Slides: 司遠征博士-記憶力與神經系統的保健

2023年4月8日星期六2023年4月8日星期六 11

健康讲座健康讲座

脑与神经系统的脑与神经系统的保保健健

司远征，司远征， M.D. Ph.D. M.D. Ph.D.


Our Brain




READ

HE

HEAR

THINK SPEAK



Brainwave research on cognitive performance has pointed to the mid Beta brainwave frequencies as the zone to create a super focus mental state, intellectual endurance, and optimize your brain to handle intensive task with high levels of mental stamina.

2023年4月8日星期六2023年4月8日星期六 882023年4月8日星期六2023年4月8日星期六 88

2. 大脑右半球1. 大脑左半球

3. 脑干 4. 小脑

中风所损及的脑组织



AlzheimerAlzheimer’’s and Dementias and Dementia

• Mild Cognitive Impairment (MCI)• Vascular Dementia• Mixed Dementia• Dementia with Lewy Bodies• AlzheimerAlzheimer’’s Diseases Disease• Parkinson's Disease• Frontotemporal Dementia• Creutzfeldt-Jakob Disease (CJD)• Normal Pressure Hydrocephalus• Huntington's Disease• Wernicke-Korsakoff Syndrome

http://www.alz.org/alzheimers_disease_mild_cognitive_impairment.asp

http://www.alz.org/alzheimers_disease_vascular_dementia.asp

http://www.alz.org/alzheimers_disease_mixed_dementia.asp

http://www.alz.org/alzheimers_disease_dementia_with_lewy_bodies.asp



http://www.alz.org/alzheimers_disease_parkinsons_disease.asp

http://www.alz.org/alzheimers_disease_frontotemporal_dementia.asp

http://www.alz.org/alzheimers_disease_frontotemporal_dementia.asp

http://www.alz.org/alzheimers_disease_creutzfeldt_Jakob_disease.asp

http://www.alz.org/alzheimers_disease_normal_pressure_hydrocephalus.asp

http://www.alz.org/alzheimers_disease_huntingtons_disease.asp

http://www.alz.org/alzheimers_disease_wernicke_korsakoff_syndrome.asp

http://www.alz.org/alzheimers_disease_wernicke_korsakoff_syndrome.asp

Healthy BrainAlzheimer’s Brain




Potential Targets for Potential Targets for Intervention in ADIntervention in AD


Alzheimer's Disease Risk Factors

Diabetes Mellitus

Cholesterol and Cholesterol-Lowering Agents

Inflammation and NSAIDs

Cardiovascular Conditions and Risk Factors

Other Lifestyle Factors

Heritage

Social and Psychological Factors

By Martha Clare Morris, ScD, Med Scope Today


Stages of Alzheimer'sStages of Alzheimer's

• Stage 1: No impairment • Stage 2: Very mild decline Stage 2: Very mild decline • Stage 3: Mild decline Stage 3: Mild decline • Stage 4: Moderate decline (mild or early Stage 4: Moderate decline (mild or early

stage) stage) • Stage 5: Moderately severe decline Stage 5: Moderately severe decline

(moderate or mid-stage) (moderate or mid-stage) • Stage 6: Severe decline (moderately severe Stage 6: Severe decline (moderately severe

or mid-stage) or mid-stage) • Stage 7: Very severe decline (severe or late Stage 7: Very severe decline (severe or late

stage) stage)

http://www.alz.org/alzheimers_disease_stages_of_alzheimers.asp

http://www.alz.org/alzheimers_disease_stages_of_alzheimers.asp


The difference between Alzheimer's and normal age-related

memory changes

Someone with Alzheimer's disease symptoms

Someone with normal age-related memory changes

Forgets entire experiences Forgets part of an experience

Rarely remembers later Often remembers later

Is gradually unable to follow written/spoken directions

Is usually able to follow written/spoken directions

Is gradually unable to use notes as reminders

Is usually able to use notes as reminders

Is gradually unable to care for self Is usually able to care for self


Vitamin B Deficiency and Vitamin B Deficiency and ADAD

• Elevated homocysteine and low folate were were associated with radiological markers of associated with radiological markers of neuropathology. Since no patient had neuropathology. Since no patient had clinically deficient folate, it may be clinically deficient folate, it may be important to rethink what defines important to rethink what defines functionally significant micronutrient functionally significant micronutrient deficiency and explore what this means in deficiency and explore what this means in different age- and health-status groups.different age- and health-status groups.

