e19 Invited Lecture Invited Lecture July 8 (Thu) 10:10 - 11:10 Room 1 Chair: Hideo FUKUI ( Axcelead Drug Discovery Partners, Inc. ) IL ○ Kohji NISHIDA Department of Ophthalmology, Osaka University Medical School Special Lecture Special Lecture 1 July 7 (Wed) 11:30 - 12:30 Room 5 Chair: Hideo FUKUI ( Axcelead Drug Discovery Partners, Inc. ) SL1 Risks and Benefits of Vaccine or Nonvaccine Therapeutic Interventions for COVID-19 ○ Kenneth L HASTINGS Hastings Toxicology Consulting LLC Special Lecture 2 July 7 (Wed) 13:50 - 14:50 Room 1 Chair: Yoshito KUMAGAI ( Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba ) SL2 Toward the Mysteries of Sleep ○ Masashi YANAGISAWA International Institute for Integrative Sleep Medicine (WPI-IIIS) Special Lecture 3 July 8 (Thu) 9:00 - 10:00 Room 1 Chair: Ikuo HORII ( Pfizer, Global ) SL3 Development Challenges for Carcinogenicity Risk Assessments of Topical Drugs ○ Brett D HOLLINGSHEAD, Nasir KHAN, Maik SCHULER, Zaher RADI Pfizer Drug Safety Research and Development Program
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e19
Invited Lecture Invited Lecture July 8 (Thu) 10:10 - 11:10
Room 1
Chair: Hideo FUKUI (Axcelead Drug Discovery Partners, Inc.)
IL ○ Kohji NISHIDA Department of Ophthalmology, Osaka University Medical School
Special Lecture Special Lecture 1 July 7 (Wed) 11:30 - 12:30
Room 5
Chair: Hideo FUKUI (Axcelead Drug Discovery Partners, Inc.)
SL1 RisksandBenefitsofVaccineorNonvaccineTherapeuticInterventionsforCOVID-19○ Kenneth L HASTINGS
Hastings Toxicology Consulting LLC
Special Lecture 2 July 7 (Wed) 13:50 - 14:50Room 1
Chair: Yoshito KUMAGAI (Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba)
SL2 TowardtheMysteriesofSleep○ Masashi YANAGISAWA
International Institute for Integrative Sleep Medicine (WPI-IIIS)
Special Lecture 3 July 8 (Thu) 9:00 - 10:00Room 1
Chair: Ikuo HORII (Pfizer, Global)
SL3 DevelopmentChallengesforCarcinogenicityRiskAssessmentsofTopicalDrugs○ Brett D HOLLINGSHEAD, Nasir KHAN, Maik SCHULER, Zaher RADI
Pfizer Drug Safety Research and Development
Program
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EducationalLectureEducationalLecture1 July 7 (Wed) 11:30 - 12:30
Room 1
Chair: Hirohiko OHTSUKA (Axcelead Drug Discovery Partners, Inc.)
1Institute of Research, Tokyo Medical and Dental University, 2Communication Design Center, Yokohama City University, 3Center for Stem Cell and Organoid Medicine, Cincinnati Children's Hospital Medical Center, 4Division of Gastroenterology, Hepatology and Nutrition and Division of Developmental Biology, Cincinnati Children's Hospital Medical Center
EducationalLecture4 July 9 (Fri) 10:10 - 11:10Room 1
Chair: Yoshito KUMAGAI (Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba)
EducationalLecture8 July 9 (Fri) 13:30 - 14:30Room 2
Chair: Ikuma YOSHIDA (Axcelead Drug Discovery Partners, Inc.)
EL8 Computationaltoxicologyandtheregulatoryenvironment– past,present,andfuture○ David R WOOLLEY
ForthTox Limited
Program
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SymposiumSymposium1 July 7 (Wed) 9:20 - 11:20
Room 1
Toxico-epigenomicslearnedfromaviewpointofdevelopmentalbiologyandcongenitalanomaly2.0Chairs: Kinichi NAKASHIMA (Graduate School of Medical Sciences, Kyushu University)
Satoshi KITAJIMA ( Division of Cellular & Molecular Toxicology, Center for Biological Safety & Research, National Institute of Health Sciences)
Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
11:13 - 11:20Conclusion
○ Masahito IKAWA RIMD, Osaka University
Symposium3 July 7 (Wed) 9:20 - 11:50Room 3
NewtrendsingenotoxicityresearchinvolvinggenomeinstabilityChairs: Kei-ichi SUGIYAMA ( Division of Genetics and Mutagenesis, Center for Biological Safety and Research, National
Institute of Health Sciences)Masayuki MISHIMA (Translational Research Division, Chugai Pharmaceutical)
1Division of Genetics and Mutagenesis, Center for Biological Safety and Research, National Institute of Health Sciences, 2National Institute of Health Sciences
Chemicalsensingtranscriptionfactors:TowardunderstandingtoxicitymechanismandriskassessmentChairs: Kouichi YOSHINARI (Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka)
Hiroyuki KOJIMA ( Division of Environmental Health and Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido)
1Division of Environmental Health and Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 2Division of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, 3Laboratory of Organic Geochemistry, Faculty of Agriculture, Tokyo University of Agriculture and Technology
1Division of Vaccine Science, The Institute of Medical Science, The University of Tokyo, 2National Institute of Biomedical Innovation, Health and Nutrition
1Center for Clinical Trial and Research Support, Research Promotion and Support Headquarters, Fujita Health University, 2Department of Ophthalmology, School of Medicine, Kanazawa Medical University, 3Division of Risk Assessment, NIHS
Chromosome Engineering Research Center, Tottori University
12:29 - 12:30ClosingRemark
Program
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Symposium7 July 7 (Wed) 14:50 - 16:50Room 2
Speciesdifferencesandpredictionofhumanresponseswithbiotherapeutics:reviewthemonkeyasalaboratoryanimalChairs: Satoshi KITAJIMA ( Division of Cellular & Molecular Toxicology, Center for Biological Safety & Research, National
Institute of Health Sciences)Mutsumi SUZUKI ( Toxicological Research Laboratories, Translational Research Unit, R&D Division Kyowa Kirin Co., Ltd.)
