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1. Andrea Murray Shedding light on scleroderma
2. Aim and drive for developing technologies To develop better,
more sensitive and robust imaging techniques to measure disease
severity, progression & treatment response Better targeting and
monitoring of treatments Improved disease management
3. Light based - techniques Advancement of nailfold
capillaroscopy Laser Doppler imaging Multispectral imaging
4. Light based - techniques Advancement of nailfold
capillaroscopy Laser Doppler imaging Multispectral imaging
5. Capillaroscopy equipment
6. Nailfold capillaroscopy in action
7. Nailfold capillary architecture
8. Nailfold capillaroscopy Developed software for automated
capillary recognition Capable of measuring individual and average
capillary width, density, tortuosity Berks et al. Med Image Comput
Comput Assist Interv. 2014;17(Pt 1):658-65.
9. Comparison of capillary measures between subject groups
10. Blood flow in nailfold capillaroscopy Tresadern et al. Conf
Proc IEEE Eng Med Biol Soc. 2013;2013
11. Light based - techniques Advancement of nailfold
capillaroscopy Laser Doppler imaging Multispectral imaging
12. Laser Doppler imaging
13. Measuring blood flow in digital ulcers LDI can image
ischaemia/hyperaemia in ulceration 61 DU imaged; 60% ulcers were
ischaemic Murray A, et al. Arthritis and Rheumatism 2011; 63:
s574
14. Measurement of healing in digital ulcers LDI can measure
healing of ulcers with respect to blood flow increase in ulcer
blood flow and decrease in adjacent blood flow Baseline At healing
(as clinically assessed ) Murray A, et al. Arthritis and Rheumatism
2011; 63: s574
15. Pilot iontophoresis - perfusion increase with time Good
local method of delivery (no side effects) we need a longer lasting
drug
16. Light based - techniques Advancement of nailfold
capillaroscopy Laser Doppler imaging Multispectral imaging
17. Hyperspectral or Multispectral imaging Spectroscopy
spectrometer White light
18. Hyperspectral or Multispectral imaging Spectroscopy
spectrometer White light
19. Hyperspectral or Multispectral imaging Spectroscopy
spectrometer
20. Hyperspectral or Multispectral imaging Spectroscopy
spectrometer
21. Hyperspectral or Multispectral imaging Spectroscopy
spectrometer
22. 10 HC, 10 LcSSc, 7 DcSSc Digital occlusion; 200 mmHg, 2
mins Imaged baseline, during, upon release and after 1 minute,
after 5 mins Oxygenation Pilot study of multispectral imaging in
patients with systemic sclerosis and healthy controls Poxon I et
al. Rheumatology (2015) 54 : i161.
23. Pilot study of multispectral imaging in patients with
systemic sclerosis and healthy controls oxygenation
Oxygenation
24. Pilot study of multispectral imaging in patients with
systemic sclerosis and healthy controls oxygenation Oxygenation
Possible to differentiate between controls and patients with SSc
using changes in oxygenation Poxon I et al. Rheumatology (2015) 54
: i161.
25. Summary Light based imaging techniques help us to learn
more about Raynauds phenomenon and scleroderma non-invasively Some
techniques remain in the research arena, others move towards
clinical diagnostic status Aim is to validate techniques in order
to measure disease severity, progression & treatment response
Improve disease management
26. Ariane Herrick Tonia Moore Joanne Manning Paul New Sarah
Leggett Christopher Griffiths Mark Dickinson Chris Taylor Danny
Allen Phil Tresadern Mike Berks Graham Dinsdale Donna Arthur Ian
Poxon Mike Hughes Elizabeth Evans I am grateful to: All our
volunteers who make it possible! Our funders