• Am J Geriatr Psychiatry. 2004 Nov-Dec;12(6):631-8Am J Geriatr Psychiatry. 2004 Nov-Dec;12(6):631-8

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15545331





Candidate strategies for Candidate strategies for primary prevention of AD primary prevention of AD

By Peter Zandi and John Breitner,By Peter Zandi and John Breitner, Dept. Mental Hygiene, Johns Hopkins University, Baltimore, USADept. Mental Hygiene, Johns Hopkins University, Baltimore, USA

• Non-steroidal anti-inflammatory Non-steroidal anti-inflammatory drugsdrugs

• Hormone replacement therapyHormone replacement therapy

• Antioxidants & vitaminsAntioxidants & vitamins

• Statins and histamine H2 blockersStatins and histamine H2 blockers




Nutritional Supplements for Brain and Nutritional Supplements for Brain and Mental HealthMental Health

• OPC-3 OPC-3 • Vita-Mind Vita-Mind • Oxygen PlusOxygen Plus• Cognitin Cognitin • Vit B Complex Vit B Complex • Omega III Fish Oil with Vitamine EOmega III Fish Oil with Vitamine E• Coenzyme Q10Coenzyme Q10• ResVeratrol• Isotonic Acai• Calcium PlusCalcium Plus• HeadrestHeadrest• Bliss Bliss Anti-Stress Formula

23/4/823/4/8 2222

AAntioxidant ntioxidant OPC-3OPC-3TMTM



Dr. Steven LammDr. Steven LammNew York University ProfessorNew York University ProfessorBellevue HospitalBellevue Hospital

““ One of the principal ingredients One of the principal ingredients that makes Market Americathat makes Market America’’s s IsotonixIsotonix®® OPC-3 OPC-3™™ probably probably the the best antioxidant cocktailbest antioxidant cocktail in the in the marketplace is marketplace is PycnogenolPycnogenol..””


Isotonix OPC-3Isotonix OPC-3

• Potent antioxidants that neutralize oxygen Potent antioxidants that neutralize oxygen free radicals and regenerate the free radicals and regenerate the antioxidant potency of vitamin C and antioxidant potency of vitamin C and vitamin Evitamin E

• Reduces cell damage which allows for Reduces cell damage which allows for improved cellular metabolism and improved cellular metabolism and functionfunction

• Improve circulation, especially capillaryImprove circulation, especially capillary• Helps boost immune system and decrease Helps boost immune system and decrease

inflammationinflammation


Vita-MindVita-Mind

• Contains vitamins, minerals, nutrients and Contains vitamins, minerals, nutrients and natural herbs.natural herbs.

• Increase the amount of blood and oxygen to the Increase the amount of blood and oxygen to the brain.brain.

• Fortifying the brain against stress.Fortifying the brain against stress. • Protecting it against the ravages of free radical Protecting it against the ravages of free radical

damage.damage. • Heightening electrical activity so that vital Heightening electrical activity so that vital

neurotransmitters can operate efficiently.neurotransmitters can operate efficiently.• Enhance mental resistance to stress, mental Enhance mental resistance to stress, mental

clarity, alertness and improve working and long-clarity, alertness and improve working and long-term memory term memory


2023年4月8日星期六2023年4月8日星期六282828

Oxygen PlusOxygen Plus

抗氧化长青素


Oxygen PlusOxygen Plus• Contains a wide array of antioxidants Contains a wide array of antioxidants

which are effective against 7 forms of free which are effective against 7 forms of free radicalsradicals

• Most complete antioxidant formulationMost complete antioxidant formulation availableavailable• Complements the Isotonix program of Complements the Isotonix program of

OPC-3, Antioxidant, Vitamin C & OPC-3, Antioxidant, Vitamin C & Isochrome/CoQ10Isochrome/CoQ10

• Improve circulation and oxygen delivery Improve circulation and oxygen delivery (Ginko, Glutathion)(Ginko, Glutathion)

