SEER Cancer Statistics Review 1975-2017 National Cancer Institute Joinpoint Regression Program Version 4.8, April 2020, National Cancer Institute. (https://surveillance.cancer.gov/joinpoint/). The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends are from the SEER 9 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, and Atlanta). b Trends are from the SEER 21 areas (SEER 9 areas, Los Angeles, Alaska Native Registry, Rural Georgia, California excluding SF/SJM/LA, Kentucky, Louisiana, New Jersey, Georgia excluding ATL/RG, Idaho, New York and Massachusetts). c Trends are from US Mortality Files, National Center for Health Statistics, Centers for Disease Control and Prevention. d The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpoint. e API - Asian/Pacific Islander, AI/AN - American Indian/Alaska Native, NH - Non-Hispanic f Hispanic and Non-Hispanic are not mutually exclusive from whites, blacks, Asian/Pacific Islanders, and American Indians/Alaska Natives. Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registry. g Data for American Indian/Alaska Native are based on the Purchased/Referred Care Delivery Area (PRCDA) counties. * The APC/AAPC is significantly different from zero (p<.05). - Joinpoint regression line analysis could not be performed on data series. JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPC d Years APC Years APC Years APC Years APC Years APC Years APC 2008-17 2013-17 SEER 9 Delay-Adjusted Incidence a , 1975-2017 All Races 1975-84 1.3* 1984-98 4.8* 1998-01 0.6 2001-11 4.3* 2011-17 0.9 2.0* 0.9 White 1975-87 1.6* 1987-98 5.4* 1998-01 -0.8 2001-11 4.9* 2011-17 1.7* 2.7* 1.7* Black 1975-02 2.9* 2002-09 6.2* 2009-17 0.4 1.0 0.4 SEER 21 Delay-Adjusted Incidence b , 2000-2017 All Races 2000-02 1.9 2002-07 4.8* 2007-15 2.5* 2015-17 -1.4 1.6* 0.5 White 2000-02 0.6 2002-06 5.6* 2006-14 3.4* 2014-17 0.0 2.2* 0.9 White NH ef 2000-14 3.8* 2014-17 0.1 2.5* 1.0 Black 2000-12 4.2* 2012-17 -0.5 1.5* -0.5 Black NH ef 2000-09 5.0* 2009-17 1.0 1.4* 1.0 API e 2000-07 0.9 2007-17 -1.9* -1.9* -1.9* AI/AN eg 2000-17 3.4* 3.4* 3.4* Hispanic f 2000-14 2.6* 2014-17 -2.2 1.0 -1.0 U.S. Cancer Mortality c , 1975-2017 All Races 1975-80 0.2 1980-87 2.0* 1987-95 3.8* 1995-07 1.9* 2007-13 3.2* 2013-17 0.6 2.0* 0.6 White 1975-78 -1.2 1978-87 1.6* 1987-96 3.9* 1996-00 0.5 2000-13 2.8* 2013-17 1.4* 2.2* 1.4* Black 1975-88 0.8* 1988-95 3.2* 1995-00 0.3 2000-13 2.5* 2013-17 0.1 1.4* 0.1 U.S. Cancer Mortality c , 2000-2017 All Races 2000-04 2.7* 2004-07 1.6 2007-13 3.1* 2013-17 0.7* 2.0* 0.7* White 2000-08 2.4* 2008-13 3.3* 2013-17 1.1* 2.3* 1.1* White NH ef 2000-08 2.3* 2008-12 3.6* 2012-17 1.3* 2.3* 1.3* Black 2000-13 2.5* 2013-17 0.1 1.4* 0.1 Black NH ef 2000-13 2.6* 2013-17 0.1 1.5* 0.1 API e 2000-17 -1.2* -1.2* -1.2* AI/AN eg 2000-17 1.8* 1.8* 1.8* Hispanic f 2000-17 1.4* 1.4* 1.4* Table 14.1 Cancer of the Liver and Intrahepatic Bile Duct (Invasive) Trends in SEER Incidence ab and U.S. Mortality c Using the Joinpoint Regression Program, 1975-2017 With up to Five Joinpoints, 2000-2017 With up to Three Joinpoints, Both Sexes by Race/Ethnicity
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SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding
SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska
Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program
1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints
Both Sexes by RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding
SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska
Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program
1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints
Males by RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding
SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska
Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program
1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints
Females by RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Reference Cancer Incidence Rates Adjusted for Reporting DelayIndividual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Review
a SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
- Delay-adjusted rate is not shown for observed rates based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 144Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Delay-adjusted SEER Incidencea Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Reviewa SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 145Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted SEER Incidencea Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 146Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted US Deatha Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted
b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted
c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 147Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)
Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey
Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017
d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)
e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 148Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 149Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males and Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 1410Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding
SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska
Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program
1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints
Males by RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding
SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska
Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program
1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints
Females by RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Reference Cancer Incidence Rates Adjusted for Reporting DelayIndividual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Review
a SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
- Delay-adjusted rate is not shown for observed rates based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 144Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Delay-adjusted SEER Incidencea Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Reviewa SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 145Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted SEER Incidencea Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 146Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted US Deatha Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted
b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted
c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 147Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)
Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey
Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017
d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)
e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 148Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 149Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males and Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 1410Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding
SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska
Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program
1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints
Females by RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Reference Cancer Incidence Rates Adjusted for Reporting DelayIndividual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Review
a SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
- Delay-adjusted rate is not shown for observed rates based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 144Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Delay-adjusted SEER Incidencea Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Reviewa SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 145Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted SEER Incidencea Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 146Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted US Deatha Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted
b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted
c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 147Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)
Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey
Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017
d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)
e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 148Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 149Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males and Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 1410Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Reference Cancer Incidence Rates Adjusted for Reporting DelayIndividual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Review
a SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
- Delay-adjusted rate is not shown for observed rates based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 144Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Delay-adjusted SEER Incidencea Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Reviewa SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 145Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted SEER Incidencea Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 146Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted US Deatha Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted
b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted
c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 147Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)
Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey
Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017
d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)
e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 148Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 149Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males and Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 1410Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Reviewa SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 145Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted SEER Incidencea Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 146Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted US Deatha Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted
b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted
c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 147Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)
Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey
Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017
d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)
e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 148Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 149Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males and Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 1410Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 146Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted US Deatha Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted
b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted
c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 147Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)
Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey
Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017
d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)
e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 148Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 149Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males and Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 1410Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted
b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted
c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 147Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)
Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey
Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017
d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)
e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 148Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 149Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males and Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 1410Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)
Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey
Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017
d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)
e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 148Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 149Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males and Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 1410Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 149Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males and Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 1410Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 1410Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity
Graph - 5-Year SEER Conditional Relative Survival
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Trends in SEER Incidence and US Mortality Both Sexes
Trends in SEER Incidence and US Mortality Males
Trends in SEER Incidence and US Mortality Females
Annual Delay-adjusted Incidence Rates
Annual Incidence Rates
Annual Death Rates
Incidence and Mortality Rates by Age
5-year Relative and Period Survival
Relative Survival by Year of Diagnosis Both Sexes
Relative Survival by Year of Diagnosis Males
Relative Survival by Year of Diagnosis Females
Risk of DevelopingDying Both Sexes
Risk of DevelopingDying Males
Risk of DevelopingDying Females
Rates and Trends by RaceEthnicity
Age-Adjusted SEER Incidence Rates by Registry
Age-Adjusted SEER Death Rates by Registry
Age-Adjusted Cancer Death Rates By State Both Sexes
Age-Adjusted Cancer Death Rates By State Males
Age-Adjusted Cancer Death Rates By State Females
US Prevalence Estimates
Case Distribution by Histology
Graph - SEER Incidence and Delay Adjusted Incidence by Race and Sex
Graph - SEER Incidence and US Death Rates by RaceEthnicity