Single dose for rabies Single dose for rabies pre-immunization pre-immunization P. Khawplod 1 , H. Wilde 2 ,T. Kamolthum 3 ,Visith Sitprija 1 . 1Queen Saovabha Memorial Institute, The Thai Red Cross Society, Bangkok, Thailand. 2 Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand. 3 Provincial Public Health Office of Pitsanulok , Thailand.
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Single dose for rabies pre-immunization P. Khawplod 1, H. Wilde 2,T. Kamolthum 3,Visith Sitprija 1. 1Queen Saovabha Memorial Institute, The Thai Red Cross.
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Single dose for rabies Single dose for rabies pre-immunizationpre-immunization
P. Khawplod1 , H. Wilde2 ,T. Kamolthum3 ,Visith Sitprija1.
1Queen Saovabha Memorial Institute, The Thai Red Cross Society, Bangkok, Thailand.
2 Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand.
3 Provincial Public Health Office of Pitsanulok , Thailand.
The Ab response in incomplete PET casesThe Ab response in incomplete PET cases(1 - 3 injections)(1 - 3 injections)
SubjectsSubjects nn Day 0Day 0 Day 7Day 7 Day 14Day 14 Day 28Day 28
I. No previous I. No previous
rabies rabies
vaccinationvaccination1010 <0.03<0.03 0.060.06
(<0.03–0.2)(<0.03–0.2)
7.137.13(1.15-58.8)(1.15-58.8)
6.446.44(1.8-20.7)(1.8-20.7)
II. 1-3 II. 1-3
injections injections
previouslypreviously
20200.260.26
(<0.03-22.0)(<0.03-22.0)
6.736.73(1.1-80.5)(1.1-80.5)
38.9138.91(16.7-248.4)(16.7-248.4)
23.8623.86(6.7-175.6)(6.7-175.6)
All subjects received TRC-ID 2-2-2-0-1-1
(PVRV lot.no. L1012, potency 8.7
IU/0.5mL)
Pre-exposure vaccination
Shorten time & reduce cost
Objective :
To evaluate the immune memory of
two abbreviated pre-exposure rabies
vaccination schedules
Study 1 One week schedule
( 3 injections on day 0,3,7)
Study 2 One clinic visit (Single dose)
One week scheduleOne week schedule
Gr.A ID (2 sites) on day 0, 7 ,280, 7 ,28
Gr.B ID (2 sites) on day 0, 3, 70, 3, 7
Gr.C IM on day 0, 3, 70, 3, 7
PVRV potency 7.5 IU/0.5 mL
PVRV potency 7.5 IU/0.5 mL
Booster : ID (2 sites) on day 0,3 1 year later
One week scheduleOne week schedule
Blood collection : before booster (1 year) , 7 and 14 days
Group Day 360 Day 367 Day 374
A. IDx2 Age 18-35 GMT 0.96 29.14 49.39 day 0,7,28 M/F 5/11 Range 0.32-2.95 6.7-227.8 13.1-308.4
(n=16 ) >0.5 IU/ml 81% 100% 100%
B. IDx 2 Age 18-32 GMT 1.12 22.99 105.08 day 0,3,7 M/F 4/12 Range 0.30-4.76 5.9-295.4 26.1-496.7
(n=16 ) >0.5 IU/ml 94% 100% 100%
C. IM Age 18-40 GMT 0.97 35.16 125.0 day 0,3,7 M/F 8/12 Range 0.27-4.76 12.0-191.5 29.7-800.0
(n=20 ) >0.5 IU/ml 80% 100% 100%
Booster : ID(2 sites) on day 0,3 1 year later
Previous vaccination
regimen Times
(yrs)
day0 day7 day14 day28
PVRV ID 8 mths 0.08 16.0 25.0 19.3
PVRV ID 1 neg 1.1 18.2 6.7
PVRV ID 2 0.18 5.0 16.7 11.8
PVRV ID 3 1.14 36.4 34.9 20.8
unknown IM 4 neg 2.4 30.6 32.0
No previous vaccination
TRC-ID2-2-2-0-1-1
neg 0.06 5.56 5.84
One injection for 1- 4 years( at QSMI )
Conclusions:
3 injections on day 0,3,7 is as immunogenic as 3 injections on day 0,7,28
Provide at least 1 year of immune memory
Single dose for rabies pre-immunizationSingle dose for rabies pre-immunization( one clinic visit )( one clinic visit )
Pre-immunization
ID 0.1 ml (2 sites) on day 0
Single dose for rabies pre-immunizationSingle dose for rabies pre-immunization
Booster ( 1 year later )
ID 0.1 ml ( 2 sites ) on day 0, 3
PVRV lot no 0525 potency 7.5 IU/0.5mL
Primary vaccinationPrimary vaccination Day 360( Before booster )
Day 367( 7 days)
Day 374( 14 days )
I. ID 0.1 ml (2sites) on day 0 I. ID 0.1 ml (2sites) on day 0 booster ID 0.1ml (2 sites )booster ID 0.1ml (2 sites )
day0,3day0,3 >0.5 IU/ml
0.41(0.06–3.7)
5/13
38%
9.15(3.36-22.6)
10/10
100%
51.96(13.6-141.4)
9/9
100%
Single dose rabies pre-immunizationSingle dose rabies pre-immunization
Primary vaccinationPrimary vaccination Day 360 (Before booster)
Day 367( 7 days)
Day 374( 14 days)
I. ID 0.1 ml (2sites) on day 0I. ID 0.1 ml (2sites) on day 0