• Enhance the alert of brain (Green tea)Enhance the alert of brain (Green tea)

2023年4月8日 30

Oxygen Plus Oxygen Plus

Ingredients ：•抗氧化维生素和微量元素组

合， A 、 E 满足日推荐量， C 为推荐量的三倍，硒也接近推荐量的三倍。

•多种天然植物提取物：高剂量的绿茶提取物、银杏叶提取物、奶蓟提取物、覆盆子粉末。


Cognitin™ Memory Support Formula

Acetyl Product Code: 13095

23/4/823/4/8 3232

Type of Free RadicalsType of Free Radicals

• Superoxide anion Superoxide anion

(( 過氧化陰離子過氧化陰離子 ,, OO--22 和和 OO--

22 含的鹽類含的鹽類 ))• Hydroxyl radical (Hydroxyl radical ( 羻基羻基﹑﹑氫氧基氫氧基 ,,

OHOH- - ))• Hypochlorous acid (Hypochlorous acid ( 次氯酸次氯酸 , ClO, ClO-- ) )

• Nitric oxide (Nitric oxide ( 硝基硝基 , NO, NO-- ) )• Singlet oxygen (Singlet oxygen ( 单一氧原子单一氧原子 OO-- ))

• Hydrogen peroxide (Hydrogen peroxide ( 过氧化氢过氧化氢 , H, H22OO22))• Fatty acid hydroperoxides Fatty acid hydroperoxides (( 脂肪酸氫氧化物脂肪酸氫氧化物 ROOH)ROOH)


Cognitin™ Memory Support Formula

• Acetyl-L-carnitine: Helps promote enhanced memory Acetyl-L-carnitine: Helps promote enhanced memory and cognitive function. It is able to travel through the and cognitive function. It is able to travel through the blood-brain barrier where it helps form the brain blood-brain barrier where it helps form the brain chemical acetylcholine.chemical acetylcholine.

• Alpha-lipoic acid: Both water and fat soluble and can Alpha-lipoic acid: Both water and fat soluble and can regenerate antioxidants, such as vitamin E, vitamin C regenerate antioxidants, such as vitamin E, vitamin C and glutathione. and glutathione.

• Vinpocetine: Supports healthy brain energy and blood Vinpocetine: Supports healthy brain energy and blood supply. It has been noted to support oxygen and supply. It has been noted to support oxygen and glucose utilization by brain cells and help maintain glucose utilization by brain cells and help maintain their resistance to damage by hypoxia, or lack of their resistance to damage by hypoxia, or lack of oxygen to the brain. oxygen to the brain.

•


Isotonix Advanced B Isotonix Advanced B ComplexComplex

• This product contains Vitamines B12, B2, B6, This product contains Vitamines B12, B2, B6, Folic Acid and Magnesium.Folic Acid and Magnesium.

• Vitamin B12 is essential for the normal Vitamin B12 is essential for the normal functioning of all body cells, but especially functioning of all body cells, but especially those of the nervous system, bone marrow, those of the nervous system, bone marrow, and intestinal tract. Both folic acid and vitamin and intestinal tract. Both folic acid and vitamin B12 are involved in the normal development B12 are involved in the normal development and functioning of the red blood cells and and functioning of the red blood cells and they work in conjunction to construct the they work in conjunction to construct the genetic material of the cells. Vitamin B12 is genetic material of the cells. Vitamin B12 is important for the metabolism of carbohydrate important for the metabolism of carbohydrate and lipids. Folic acid is also responsible for and lipids. Folic acid is also responsible for normal utilization of amino acids and proteins.normal utilization of amino acids and proteins.


Vit B ComplexVit B Complex

• Necessary for the synthesis of red blood Necessary for the synthesis of red blood cells. cells.

• Important in maintaining the nervous system.Important in maintaining the nervous system. • Plays a vital role in the metabolism of fatty Plays a vital role in the metabolism of fatty

acids essential for the maintenance of acids essential for the maintenance of myelin.myelin.

• Prolonged B12 deficiency can lead to nerve Prolonged B12 deficiency can lead to nerve degeneration and irreversible neurological degeneration and irreversible neurological damage.damage.


