Signaling via Ras See: www.mpi-dortmund.mpg.de/imprs/Experiment3.pdf
Dec 19, 2015
Signaling via Ras
See: www.mpi-dortmund.mpg.de/imprs/Experiment3.pdf
Inhibitors of Farnesylation
From: Johnston, Lancet Oncol. 2001, 2, 18
N-Glycosylation
Glycosylation in the ER
From: http://glycores.ncifcrf.gov/
Glycan Diversity Generated in Golgi
Structure of N-Glycan
Imperiali, Curr. Opin. Chem. Biol. 1999, 3, 643
Pharmacological Inhibitors of Glycosylation
Glycosylation is Essential
D. S. Peal, unpublished results
Glycosylation Involved in Quality Control of Protein Folding
Notch Signaling Pathway
Blacklow, Curr. Opin. Chem. Biol. 2002, 6, 501
Notch Regulation by Glycosylation
Haltiwanger, Curr. Opin. Struct. Biol. 2002, 12, 593
Notch – Ligand Preference Influenced by Glycosylation