-9
9
www.springer.com/978-1-4419-9529-2www.springer.com/978-1-4614-2366-9
-
Biomedicine springer.com/NEWSonline
20
S. Modrow, University of Regensburg, Germany;
D. Falke, Mainz, Germany; U. Truyen, University Leipzig,
Germany; H. Schätzl, Technical University Munich, Germany
Molecular VirologyContents A General part.- Historical
overview.- Viru-ses: definition, structure, classification.- Virus
proliferation and replication.- Pathogenesis.- Cell damage.-
Transformation and carcinogene-sis.- Immunology.- Cytokines,
chemokines and interferons.- Chemotherapy.- Vaccines.-
Epide-miology.- Virus evolution.- Laboratory methods for detection
virus infections.- B Special part.- Vi-ruses with
single-stranded, positive-sense RNA genomes.- Viruses with
single-stranded, non-seg-mented, negative-sense RNA genomes.-
Viruses with single-stranded, segmented, negative-sense RNA
genomes.- Viruses with double-stranded, segmented RNA genomes.-
Viruses with single-stranded RNA genomes and double stranded DNA as
intermediate products. [...]
Fields of interestsMolecular Medicine; Virology; Medical
Micro-biology
Target groupsGraduate
Product categoryReference work
Due September 2012
Print
2013 2013. XX, 800 p. 161 illus. 7 *
€ (D) 533,93 | € (A) 548,90 |
sFr 715,507 € 499,00 | £449.50ISBN
978-3-642-20717-4
9 eReference
2013 2013. XX, 800 p. 161 illus. 7 **
€ (D) 593,81 | € (A) 598,80 |
sFr 752,007 € 499,00 | £449.50ISBN
978-3-642-20718-1
9 Print + eReference
2013 2013. XX, 800 p. 161 illus. 7 *
€ (D) 667,68 | € (A) 686,40 |
sFr 895,007 € 624,00 | £562.00ISBN
978-3-642-20719-8
9
P. Salvi, IRCCS Istituto Auxologico Italiano, Milano,
Italia
Onde di polsoCome l‘emodinamica vascolare determina la pressione
arteriosa
Come origina la pressione arteriosa? Come interpretare i valori
pressori? È più importante la pressione sistolica o la diastolica?
Questi sono solo alcuni degli interrogativi che si pone il medico
quando affronta nella pratica clinica quotidiana il problema
dell’ipertensione arteriosa. Questo libro intende presentare, in
maniera imme-diata ed efficace, le complesse nozioni di base
dell’emodinamica vascolare e della sua fisiopato-logia,
sottolineando l’importanza delle proprietà meccaniche delle grandi
arterie nella genesi della pressione arteriosa.
Features 7 I concetti fisici più complessi sono
presentati in maniera immediata ed efficace 7 Le
numerose figure e il linguaggio accessibile rendono il testo
più comprensibile e la lettura più agevole 7 Box e riquadri
individuano gli argomenti più speciali-stici e distinguono le parti
essenziali del testo dagli ulteriori approfondimenti
Contents Introduzione.- La pressione arteriosa media.- La
pressione pulsatoria; Le proprietà meccaniche delle grandi
arterie.- Valutazione delle proprietà meccaniche delle grandi
arterie.- La pressione arteriosa centrale.- Analisi della
curva di pressione centrale.- Pressione centrale e rischio
cardiovasco-lare.- Acquisizione non-invasiva della pressione
arteriosa centrale.- Strumenti per l’analisi dell’onda
pressoria e la misura della velocità dell’onda di
polso.- Velocità dell’onda di polso e pressione cen-trale in
animali da laboratorio.- Bibliografia.
Fields of interestsHuman Physiology; Cardiology
Target groupsProfessional/practitioner
Product categoryMonografia
Pubblicazione prevista per il mese di January 2012
2012. Approx. 150 pagg. 120 figg.
Brossura7 approx. * € (D) 36,99 |
€ (A) 38,02 | sFr 46,507 approx.
€ 34,57 | £31.99ISBN 978-88-470-2423-6
9
R. Scatena, P. Bottoni, B. Giardina, Catholic
University, Rome, Italy (Eds)
Advances in Mitochondrial MedicineContents Section I –
Physiology and structure of Mito-chondria.-
1.
