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Selective serotonin reuptake inhibitor fluoxetine inhibits replication of Human Enterovirus B and D 1
by targeting viral protein 2C 2
Rachel Ulferts1, Lonneke van der Linden2,3,Hendrik Jan Thibaut3, Kjerstin H.W. Lanke2, Pieter Leyssen3, 3
Bruno Coutard4, Armando M. de Palma3, Bruno Canard4, Johan Neyts3, and Frank J.M. van Kuppeveld1,* 4
5
6
1 Department of Infectious Diseases and Immunology, Virology Division, Faculty of Veterinary Medicine, 7
Utrecht University, Utrecht, The Netherlands 8
2 Department of Medical Microbiology, Virology Section, Nijmegen Centre for Molecular Life Sciences & 9
Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Nijmegen Medical 10
Centre, Nijmegen, The Netherlands 11
3 Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, University of Leuven, 12
Leuven, Belgium 13
4 Aix-Marseille Université, CNRS, AFMB UMR 7257, 13288, Marseille, France 14
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28. Lantez V, Dalle K, Charrel R, Baronti C, Canard B, Coutard B. 2011. Comparative 257 production analysis of three phlebovirus nucleoproteins under denaturing or non-denaturing 258 conditions for crystallographic studies. PLoS Negl Trop Dis 5:e936. 259
29. UCLA researchers discover that fluoxetine (a.k.a. Prozac) is effective as an anti-viral - 260 California Nanosystems Institute webpage. 261 http://www1.cnsi.ucla.edu/news/item?item_id=2073996 262
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