Search in electronic databases (n=1558) PubMed: 760 Embase: 795 Web of Science: 3 Retrieved (n=1579) Hand-searching (n=21) Title review (n=782) Abstract review (n=341) Article review for more detailed evaluation (n=117) Included 79 studies in 75 articles Excluded duplicates (n=797) Excluded; no relevance (n=441) Articles excluded (n=42) For reasons see Supplementary Table 1 plementary Figure 1. Study flow diagram
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Search in electronic databases (n=1558) PubMed: 760 Embase: 795 Web of Science: 3
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Search in electronic databases (n=1558)PubMed: 760Embase: 795Web of Science: 3
Retrieved (n=1579)
Hand-searching(n=21)
Title review (n=782)
Abstract review (n=341)
Article review for more detailed evaluation (n=117)
Included 79 studies in 75 articles
Excluded duplicates(n=797)
Excluded; no relevance(n=441)
Articles excluded (n=42)For reasons see Supplementary Table 1
Supplementary Figure 1. Study flow diagram
Supplementary Figure 2. Detailed meta-analysis of Arg702Trp on the basis of allele frequencies. Crohn’s disease. All studies.
Random effectFixed effect
Hugot JP (2001)
Hampe J (2002)
Study
Ernst A (2007)Cavanaugh JA (2003)
Canto E (2007)
Heresbach D (2004)
Karban A (2005)
Nunez C (2004)
Newman B (2004)
Karban A (2005)
Arnot IDR (2004)
Tukel T (2004)Ince AT (2008)
Weersma RK (2009)
Leung E (2005)
Bene J (2006)
Oostenbrug LE (2006)
Jess T (2005)
Vermeire S (2002)
Ahmad T (2002)
Zouiten-Mekki L (2005)
Cottone M (2006)
Riss L (2007)
Giachino D (2004)
Brant SR (2007)
Ferraris A (2006)
Lakatos PL (2005)Baptista ML (2008)
Vermeire S (2004)
Crawford NPS (2007)
Protic MB (2007)
Esters N (2004)
Mendoza JL (2003)
Russel RK (2005)Cukovic-Cavak S (2006)
Tomer G (2003)
Lappalainen M (2008)
Sugimura K (2003)
Economou M (2007)
Torkvist L (2006)
van der Linde K (2007)
Tukel T (2004)
Braat H (2005)Diego CD (2006)
Nagy Z (2005)
Magyari L (2009)
Vind I (2005)
de Ridder L (2007)
Cucchiara S (2007)Kugathasan S (2005)
Bonen DK (2003)
Bianchi V (2007)
Buhner S (2006)Karban A (2004)
Zhou Z (2002)
Hradsky O (2008)
Cuthbert AP (2002)
Rigoli L (2008)
Ozen SC (2006)
Annese V (2005)
Buning C (2005)
Gazouli M (2004)
Helio T (2003)
Rodrigo L (2007)
Zaahl MG (2005)
Vavassori P (2004)
Kugathasan S (2005)
Mascheretti S (2002)
Ferreira AC (2005)
Kugathasan S (2005)
Derakhshan F (2008)
Gearry RB (2007)
2.24 (2.03, 2.48)
3.06 (1.47, 6.39)
2.72 (1.92, 3.84)
2.02 (1.32, 3.09)2.35 (1.56, 3.56)
6.59 (1.52, 28.55)
2.60 (1.25, 5.43)
4.24 (1.46, 12.30)
1.17 (0.62, 2.20)
2.26 (1.31, 3.90)
5.58 (0.23, 137.89)
1.48 (0.88, 2.51)
6.71 (1.04, 43.16)0.16 (0.02, 1.26)
1.65 (1.33, 2.04)
1.47 (0.80, 2.69)
1.89 (0.58, 6.10)
1.88 (1.21, 2.92)
3.76 (1.11, 12.80)
3.38 (1.43, 8.01)
2.63 (1.71, 4.04)
3.51 (0.41, 30.30)
OR (95% CI)
2.98 (1.33, 6.70)
2.31 (1.50, 3.57)
1.56 (0.89, 2.76)
3.49 (2.08, 5.86)
4.51 (1.91, 10.64)
2.55 (1.37, 4.73)3.77 (2.00, 7.10)
2.94 (1.74, 4.96)
5.50 (1.67, 18.18)