1Faculty of Advanced Science and Technology, Kumamoto University, 2Graduate School of Engineering, Nagoya University, 3Graduate School of Informatics, Kyoto University, 4Section of Liaison Psychiatry and Palliative Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 5Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
16:48 - 16:50Conclusion
Symposium9 July 7 (Wed) 14:50 - 17:20Room 4
ToxicOmicAIanalysisenhancedwithepigenomicsdataChairs: Masatoshi HAGIWARA ( Deaprtment of Anatomy and Developmental Biology, Graduate School of Medicine,
Kyoto University)Jun KANNO (National Institute of Health Sciences)
1National Institutes of Biomedical Innovation, Health and Nutrition, 2National Institute of Health Sciences, 3The Systems Biology Institute, 4SBX Corporations, 5Okinawa Institute of Science and Technology Graduate University, 6Osaka University
○ Omi WATANABE Japan Drug Information Institute in Pregnancy, National Center for Child Health and Development
16:46 - 16:50Conclusion
Symposium12 July 8 (Thu) 9:00 - 11:30Room 2
AIandInformaticsforthesafetyevaluationofchemicalcompoundsChairs: Kouichi YOSHINARI (Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka)
Yoshihiro YAMANISHI (Kyushu Institute of Technology)
1Center for iPS Cell Research and Application, Kyoto University, 2Translational Research Unit, R&D Division, Kyowa Kirin Co., Ltd., 3Environmental Health and Prevention Research Unit, Yokohama University of Pharmacy
JSTP-JSOTJointSymposium:TopicsfromtheSocietyofToxicologicalPathology:ApproachofModeofActionforsafetyevaluationofchemicalsubstancesChairs: Kumiko OGAWA (National Institute of Helath Sciences)
Kosei INUI (Ishihara Sangyo Kaisha, Ltd.)
9:00 - 9:05Introduction
○ Kumiko OGAWANational Institute of Helath Sciences
1Toxicology & Environmental Science Department, Biological Research Laboratories, Nissan Chemical Corporation, 2The Institute of Environmental Toxicology
1Research Center for Child Mental Development, Hamamatsu University School of Medicine, 2United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University, and University of Fukui, 3Nagoya University Graduate School of Medicine, Department of Child and Adolescent Psychiatry
○ Hirokatsu SAITO1, Satoshi KITAJIMA1, Jun KANNO3, Kentaro TANEMURA2
1Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences, 2Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University, 3National Institute of Health Sciences
11:01 - 11:29Discussion
○ Taiichi KATAYAMA (Osaka University, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui)
○ Yuuki MIYATAKE (Ministry of Health, Labour and Welfare), Chairs and Speakers
11:29 - 11:30Conclusion
Symposium17 July 8 (Thu) 15:00 - 17:00Room 2
LatestinformationonsafetyevaluationofpesticideintheworldChairs: Mie WATANABE-AKANUMA (Safety Resear Center, KUREHA CORPORATION )
1Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 2Faculty of Pharmaceutical Sciences, Showa University, 3National Institutes for Quantum and Radiological Science and Technology
Prevalenceofcomputationaltoxicologyforpharmaceutical: CasestudyforSystemconstructionunderontologyChairs: Hajime KOJIMA (National Institute of Health Sciences)
Shoji ASAKURA (Global Drug Safety, Eisai Co., Ltd)
knowledgeofexpertreview○ Naoki KOYAMA1, Megumi IKEMORI2, Tomoki NISHIOKA3, Seiji HITAOKA3, Atsushi HAKURA1, Chihiro NAKAZAWA1, Chakravarti K SUMAN4, Saiakhov D ROUSTEM4, Shinada K NICOLAS5, Palaniappan K SUCHEENDRA5, Yukiko MATSUOKA5, Shoji ASAKURA1
1Global Drug Safety, Eisai Co., Ltd., 2Planning & Operation. hhc Data Creation Center, Eisai Co., Ltd., 35D Integration Unit, hhc Data Creation Center, Eisai Co., Ltd., 4MultiCASE Inc., 5SBX Corporation
Drug Safety Research and Evaluation, Takeda Pharmaceutical Company Limited
Program
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Symposium20 July 8 (Thu) 15:00 - 17:00Room 5
JSOT-JCAJointSymposium:Molecularbasisandperspectiveforcarcinogenicityassessment:humanextrapolationbaseduponmutationsignatureandepigenomeChairs: Toshikazu USHIJIMA (Division of Epigenomics, National Cancer Center Research Institute)
Jun KANNO (National Institute of Health Sciences)
15:00 - 15:03Introduction
15:03 - 15:33S20-1 Evaluationofepigenomictoxicity
○ Toshikazu USHIJIMA, Naoko HATTORI Division of Epigenomics, National Cancer Center Research Institute
○ Jun KANNO, Atsuya TAKAGI, Ken-ichi AISAKI, Satoshi KITAJIMA National Institute of Health Sciences, Division of Cellular and Molecular Toxicolog7, CBSR.
1Department of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences, 2Division of Cellular Molecular Toxicology, National Institute of Health Sciences
1Division of Cellular and Molecular Toxicolog, CBSR, National Institute of Health Sciences, 2Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University
10:56 - 11:00Conclusion
Symposium24 July 9 (Fri) 9:00 - 11:30Room 6
JSIT-JSOTJointSymposium:CurrentstatusandchallengesfortheimmunotoxicitystudiesofvariousdrugmodalitiesChairs: Yasumitsu NISHIMURA (Department of Hygiene, Kawasaki Medical School)
1Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 2Laboratory of Hepatocyte Regulation, National Institutes of Biomedical Innovation, Health and Nutrition, 3The Center for Advanced Medical Engineering and Informatics, Osaka University, 4Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University
○ Matthew WAGONER, Tadahiro SHINOZAWA Drug Safety Research and Evaluation, Takeda Pharmaceuticals
Symposium28 July 9 (Fri) 14:00 - 16:00Room 5
JSCT-JSOTJointSymposium:Basicstudyandclinicalapplicationoftheposioningduetoinhaleddrugsand/orinhalableformulationsChairs: Manabu SUGITA (Dept. of Emergency and Critical Care Medicine, Juntendo University Nerima Hospital)
Satoshi KITAJIMA ( Division of Cellular & Molecular Toxicology, Center for Biological Safety & Research, National Institute of Health Sciences)
1Section of Preventive and Public Health Dentistry, Faculty of Dental Science, Kyushu University, 2OBT Research Center, Faculty of Dental Science, Kyushu University
1RIKEN Cluster for Pioneering Research, 2RIKEN Center for Sustainable Resource Science
10:27 - 10:30Conclusion
Workshop3 July 8 (Thu) 10:40 - 12:10Room 7
NonclinicalSafetyAssessmentofPharmaceuticalsin2035:AlternativestoAnimalExperimentsChairs: Dai KAKIUCHI (Eisai Co., Ltd. Biopharmaceutical Assessment Core Function Unit, Global Drug Safety)
Takeshi SATO (Drug Safety Research Labs, Drug Discovery Research, Astellas Pharma Inc.)
