The Fascinating Living Skeleton Neveen A.T. Hamdy Department of Medicine, Division of Endocrinology & Centre for Bone Quality Leiden University Medical Center , The Netherlands Neveen A.T. Hamdy has no Disclosures relevant to this Talk Bone: A Dynamic Multifunctional Organ Functions • Mechanical • Protective for vital organs • Metabolic : • Reservoir for minerals • Bone remodeling Bone is a unique tissue Complex tissue • Cells • Organic matrix • Mineral Continuously renewed tissue A normal bone remodeling cycle is essential for the maintenance of bone mass and quality Seeman E and Delmas PD. N Engl J Med 2006; 354:2250 – 2261 Mineralisation - calcium - phosphate - vitamin D Bone Mineralization copyright Mw. Dr. N.A.T. Hamdy
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The Fascinating Living Skeleton
Neveen A.T. Hamdy
Department of Medicine, Division of Endocrinology
& Centre for Bone Quality
Leiden University Medical Center , The Netherlands
Neveen A.T. Hamdy has no Disclosures
relevant to this Talk
Bone: A Dynamic Multifunctional Organ
Functions
• Mechanical
• Protective for vital organs
• Metabolic:
• Reservoir for minerals
• Bone remodeling
Bone is a unique tissue
Complex tissue
• Cells
• Organic matrix
• Mineral
Continuously renewed tissue
A normal bone remodeling cycle is essential
for the maintenance of bone mass and quality
Seeman E and Delmas PD. N Engl J Med 2006; 354:2250–2261
Mineralisation
- calcium
- phosphate
- vitamin D
Bone Mineralization
copy
right
Mw. Dr. N
.A.T. H
amdy
Bone Remodeling
The Basic Multicellular Unit (BMU) Bone Cells: The Osteoclast
Tolar et al, N Engl J Med 2004;351:2839-2849
Specific Factors Are Needed for the
Maturation of Haematopoietic Stem CellsHaematopoietic