Slide No. 9: (2 Marks) Slide No. 9: (2 Marks) A 15 years female complaining of delayed menarche: A 15 years female complaining of delayed menarche: Findings Findings (A) Inspection of abdomen (B) Inspection of vulva (A) Inspection of abdomen (B) Inspection of vulva Most Probable Diagnosis: Most Probable Diagnosis: Imperforate Hymen Imperforate Hymen Treatment: Treatment: Hymenectomy or Hymontomy Hymenectomy or Hymontomy
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Slide No. 9: (2 Marks) A 15 years female complaining of delayed menarche: Findings (A) Inspection of abdomen (B) Inspection of vulva Most Probable Diagnosis:
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Slide No. 9: (2 Marks)Slide No. 9: (2 Marks)A 15 years female complaining of delayed menarche: A 15 years female complaining of delayed menarche: FindingsFindings(A) Inspection of abdomen (B) Inspection of vulva(A) Inspection of abdomen (B) Inspection of vulva
Most Probable Diagnosis: Most Probable Diagnosis: Imperforate Imperforate HymenHymen
Treatment: Treatment: Hymenectomy or Hymenectomy or HymontomyHymontomy
Slide No. 5: (2 Marks)Slide No. 5: (2 Marks)
Before surgery During surgery
•What is your diagnosis? Imperforate Hymen
•The most serious complication of this operation: Infection
A 16-years girl with delayed menarche
Slide No. 7Slide No. 7::
Name three possible complains?1. Hirsutism.2. Oligmenorrhea / amenorrhea.3. Infertility.
Laparoscopy
Ultrasonography
Ovarian findings
Gross appearance
SLIDE 1SLIDE 1
SLIDE 2SLIDE 2
SLIDE 9SLIDE 9
UTERUTERUSUS
Local Examination
During surgery
UltrasonographyAbdominal Examination
Imperforate hymen
15% 15% of 1ry amenorrhea of 1ry amenorrhea Normal breasts and Sexual Hair Normal breasts and Sexual Hair
development & Normal looking development & Normal looking external female genitaliaexternal female genitalia
Normal female range testosterone Normal female range testosterone levellevel
Absent uterus and upper vagina & Absent uterus and upper vagina & Normal ovariesNormal ovaries
Karyotype 46-XXKaryotype 46-XX 30% renal,10% skeletal and 30% renal,10% skeletal and
Clinical suspicion : Clinical suspicion : Hirsutism, truncal obesity, Hirsutism, truncal obesity, purple striae,purple striae, BP BP
If Suspicion is high : If Suspicion is high : dexamethasone dexamethasone
suppression test (1 mg PO suppression test (1 mg PO 11 pm ) and obtaine 11 pm ) and obtaine serum cortisol level at 8 serum cortisol level at 8 am : am :
24 hours total urine free 24 hours total urine free cortisol level to confirm cortisol level to confirm diagnosisdiagnosis
2 forms ; adrenal tumour 2 forms ; adrenal tumour or ACTH hypersecretion or ACTH hypersecretion (pituitary or ectopic site)(pituitary or ectopic site)
Clinical suspicion : Clinical suspicion : Hirsutism, truncal obesity, Hirsutism, truncal obesity, purple striae,purple striae, BP BP
If Suspicion is high : If Suspicion is high : dexamethasone dexamethasone
suppression test (1 mg PO suppression test (1 mg PO 11 pm ) and obtaine 11 pm ) and obtaine serum cortisol level at 8 serum cortisol level at 8 am : am :
24 hours total urine free 24 hours total urine free cortisol level to confirm cortisol level to confirm diagnosisdiagnosis
2 forms ; adrenal tumour 2 forms ; adrenal tumour or ACTH hypersecretion or ACTH hypersecretion (pituitary or ectopic site)(pituitary or ectopic site)
11o o or 2or 2o o Amenorrhea is often first signAmenorrhea is often first sign A body mass index (BMI) <17 kg/mA body mass index (BMI) <17 kg/m²²
menstrual irregularity and amenorrheamenstrual irregularity and amenorrhea Hypothalamic suppression Hypothalamic suppression Abnormal body image, intense fear of Abnormal body image, intense fear of
weight gain, often strenuous exerciseweight gain, often strenuous exercise Mean age onset 13-14 yrs (range 10-21 yrs)Mean age onset 13-14 yrs (range 10-21 yrs) Low estradiol Low estradiol risk of osteoporosis risk of osteoporosis Bulemics less commonly have amenorrhea Bulemics less commonly have amenorrhea
due to fluctuations in body wt, but any due to fluctuations in body wt, but any disordered eating pattern (crash diets) can disordered eating pattern (crash diets) can cause menstrual irregularity.cause menstrual irregularity.
Treatment : Treatment : body wt. (Psychiatrist referral) body wt. (Psychiatrist referral)
11o o or 2or 2o o Amenorrhea is often first signAmenorrhea is often first sign A body mass index (BMI) <17 kg/mA body mass index (BMI) <17 kg/m²²
menstrual irregularity and amenorrheamenstrual irregularity and amenorrhea Hypothalamic suppression Hypothalamic suppression Abnormal body image, intense fear of Abnormal body image, intense fear of
weight gain, often strenuous exerciseweight gain, often strenuous exercise Mean age onset 13-14 yrs (range 10-21 yrs)Mean age onset 13-14 yrs (range 10-21 yrs) Low estradiol Low estradiol risk of osteoporosis risk of osteoporosis Bulemics less commonly have amenorrhea Bulemics less commonly have amenorrhea
due to fluctuations in body wt, but any due to fluctuations in body wt, but any disordered eating pattern (crash diets) can disordered eating pattern (crash diets) can cause menstrual irregularity.cause menstrual irregularity.
Treatment : Treatment : body wt. (Psychiatrist referral) body wt. (Psychiatrist referral)
Common in women who Common in women who participate in sports (e.g. participate in sports (e.g. competitive athletes, ballet competitive athletes, ballet dancers)dancers)
Eating disorders have a higher Eating disorders have a higher prevalence in female athletes prevalence in female athletes than non-athletesthan non-athletes
Hypothalamic disorder caused by Hypothalamic disorder caused by abnormal gonadotrophin-releasing abnormal gonadotrophin-releasing hormone pulsatility, resulting in hormone pulsatility, resulting in impaired gonadotrophin levels, impaired gonadotrophin levels, particularly LH, and subsequently particularly LH, and subsequently low oestrogen levelslow oestrogen levels
Common in women who Common in women who participate in sports (e.g. participate in sports (e.g. competitive athletes, ballet competitive athletes, ballet dancers)dancers)
Eating disorders have a higher Eating disorders have a higher prevalence in female athletes prevalence in female athletes than non-athletesthan non-athletes
Hypothalamic disorder caused by Hypothalamic disorder caused by abnormal gonadotrophin-releasing abnormal gonadotrophin-releasing hormone pulsatility, resulting in hormone pulsatility, resulting in impaired gonadotrophin levels, impaired gonadotrophin levels, particularly LH, and subsequently particularly LH, and subsequently low oestrogen levelslow oestrogen levels