10:40 - 10:43Introduction
○ Takeshi SATODrug Safety Research Labs, Drug Discovery Research, Astellas Pharma Inc.
1Laboratory of Pharamacology and Therapeutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2Department of Pharmacology and Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA, 3Division of Pharmacy, National Cancer Center Hospital East
Candidates for the Excellent Presentation Award (Oral)
Candidates for the Excellent Presentation Award (Oral) 1 July 7 (Wed) 10:30 - 12:00Room 7
Chairs: Yuhji TAQUAHASHI ( Division of Cellular & Molecular Toxicology, Center for Biological Safety & Research, National Institute of Health Sciences)
1Life Science Research Center, University of Toyama, 2Translational Research Unit, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, 3Laboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University
double-walledcarbonnanotubes(DWCNT)withmulti-walledcarbonnanotubes-7(MWCNTS-7)inaratmodel○ Dina M. SALEH1, 2, 3, Shengyong LUO5, David B. ALEXANDER1, Ahmed M. EL-GAZZAR7, Mohammed ABDELGAIED6, Omnia H. MOHAMMED1, 2, 4, Willim T. ALEXANDER1, Sivagami GUNASEKARAN1, Takamasa NUMANO1, Hiroshi TAKASE8, Makoto OHNISHI9, Satoru TAKAHASHI2, Hiroyuki TSUDA1
1Nanotoxicology Lab Project, Nagoya City University, Nagoya, Japan, 2Departement of Experimental Pathology and Tumor Biology, Graduate School of Medicine, Nagoya City University, Nagoya, Japan, 3Departement of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Assuit University, Assuit, Egypt, 4Departement of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Aswan University, Aswan, Egypt, 5Anhui Medical University, College of Basic Medical Sciences, Hefei, China, 6Departement of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Beni-suef University, Beni-suef, Egypt, 7Departement of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt, 8Core Laboratory, Graduate School of Medicine, Nagoya City University, Nagoya, Japan, 9Japan Industrial Safety and Health Association, Japan Bioassay Research Center, Hadano, Kanagawa, Japan
ischemic stroke in mice○ Miki TANAKA1, Ami OGURO1, Yu NABETANI2, Tomoaki OKUDA3, Kouichi ITOH4, Yasuhiro ISHIHARA1
1Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, 2Department of Applied Chemistry, University of Miyazaki, 3Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 4Laboratory for Pharmacotherapy and Experimental Neurology, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University
1Laboratory of Toxicology, School of Veterinary Medicine, Hokkaido University, 2Department of Anatomy and Molecular Cell Biology, Graduate School of Medicine, Nagoya University, 3Faculty of Pharmaceutical Sciences, Toho University, 4Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, 5Life Science Research Center, University of Toyama, 6Student Affairs Section, Graduate School of Agricultural Science, Kobe University, 7Albany College of Pharmacy and Health Sciences, 8Department of Anaesthesiology, Medical Center East, Tokyo Women’s Medical University, 9Water Research Group, Unit for Environmental Sciences and Management, North-West University
1Department of Drug Metabolism and Pharmacokinetics, Nonclinical Research Center,Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, 2Department of Drug Safety, Nonclinical Research Center,Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, 3Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University
1Center for iPS Cell Research and Application, Kyoto University, 2Graduate School of Pharmaceutical Sciences, Osaka University, 3Graduate School of Pharmaceutical Sciences, Kyoto University, 4Graduate School of Engineering, Kyoto University
ReproductivesystemP-69E Risk assessment of AAV transmission to the next generation-in-situ
1Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 2Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
1Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 2Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
1Division of Pathology, National Institute of Health Sciences, 2Laboratory of Veterinary Medicine, Tokyo University of Agriculture and Technology, 3Division of Environmental Chemistry, National Institute of Health Sciences
Laboratory for Drug Discovery and Development, Shionogi & CO.,LTD.
Candidates for the Excellent Presentation Award (Oral) 2 July 7 (Wed) 14:50 - 16:14Room 7
Chairs: Makoto SHIBUTANI (Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology)Toyohiko AOKI (DIMS Institute of Medical Science, Inc.)
1Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 2Global Center for Medical Engineering and Informatics, Osaka University
1Toxicological Research Laboratories, Translational Research Unit, R&D Division, 2Center for iPS Cell Research and Application (CiRA), Kyoto University
1Drug Safety Research & Evaluation, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 2Drug Metabolism & Pharmacokinetics Research Laboratories
1Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Japan, 2Water Research Group, Unit for Environmental Sciences and Management, North-West University, Potchefstroom, South Africa, 3Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, USA, 4Chemistry Department, Kwame Nkrumah University of Science and Technology, Ghana, 5Department of Anesthesiology, Tokyo Women’s Medical University Center East, Japan, 6Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Japan, 7Faculty of Pharmaceutical Sciences, Toho University, Japan, 8Translational Research Unit, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Japan
Program
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Alternatives to mammalian modelsP-158E Characteristicsofsmallintestinalepithelialcellsderivedfromhuman
1Bio Science & Engineering Laboratory, FUJIFILM Corporation, 2Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University
1Drug Safety Research Laboratories, Drug Discovery Research, Astellas Pharma Inc., 2Drug Discovery Research, Astellas Pharma Inc., 3Advanced Informatics and Analytics, Astellas Pharma Inc.
Program
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OralSession
OralSession1 July 7 (Wed) 11:30 - 12:30Room 2
Chairs: Daigo SUMI (Faculty of Pharmaceutical Sciences, Tokushima Bunri University)Akio KOBAYASHI (Toxicology Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc.)
1Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, 2Department of Biomedical Chemistry, School of Science and Technology Kwansei Gakuin University
O-3 StudyonthemechanismunderlyingactivationofNrf2/SKN-1andlifespanelongationinCaenorhabditiselegansbychlorogenicacid○ Ferbian M. SISWANTO, Susumu IMAOKA
Department of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University
1Laboratory of Immunology and Microbiology, College of Pharmaceutical Science, Ritsumeikan University, 2Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, 3Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 4CREST, Japan Science and Technology Agency (JST), 5PRESTO, JST
Radioisotope Center, Kyoto Prefectural University of Medicine
OralSession2 July 8 (Thu) 11:10 - 12:10Room 4
Chairs: Yasumitsu NISHIMURA (Department of Hygiene, Kawasaki Medical School)Yasuhiro SHINKAI (Environmental Biology Lab, Faculty of Medicine, University of Tsukuba)
1Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 2Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, 3Laboratory of Biochemistry, Gifu Pharmaceutical University, 4School of Pharmacy, Gifu University of Medical Science
1Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, 2Graduate School of Environmental Science, Hokkaido University, 3Faculty of Environmental Earth Science, Hokkaido University
OralSession3 July 9 (Fri) 13:30 - 15:06Room 3
Chairs: Kumiko OGAWA (National Institute of Health Sciences)Misaki NAOTA (Pharmaceuticals and Medical devices Agency)
National Institute for Environmental Studies, Center for Health and Environmental Risk Reseach
Program
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O-13 Roleofmacrophagesincytotoxicity,reactiveoxygenspeciesproductionandDNAdamagein1,2-dichloropropane-exposedhumancholangiocytesinvitro○ Abigail EKUBAN1, Cai ZONG1, Frederick Adams EKUBAN1, Yusuke KIMURA1, Ryoya TAKIZAWA1, 3, Kota MORIKAWA1, Kazuo KINOSHITA2, Sahoko ICHIHARA3, Seiichiroh OHSAKO4, Gaku ICHIHARA1
1Department of Occupational and Environmental Health, Tokyo University of Science, Noda, Japan, 2Evolutionary Medicine, Shiga Medical Center Research Institute, Moriyama, Japan, 3Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan, 4Laboratory of Environmental Health Sciences, Faculty of Medicine, University of Tokyo, Tokyo, Japan
O-14 SulforaphaneAttenuatesAcrylamide-inducedNeuropathyinMiceChand Basha DAVULJIGARI, ○ Frederick Adams EKUBAN, Cai ZONG, Alzahraa A.M. FERGANY, Kota MORIKAWA, Gaku ICHIHARA
Department of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science
1Graduate School of Engineering Science, Yokohama National University, 2Division of Risk Assessment, Center for Biological Safety and Research, National Institute of Health Sciences, 3Faculty of Engineering, Yokohama National University
DanubeSurvey4(JDS4)byabatteryofin vitro bioassays○ Pavel SAUER1, Beate I. ESCHER2, Branislav VRANA3, Zuzana TOUSOVA3, Maria KOENIG2, Lili NIU2, Martin KRAUSS2, Petra MIKUSOVA3, Roman PROKES3, Jaromir SOBOTKA3, Pavla FIALOVA3, Rita SCHLICHTING2, Jiri NOVAK3, Roman GRABIC1, Klara HILSCHEROVA3
1University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, Research Institute of Fish Culture and Hydrocenoses, the Czech Republic, 2UFZ, Helmholtz Centre for Environmental Research, Cell Toxicology, Germany, 3Masaryk University, Faculty of Science, RECETOX, the Czech Republic
1College of Pharmaceutical Sciences, Ritsumeican University, 2Graduate School of Information Sciences, Tohoku University, 3College of Life Sciences, Ritsumeican University, 4PRESTO, JST
Program
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OralSession4 July 9 (Fri) 15:10 - 16:34Room 3
Chairs: Kazunori FUJIMOTO (Daiichi Sankyo Co., Ltd.)Yasuo YOSHIOKA (Institute for Open and Transdisciplinary Research Initiatives, Osaka University)
1Phenovance Research & Technology, LLC, 2Center for Health and Environmental Risk Research National Institute for Environmental Studies, 3Faculty of Medicine, University of Tsukuba
O-23 (Epi)GeneticEffectsofδ-AminolevulinicAcidDehydratase(ALAD)inChildrenExposedtoEnvironmentalLead-aprimarystudyfromKabwe,Zambia○ Yared B. YOHANNES1, 2, Shouta NAKAYAMA1, John YABE3, Hokuto NAKATA1, Haruya TOYOMAKI1, Andrew KATABA1, 3, Kaampwe MUZANDU3, Yoshinori IKENAKA1, Kennedy CHOONGO3, Mayumi ISHIZUKA1
1Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, 2Department of Chemistry, University of Gondar, Gondar, Ethiopia, 3School of Veterinary Medicine, University of Zambia, Lusaka, Zambia
1Faculty of Engineering, Yokohama National University, 2Division of Cellular and Molecular Toxicology, Biological Safety and Research Center, National Institute of Health Sciences
OralSession5 July 9 (Fri) 13:30 - 15:18Room 7
Chairs: Izuru MIYAWAKI (Preclinical Research Unit, Research Division, Sumitomo Dainippon Pharma Co., Ltd)Kouichi YOSHINARI (Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka)
1Institute of Neuroscience, Tokushima Bunri University, 2Kagawa School Pharmaceutical Sciences, Tokushima Bunri University, 3Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University
Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University
O-28 Role of microglia in mediating neurite retraction of noradrenergic neuronsfollowingacrylamideexposureandtranscriptomicanalysis○ Cai ZONG1, Harue SATO1, Sho IWAMA1, Schneider BENOIT2, Makoto URUSHITANI3, Shigeyuki SHICHINO4, Kouji MATSUSHIMA4, Seiichiroh OHSAKO5, Gaku ICHIHARA1
1Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2University of Paris, Inserm UMR-S1124, Paris, France, 3Department of Neurology, Shiga University of Medical Science, 4Research Institute for Biomedical Sciences, Tokyo University of Science, 5Graduate School of Medicine, The University of Tokyo
screeningonamicrofluidicproximaltubulemodel○ Linda GIJZEN1, M.K. VORMANN1, S. HUTTER1, J. VRIEND2, A. vd HEUVEL1, S. J. TRIETSCH1, J. JOORE1, M. WILMER2, L. SUTER-DICK3, R. MASEREEUW4, P. VULTO1, H. L. LANZ1
1MIMETAS BV, 2Department of Pharmacology and Toxicology, Radboud UMC, PO Box 9101, 6500HB, Nijmegen, The Netherlands, 3University of Applied Sciences Northwestern Switzerland, Muttenz, Switzerland, 4Div. Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
Department of Nutritional Science and Food Safety, Faculty of Bioscience, Tokyo University of Agriculture
O-32 AutomationandvalidationoftheOrganoPlateLiverToxforhepatotoxicitydetection○ Kristin BIRCSAK1, Richard DEBIASIO2, Mark MIEDEL2, Alaa ALSEBAHI1, Ryan REDDINGER1, Anthony SALEH1, Tongying SHUN2, Lawrence VERNETTI2, Albert GOUGH2
1Mimetas Inc, Gaithersburg, MD, 2University of Pittsburgh Drug Discovery Institute, Pittsburgh, PA
1Division of Risk Assessment, Center for Biological Safety and Research, National Institute of Health Sciences, 2Innovation Centre of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences, 4Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 5Department of Clinical Genomics, National Cancer Center Research Institute, 6USACE ERDC Environmental Laboratory, 7Department of Pathology, Kobe University of Graduate School of Medicine, 8Department of Translational Oncology, National Cancer Center Research Institute
OralSession6 July 9 (Fri) 15:20 - 16:44Room 7
Chairs: Kiyoshi MATSUMOTO (Takeda Pharmaceutical Company Limited)Makiko KUWAGATA (Division of Cellular and Molecular Toxicology, CBSR, National Institute of Health Sciences)
1Division of Cellular & Molecular Toxicology, Center for Biological Safety & Research, National Institute of Health Sciences, 2Department of Hygiene Chemistry, School of Pharmaceutical Sciences, Ohu University, Koriyama, Fukushima, Japan
ReproductiveanddevelopmentaltoxicologyO-36 Developmentofashort-termin vivo assayforthyroidhormone
1Laboratory for Drug Discovery and Development, SHIONOGI & CO., LTD., 2Shionogi Techno Advance Research & Co., Ltd., 3Laboratory for Medicinal Chemistry Research, SHIONOGI & CO., LTD., 4Laboratory for Drug Discovery and Disease Research, SHIONOGI & CO., LTD.
