Some stuff about cortical network modelling what I done Richard Tomsett 1,2 , Miles Whittington 3 , Mark Cunningham 4 , Marcus Kaiser 2,4 1.Institute of Ageing and Health, Newcastle University 2. School of Computing Science, Newcastle University 3. Hull York Medical School, University of York 4. Institute of Neuroscience, Newcastle University OSB Hackathon, UCL, 6 th November 2013
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Some stuff about cortical network modelling what I done
Some stuff about cortical network modelling what I done. Richard Tomsett 1,2 , Miles Whittington 3 , Mark Cunningham 4 , Marcus Kaiser 2,4 - PowerPoint PPT Presentation
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Some stuff about cortical network modelling what I done
Richard Tomsett1,2, Miles Whittington3,Mark Cunningham4, Marcus Kaiser2,4
1.Institute of Ageing and Health, Newcastle University2. School of Computing Science, Newcastle University
3. Hull York Medical School, University of York4. Institute of Neuroscience, Newcastle University
OSB Hackathon, UCL, 6th November 2013
OSB Hackathon, UCL, 6th November 2013
Matthew Ainsworth
OSB Hackathon, UCL, 6th November 2013
Matthew Ainsworth
OSB Hackathon, UCL, 6th November 2013
OSB Hackathon, UCL, 6th November 2013
NB: wrong dimensions in Bush & Sejnowski 1993
OSB Hackathon, UCL, 6th November 2013
Thanks to:
-Anna Simon-Mark Cunningham-Marcus Kaiser
-BBSRC, Wellcome Trust
OSB Hackathon, UCL, 6th November 2013
OSB Hackathon, UCL, 6th November 2013
OSB Hackathon, UCL, 6th November 2013
LFP simulation
100um – 1000um
OSB Hackathon, UCL, 6th November 2013
LFP simulation
OSB Hackathon, UCL, 6th November 2013
LFP simulation
100um – 1000um
OSB Hackathon, UCL, 6th November 2013
LFP simulation
Edge Half-way to gamma generating region
OSB Hackathon, UCL, 6th November 2013
LFP simulation
100um – 1000um
OSB Hackathon, UCL, 6th November 2013
LFP simulation
Top Middle Bottom
OSB Hackathon, UCL, 6th November 2013
Kawaguchi & Kondo, 2002
Basket cell
Bitufted cell
Axo-axonic cell
Pyramidal cell
GABAA
GABAA
GABAA
GABAA
GABAA
+GABAB
Neurogliaform cell
“Regular spiking non pyramidal cell”
Slide courtesy of Anna Simon
Basket cell
Other interneurons
Pyramidal cell
GABAA
OSB Hackathon, UCL, 6th November 2013
90% basket cell reduction in central 2mm section, replaced by non-basket interneurons (regular spiking)
OSB Hackathon, UCL, 6th November 2013
Thanks to:
- Matt Ainsworth (York)- Anna Simon (Newcastle)- Mark Cunningham (Newcastle)- Miles Whittington (York)- Marcus Kaiser (Newcastle)