1.50 (0.90, 2.50)
2.42 (1.48, 3.97)
3.52 (1.70, 7.26)
1.19 (0.58, 2.43)2.79 (1.35, 5.76)
5.47 (1.48, 20.16)
2.15 (0.83, 5.55)
1.73 (1.10, 2.73)
3.85 (1.25, 11.93)
6.68 (1.52, 29.31)
1.53 (0.68, 3.45)
2.11 (0.92, 4.84)
2.89 (1.47, 5.65)2.29 (1.15, 4.58)
2.30 (1.00, 5.27)
1.41 (0.66, 3.03)
1.01 (0.41, 2.49)
2.96 (1.77, 4.93)
3.01 (1.83, 4.95)1.26 (0.76, 2.07)
1.95 (1.26, 3.04)
1.79 (0.94, 3.42)
3.15 (1.06, 9.32)4.13 (1.38, 12.34)
1.13 (0.56, 2.26)
1.48 (0.95, 2.30)
2.72 (1.64, 4.50)
4.36 (1.64, 11.55)
0.75 (0.14, 4.17)
2.20 (1.26, 3.85)
2.81 (1.33, 5.92)
11.00 (2.57, 47.14)
1.84 (0.86, 3.93)
0.79 (0.36, 1.72)
2.10 (0.62, 7.08)
1.52 (0.28, 8.37)
0.53 (0.06, 4.80)
2.05 (1.33, 3.14)
3.31 (2.03, 5.38)
0.44 (0.02, 7.89)
9.51 (3.00, 30.16)
2.59 (1.41, 4.76)
1.31
2.97
2.502.57
0.42
1.31
0.73
1.61
1.93
0.09
2.02
0.270.22
3.81
1.71
0.62
2.44
0.58
1.04
2.48
0.20
Weight, %
1.14
2.46
1.85
2.05
1.04
1.661.61
2.03
0.60
2.08
2.16
1.34
1.371.34
0.52
0.89
2.35
0.66
0.41
1.13
1.09
1.491.43
1.10
1.24
0.96
2.08
2.142.14
2.42
1.57
0.710.70
1.42
2.43
2.11
0.85
0.32
1.88
1.29
0.42
1.25
1.20
0.59
0.32
0.20
2.50
2.20
0.12
0.64
1.69
2.24 (2.03, 2.48)
3.06 (1.47, 6.39)
2.72 (1.92, 3.84)
2.02 (1.32, 3.09)2.35 (1.56, 3.56)
6.59 (1.52, 28.55)
2.60 (1.25, 5.43)
4.24 (1.46, 12.30)
1.17 (0.62, 2.20)
2.26 (1.31, 3.90)
5.58 (0.23, 137.89)
1.48 (0.88, 2.51)
6.71 (1.04, 43.16)0.16 (0.02, 1.26)
1.65 (1.33, 2.04)
1.47 (0.80, 2.69)
1.89 (0.58, 6.10)
1.88 (1.21, 2.92)
3.76 (1.11, 12.80)
3.38 (1.43, 8.01)
2.63 (1.71, 4.04)
3.51 (0.41, 30.30)
2.98 (1.33, 6.70)
2.31 (1.50, 3.57)
1.56 (0.89, 2.76)
3.49 (2.08, 5.86)
4.51 (1.91, 10.64)
2.55 (1.37, 4.73)3.77 (2.00, 7.10)
2.94 (1.74, 4.96)
5.50 (1.67, 18.18)
1.50 (0.90, 2.50)
2.42 (1.48, 3.97)
3.52 (1.70, 7.26)
1.19 (0.58, 2.43)2.79 (1.35, 5.76)
5.47 (1.48, 20.16)
2.15 (0.83, 5.55)
1.73 (1.10, 2.73)
3.85 (1.25, 11.93)
6.68 (1.52, 29.31)
1.53 (0.68, 3.45)
2.11 (0.92, 4.84)
2.89 (1.47, 5.65)2.29 (1.15, 4.58)
2.30 (1.00, 5.27)
1.41 (0.66, 3.03)
1.01 (0.41, 2.49)
2.96 (1.77, 4.93)
3.01 (1.83, 4.95)1.26 (0.76, 2.07)
1.95 (1.26, 3.04)
1.79 (0.94, 3.42)
3.15 (1.06, 9.32)4.13 (1.38, 12.34)
1.13 (0.56, 2.26)
1.48 (0.95, 2.30)
2.72 (1.64, 4.50)
4.36 (1.64, 11.55)
0.75 (0.14, 4.17)
2.20 (1.26, 3.85)
2.81 (1.33, 5.92)
11.00 (2.57, 47.14)
1.84 (0.86, 3.93)
0.79 (0.36, 1.72)
2.10 (0.62, 7.08)
1.52 (0.28, 8.37)
0.53 (0.06, 4.80)
2.05 (1.33, 3.14)
3.31 (2.03, 5.38)
0.44 (0.02, 7.89)
9.51 (3.00, 30.16)
2.59 (1.41, 4.76)
1.31
2.97
2.502.57
0.42
1.31
0.73
1.61
1.93
0.09
2.02
0.270.22
3.81
1.71
0.62
2.44
0.58
1.04
2.48
0.20
1.14
2.46
1.85
2.05
1.04
1.661.61
2.03
0.60
2.08
2.16
1.34
1.371.34
0.52
0.89
2.35
0.66
0.41
1.13
1.09
1.491.43
1.10
1.24
0.96
2.08
2.142.14
2.42
1.57
0.710.70
1.42
2.43
2.11
0.85
0.32
1.88
1.29
0.42
1.25
1.20
0.59
0.32
0.20
2.50
2.20
0.12
0.64
1.69
1.05 1 5 10 50
Crohn’s disease
Odds ratio (95% CI)
2.21 (2.06, 2.37)
Supplementary Figure 3. Detailed meta-analysis of Gly908Arg on the basis of allele frequencies. Crohn’s disease. All studies.