1Department of Systems Pharmacology, Mie University Graduate School of Medicine, 2Medical Zebrafish Research Center, Mie University, 3Division of Risk Assessment, National Institute of Health Sciences, 4Drug Safety Research Laboratories, Astellas Pharma Inc.
1School of Pharmaceutical Sciences, Ohu University, 2Faculty of Medical health Sciences, Tokyo International University, 3Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Science
1Life Science Research Center, University of Toyama, 2Translational Research Unit, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, 3Laboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University
1Laboratory of Environmental and Health Sciences, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 2Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 2Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 3Japan Synchrotron Radiation Research Institute, 4School of Pharmacy, Showa University
1Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 2Department of Environmental Health, Faculty of Pharmaceutical Sciences, Toho University, 3Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science
1Environmental and Health Sciences, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 2Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 2Institute for Quantum Life Science (iQLS), National Institute for Quantum and Radiological Science and Technology, Japan, 3Materials Sciences Research Center, Japan Atomic Energy Agency, 4Quantum Beam Science Research Directorate, National Institutes for Quantum and Radiological Science and Technology
1Department of Basic Medical Sciences, National Institute for Minamata Disease, 2Division of Neuroimmunology, Joint Research Center for Human Retrovirus Infection, Kagoshima University
1Research Center for Drug Discovery, Faculty of Pharmacy, Keio University, 2Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba
1Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 2Department of Neurosurgery, Tokyo Medical University
1Department of Life Science, Faculty of Science and Engineering, Setsunan University, 2Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University
cutaneousbarrierfunctioninamousemodelofatopicdermatitis○ Mana ANDO1, Ai MORIMOTO1, Hiroki YAMAGUCHI1, Naoki IWASHITA2, Yoshiichi TAKAGI3, Tomoya YOSHINARI4, Tomoki FUKUYAMA1
1Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, 2Bioalchemis, 3Japan SLC,Inc., 4National Institute of Health Sciences
1Global Food Safety Institute, Nissin Foods Holdings Co., Ltd., 2Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3Department of Health Pharmacy, Yokohama University of Pharmacy
1Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba, 2Master's Program in Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 3Research Center for Drug Discovery Faculty of Pharmacy, Keio University
1Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2Biomolecular Characterization Unit, Center for Sustainable Resource Science, Institute of Physical and Chemical Research
1Department of Basic Medical Sciences, National Institute for Minamata Disease, 2Faculty of Pharmacy, Keio University, 3Showa Pharmaceutical University, 4Faculty of Medicine, University of Tsukuba
1Collage of Animal Science and Technology, Inner Mongolia University for Nationalities, 2School of Veterinary Medicine, Rakuno Gakuen University, 3Institute of Oceanography, Minjiang University
P-26 EnhancedTCDDtoxicityonzebrafishembryoscausedbyaraisedtemperature○ Hao CHEN, Hongsong CHEN, Xiaoyu YIN, Chi FENG, Chelimuge QI, Lei SONG, Wenjing DONG, Bao CHAO, Jingfeng YANG, Wu DONG
Collage of Animal Science and Technology, Inner Mongolia University for Nationalities
1Life Science Research Institute, Kumiai Chemical Industry Co. Ltd, 2Department of Biological Science, Graduate School of Science, Osaka Prefecture University
1The Center for Environmental Health Science for the Next Generation, Research Institute for Science and Technology, Tokyo University of Science, 2Faculty of Pharmaceutical Sciences, Tokyo University of Science, 3Faculty of Pharmaceutical Sciences, Sanyo-Onoda City University, 4Faculty of Veterinary Medicine, Damanhour University, 5Research Institute for Biomedical Sciences, Tokyo University of Science, 6Strategic Innovation and Research Center, Teikyo University, 7Faculty of Industrial Science and Technology, Tokyo University of Science
1Tokyo Metropolitan Institute of Public Health, 2National Institute of Health Sciences, 3Tokyo University of Agriculture
P-32S PulmonaryeffectsofFe3O4-PEG-PLGAnanoparticlesinwildtypeandNrf2knockoutmicefollowingpharyngealaspiration○ Harue SATO1, Cai ZONG1, Stéphanie DEVINEAU2, Claire MCCORD2, Sahoko ICHIHARA3, Oliver BROOKES2, Frederick Adams EKUBAN1, Ken ITOH4, Masayuki YAMAMOTO5, Sonja BOLAND2, Armelle BAEZA-SQUIBAN2, Gaku ICHIHARA1
1Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2Université de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France, 3School of Medicine, Jichi Medical University, 4Graduate School of Medicine, Hirosaki University, 5Graduate School of Medicine, Tohoku University
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P-33E Comparativetoxicityandcarcinogenicitypulmonarystudyofdouble-walledcarbonnanotubes(DWCNT)withmulti-walledcarbonnanotubes-7(MWCNTS-7)inaratmodel○ Dina M. SALEH1, 2, 3, Shengyong LUO5, David B. ALEXANDER1, Ahmed M. EL-GAZZAR7, Mohammed ABDELGAIED6, Omnia H. MOHAMMED1, 2, 4, Willim T. ALEXANDER1, Sivagami GUNASEKARAN1, Takamasa NUMANO1, Hiroshi TAKASE8, Makoto OHNISHI9, Satoru TAKAHASHI2, Hiroyuki TSUDA1
1Nanotoxicology Lab Project, Nagoya City University, Nagoya, Japan, 2Departement of Experimental Pathology and Tumor Biology, Graduate School of Medicine, Nagoya City University, Nagoya, Japan, 3Departement of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Assuit University, Assuit, Egypt, 4Departement of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Aswan University, Aswan, Egypt, 5Anhui Medical University, College of Basic Medical Sciences, Hefei, China, 6Departement of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Beni-suef University, Beni-suef, Egypt, 7Departement of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt, 8Core Laboratory, Graduate School of Medicine, Nagoya City University, Nagoya, Japan, 9Japan Industrial Safety and Health Association, Japan Bioassay Research Center, Hadano, Kanagawa, Japan
