Chloé Maignien, Resident C. Maignien, P. Santulli, D. Korb, L. Marcellin, V. Gayet, V. Blanchet, J. Gonnot, D. de Ziegler, C. Chapron Université Paris Descartes, Sorbonne Paris Cité, Faculté de médecine, AP-HP, Cochin Saint Vincent de Paul, Department of Gynecology Obstetrics II and Reproductive Medicine, Paris, France Inserm, Unité de recherche U1016 – équipe Pr F. Batteux, Institut Cochin, Paris, France SEUD 2015 Society Of Endometriosis and Uterine Disorders Prognostic factors of ART outcome in a continuous series of 359 endometriosis patients
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Chloé Maignien, Resident
C. Maignien, P. Santulli, D. Korb, L. Marcellin, V. Gayet, V. Blanchet, J. Gonnot, D. de Ziegler, C. Chapron
Université Paris Descartes, Sorbonne Paris Cité, Faculté de médecine, AP-HP,
Cochin Saint Vincent de Paul, Department of Gynecology Obstetrics II and Reproductive Medicine, Paris, France
Inserm, Unité de recherche U1016 – équipe Pr F. Batteux, Institut Cochin, Paris,
France
SEUD 2015
Society Of Endometriosis
and Uterine Disorders
Prognostic factors of ART outcome in a continuous series of 359 endometriosis patients
Endometriosis and IVF : conflicting evidence in the literature
Hamdan et al. Obstet Gynecol (2015)
Barbosa et al. Ultrasound Obstet Gynecol (2014)
Stage I/II vs controls
Stage III/IV vs controls
Live birth (OR, 95% CI)
0.96 (0.82 - 1.12) 0.77 (0.64 – 0.92)
Clinical pregnancy (OR, 95% CI)
0.84 (0.69 – 1.03) 0.60 (0.44 – 0.81)
Endometriosis and IVF : conflicting evidence in the literature
Why?
OMA SUP DIE
SUP = superficial endometriosis; OMA = endometrioma; DIE = deep infiltrating endometriosis
Implantation theory
Impact of surgery ?
Heterogeneous populations
Impact of adenomyosis ? ! Benaglia et al. (2014): similar implantation
rates ! Vercellini et al. (2014): negative impact on
clinical pregnancy and implantation Benaglia et al. Reprod Biomed Online (2014)
Vercellini et al. Human Reprod (2014)
Objective of the study
To evaluate the IVF/ICSI outcomes in a continuous series of endometriosis