Short Sleep Duration is Associated with Short Sleep Duration is Associated with Hypertension only among Women: A Hypertension only among Women: A Population-based Study Population-based Study Stranges S Stranges S * * , Dorn JM , Dorn JM * * , , Cappuccio FP Cappuccio FP * * , Donahue RP , Donahue RP * * , , Hovey KM Hovey KM * * , Kandala N-B , Kandala N-B * * , Miller MA , Miller MA * * , Trevisan M , Trevisan M * * * * University of Warwick Medical School, UK University of Warwick Medical School, UK * * State University of New York at Buffalo, USA State University of New York at Buffalo, USA E.S.R.S. Glasgow 2008
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Short Sleep Duration is Associated with Hypertension only among Women: A Population-based Study Stranges S *, Dorn JM *, Cappuccio FP *, Donahue RP *,
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Short Sleep Duration is Associated with Short Sleep Duration is Associated with Hypertension only among Women: A Hypertension only among Women: A Population-based StudyPopulation-based Study
Stranges S Stranges S **, Dorn JM , Dorn JM **, , Cappuccio FPCappuccio FP **, Donahue RP , Donahue RP **, ,
Hovey KM Hovey KM **, Kandala N-B , Kandala N-B **, Miller MA , Miller MA **, Trevisan M , Trevisan M **
**University of Warwick Medical School, UKUniversity of Warwick Medical School, UK
**State University of New York at Buffalo, USAState University of New York at Buffalo, USA
E.S.R.S. Glasgow 2008
Total and Cause-Specific MortalityTotal and Cause-Specific MortalityA decrease in sleep duration is associated with an increase in A decrease in sleep duration is associated with an increase in
mortality via cardiovascular deathsmortality via cardiovascular deaths (Ferrie JE et al. (Ferrie JE et al. SleepSleep 2007;30:1659-66) 2007;30:1659-66)
Obesity/Body Fat DistributionObesity/Body Fat Distribution (Gangwisch JE et al. (Gangwisch JE et al. SleepSleep 2005;28:1289-96 - Patel SR et al. 2005;28:1289-96 - Patel SR et al. A.J.E.A.J.E. 2006;164:947-54 – 2006;164:947-54 –
Stranges S et al. Stranges S et al. A.J.E.A.J.E. 2008;167:321-9 - Cappuccio FP et al. 2008;167:321-9 - Cappuccio FP et al. SleepSleep 2008;31:619-26) 2008;31:619-26)
Type 2 Diabetes Type 2 Diabetes
(Ayas NT et al. (Ayas NT et al. Diab CareDiab Care 2003;26:380-4 – Yaggi HK et al. 2003;26:380-4 – Yaggi HK et al. Diab CareDiab Care 2006;29:657-61) 2006;29:657-61)
Coronary Heart DiseaseCoronary Heart Disease
(Meisinger C et al. (Meisinger C et al. SleepSleep 2007;30:1121-7) 2007;30:1121-7)
Hypertension Hypertension
(Gangwisch JE et al. (Gangwisch JE et al. HypertensionHypertension 2006;47:833-9 - Cappuccio FP et al. 2006;47:833-9 - Cappuccio FP et al. HypertensionHypertension 2007;50:693-701 - 2007;50:693-701 - Stang A et al. Stang A et al. HypertensionHypertension 2008;51:e15-6) 2008;51:e15-6)
Baseline examination (Sept 1996 – May 2001)Baseline examination (Sept 1996 – May 2001)• Eligible Participants: a) Eligible Participants: a) cancer free; b) cancer free; b) age 35-79 years age 35-79 years • Actual Participants: 4,065, random sample Actual Participants: 4,065, random sample • Participation rate: 59.5%Participation rate: 59.5%
Exclusion CriteriaExclusion Criteria• Self-reported history of prevalent CVD, ethnicity other than whiteSelf-reported history of prevalent CVD, ethnicity other than white• Included: 3,207 participants (56.5% women)Included: 3,207 participants (56.5% women)
The Western New York Health StudyThe Western New York Health Study
Exposure: Sleep DurationExposure: Sleep DurationSeven-Day Physical Activity Recall questionnaire‘On the average, how many hours did you sleep each night in the last five weekday nights (Sunday-Thursday)?’
Short sleep (<6 hours)
Mid-range sleep (6-8 hours)
Long sleep (>8 hours)
Outcome: Prevalent HypertensionOutcome: Prevalent HypertensionSystolic BP Systolic BP ≥≥ 140 mmHg, 140 mmHg, OROR Diastolic BP Diastolic BP ≥≥ 90 mmHg, 90 mmHg, OROR on antihypertensive medication at the on antihypertensive medication at the
baseline visitbaseline visit
Statistical analysisStatistical analysis
Multivariable logistic regression
Model 1Model 1: age, education, marital status, household income: age, education, marital status, household income
Odds ratiosOdds ratios of prevalent HTN comparing short and long duration of sleep vs. mid-range category of prevalent HTN comparing short and long duration of sleep vs. mid-range category
Exposure: Sleep DurationExposure: Sleep DurationSeven-Day Physical Activity Recall questionnaire‘On the average, how many hours did you sleep each night in the last five weekday nights (Sunday-Thursday)?’
Short sleep (<6 hours)
Mid-range sleep (6-8 hours)
Long sleep (>8 hours)
Outcome: Prevalent HypertensionOutcome: Prevalent HypertensionSystolic BP Systolic BP ≥≥ 140 mmHg, 140 mmHg, OROR Diastolic BP Diastolic BP ≥≥ 90 mmHg, 90 mmHg, OROR on antihypertensive medication at the on antihypertensive medication at the
baseline visitbaseline visit
Statistical analysisStatistical analysis
Multivariable logistic regression
Model 1Model 1: age, education, marital status, household income: age, education, marital status, household income
Odds ratiosOdds ratios of prevalent HTN comparing short and long duration of sleep vs. mid-range category of prevalent HTN comparing short and long duration of sleep vs. mid-range category
Exposure: Sleep DurationExposure: Sleep DurationSeven-Day Physical Activity Recall questionnaire‘On the average, how many hours did you sleep each night in the last five weekday nights (Sunday-Thursday)?’
Short sleep (<6 hours)
Mid-range sleep (6-8 hours)
Long sleep (>8 hours)
Outcome: Prevalent HypertensionOutcome: Prevalent HypertensionSystolic BP Systolic BP ≥≥ 140 mmHg, 140 mmHg, OROR Diastolic BP Diastolic BP ≥≥ 90 mmHg, 90 mmHg, OROR on antihypertensive medication at the on antihypertensive medication at the
baseline visitbaseline visit
Statistical analysisStatistical analysis
Multivariable logistic regression
Model 1Model 1: age, education, marital status, household income: age, education, marital status, household income
Odds ratiosOdds ratios of prevalent HTN comparing short and long duration of sleep vs. mid-range category of prevalent HTN comparing short and long duration of sleep vs. mid-range category