1Graduate School of Pharmaceutical Sciences, Tokushima Bunri University, 2Institute of Neuroscience, Tokushima Bunri University, 3Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University
P-36E Effectsofparticlematter2.5(PM2.5)exposureontheprognosisofischemic stroke in mice○ Miki TANAKA1, Ami OGURO1, Yu NABETANI2, Tomoaki OKUDA3, Kouichi ITOH4, Yasuhiro ISHIHARA1
1Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, 2Department of Applied Chemistry, University of Miyazaki, 3Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 4Laboratory for Pharmacotherapy and Experimental Neurology, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University
1Laboratory of Toxicology, School of Veterinary Medicine, Hokkaido University, 2Department of Anatomy and Molecular Cell Biology, Graduate School of Medicine, Nagoya University, 3Faculty of Pharmaceutical Sciences, Toho University, 4Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, 5Life Science Research Center, University of Toyama, 6Student Affairs Section, Graduate School of Agricultural Science, Kobe University, 7Albany College of Pharmacy and Health Sciences, 8Department of Anaesthesiology, Medical Center East, Tokyo Women’s Medical University, 9Water Research Group, Unit for Environmental Sciences and Management, North-West University
1Technical Research Institute, TOPPAN PRINTING CO., LTD., 2Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 3Drug Safety Research and Evaluation, Takeda Pharmaceutical Company Limited, 4Joint Research Laboratory (TOPPAN) for Advanced Cell Regulatory Chemistry, Graduate School of Engineering, Osaka University
1Department of Pharmacotherapeutics, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 2Department of Pharmacology, College of Pharmacy, Kinjo Gakuin University
1Department of Drug Metabolism and Pharmacokinetics, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, 2Department of Drug Safety, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, 3Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University
1Department of Applied Life Science, Faculty of Biotechnology and Life Science, Sojo University, 2Division of Pharmacology, National Institute of Health Sciences
1Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, 2WPI Nano Life Sciences Institute (WPI-NanoLSI), Kanazawa University
1Center for iPS Cell Research and Application, Kyoto University, 2Graduate School of Pharmaceutical Sciences, Osaka University, 3Graduate School of Pharmaceutical Sciences, Kyoto University, 4Graduate School of Engineering, Kyoto University
1Department of Nutritional Science and Food Safety, Graduate School of Applied Bioscience, Tokyo University of Agriculture, 2Department of Nutritional Science and Food Safety, Faculty of Bioscience, Tokyo University of Agriculture, 3Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture, 4Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture, 5Advantec Co.,Ltd. Pathology Department, 6Division of Pathology, National Institute of Health Science, 7Faculty of Animal Health Techolorgy, Yamazaki University of Animal Health Techology
1Department of Nutritional Science and Food Safety, Graduate School of Applied Biological Sciences, Tokyo University of Agriculture, 2Department of Department of Food and Nutrition Science, Graduate School of Agriculture, Tokyo University of Agriculture, 3Department of Nutritional Science and Food Safety, Faculty of Applied Biological Sciences, Tokyo University of Agriculture
1Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Graduate School of Tokyo University of Agriculture, 2Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, 3Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture, 4Department of Food and Nutrition Science, Graduate School of Agriculture, Tokyo University, 5Tokyo Animal & Diet Dept. CLEA Japan, Inc., 6Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University
P-54S Alterationofbileacidcompositionisapossibleriskfactorofantibiotics-inducedliverinjury○ Yusuke KINOSHITA, Kotaro HAYASAKI, Akinori TAKEMURA, Kousei ITO
Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Science, Chiba University
P-55 Associationbetweenin vitro nuclearreceptor-activatingprofilesandtheir in vivo rathepatotoxicphenotypesofchemicalcompounds○ Susumu KODAMA1, Nao YOSHII1, Akihiro OTA1, Kouichi YOSHINARI2, Atsushi ONO1
1Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2School of Pharmaceutical Sciences, University of Shizuoka
1Scientific Product Assessment Center, R&D Group, Japan Tobacco Inc., 2Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 3Division of Risk Assessment, National Institute of Health Sciences
P-62 Utilityofcomputedtomography(CT)inbleomycin-inducedlungfibrosismicemodel:Non-invasivequantitativeevaluationoflunginjury,2ndreport○ Masao OGUCHI, Yasuhiro DANBARA, Daisuke IDO, Jun WATANABE, Rie AMEMIYA, Hiromasa SATO, Ryota SEKI, Atsushi FUJIWARA, Shin-ichi SATO
P-64S Comparativeinvestigationofrespiratorytoxicityinducedbyozoneexposurebetweenuntreatedmouseandmousemodelofacuterespiratorydistresssyndrome○ Toa OKAWARA1, Ryota AIHARA1, Ai MORIMOTO1, Kengo TOMITA2, Takashi KURIHARA2, Tomoki FUKUYAMA1
1Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, 2Medical Environment Engineering Group, Center for Environmental Engineering, Institute of Technology, Shimizu Corporation
1Inhalation Toxicity Research Group, Korea Institute of Toxicology, 2Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University
1Department of Pharmacology, Division of Bio-Matrix, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 2Department of Advanced General Dentistry, Mahidol University, Faculty of Dentistry, Bangkok, Thailand, 3The Center for Promotion of Pharmaceutical Education, Nihon Pharmaceutical University, 4Laboratory of Clinical Medicine, School of Pharmacy, Nihon University
CommonTemplates○ Tamio FUKUSHIMA3, Joseph HORVATH4, Peter R BRINCK1, Sophia G MOESGAARD1, Mark CARFAGNA2, Sarah H LOPES5, Nichole VANSELL5, Jennifer R INGRAM6, Lynch PHILLIP4, Emde BARBARA7
