Detection of structural abnormalities in tumour genomes using model based approaches: application to 107 patients with follicular lymphoma Sohrab Shah Department of Computer Science University of British Columbia UBC computer science: Kevin Murphy Raymond Ng BC Cancer Research Centre: Doug Horsman K-John Cheung Jr.
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Sohrab Shah Department of Computer Science University of British Columbia
Detection of structural abnormalities in tumour genomes using model based approaches: application to 107 patients with follicular lymphoma. Sohrab Shah Department of Computer Science University of British Columbia. BC Cancer Research Centre : Doug Horsman K-John Cheung Jr. - PowerPoint PPT Presentation
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Detection of structural abnormalities in tumour genomes using model based
approaches: application to 107 patients with follicular lymphoma
Sohrab ShahDepartment of Computer Science
University of British Columbia
UBC computer science:Kevin MurphyRaymond Ng
BC Cancer Research Centre:Doug HorsmanK-John Cheung Jr.
2Detection of structural abnormalities in tumour genomes using model based approaches
Structural abnormalities in cancer
3Detection of structural abnormalities in tumour genomes using model based approaches
Copy number alterations (CNA) can lead to disease
• CNAs are a hallmark of tumor genomes• CNAs can lead to adverse expression
changes of affected genes • Recurrent CNAs in patients with common
phenotype potentially represent molecular markers of disease