Spectrum’s mission is to provide quality Membrane Separations Technology to the Life Science market.

Spectrum’s mission is to provide quality Membrane Separations Technology to

the Life Science market

Tangential F

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Filtra

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Tangential Flow Filtration

Shanghai, Oct. 26, 2011

Yingqing Huang, General Manager for Greater China

• Introduction to TFF• Applications• Challenges• Our Offerings

– Membranes, mPES,– System, KRIIi– Single Use Technology

• Designed for Scalability• Summary

Overview

Hollow Fiber TFF

• Effective Reduction of Membrane Fouling

• Tubular Membrane Geometry

• Large Surface Area in a Compact Size

• Gentle Separations with Relatively Low Pressure

• Available in UF and MF pore size ranges

• Directly Scalable by Increasing Number of Fibers

Applications

• Alternatives to centrifugation, depth filtration, etc.• Separation • Purification• Sterilization• Buffer exchange• Concentration

Company Application MERCK Drug delivery, vaccines

ACCELERON PHARMA Theoepeutical rProteins, IgG

NOVARTIS VACCINES & DIAGNOSTICS E.Coli concentration

SAIC FREDERICK Vaccines

BAXTER HEALTHCARE CORP. Pertusis, Mening C

MEDIMMUNE Vaccines

ABBOTT LABORATORIES Diagnostics

INTEGRA BIOLOGICS Bone Repair

AMGEN, INC. Cell Perfusion

ROCHE DIAGNOSTICS Diagnostics, latex

NANOSPECTRA BIOSCIENCES, INC. Gold nanoparticles

BECKMAN COULTER, INC. Diagnostics

GENENTECH INC Cell Culture, drug development

REFINE Perfusion

STEMCELL TECNOLOGIES Particle concentration / reactor

Industries

Challenges

Operation Time

• Membrane fouling• Pressure, flow, TMP, recirculation• System configuration• Interactions of parameters• Scale up loopholes

Our Offerings

• Wide range of membrane selections to meet diversified applications– Materials, SA, Pore size, Geometry, etc.

• Systems for both R&D and productions

• Pre-assembled Membrane, Bags, and Tubing packages to improve your efficiencies

• Direct tech support from application experts

Spectrum Hollow Fiber Modules

• Broadest Range of MWCO’s (1kD through 0.65 µm)

• Membrane Types = PS, mPES, ME, RC, PP

• Small Scale = MicroKros (5 cm2)

• Large Scale = KrosFlo Max module (22 m2)

• Sterile, Non-Sterile

Benefits of mPES Membranes

• Hydrophilic membrane• Low protein binding

& slow fouling• High selectivity • High permeability

• Easier R & D• Stable operations• High performance• Cost effective

Characteristics Benefits

KRIIi makes R&D Easier

• Provides all necessary components for your study

• Automated TMP control• Real time data collection and

graphic analysis• Small footprint• Provide solid data for scale up• Ideal for R&D and low volume

production

KF Comm Data Collection System

• Process data exports directly into MS Excel in real time

• Calculated feed flow rate , shear, TMP, etc.

• Customizable alarm setting for process safety

• Pressure control with non-invasive valves• Real-time graphing (virtual recording)• Make the most of your experiment• Recorded data for analysis

MBT Assemblies

Permeate Flow Meter

Pressure Transmitter

MBT Assemblies

• Reduce your setup or preparation time

• Reduce process variability• Reduce your logistics

burden• Improve your efficiencies

and productivity

Designed for Scalability

• Membrane module sizes• Customizable

Designed for Scalability

KrosFlo Research IIi KrosFlo MiniKros Pilot KrosFlo LDF-55

• Complete line of process systems

• KF Comm Date Collection System generates solid data for scale

up

• Scale up guided by technical sound rationales

MBT Systems for different scales• Compatible with KFComm

data collection systems. • Customizable and optimized

system setup and configuration for different systems

– KR2i – Bench Scale– KMP – Pilot Scale– LDF37 – Production – Khameleon Perfusion

Systems

• Wide selection of membranes including our unique offering of high performance mPES membrane.

• KRIIi research TFF system make your R&D easier.

• Single use MBT system improve your efficiency

• Complete product line and common data collection software ensures smooth transfer for R&D to production.

• Direct onsite technical service available

• Competitive price

SUMMARY

Thank You  多谢光临