P-79 UtilizingCDISCSENDDatatoGenerateHistoricalControlIncidencefromaLargeDatabaseofToxicologyStudies○ Tamio FUKUSHIMA4, Joseph HORVATH1, Mark CARFAGNA2, Christopher ELEY3, William HOUSER1, Cheryl SLOAN1, Todd PAGE2, Jesse ANDERSON5, Kevin SNYDER5, Rick THOMPSON6, Bo LARSEN7, Gitte ULLMANN7, Yousuf ALI5, 8
1Bristol Myers Squibb, 2Eli Lilly, 3Pfizer, Inc, 4Shionogi & Co., Ltd., 5CDER, US FDA, 6Janssen, 7Novo Nordisk, 8Oak Ridge Institute for Science and Education
mice:Fixed-dosestudyofimazalil○ Toyohito TANAKA1, Jin SUZUKI1, Akiko INOMATA2, Takako MORIYASU2
1Division of Toxicology, Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health, 2Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health
P-85 InvitroEvaluationofAcetyl-CoACarboxylaseInhibitor-MediatedDevelopmentalToxicity○ Yuji ISOBE1, Sarah N CAMPION2, Christine M STETHEM2, Gregg D CAPPON2
1DSRD-Tokyo, Drug Safety Research & Development, Pfizer R&D Japan, 2Pfizer Inc., Groton, CT, USA
1Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 2Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
1Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy, 2Pharmacological Research Center, Showa University
1Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 2Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
1Division of Cellular and Molecular Toxicology, CBSR, National Institute of Health Sciences, 2The 1st Toxicology Division, Gotenba Laboratory, BoZo Research Center, 3Analysis Department, Tsukuba Laboratory, BoZo Research Center, 4Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
1Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 2Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3San-Ei Gen F.F.I., Inc.
1Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 2Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
1Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 2Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
1Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 2Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3San-Ei Gen F.F.I., Inc.
1Division of Pathology, National Institute of Health Sciences, 2Laboratory of Veterinary Medicine, Tokyo University of Agriculture and Technology, 3Division of Environmental Chemistry, National Institute of Health Sciences
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P-104 Relationshipbetweenurinarybladdercarcinogenicityandurinarymetabolitesofoccupationalurinarybladdercancer-relatedaromaticamines○ Shugo SUZUKI, Min GI, Masaki FUJIOKA, Anna KAKEHASHI, Hideki WANIBUCHI
Department of Molecular Pathology, Osaka City University Graduate School of Medicine
P-105 Anultra-short-termratmodelfordetectinggenotoxichepatocarcinogens○ Min GI1, Shugo SUZUKI2, Masaki FUJIOKA2, Hideki WANIBUCHI2
1Department of Environmental Risk Assessment, Osaka City University Graduate School of Medicine, 2Department of Molecular Pathology, Osaka City University Graduate School of Medicine
1Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University, 2Laboratory of Functional Morphology, Graduate School of Agricultural Science, Tohoku University
P-108S Developmentaltoxicityofcefiximeontheembryonicearofzebrafish○ Bao CHAO, Nini BU, Shuaiyu WANG, Xiaoyu YIN, Hao CHEN, Wu DONG
Collage of Animal Science and Technology, Inner Mongolia University for Nationalities
1Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, 2Bioalchemis, 3Japan SLC,Inc., 4Food Research Institute, National Agriculture and Food Research Organization
1Department of Nutritional Science and Food Safety, Graduate School of Applied Biosciences,Tokyo University of Agriculture, 2Department of Food and Nutritional Science, Graduate School of Agriculture Tokyo University of Agriculture, 3Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences, Tokyo University of Agriculture, 4Advantech Co., Ltd.
1Division of Toxicology, Showa University School of Pharmacy, 2Pharmacological Research Center, Showa University, 3Department of Hospital Pharmaceutics, Showa University School of Pharmacy
1Faculty of Pharmaceutical Sciences, Hiroshima International University (HIU), 2Daiichi University of Pharmacy, 3Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
1Laboratory of Environmental and Molecular Toxicology, Faculty of Pharmaceutical Sciences, Yokohama University of Pharmacy, 2Faculty of Pharmacy, Meijo University
P-125S Possibleinvolvementofplateletmitochondrialpermeabilitytransitioninacetaminophen-inducedliverinjury○ Yugo IKEYAMA, Akinori TAKEMURA, Kousei ITO
The Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
1Laboratory of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Sojo University, 2International University of Health and Welfare, School of Pharmacy at Fukuoka, 3Laboratory of Organic Chemistry, Faculty of Pharmaceutical Sciences, Sojo University
1Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Medicinal Pharmacology, Okayama University, 2Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba, 3Toxicologic Pathology Section, Department of Basic Medical Science, National Institute for Minamata Disease
1Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 2Global Center for Medical Engineering and Informatics, Osaka University
P-134 Automatedscreeningforangiogenicmodulationandtoxicityof1546compoundsonanOrgan-on-a-Chipplatform○ Sander P.M. DE RUITER, Camilla SORAGNI, Jeroen HEIJMANS, Arthur STOK, Thomas OLIVIER, Elvira VAN DER VIJVER, Sebastiaan TRIETSCH, Paul VULTO, Jos JOORE, Henriëtte LANZ
MIMETAS BV
P-135 Blood-brainbarrieron-a-chipforhighthroughputbarrierandtransportstudies○ Tania FOWKE, Nienke WEVERS, Arnaud NICOLAS, Arya Lekshmi NAIR, Maria PONTIER, Gwenaëlle RABUSSIER, Remko van VUGTH, Paul VULTO, Henriette LANZ
1Laboratory of Biofunctional Science, School of Pharmacy and Pharmaceutical Sciences, 2Department of Psychiatry, University of Texas Southwestern Medical Center, 3Institute for Advanced Life Sciences, Hoshi University, 4Laboratory of Animal Reproduction and Development, School of Agricultural Science, Tohoku University, 5Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, 6Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 7Institute of Global Innovation Research, Tokyo University of Agriculture and Technology
