Signaling Energy Revolutionizes Anti-Aging Presenting two Experimental Studies on the Ion Magnum By Dr Xanya Sofra-Weiss.

Signaling Energy Signaling Energy Revolutionizes Anti-AgingRevolutionizes Anti-Aging

Presenting two Experimental Studies Presenting two Experimental Studies on the Ion Magnum on the Ion Magnum

By Dr Xanya Sofra-WeissBy Dr Xanya Sofra-Weiss

Signaling Technology views aging and desease as the result of faded ormissing signals that would otherwise give the instructions for the adequatesynthesis of hormones, antibodies, enzymes and other proteins such ascollagen, elastin, hemoglobin, actin, myosin, ATPace, etc

The proteins in each cell receive a complex combination of signals which simultaneously trigger many different signaling pathways which provide an opportunity for cross-talk between different signals. The cell integrates information from many different signaling pathways to initiate an appropriate response. Missing signals leave the cell with incoherent instructions hence leading to an inappropriate response that may be deleterious to the cell.

Aging and Aging and DiseaseDisease

Aging is the result of deteriorated protein Aging is the result of deteriorated protein signals leaving the body with multiple signals leaving the body with multiple deficiencies in terms of hormones, deficiencies in terms of hormones, antibodies, enzymes and other proteins antibodies, enzymes and other proteins such as collagen, elastin, hemoglobin, such as collagen, elastin, hemoglobin, actin, myosin, ATPace, etcactin, myosin, ATPace, etc

Cancer is not the result of a number of Cancer is not the result of a number of “rebel” cells that refuse to follow the rules “rebel” cells that refuse to follow the rules of cellular proliferation and differentiation of cellular proliferation and differentiation but a number of “obedient” cells who got but a number of “obedient” cells who got the wrong instructions as a result of the wrong instructions as a result of Singaling deficiencySingaling deficiency

Some of the Functions of ProteinsSome of the Functions of Proteins enzymatic catalystsenzymatic catalysts

DNA repairDNA repair

transport molecules (hemoglobin transports oxygen) transport molecules (hemoglobin transports oxygen)

storage molecules storage molecules

they are used in movement --proteins are the major they are used in movement --proteins are the major component of musclescomponent of muscles

needed for mechanical support (collagen)needed for mechanical support (collagen)

mediate cell migrations mediate cell migrations

antibody proteins are needed for immune protectionantibody proteins are needed for immune protection

control of growth and cell differentiation uses proteinscontrol of growth and cell differentiation uses proteins

Collagen, Elastin are Proteins along with about 100,000 Collagen, Elastin are Proteins along with about 100,000 more types of Proteins that exist in the human bodymore types of Proteins that exist in the human body

Investigating how such signaling pathways are organized is relevant not only for understanding how normal cells work, but also for appreciating the molecular basis for aging and disease, since aging as well as many human disorders result from breakdowns in signal transduction

Among 4,087 different proteins identified with highconfidence by massspectrometry from 2,357 successful purifications, our core dataset(median precision of 0.69)comprises 7,123 proteinto protein interactions.

Result of examing these comprises 7,123 protein to protein interactions in aged vs young subjects demonstrated that Aging is the result of the disorganization in the interactions or communications between Protein to Protein interactions

Several studies have indicated an alteration in signal transduction with ageing. Eg. T cells from aged have decreased membrane fluidity. T cells activation and proliferation is decreased as a result of decreased recruitment of signaling proteins associated with the initial complex of signal transduction

Contrast ofPixel

Intensities

Diminished protein signals from the Champerone proteins during protein synthesis leads to decreased synthesis of proteins and a subsequent deficiency in the aged.

EXAMPLES:Less collagen and elastin (wrinkles);Less actin and myosin (sagging muscles);Less hormones (weight gain from decreased TSH, T3, muscular hypotrophy from decreased IGF-1)Less Atpace leading to decreased ATP synthesis, etcZhang et al (2002) showed that that human age-related cataract is associated with decreased expression of L21 and other ribosomal proteins.

Ziv et al (2011) Mutations of genes involved in the insulin/insulin-like growth factor-1 (IGF-1) signaling pathway affect lifespan in several model organisms. decreased IGF-1 receptor levels due to a single gene knockout have been demonstrated to have increased lifespan.

Insulin Signaling

Insulin Code

Stem Cells Need Specific SignalsStem Cells Need Specific SignalsFor Correct DifferentiationFor Correct Differentiation

Researchers from Johns Hopkins have discovered the Researchers from Johns Hopkins have discovered the presence of functional ion channels (that act like presence of functional ion channels (that act like electrical wires) in human embryonic stem cells (ESCs). electrical wires) in human embryonic stem cells (ESCs). Li's lab (John Hopkins University) genetically engineered Li's lab (John Hopkins University) genetically engineered heart cells derived from human ESCs, suggesting the heart cells derived from human ESCs, suggesting the possibility of transplanting unlimited supplies of healthy, possibility of transplanting unlimited supplies of healthy, specialized cells into damaged organs. A major concern specialized cells into damaged organs. A major concern for human ESC-based therapies is the potential for for human ESC-based therapies is the potential for engineered grafts to go haywire after transplantation and engineered grafts to go haywire after transplantation and form tumors... form tumors... ““We therefore decided to explore the We therefore decided to explore the existence of ION CHANNELS in pluripotent, or versatile, existence of ION CHANNELS in pluripotent, or versatile, human ESCs because ELECTRICAL ACTIVITY IS KNOWN human ESCs because ELECTRICAL ACTIVITY IS KNOWN TO REGULATE CELL DIFFERENTIATION AND TO REGULATE CELL DIFFERENTIATION AND PROLIFERATION," says Li.PROLIFERATION," says Li.

Jan van Deursen (2002 -2011) studied study a protein called BubR1, which helps ensure that each cell has the correct number of chromosomes during cell divisionThey found that a deficiency in protein BubR1 causes premature aging. They also found that BubR1 decreases with age. Decreased BubR1 also correlated with abnormal chromosome numbers in sperm and eggs, associating this protein with infertility. It is also associated with cataracts, heart desease and other age related diseases.

AGING iS THE RESULT OF INCREASINGAGING iS THE RESULT OF INCREASINGIMBALANCES AS A RESULT OF:IMBALANCES AS A RESULT OF:

1. Decreased Number of Proteins. 1. Decreased Number of Proteins. Underneath that there is a Underneath that there is a2 . A decrease in the Champerone 2 . A decrease in the Champerone proteins that help in the protein proteins that help in the protein folding.folding.3. A decrease or the absence of 3. A decrease or the absence of signalssignals initiating and initiating and completing the process of protein completing the process of protein synthesissynthesis

2011: Examination of a mechanism 2011: Examination of a mechanism involving the protein stromal-derived involving the protein stromal-derived factor-1 (SDF1), and its receptor factor-1 (SDF1), and its receptor CXCR4 provides proof that cancer is CXCR4 provides proof that cancer is the result of cells getting the wrong the result of cells getting the wrong signals giving them the wrong signals giving them the wrong instructions. instructions.

A DNA mutation while it is unfolding A DNA mutation while it is unfolding to copy itself during division or a to copy itself during division or a mutation anywhere in the signaling mutation anywhere in the signaling pathways of thepathways of theseries of proteins carrying the DNA series of proteins carrying the DNA info means that the wrong order is info means that the wrong order is sent. sent.

Even when the right one Even when the right one arrives, our cellular copiers arrives, our cellular copiers can make mistakes, leading to can make mistakes, leading to new genes that bark out the new genes that bark out the wrong orderswrong orders.. Fortunately, our Fortunately, our bodies have patrols that bodies have patrols that constantly neutralize most constantly neutralize most genetic mistakes, but get genetic mistakes, but get enough of them and cancer enough of them and cancer develops. develops.

SINGALING TECHNOLOGY:

1. IDENTIFY THE SIGNALS THAT REINSTATE THE SYNTHESIS OF KEY PROTEINS ( researchstarted in Cambridge University) 2. INDENTIFY THE SIGNALS OF PROTEIN INTERACTIONS DURINGIMPORTANT BIOLOGICAL FUNCTIONS SUCH AS CELLULARPROLIFERATION AND DIFFERENTIATIONCONCEPTUALIZE SUCH PROTEIN INTERACTIONS AS A DYNAMIC PROCESSLIKE THE NOTES OF A MUSICAL PIECE OR THEIMAGES FORMING A MOVING PICTURE

Signaling Energy Amplifies or substitutes protein (antibodies, hormones, enzymes, etc) signaling that has diminished or paused with age leading to a revival of endogenous protein synthesis, energy production while acting as a MEGAANTI-OXIDANT

Fate and behavior of Cells is controlled

by signaling pathways which deliver information from 1. Protein signals in surrounding tissue 2. Proteins signals emitted by other cells.

Proteins and their signals are transported by microtubules

We have been researching the aging process ofhealthy individuals with a device built in Cambridgeon the basis of specifications that were researched in Cambridge by comparing the signaling propertiesof young vs aged cells and by artificially sendingthe signals derived from a colony of young cells toa colony of old cells and seeing it this “transfer” of signals from the young to the old with in any way alterthe signaling pathways of the signaling propertiesof the old colony of cells.

Results have shown a significant increase in a number of proteins:①Collagen Increase by 62%②Actin Increase by 45%③Myosyn Increase by 38%④Hemoglobin Increase by 76%⑤ATPace Increase by 80%⑥Testosterone Increase by 46%⑦IGF-1 Increase by 62%⑧Insuline Increase by 23%⑨BubR1 by 18%⑩Cyclic Amp by 63%⑪G Proteins by 57%⑫Sitruins by 45%

Clinical Studies Results have revealed the visibly dramatic results that persist from five to nine months with at least three treatments

How are these waveforms composed? First we record the signals of interacting cells by cell recording methods that focus on cellular interactions, using advanced computer software that were developed specifically for that reason. Then we go through thousands of combinations of signals to recompose the biological decoded signals

Combining the signalsis like editing a movieor composing a symphony

Timing is Crucial

THE IMPORTANCE OF TIMING

FACIAL REJUVENATION RESULTS

THANK YOU FOR YOUR KIND ATTENTION

THANK YOU FOR YOUR KIND ATTENTION