Advanced Vit B ComplexAdvanced Vit B Complex

• Promotes normal cognitive performancePromotes normal cognitive performance• Increases energy Increases energy • Deficiencies in folic acid, vitamin B12, vitamin B6 Deficiencies in folic acid, vitamin B12, vitamin B6

or biotin may result in feelings of fatigue or biotin may result in feelings of fatigue • Promotes healthy levels of homocysteine Promotes healthy levels of homocysteine

and supports normal endothelial functionand supports normal endothelial function• Promotes cardiovascular healthPromotes cardiovascular health• Helps decrease stress and improve moodHelps decrease stress and improve mood• Helps maintain healthy levels of serotoninHelps maintain healthy levels of serotonin• B Vitamins are essential for many key functions in B Vitamins are essential for many key functions in

the bodythe body


Dendrite

Soma

Axon Terminal

Node ofRanvier

Schwann cell

Myelin sheath

Nucleus

Axon

http://en.wikipedia.org/wiki/Dendrite

http://upload.wikimedia.org/wikipedia/commons/b/ba/Neuron-no_labels.png




人人體體內內秘密秘密殺殺手手

人人體體內內秘密秘密殺殺手手


Essential Omega III Fish Oil Essential Omega III Fish Oil with Vitamin Ewith Vitamin E

• Each daily serving provides 6000 mg of fish oil to Each daily serving provides 6000 mg of fish oil to supply 1800 mg of EPA and 1200 mg DHAsupply 1800 mg of EPA and 1200 mg DHA

• Promotes overall cardiovascular healthPromotes overall cardiovascular health• Helps maintain healthy levels of C-reactive proteinHelps maintain healthy levels of C-reactive protein• Helps maintain normal triglyceride levels in the Helps maintain normal triglyceride levels in the

bloodblood• Helps maintain normal blood flowHelps maintain normal blood flow• Promotes healthy blood pressure levelsPromotes healthy blood pressure levels• Helps maintain normal cholesterol levelsHelps maintain normal cholesterol levels• Helps enhance moodHelps enhance mood• Promotes a healthy complexionPromotes a healthy complexion


Essential Omega III Fish Oil Essential Omega III Fish Oil with Vitamin Ewith Vitamin E

• Each daily serving provides 6000 mg of fish oil to Each daily serving provides 6000 mg of fish oil to supply 1800 mg of EPA and 1200 mg DHAsupply 1800 mg of EPA and 1200 mg DHA

• Promotes overall cardiovascular healthPromotes overall cardiovascular health• Helps maintain healthy levels of C-reactive proteinHelps maintain healthy levels of C-reactive protein• Helps maintain normal triglyceride levels in the Helps maintain normal triglyceride levels in the

bloodblood• Helps maintain normal blood flowHelps maintain normal blood flow• Promotes healthy blood pressure levelsPromotes healthy blood pressure levels• Helps maintain normal cholesterol levelsHelps maintain normal cholesterol levels• Helps enhance moodHelps enhance mood• Promotes a healthy complexionPromotes a healthy complexion




Coenzyme Q10 In The MitochondrionCoenzyme Q10 In The Mitochondrion

Outer Membrane

Inner Membrane

Cristae

Intermembrane space

Matrix


CoQ10 CoQ10 研究结果研究结果

• “ … This has implications for therapeutic applications in human diseases, and there is evidence for its beneficial effect in cardiovascular and neurodegenerative diseases. CoQ10 has an excellent safety record.”

• Bhagavan, Hemmi N., Chopra, Raj K. : Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics, Free Radical Research, Volume 40, Number 5, May 2006, pp. 445-453(9)


Coenzyme Q10 Coenzyme Q10

• Concentrated in high energy tissues: Concentrated in high energy tissues: heart,heart,

lung, brain, kidneys, spleen and lung, brain, kidneys, spleen and musclesmuscles

• Mainly locate in mitochondria (energyMainly locate in mitochondria (energy

• producing powerhouse) of cells.producing powerhouse) of cells.