The oxidative phospho-rylation system in mammalian mitochondria.-
2. Physiology and pathophysiology of mitochondrial DNA.-
3. Mitochondrial calcium as a key regulator of mitochondrial
activities.- 4. Mitochondria and Nitric Oxide: Chemistry and
Pathophysiology.- 5. Mitochondria and reactive oxygen species -
which role in physiology and pathophysiology?.- 6. Uncoupling
proteins: molecular, functional, re-gulatory, physiological and
pathological aspects.- 7. The mitochondrial pathways of
apoptosis.- Sec-tion II – Mitochondria and disease.- 8. Inherited
mitochondrial disorders.- 9. Mitochondria and metabolism diseases.-
10. Mitochondria and diabetes. An intriguing pathogenetic role.-
11. Mi-tochondria and heart diseases.- 12. Mitochondria in
neurodegeneration.- 13. Mitochondria and cancer: a growing role in
apoptosis, cancer cell metabolism and dedifferentiation.- Section
III – Mitochondria and Aging.- 14.Mitochondria and aging.- 15.
Mitochondria and pharmacology. -16. Iatrogenic mitochondriopathies:
a recent lesson from nucleoside/nucleotide reverse transcriptase
inhibitors.- 17. Dysfunction of mitochondrial respiratory chain
complex I in neurological dis-orders: genetics and pathogenetic
mechanisms.- 18. Anthracyclines and mitochondria.- Section IV-
Applications of Mitochondrial science.- 19. Mitochondrial
proteomics approaches for new potential diagnostic and prognostic
biomarkers in cancer.- 20. Mitochondria in Anthropology and
forensic medicine.
Fields of interestsBiomedicine general; Cancer Research;
Molecular Medicine
Target groupsResearch
Product categoryContributed volume
Due February 2012
2012. VII, 492 p. 59 illus., 28 in color.
(Advances in Experimental Medicine and Biology, Volume 942)
Hardcover7 * € (D) 160,45 |
€ (A) 164,94 | sFr 200,007 € 149,95 |
£135.00ISBN 978-94-007-2868-4
9
www.springer.com/978-3-642-20717-4www.springer.com/978-3-642-20718-1www.springer.com/978-3-642-20719-8www.springer.com/978-88-470-2423-6www.springer.com/978-94-007-2868-4
-
News 12/2011 Biomedicine
21
S. Shankar, R. Srivastava, University of Kansas
Medical Center, Kansas City, KS, USA (Eds)
Nutrition, Diet and CancerContents 1.Aberrant signaling pathways
in cancer: Mo-dulation by the dietary flavonoid, quercetin.- 2.
“Micronutrient and Cancer: Add Spice to Your Life”.- 3.
Chemoprevention of prostate cancer with cruciferous vegetables:
role of epigenetics.- 4. Molecular insight and preclinical
perspective of thymoquinone as chemopreventive agent and
the-rapeutic adjunct in cancer.- 5. Dietary biofactors in the
management of cancer: Reality or Myth?.- 6. Nutritional Compounds
as Chemopreventive Agents by Proteasome Inhibition. -7. STAT
Sig-naling in Cancer Prevention.- 8. gdT cells, tea and cancer.- 9.
Phytochemical Intakes with a Mediter-ranean Diet: Levels Achievable
with an Exchange List Diet and Potential Biomarkers in Blood.- 10.
Plant polyphenols and their role in cancer prevention and
chemotherapy.- 11. Role of Food Micro-molecules in the Prevention
of Cancer.- 12. The protective role of zinc in cancer: A potential
chemopreventive agent.- 13. Diet-induced Epige-netic Changes and
Cancer Prevention: A Mantra for Healthy Living.- 14. Western
Diet-Induced Pancreatic Cancer.- 15. Intracellular signaling
net-work as a prime chemotherapy target of green tea catechin,
(–)-epigallocatechin-3-gallate.- 16. Role of Dietary Antioxidants
in Cancer.- 17. Curcumin: Structure, Biology and Clinical
Applications.- 18. Obesity, cancer and psychopathology: can
vegetarian diet be of help?.- 19. Dietary Phytoche-micals as
Epigenetic Modulators in Cancer.-
20. “Modulation of the
Nrf2 signaling pathway by chemopreventive dietary
phytoconstituents”.- 21. Role of fish oil from gene expression to
pharmaco-logical effects in cancer prevention.- 22. “Antioxi-dant
supplements: An evidence-based approach to health benefits and
risks“. [...]
