11/2/2012 1 SLEEP, STRESS, and SCRIPTS What’s Holding Back Your Weight Loss? Holly F. Lofton, MD Assistant Professor of Surgery and Medicine NYU Langone Medical Center OBJECTIVES Discuss role of sleep deprivation on hunger/ weight Define important weight related hormones Discuss role of stress on fat storage Review medications that typically cause weight gain Present options to help combat weight gain related to sleep deprivation, stress, and medications
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11/2/2012
1
SLEEP, STRESS, and SCRIPTSWhat’s Holding Back Your
Weight Loss?Holly F. Lofton, MD
Assistant Professor of Surgery and MedicineNYU Langone Medical Center
OBJECTIVES Discuss role of sleep deprivation on hunger/ weight
Define important weight related hormones
Discuss role of stress on fat storage
Review medications that typically cause weight gain
Present options to help combat weight gain related to sleep deprivation, stress, and medications
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Sleep and Weight Management
HOW TO GET A GOOD NIGHT’S SLEEP INFANTS 3-11 months 14 - 15 hours
WEIGHT GAINJosiane L. Broussard, David A. Ehrmann, Eve Van Cauter, Esra Tasali, Matthew J. Brady;
Impaired Insulin Signaling in Human Adipocytes After Experimental Sleep Restriction A Randomized, Crossover Study. Annals of Internal Medicine. 2012 Oct;157(8):549-557.
Medical Study
Short sleep duration appears to be independently associated with weight gain, particularly in
younger age groups
There is a positive association between short sleep duration and future weight gain. This
relationship appears to wane with agePatel, SR and Hu, FB (2008). Short Sleep Duration and Weight: A Systematic Review. Obesity, 16:643-653.
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HOW TO GET A GOOD NIGHT’S SLEEP
INFANTS 3-11 months 14 - 15 hours
TODDLERS 12 -14 hours
PRE-SCHOOLERS 11 - 13 hours
SCHOOL - AGED CHILDREN 10 - 11 hours
ADOLESCENTS 9 HOURS
ADULTS 7 - 9 HOURS
GHRELIN
LEPTIN
SLEEP DEPRIVATION
SLEEP HYGIENE
Avoid daytime naps
Same sleep/ wake times every day
Avoid vigorous activity, caffeine, nicotine, alcohol, stimulants near bedtime
MEDICATIONS Topiramate has been shown, in some studies, to
reduce appetite and limit weight gain (particularly weight gain associated with atypical antipsychotics)
Metformin is being studied to see if it may reduce weight gain and/or the risk of developing diabetes associated with some psychiatric medications
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TAKE HOME POINT
Be proactive in weight management when on certain medications
Focus on low calorie density foods, regular exercise
Minimize duration of therapy
ACTION PLANConsult with dietician or physician
weight management specialist
Monitor response to medication to minimize duration of therapy
Consider weight-neutral alternatives
Regular exercise
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Stress and Cortisol
What Is Cortisol? Steroid hormone secreted by the adrenal
gland in response to stress and in normal circumstances
Increases blood glucose (sugar) by increasing glucose production in the organs
Suppresses immune function Enhances lipogenesis (fat production)
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Stress and CortisolAnger Anxiety
CORTISOL
Fright Stress
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Cortisol (Stress) ResponseBody needs to refuel in response to “threat”
Increased desire for carbohydrates and fats STRESS EATING
Moves fat to deposits in the abdomen
Medical Study 7965 British civil servants
Measured work stress and BMI at baseline and 5 years later
Men with BMI< 22 stress associated with WEIGHT LOSS
Men with BMI >27, stress associated with WEIGHT GAIN
Kivimaki, M, et al. Work stress, weight gain and weight loss: evidence for bidirectional effects of job strain on body mass index in the Whitehall II study. Intl Journal of Obesity (2006) 30, 982-987.
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Medical Study
Women with mostly abdominal obesity produce especially large amounts of cortisol when faced with a difficult task AND consumed more calories
afterwards
Epel, ES Stress and Body Shape: Stress induced cortisol secretion is consistently greater among women with central fat. Psychosomatic Medicine. 2000. 62: 623-632
Medical Study
Subjects prone to binge eating have higher cortisol levels upon
awakening and after a physically stressful task
Gluck, ME et al. Cortisol stress response is positively correlated with central obesity in obese women with binge eating disorder (BED) before and after the cognitive behavioral treatment. Annals of the New York Academy of Sciences. Dec 2004.1032: 202-207.
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Battling Stress-Related Weight Gain 30 – 90 minutes exercise
Relaxation Exercises
Yoga/ Meditation
Cognitive Behavioral Therapist
Battling Stress-Related Weight Gain Ask yourself “Am I truly hungry?”
Keep comfort foods out of home/ office
Don’t skip meals
Record mood and eating habits and develop coping skills
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Battling Stress-Related Weight Gain
Claims of cortisol-reducing supplements have NOT been substantiated with medically
sound evidence
Exercise is the best method to reduce cortisol levels in response to stress AND burns
calories
Overeating may lead to temporary satisfaction
Staying healthy is the ultimate victory over
stress
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TAKE HOME POINT
Stressful circumstances cause increased cortisol secretion and, thus, increased
fat production and cravings
This can be overcome with stress management techniques
SUMMARYSleeping less than 7 hours a night for as few as 1 night can cause unfavorable regulation of leptin/
ghrelin and lead to : hunger, fat deposition in organs, insulin resistance, and cravings for high
calorie foods
Some prescription medication leave the user prone to weight gain. If these are necessary, being proactive to minimize weight gain is
essential
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SUMMARYEmotional and physical stress can cause elevations
in cortisol that trigger abdominal fat deposition and stress eating
Healthy amounts of sleep, exercise, stress management skills as well as a carefully planned
diet can help combat weight gain related to hormonal factors