• 2 Vital roles:2 Vital roles:

• Potent antioxidantPotent antioxidant

• Energy productionEnergy production


Isotonix® Resveratrol The new Isotonix Resveratrol*:•Promotes apoptosis (programmed cell death) in unhealthy cells•Helps maintain cell health•Promotes cardiovascular health (promotes normal platelet activity, helps maintain normal vasorelaxation, provides antioxidant protection of LDL particles)•Promotes normal activity of the SIRT-1 gene (involved in calorie restriction, fat mobilization, mitochondrial function)•Promotes normal cell cycle traverse•Promotes normal nuclear factor kappa B (NF-Kappa B — protein) and cyclooxygenase-2 (COX-2 — enzyme) activity•Superior antioxidant and high ORAC value

Single Bottle (30 Servings) Code: 13061 DC: $32.00; SR: $44.95; BV: 27.00

2023年4月8日星期六2023年4月8日星期六

Resveratrol Fresh grape skin contains about 50 to 100 micrograms of resveratrol per gram

4949


Red Wine Extract Prevents Neuronal Apoptosis in Vitro and Reduces Mortality of Transgenic Mice .

Rosalaba Amodio et alAnnals of the New York Academy of Sciences. November 2006 , Vol. 1089: 88-97




2023年4月8日2023年4月8日

Isotonix AcaiIsotonix Acai

5454

2023年4月8日星期六2023年4月8日星期六

Primary Benefits• Increases energy • Provides strong antioxidant protection • Supports normal cell cycle and cell integrity • Helps maintain cardiovascular health • Helps maintain healthy cholesterol levels • Supports immune functions • Promotes cognitive health • Helps improve mental focus • Helps improve memory • Promotes healthy blood sugar levels • Supports weight control • Promotes prostate health • Promotes normal regulation of enzymes and

hormones •


Calcium Plus Calcium Plus ((FDA Supported)FDA Supported)

• Provides the body with an advanced, cost-effective and generous 700 mg dose of needed calcium through an optimized blend of calcium, vitamin D3, magnesium, vitamin C, and boron.

• Vitamin D3 helps to get calcium across cell membranes and store the mineral inside the cells.

• Plays a critical role in the building and maintaining of strong bones.

• plays a major role in blood clotting, the contraction of skeletal and heart muscles

• Support an effort to prevent osteoporosis.


Calcium PlusCalcium Plus

• Contains 5 kinds of calcium and Vit Contains 5 kinds of calcium and Vit D3 and other vitamins and mineralsD3 and other vitamins and minerals

• Adjust the electrical activity of nerve Adjust the electrical activity of nerve cells in our bodies.cells in our bodies.

• Initiates the changes in sodium and Initiates the changes in sodium and potassium conductance .potassium conductance .

• helps to calm down the nerve system helps to calm down the nerve system and promote sleeping.and promote sleeping.


Product Code: 13182

Awake - Caffeine Free Energy Drinks

5959

HeadRest• Helps maintain optimal blood flow to the brain • Helps the body maintain a healthy (or sufficient or

proper) level of magnesium, which correlates with brain health

• Helps to maintain brain health • In clinical trials in both Germany and the United

States, butterbur reduced the incidence of head cavity discomforts by up to 61 percent

• Magnesium deficiency is common among head discomfort sufferers

• Promotes normal sinus function • Promotes proper blood circulation in the brain which

helps to maintain head comfort (or which works to support head comfort)

• Supports/promotes head comfort (reduces the frequency, severity, and duration of head discomfort)

• Supports/Promotes healthy cognitive function • Supports/promotes healthy platelet activity and blood

vessel dilation (inhibits serotonin release from platelets and leucocytes)

• Supports/Promotes healthy respiratory functions • Supports a healthy immune system

DepressionDepression


Bliss: How does it work?

• Bliss is comprised of several stress-reducing herbs. These herbs work together to help reduce overall stress

Primary Benefits

• Helps body adapt to stress

• Promotes relaxation without drowsiness

• Maintains healthy levels of both serotonin and dopamine

• Helps enhance and stabilize mood


THE ENDTHE END

THANK YOUTHANK YOU

Slides: 司遠征博士-記憶力與神經系統的保健

Documents

midstage stage

mild decline stage

stages of alzheimers

impairment stage

severe decline severe

earlystage stage

alzheimers disease symptoms

healthy brain alzheimers