SABINSA Authors: Muhammed Majeed, Ph.D., Pritee Paliwal, Ph.D., Anurag Pande, Ph.D. TETRAPURE ® SKIN. HAIR. NAILS. NATURALLY. TETRAPURE ® HIGHLIGHTS: ! Anti-Fungal ! Anti-Oxidant ! Anti-Dandruff ! Skin Lightening Agent ! Use in: o Creams / Lotions / Spray / Powder TetraPure ® is standardized for a minimum of 99% of Tetrahydrocurcumin (1, 79Bis(49 hydroxy939methoxyphenyl)93,59 heptanedione). It is known to exhibit similar physiological and pharmacological actions as curcumin, in some cases even better. HO OH O O H CO 3 OCH 3
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SABINSAAuthors: Muhammed Majeed, Ph.D., Pritee Paliwal, Ph.D., Anurag Pande, Ph.D.
TETRAPURE®
SKIN. HAIR. NAILS. NATURALLY.
TETRAPURE® HIGHLIGHTS:! Anti-Fungal! Anti-Oxidant! Anti-Dandruff! Skin Lightening Agent! Use in:
o Creams / Lotions / Spray / Powder
TetraPure®!is!standardized!for!a!minimum!of! 99%! of! Tetrahydrocurcumin! (1,! 79Bis(49h y d r o x y 9 3 9 m e t h o x y p h e n y l ) 9 3 , 5 9heptanedione).! It! is! known!to! exhibit! similar!physiological! and!pharmacological! actions!as!curcumin,!in!some!cases!even!better.!
A rhizomatous herbaceous perennial plant of the ginger family, Zingiberaceae. It is native to tropical South Asia and needs temperatures between 20 °C and 30 °C (68 °F and 86 °F) and a considerable amount of annual rainfall to thrive. Plants are gathered annually for their rhizomes, and propagated from some of those rhizomes in the following season.
In(vitro(studies!indicate !that!TetraPure®!efficiently!inhibits !tyrosinase,!the !rate!limi5ng!enzyme!in!the!synthesis!of!melanin.!Its!efficacy! is !superior! to!that!of!commonly!used!natural !skin!lightening!agents!such!as !kojic!acid,!and!of!related!compounds!(Table!5).
5.(Safety(Studies(of(TetraPure®
TetraPure® 1.8 3.2Vitamin C 9.33 25Kojic Acid 7 100Arbutin 193.6 100Source: Sami Labs Ltd.
Table 5: Comparison of Skin Lightening Activities
Product Melanin
Inhibition(IC ìg/ml)50
Tyrosinase Inhibition(IC ìg/ml)50
Lower the IC value, greater is the Skin lightening activity.50
Dermal Irritation Non-IrritantRepeated insult patch test Did not induce skin sensitization or any reactionPrimary Skin Irritation Did not cause any irritation