1Department of Investigative Toxicology, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., 2Department of Drug Metabolism and Pharmacokinetics, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
1College of Animal Science and Technology, Inner Mongolia University for Nationalities/Inner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, 2School of Veterinary Medicine, Rakuno Gakuen University, 3Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences
1Shin Nippon Biomedical Laboratories, LTD., 2Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 3Biomedical Research Laboratory, Gifu Pharmaceutical University
1Endowed Laboratory of Human Cell-Based Drug Discovery, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2Department of Pharmacology, Gunma University Graduate School of Medicine
1Toxicological Research Laboratories, Translational Research Unit, R&D Division, 2Center for iPS Cell Research and Application (CiRA), Kyoto University
1Drug Safety Research & Evaluation, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 2Drug Metabolism & Pharmacokinetics Research Laboratories
1Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Japan, 2Water Research Group, Unit for Environmental Sciences and Management, North-West University, Potchefstroom, South Africa, 3Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, USA, 4Chemistry Department, Kwame Nkrumah University of Science and Technology, Ghana, 5Department of Anesthesiology, Tokyo Women’s Medical University Center East, Japan, 6Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Japan, 7Faculty of Pharmaceutical Sciences, Toho University, Japan, 8Translational Research Unit, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Japan
1Division of Pathology, National Institute of Health Sciences, 2The Institute of Environmental Toxicology
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P-157 INHAND:InternationalHarmonizationofNomenclatureandDiagnosticCriteriaforLesions-AnUpdate2021○ Shim-mo HAYASHI1, CM KEENAN2, A BRADLEY3, DG GOODMAN4, Takanori HARADA5, R HERBERT6, Hijiri IWATA7, M JACOBSEN8, R KELLNER9, B MAHLER6, E MESECK10, T NOLTE11, S RITTINGHAUSEN9, J VAHLE12, Katsuhiko YOSHIZAWA13
1National Institute of Health Sciences, 2CM Keenan ToxPath Consulting, 3Charles River, 4Independent Consultant, 5The Institute of Environmental Toxicology, 6National Institute of Environmental Health Sciences, 7LunaPath LLC, 8Astra Zeneca, 9Fraunhofer ITEM, 10Novartis, 11Boehringer Ingelheim, 12Eli Lily, 13Mukogawa Women's University
Alternatives to mammalian modelsP-158E Characteristicsofsmallintestinalepithelialcellsderivedfromhuman
1Bio Science & Engineering Laboratory, FUJIFILM Corporation, 2Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University
1Nihon Bioresearch Inc., 2Animal Medical Center, Faculty of Applied Biological Sciences, Gifu University, 3Veterinary Medical Center, Obihiro University of Agriculture and Veterinary Medicine
1Department of Food and Nutrition Science, Faculty of Agriculture, Graduate School of Tokyo University of Agriculture, 2Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Undergraduate School of Tokyo University of Agriculture, 3Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Graduate School of Tokyo University of Agriculture, 4Tokyo Animal & Diet Dept. CLEA japan, Inc., 5Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University
1Division of Risk Assessment, National Institute of Health Sciences, 2Division of Genetics and Mutagenesis, National Institute of Health Sciences
P-185 Developmentofanewthresholdoftoxicologicalconcern(TTC)databaseofnon-cancertoxicityendpointsforindustrialchemicals○ Takashi YAMADA1, Masayuki KURIMOTO1, Akihiko HIROSE1, Chihae YANG2, 3, James F RATHMAN2, 3
1Division of Risk Assessment, National Institute of Health Sciences, 2Molecular Networks GmbH, 3Department of Chemical and Biomolecular Engineering, College of Engineering, The Ohio State University
1CDISC Japan User Group SEND team, 2CAC Croit Corporation, 3KYORIN Pharmaceutical Co.,Ltd., 4Kyowa Kirin Co., Ltd., 5Eisai Co., Ltd., 6Takumi Information Technology Inc., 7Bristol-Myers Squibb K.K., 8Japan Tobacco Inc.
1Toxicological laboratory for Small Animals, Research Division, BioSafety Research Center Inc., 2Ina Research Inc., 3Showa University School of Medicine
1Regulatory Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, 2Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka
1CDISC Japan User Group SEND Team, Quality Control Subteam, 2Japan Tobacco Inc., 3KYORIN Pharmaceutical Co., Ltd., 4Taisho Pharmaceutical, Co., Ltd., 5Mitsui E&S Systems Research Inc., 6CAC Croit Corporation, 7LSIM Safety Institute Corporation, 8Takumi Information Technology Inc., 9BoZo Research Center Inc., 10FUJITSU LIMITED, 11Chugai Pharmaceutical Co., Ltd., 12Ina Research Inc., 13SHIONOGI & CO., LTD., 14Kyowa Kirin Co., Ltd.
1Toxicogenomics Informatics Project, National Institutes of Biomedical Innovation, Health and Nutrition, 2Department of Biomedical Data Intelligence, Graduate School of Medicine, Kyoto University
P-201 TranslationalSafetyCharts:VisualisingtheSafetyLifetimeofDrugsfromPreclinicalDiscoverytoPostmarketingSurveillanceRicard GARCIA-SERNA1, Montserrat CASES1, Nikita REMEZ1, Joaquim OLIVéS1, Oriol LóPEZ-MASSAGUER1, Maria C CARRASCOSA1, Antonino LATTENE1, Elisabet GREGORI-PUIGJANé1, Jordi MESTRES1, ○ Atsushi MIDORIKAWA2
1Chemotargets S.L., 2WorldFusion Co,. Ltd.
P-202S In-silicoAnalysesofDrug-inducedLiverMalignantTumorSignalsBasedonMolecularInitiatingEventsandMutagenicityUsingFDAAdverseEventReportingSystemDatabase○ Kota KUROSAKI, Yoshihiro UESAWA
Department of Medical Molecular Informatics, Meiji Pharmaceutical University
1CDISC Japan User Group (CJUG) SEND team, nSDRG subteam, 2Axcelead Drug Discovery Partners, Inc., 3LSIM Safety Institute Corporation, 4KYORIN Pharmaceutical Co., Ltd., 5Kyowa Kirin Co., Ltd., 6Shin Nippon Biomedical Laboratories Co., Ltd., 7Japan Tobacco Inc.
1Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 2Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, 3Department of Urology, Graduate School of Medicine, Yamaguchi University, 4Laboratory of Veterinary Anatomy, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology