Short title: Intra-cluster and mutual regulation of AP2/ERFs · 54 NICOTINE2 (NIC2) ERF cluster. Moreover, overexpression of ORCA5 in tobacco and of NIC2 55 ERF189 in C. roseus hairy
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Short title: Intra-cluster and mutual regulation of AP2/ERFs 1
Corresponding authors: Ling Yuan and Sitakanta Pattanaik, Department of Plant and Soil 2
Sciences and Kentucky Tobacco Research and Development Center, University of Kentucky, 3
Boycheva S, Daviet L, Wolfender JL, Fitzpatrick TB (2014) The rise of operon-like gene 806
clusters in plants. Trends Plant Sci 19: 447-459 807
Camacho C, Coulouris G, Avagyan V, Ma N, Papadopoulos J, Bealer K, Madden TL 808 (2009) BLAST+: architecture and applications. BMC Bioinformatics 10: 421 809
Cardenas PD, Sonawane PD, Pollier J, Vanden Bossche R, Dewangan V, Weithorn E, Tal 810
L, Meir S, Rogachev I, Malitsky S, Giri AP, Goossens A, Burdman S, Aharoni A 811 (2016) GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids 812
in the plant mevalonate pathway. Nat Commun 7: 10654 813
Carqueijeiro I, Brown S, Chung K, Dang TT, Walia M, Besseau S, Duge de Bernonville T, 814
Oudin A, Lanoue A, Billet K, Munsch T, Koudounas K, Melin C, Godon C, 815
Razafimandimby B, de Craene JO, Glevarec G, Marc J, Giglioli-Guivarc'h N, 816 Clastre M, St-Pierre B, Papon N, Andrade RB, O'Connor SE, Courdavault V (2018) 817
Two Tabersonine 6,7-Epoxidases Initiate Lochnericine-Derived Alkaloid Biosynthesis in 818
Carqueijeiro I, Duge de Bernonville T, Lanoue A, Dang TT, Teijaro CN, Paetz C, Billet K, 820
Mosquera A, Oudin A, Besseau S, Papon N, Glevarec G, Atehortua L, Clastre M, 821
Giglioli-Guivarc'h N, Schneider B, St-Pierre B, Andrade RB, O'Connor SE, 822 Courdavault V (2018) A BAHD acyltransferase catalyzing 19-O-acetylation of 823
tabersonine derivatives in roots of Catharanthus roseus enables combinatorial synthesis of 824
Chae L, Kim T, Nilo-Poyanco R, Rhee SY (2014) Genomic signatures of specialized 826
metabolism in plants. Science 344: 510-513 827
Chatel G, Montiel G, Pre M, Memelink J, Thiersault M, Saint-Pierre B, Doireau P, Gantet 828 P (2003) CrMYC1, a Catharanthus roseus elicitor- and jasmonate-responsive bHLH 829
transcription factor that binds the G-box element of the strictosidine synthase gene 830
promoter. J Exp Bot 54: 2587-2588 831
Chini A, Fonseca S, Fernandez G, Adie B, Chico JM, Lorenzo O, Garcia-Casado G, Lopez-832 Vidriero I, Lozano FM, Ponce MR, Micol JL, Solano R (2007) The JAZ family of 833
repressors is the missing link in jasmonate signalling. Nature 448: 666-671 834
Colinas M, Goossens A (2018) Combinatorial Transcriptional Control of Plant Specialized 835
Metabolism. Trends Plant Sci 23: 324-336 836
De Boer K, Tilleman S, Pauwels L, Vanden Bossche R, De Sutter V, Vanderhaeghen R, 837 Hilson P, Hamill JD, Goossens A (2011) APETALA2/ETHYLENE RESPONSE 838
FACTOR and basic helix–loop–helix tobacco transcription factors cooperatively mediate 839
Fernandez-Pozo N, Menda N, Edwards JD, Saha S, Tecle IY, Strickler SR, Bombarely A, 841 Fisher-York T, Pujar A, Foerster H, Yan A, Mueller LA (2015) The Sol Genomics 842
Network (SGN)--from genotype to phenotype to breeding. Nucleic Acids Res 43: D1036-843
1041 844
Finn RD, Coggill P, Eberhardt RY, Eddy SR, Mistry J, Mitchell AL, Potter SC, Punta M, 845 Qureshi M, Sangrador-Vegas A, Salazar GA, Tate J, Bateman A (2016) The Pfam 846
protein families database: towards a more sustainable future. Nucleic Acids Res 44: 847
Ganko EW, Meyers BC, Vision TJ (2007) Divergence in Expression between Duplicated 852
Genes in Arabidopsis. Mol Biol and Evol 24: 2298-2309 853
Giddings L-A, Liscombe DK, Hamilton JP, Childs KL, DellaPenna D, Buell CR, O'Connor 854 SE (2011) A stereoselective hydroxylation step of alkaloid biosynthesis by a unique 855
Lewis RS, Jack AM, Morris JW, Robert VJ, Gavilano LB, Siminszky B, Bush LP, Hayes 877 AJ, Dewey RE (2008) RNA interference (RNAi)-induced suppression of nicotine 878
demethylase activity reduces levels of a key carcinogen in cured tobacco leaves. Plant 879
Biotechnol J 6: 346-354 880
Li J, Zhang K, Meng Y, Hu J, Ding M, Bian J, Yan M, Han J, Zhou M (2018) Jasmonic 881
acid/Ethylene signaling coordinates hydroxycinnamic acid amides biosynthesis through 882
Matsui K, Umemura Y, Ohme‐Takagi M (2008) AtMYBL2, a protein with a single MYB 894
domain, acts as a negative regulator of anthocyanin biosynthesis in Arabidopsis. Plant J 895
55: 954-967 896
Mirjalili N, Linden JC (1996) Methyl jasmonate induced production of taxol in suspension 897
cultures of Taxus cuspidata: ethylene interaction and induction models. Biotech Progress 898
12: 110-118 899
Montavon T, Duboule D (2013) Chromatin organization and global regulation of Hox gene 900
clusters. Philos Trans R Soc Lond B Biol Sci 368: 20120367 901
Nakano T, Suzuki K, Fujimura T, Shinshi H (2006) Genome-wide analysis of the ERF gene 902
family in Arabidopsis and rice. Plant Physiol 140: 411-432 903
Nakayasu M, Shioya N, Shikata M, Thagun C, Abdelkareem A, Okabe Y, Ariizumi T, 904 Arimura GI, Mizutani M, Ezura H, Hashimoto T, Shoji T (2018) JRE4 is a master 905
transcriptional regulator of defense-related steroidal glycoalkaloids in tomato. Plant J 906
94:975-990 907
Nützmann H-W, Osbourn A (2014) Gene clustering in plant specialized metabolism. Curr 908
Opin Biotech 26: 91-99 909
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genomics. New Phytol 211: 771-789 911
Patra B, Pattanaik S, Schluttenhofer C, Yuan L (2018) A network of jasmonate‐responsive 912
bHLH factors modulate monoterpenoid indole alkaloid biosynthesis in Catharanthus 913
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functional characterization of a floral tissue-specific R2R3 MYB regulator from tobacco. 916
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AP2/ERF transcription factor gene cluster acts downstream of a MAP kinase cascade to 923
modulate terpenoid indole alkaloid biosynthesis in Catharanthus roseus. New Phytol 213: 924
1107-1123 925
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Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and 934
aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine. Proc Natl Acad 935
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Parsed CitationsBoycheva S, Daviet L, Wolfender JL, Fitzpatrick TB (2014) The rise of operon-like gene clusters in plants. Trends Plant Sci 19: 447-459
Pubmed: Author and TitleGoogle Scholar: Author Only Title Only Author and Title
Camacho C, Coulouris G, Avagyan V, Ma N, Papadopoulos J, Bealer K, Madden TL (2009) BLAST+: architecture and applications. BMCBioinformatics 10: 421
Pubmed: Author and TitleGoogle Scholar: Author Only Title Only Author and Title
Cardenas PD, Sonawane PD, Pollier J, Vanden Bossche R, Dewangan V, Weithorn E, Tal L, Meir S, Rogachev I, Malitsky S, Giri AP,Goossens A, Burdman S, Aharoni A (2016) GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in theplant mevalonate pathway. Nat Commun 7: 10654
Pubmed: Author and TitleGoogle Scholar: Author Only Title Only Author and Title
Carqueijeiro I, Brown S, Chung K, Dang TT, Walia M, Besseau S, Duge de Bernonville T, Oudin A, Lanoue A, Billet K, Munsch T,Koudounas K, Melin C, Godon C, Razafimandimby B, de Craene JO, Glevarec G, Marc J, Giglioli-Guivarc'h N, Clastre M, St-Pierre B,Papon N, Andrade RB, O'Connor SE, Courdavault V (2018) Two Tabersonine 6,7-Epoxidases Initiate Lochnericine-Derived AlkaloidBiosynthesis in Catharanthus roseus. Plant Physiol 177: 1473-1486
Pubmed: Author and TitleGoogle Scholar: Author Only Title Only Author and Title
Carqueijeiro I, Duge de Bernonville T, Lanoue A, Dang TT, Teijaro CN, Paetz C, Billet K, Mosquera A, Oudin A, Besseau S, Papon N,Glevarec G, Atehortua L, Clastre M, Giglioli-Guivarc'h N, Schneider B, St-Pierre B, Andrade RB, O'Connor SE, Courdavault V (2018) ABAHD acyltransferase catalyzing 19-O-acetylation of tabersonine derivatives in roots of Catharanthus roseus enables combinatorialsynthesis of monoterpene indole alkaloids. Plant J 94: 469-484
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Chatel G, Montiel G, Pre M, Memelink J, Thiersault M, Saint-Pierre B, Doireau P, Gantet P (2003) CrMYC1, a Catharanthus roseuselicitor- and jasmonate-responsive bHLH transcription factor that binds the G-box element of the strictosidine synthase genepromoter. J Exp Bot 54: 2587-2588
Pubmed: Author and TitleGoogle Scholar: Author Only Title Only Author and Title
Chini A, Fonseca S, Fernandez G, Adie B, Chico JM, Lorenzo O, Garcia-Casado G, Lopez-Vidriero I, Lozano FM, Ponce MR, Micol JL,Solano R (2007) The JAZ family of repressors is the missing link in jasmonate signalling. Nature 448: 666-671
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Colinas M, Goossens A (2018) Combinatorial Transcriptional Control of Plant Specialized Metabolism. Trends Plant Sci 23: 324-336Pubmed: Author and TitleGoogle Scholar: Author Only Title Only Author and Title
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