SEDIAAN BENTUK OBAT

SELAMAT PAGI

RM. Teguh Wahjudi dr,MS,AFK

BENTUK SEDIAAN OBATDISPENSING FORMS OF DRUG

Dr.M.Teguh Wahjudi MS,AFK,PKK

BENTUK SEDIAAN OBAT

• BENTUK CAIR ( LIQUID )

• BENTUK SETENGAH PADAT ( SEMI LIQUID)

• BENTUK PADAT (SOLID )

BENTUK OBAT PADAT

• Serbuk (pulvis).

• Serbuk terbagi (pulveres).

• Tablet .

• Kapsul

• Sapo

• Emplastrum

• Susuk

BENTUK OBAT SETENGAH PADAT

• Salep

• Cream

• Pasta

• Suppositoria

BENTUK OBAT CAIR

• Solutio

• Mixtura

• Mixtura Agitanda

• Suspensi

• Emulsi

• Saturatio

• Guttae

• Galenical

• Nebula /Aerosol

• Injectio

KRITERIA MEMILIH BENTUK OBAT

1.FAKTOR OBAT : Fisik obat. Kimia obat. Onset & duration of action Rasa pahit. Iritasi lambung.

2.FAKTOR PENDERITA : Anak – dewasa – tua Compos mentis - coma

BENTUK OBAT CAIR

SOLUTIO ( LARUTAN )

ZAT PADAT DALAM ZAT CAIR – LARUT –TIDAK ADA ENDAPAN – JERNIH - HOMOGEN

PELARUT :

-AIR

-ALKOHOL

-ETHER

-PROPPYLEN GLYCOL

-MINYAK

-PARAFIN LIQUIDUM

-GLYSERIN

KELARUTAN :

-SOLUTE

-SOLVEN

-TEMPERATUR

-pH

R/ Acidi Borici 3 6

Aquadest ad 100ml 200 ml

S Boorwater

---------- paraf

R/ Acidi Borici 3% 3%

Aquadest ad 100ml 200 ml

S Boorwater

---------- paraf

R/ Jodii 2

Natrii Jodid 2,5

Spir 50% ad 100ml

rec.par

S u.e.

---------- paraf

R/ Solutio Jodii spir. 2% 100 ml

rec.par

S u.e

---------- paraf

R/ Jodium tincture 100 ml

rec. par

S u.e

---------- paraf

R/ Jodii 0,50

Kalii Jodii 0,100

Aqua ad 25 ml

f.l.a Sol

S t.dd gtt XV

------ paraf

R/ Solutio Lugolli 25 ml

S 3 dd. gtt XV

------ paraf

R/ Succus liquiritiae 5

Ammonii Chlorid 3

Sol.Ammonii spir. Anis 3

Aquadest ad 150 ml

S 3 dd C I

------ paraf

R/ Potio Nigra contra tussim 150 ml

S 3 dd. C. I

------------------ paraf

R/ O.B.H 150 ml

S 3 dd. C.I

------ paraf

Sasa tdd :

-Ammonia

-Ammon. Carbonat

-Various oils

-Spir. dil

R/ Zinci Chlorid 1

Kalii et . Alum. Sulfat 1

Acid Salicylic 0,300

Ol. Menthe Pip gtt II

Aqua ad 300ml

Filtra

S garg. 3 dd

------------ ---------- paraf

R/ Garg Kan 300 ml

S garg. 3 dd

------ ---- -------- paraf

R/ Ascal 10

Natrii Bromidi 5

Aquadest ad 300 ml

S 3 dd C.I pc prn

-------- ---- paraf

MIXTURA

• HCl + air

• Alkohol + air :

70% Spir. Dil

95% - 96% Spir. Fortior.

• Homogen – tidak ada endapan – tercampur secara molekuler

R/ Methyl Salicylic 20

Ol.Cayuputi 20

Chloroform 20

Inf. Hioscyami oleos 20

S a.u.e

------------- paraf

R/ Gandapura 80 ml

S u.e

---------------- paraf

R/ Sasa 2 ml

Syr. Simplex 10 ml

Ol. Menthe pip gtt I

Aquadest ad 100 ml

S 4-6 dd Cth I

------------- paraf

R/ Potio Alba contra tussim 100 ml

S 4-6 dd Cth I

------ ------- paraf

R/ O .B .P 100 ml

S 4-6 dd Cth I

------ ------- paraf

MIXTURA AGITANDA

R/ Acid Salicylic 1

Zinci Oxyde 10

Talc.Venet 10

Amyl.Orizae 10

Alcohol 90% ad 200 ml

S u.e

------ paraf

R/ Calamine 8

Zinci Oxyde 8

Glycerin 5 ml

Aqua Rosae ad 100 ml

S u.e

------ paraf

SUSPENSIO

DEFINISI :

SUSPENSATOR : A.ALAMI B.SYNTHETIC

SUSPENSATOR

ALAMI

• GUMMI ARAB : Pulv.

Solutio

Mucilago• TRAGACANTH :Sol.

Mucilago• AMYLUM :Mucilago• AGAR• DLL

SYNTHETIC

• CMC• Bentonit• Tween

R/ Paracetamol 2880 mg Syr. Simplex 15% CMC 1,5 % Aqua ad 120 ml f.l.a susp S 3 dd cth II ------ paraf

R/ Ampicillin 50 mg Syr simplex Orange gtt qs CMC 1,5 % Aqua ad 60 ml m.f.l.a susp S 3 dd cth I ----- paraf

R/ Tetracycline 2,3 CMC Na 1% Sol. Sorbitol 60% 20 ml Saccharin Na 0,100 Sir.Simplex 20 ml Glycerin 3,5ml Corrigens (orange) gtt qs Aquadest ad 100 ml m f l a susp S . . . . .. ----- paraf

R/ Syrop Tetracycline …ml S 2 dd cth I ----- paraf

R/ Syrop Tetracycline ….ml S . . . . . . . . . ----- paraf

R/ Magnesium hydroxyde 2400 mg Al. hydroxyde 2400 mg Simethicon 240 mg Gummi Arab 2 % Ol. Menthe pip gtt II Aquadest ad 60 ml m f l a susp S loco Mylanta susp 3 – 4 dd cthI – cth II ----- paraf

R/ Trimetoprim 480 mg Sulfametoxazole 2400 mg Sir. Simplex 10 % – 20 % P.G.A 2 % Strawberry qs Aquadest ad 60 ml m f l a susp S Susp Cotrimoxazole 2 dd cth I ------ paraf

R/ Sulfasomidin 10 C M C 1 % Saccharosa 30 % Methyl hydroxy benzoat 0,015 % Propyl hydroxy benzoat 0,015 % Sol.Amaranth 1 % gtt V Aquadest ad 100 ml S . . . . . ----- paraf

R/ Sirop Elkosin 100 ml S . . . . . . . . ----- paraf

R/ Sulfadiazine Natrii bicarb. aa 10 Sir. Aurantii 30 Sol. Gumoss ad 300 ml ∫ 3 dd C I ----- paraf

R/ Sulfadiazine 5 S a s a 1 Calcii lactas 4 Sir. Simplex 10 Pulv. Gummos 2 Aquadest ad 150 ∫ K S H D ------- paraf

EMULSIOEmulgator ~ Suspensator

R/ Ol. Zecoris aselli 40 Ol. Cinnamomi 0,100 Pulv. Gi Arab 15 Natr Hypophospis 0,500 Calc Hypophospis 0,500 Aquadest 20 Glyserin 10 Aquadest 14 m f l a emuls ∫ loco Scott’s emulsion ----- paraf

R/ Benzylis Benzoas 25 Triethanol amine 1 Acid Stearinic 5 Aqua ad 100 ml m f l a emulsi S u.e ----- paraf

R/ B.B.E 25 % 100 ml S u.e ----- paraf

GALENICALS

PELARUT ALKOHOL → TINCTURE AIR + ALKOHOL/ETHER → EXTRACT AIR 90OC / 15’ → INFUSUM AIR 90oC / 30’ → DECOCTUM

PREPARAT GALENIK

1.DENGAN PEMANASAN

90oC 15’ : INFUSUM 30’ : DECOCTUM

2.TANPA PEMANASAN ( SUHU KAMAR) * 4 – 5 hari maceratio * Diulang / remaceratio percolatio

Hasil maceratio/ remaceratio : Extractum Tinctura

Extract : CAIR : Extract Secale Cornuiti KENTAL : Extract Belladona KERING : Extract Opii

Tincture TOXIC : Kadar 10% Tinctura Opii Tinctura Belladona Tinctura Digitalis

NON TOXIC : Kadar 20% Tinctura Valeriane

Infusum

R/ Folia Piperie betle 20 Natrii Chlorid 4 Aqua qs f. Infus 200 ml S garg. 4 dd ----- paraf

R/ Folia Digitalis 15 g Aqua 900 ml Alkohol 100 ml Spirit Cinnamomi 5 ml f. Infus 1000 ml S 3 dd cth II ----- paraf

NEBULA /AEROSOL

Gas : -dichloro difluoro methane -trichloro monofluoro methane -dichloro tetrafluoro methane

Nama dagang : -Freon -Genetron -Isotron -Ucon

GUTTAE

1 ml H2O ~ 1 g H2O = 20 tetes

R/ Zinci Sulfate 0,25 % Aqua ad 10 ml f.Steril S 3 dd gtt II OD/OS ----- paraf

SIRUPUS

R/ Sukrose 65 % Aqua ad 1000 ml ∫ sirupus simplex ---- paraf

SATURATIOR/ Acid Citric 2,5 Aqua 25 Spir Citri 2,5 Sir.Simplex 12,5 Natr. Bicarbonat 3 Aqua 55 ∫ Potio Riveri ----- paraf

Injectio / Suntik

Tujuan, Keuntungan, KerugianSyarat, Bentuk, Wadah

TERIMA KASIH