Fields of interestsBiomedicine general; Cancer Research;
Nutrition
Target groupsResearch
Product categoryContributed volume
Due March 2012
2012. X, 548 p. 44 illus., 23 in color.
Hardcover7 * € (D) 160,45 |
€ (A) 164,94 | sFr 200,007 € 149,95 |
£135.00ISBN 978-94-007-2922-3
9
W. S. Spielman, N. Parameswaran, Michigan State
University, East Lansing, MI, USA (Eds)
RAMPsAmong the many GPCRs discovered, the calci-tonin family of
receptors comprise of members that regulate a number of
physiological processes and are involved in many pathological
conditions. Therefore, understanding how these receptors function
is a critical question in the field. When Foord and his colleagues
discovered that a single transmembrane protein called Receptor
Activity Modifying Proteins (RAMPs) could modulate the surface
expression of GPCRs of the calcitonin family, it widely opened the
field of receptor life cycle. Hundreds of studies have confirmed
the importance of RAMPs in the life cycle of this receptor
family.
Features 7 Source of basic studies that range from
bioche-mistry to molecular biology to receptor pharma-cology and
physiology 7 Written by authors well known in the RAMPs field
7 Provides informa-tion for scientists at different stages of
their career including graduate students, post-doctoral fellows and
senior scientists who are new to the RAMPs field
Contents Introduction to RAMPs.- RAMPs and CGRP Receptors.-
Regulation of GPCR Trafficking by RAMPs.- Regulation of Calcium
Sensing Receptor Trafficking by RAMPs.- Understanding RAMPs through
Genetically Engineered Mouse Models.- RAMPs as Drug Targets.- Ramp
Like Proteins: RTP and REEP Family of Proteins.- Regulation of RAMP
Expression in Diseases.- Perspectives on some Recent
Studies on RAMPs.
Fields of interestsBiomedicine general; Cell Biology; Molecular
Medicine
Target groupsResearch
Product categoryContributed volume
Due February 2012
2012. XVIII, 116 p. 14 illus. (Advances in
Experimental Medicine and Biology, Volume 744)
Hardcover7 approx. * € (D) 112,30 |
€ (A) 115,45 | sFr 137,507 approx.
€ 104,95 | £93.00ISBN 978-1-4614-2363-8
9
Y.-K. Tu, D. C. Greenwood, University of Leeds,
UK (Eds)
Modern Methods for EpidemiologyFeatures 7 Discussion of
modern statistical methods for epidemiology and biomedical research
that cannot be found in most textbooks, e.g. latent growth curve
models, latent class analysis, growth mixture models, regression
trees, generalised additive mo-dels, and G-estimation etc.
7 Written by experts in accessible language for upper-level
undergra-duate and postgraduate students in epidemiology and
biostatistics 7 Real life data sets are used extensively in
the book to illustrate how these method may be applied in real
research 7 Each chapter contains a section for further reading
list for readers who wish to pursue these methods in greater
details
Contents Preface.-1 Confounding and Causal path diagrams.-2
Statistical modelling of partially ob-served data using multiple
imputation: principles and practice.-3 Measurement errors in
epidemio-logy.-4 Selection bias in epidemiologic studies.-5
Multilevel modelling.-6 Modelling data that exhibit an excess
number of zeros: zero-inflated models and generic mixture models.-7
Multilevel latent class modelling.-8 Bayesian bivariate disease
mapping.-9 A multivariate random frailty effects model for multiple
spatially dependent survival data.-10 Meta-analysis of
observational studies.-11 Directed acyclic graphs and structural
equation modelling.-12 Latent growth curve models.-13 Growth
mixture modelling for life course epi-demiology.-14
G-estimations.-15 Generalised additive models.-16 Regression and
classification trees.-17 Statistical interactions and
gene-environ-ment joint effects. Index.
Fields of interestsBiomedicine general; Epidemiology;
Biostatistics
Target groupsProfessional/practitioner
Product categoryContributed volume
Due March 2012
2012. XV, 365 p. 60 illus., 10 in color.
Hardcover7 * € (D) 160,45 |
€ (A) 164,94 | sFr 200,007 € 149,95 |
£135.00ISBN 978-94-007-3023-6
9
www.springer.com/978-94-007-2922-3www.springer.com/978-1-4614-2363-8www.springer.com/978-94-007-3023-6