Slides last updated: October 2013. There are two main types of lung cancer 1 1.Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review,

Slides last updated: October 2013

There are two main types of lung cancer1

1. Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2010/, based on November 2012 SEER data submission, posted to the

SEER web site, April 2013, accessed on 15/09/2013.

NSCLC (85.3% of lung cancer)

Lung Cancer (100%)

Other NSCLC(20.2% of lung cancer)

Large cell carcinoma(2.6% of lung cancer)

Squamous cell carcinoma(21.4% of lung cancer)

Adenocarcinoma(40.1% of lung cancer)

1. Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2010/, based on November 2012 SEER data submission, posted to the SEER

web site, April 2013, accessed on 15/09/2013.

NSCLC can be further divided into different sub-types1

NSCLC: Adenocarcinoma

Adenocarcinoma

Adenocarcinoma lesions are usually peripherally located2

Most frequent in women and non-smokers2

Some patients have EGFR/ErbB1 mutations; these patients require a specific diagnosis and treatment approach3

40.1%1

1. Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2010/, based on November 2012 SEER data submission, posted to the SEER

web site, April 2013, accessed on 15/09/2013. 2. Heighway J & Betticher DC. Atlas Genet Cytogenet Oncol Haematol. February 2004. 3. Vijayalakshmi R, et al. Indian J Surg Oncol 2011;2:178‒188.

NSCLC: Squamous cell carcinoma

Squamous Cell Carcinoma2

Squamous Cell Carcinoma lesions are generally centrally located, near bronchi

Tends to spread locally

Closely correlated with smoking

21.4%1

1. Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2010/, based on November 2012 SEER data submission, posted to the SEER web site, April 2013, accessed on 15/09/2013. 2. Heighway J & Betticher DC. Atlas Genet Cytogenet Oncol

Haematol. February 2004.

NSCLC: Large cell carcinoma

Large Cell Carcinoma

Comprised of undifferentiated cells 2

Lesions are usually peripherally located but can occur anywhere 2

High tendency to metastasize 2

2.6%1

1. Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2010/, based on November 2012 SEER data submission, posted to the SEER web site, April 2013, accessed on 15/09/2013. 2. Heighway J & Betticher DC. Atlas Genet Cytogenet Oncol

Haematol. February 2004.

NSCLC: Other

Other, including Not Otherwise Specified (NOS) or Unknown

A classification of NOS or unknown is usually due to ineffective sampling and examination2

This classification is expected to decline in use due to more accurate biopsies and advances in immunohistochemistry and biomarker testing2

20.2%1

1. Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2010/, based on November 2012 SEER data submission, posted

to the SEER web site, April 2013, accessed on 15/09/2013. 2. Righi L, Graziano P, Fornari A, et al. Cancer 2011;117:3416‒3423.