1 Sleep-Wake Pharmacology Outline I. Drugs that disturb Sleep- wake II. Drugs that promote sleep III. Drugs that promote wake Antidepressants TCA -such as amitriptyline, nortriptyline, etc. Increase TST, PLMs, decrease REM and decrease alertness • SSRI – Fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram • SNRI – venlafaxine • Cause insomnia • Decrease total sleep time and REM • Cause PLMs NDRI -Bupropion • Can cause – insomnia – Vivid dreams – nightmares SARI • Trazadone –Improves sleep –Increases TST, SWS –Decreses SL, REM
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Sleep-Wake Pharmacology Outline
I. Drugs that disturb Sleep-wake
II. Drugs that promote sleepIII. Drugs that promote wake
Antidepressants
TCA-such as amitriptyline,
nortriptyline, etc.
Increase TST, PLMs,decrease REM anddecrease alertness