SIRT Dosimetry: Sometimes Less Is More Navesh K. Sharma, DO, PhD Assistant Professor, Departments of Radiation Oncology, Diagnostic Radiology and Nuclear Medicine Medical Director, Radiation Oncology, Kaufman Cancer Center University of Maryland Medical Center Baltimore, MD 1
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SIRT Dosimetry: Sometimes Less Is More SIRT Dosimetry: Sometimes Less Is More Navesh K. Sharma, DO, PhD Assistant Professor, Departments of Radiation Oncology, Diagnostic Radiology
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SIRT Dosimetry: Sometimes Less Is More
Navesh K. Sharma, DO, PhD Assistant Professor, Departments of Radiation Oncology, Diagnostic Radiology and
Nuclear Medicine Medical Director, Radiation Oncology, Kaufman Cancer Center
University of Maryland Medical Center Baltimore, MD
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Disclosures
Sirtex Medical- Speaking Engagements
Bristol-Myers Squibb- Speaking Engagement
UMMS Liver Directed Therapy Team
Surgery Surgical Oncology Transplant
Medical Oncology
Radiology
Interventional Radiology Fred Moeslein, MD, PhD Jason Mitchell, MD Brian Swehla, MD Nabeel Akhtar, MD Nuclear Medicine
Pathology
Radiation Oncology
Steven Feigenberg, MD
William Regine, MD
Pradip Amin, MD
Young Kwok, MD
Michael Chuong, MD
Navesh Sharma, DO, PhD
Svetalana Kudryasheva- SIR-
spheres coordinator
SIR-Spheres® microspheres
Biocompatible resin
32μm average diameter
Yttrium90 permanently bound
Mean pure beta emission @ 0.93MeV
Half life 64.1 hours
Penetration – 2.5mm mean
– 11mm max
Scanning electron
micrograph
SIR-Spheres® is a registered trademark of Sirtex SIR-Spheres Pty Ltd.
Data on file, Sirtex Medical Limited
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Theraspheres
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Concept of SIRT (Selective Internal Radiation Therapy) Radioembolization “Brachytherapy”
Treatment Goals:
Selectively deliver a
tumoricidal dose of beta radiation
to the liver tumor while
maintaining a low
radiation dose to the
normal liver tissue
SIRT: Microsphere Delivery Concept
SIRT takes advantage of the hepatic dual blood supply