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About Second messengers Dr. Yasser Ashour By Dr.Darine Ashraf Dr.Alaa Mamdouh
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second messenger

Jan 09, 2017

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Darine Ashraf
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Page 1: second messenger

AboutSecond messengers

Dr. Yasser Ashour

By Dr.Darine Ashraf

Dr.Alaa Mamdouh

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Second messengers are intracellular signaling molecules released by the cell to trigger physiological changes such as proliferation, differentiation, migration, survival, andapoptosis.

Secondary messengers are therefore one of the initiating components of intracellular signal transduction cascades.

 

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CAMP PATHWAY

Ligands : Epinephrine Ach

Primary Effector : Adenyl cyclase

Secondary messenger : cAMP

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CGMP PATHWAYLigands : ANP & NO

Primary Effector : Guanylate cyclase

Secondary messenger : cGMP

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CALCIUM AS SECOND MESSENGERCalcium ions – once they enter the cytoplasm exert allasteric regulatory effects on many enzymes & protien.

Calcium acts as a second messenger by indirect signal transduction pathways such as via G protein – coupled receptors.

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EICOSANOIDSThis class of llipids act as signaling molecules that binds to cell surface molecules.

They include: Prostaglandins

Prostacyclin Thromboxanes

Leukotrienes

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GENERAL SCHEMATIC OF SECOND MESSENGER MECHANISM

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