Stage 0

Stage 0

Frontal

Occipital

Stage 1

trans-entorhinal cortex

trans-entorhinal cortex

Stage 2

Entorhinal cortex

likely asymptomatic

Entorhinal cortex

Stage 3

Hippocampus

possible MCI

Hippocampus

Stage 4

probable MCI

Temporal pole

Temporal pole (BA 38)

Stage 5

inferior temporal cortex

very probable MCI

Stage 6

Subtle but significant cognitive impairment

mid temporal cortex

mid temporal cortex

Stage 7

First stage of clinical Alzheimer’s disease

polymodal association cortex

polymodal association cortex

Stage 8

Broca area(BA 44)

Intermediate stage of AD

Stage 9

Moderate to severe AD

Unimodal areas

Unimodal areas

Stage 10

Last stage of AD

All neocortical areas are affected, and many subcortical areas as well