Random effectFixed effect
Vind I (2005)
Ince AT (2008)
Ferreira AC (2005)
Sugimura K (2003)
Zouiten-Mekki L (2005)
Buhner S (2006)
Torkvist L (2006)
Ferraris A (2006)
Tukel T (2004)
Bonen DK (2003)
Tomer G (2003)
Kugathasan S (2005)
Canto E (2007)
Protic MB (2007)
Braat H (2005)
Annese V (2005)
Esters N (2004)
Magyari L (2009)
Ernst A (2007)
Newman B (2004)
Leung E (2005)
Rigoli L (2008)
Rodrigo L (2007)
Kugathasan S (2005)
Riss L (2007)Lakatos PL (2005)
Jess T (2005)
Cukovic-Cavak S (2006)
Vermeire S (2002)
Nunez C (2004)
Study
Crawford NPS (2007)
Cavanaugh JA (2003)
Lappalainen M (2008)
Karban A (2004)
van der Linde K (2007)
Hradsky O (2008)
Baptista ML (2008)
Ozen SC (2006)
Ahmad T (2002)
Diego CD (2006)Buning C (2005)
Arnot IDR (2004)
Derakhshan F (2008)
Cuthbert AP (2002)
Bene J (2006)
Mendoza JL (2003)
Cucchiara S (2007)
Hugot JP (2001)
Oostenbrug LE (2006)
Giachino D (2004)
Heresbach D (2004)
Zaahl MG (2005)
Gazouli M (2004)
Hampe J (2002)
de Ridder L (2007)
Bianchi V (2007)
Zhou Z (2002)
Queiroz DM, (2009)
Karban A (2005)
Weersma RK (2009)
Brant SR (2007)
Karban A (2005)
Vavassori P (2004)
Kugathasan S (2005)
Vermeire S (2004)
Cottone M (2006)
Nagy Z (2005)
Mascheretti S (2002)
Helio T (2003)
Economou M (2007)
Gearry RB (2007)
Russel RK (2005)
Tukel T (2004)
2.56 (2.23, 2.94)
3.11 (0.69, 14.06)
0.65 (0.06, 7.21)
OR (95% CI)
2.19 (0.90, 5.33)
1.58 (0.95, 2.63)
1.99 (0.70, 5.63)
2.63 (0.57, 12.19)
12.30 (0.70, 216.21)
6.89 (2.33, 20.32)
2.50 (1.30, 4.78)
3.31 (1.80, 6.10)
1.96 (0.98, 3.93)
4.27 (2.23, 8.17)
5.83 (0.32, 106.57)
20.60 (1.22, 347.57)
1.11 (0.59, 2.09)
2.85 (1.46, 5.56)
3.43 (1.47, 7.97)
8.20 (1.83, 36.73)
1.55 (0.73, 3.29)
1.52 (0.80, 2.91)
1.48 (0.62, 3.50)
1.03 (0.43, 2.50)
1.20 (0.24, 5.99)
0.96 (0.05, 18.98)
1.21 (0.53, 2.76)1.76 (0.77, 4.02)
2.31 (0.38, 14.24)
4.15 (0.92, 18.78)
7.73 (1.04, 57.63)
5.19 (1.49, 18.10)
2.30 (0.66, 8.06)
2.13 (0.85, 5.33)
3.98 (0.19, 83.06)
7.00 (3.12, 15.69)
9.88 (1.29, 75.93)
2.82 (1.55, 5.12)
1.20 (0.43, 3.33)
2.30 (0.38, 13.94)
2.33 (1.05, 5.18)
2.63 (0.83, 8.35)2.58 (0.85, 7.77)
7.10 (0.93, 54.19)
5.21 (0.94, 29.04)
6.71 (2.03, 22.14)
6.28 (0.78, 50.38)
4.64 (1.62, 13.25)
2.97 (1.63, 5.42)
6.49 (1.57, 26.82)
1.42 (0.83, 2.45)
3.17 (1.15, 8.76)
2.37 (0.68, 8.28)
0.81 (0.03, 19.99)
4.55 (1.97, 10.51)
5.72 (2.91, 11.25)
1.31 (0.78, 2.22)
4.79 (1.37, 16.71)
1.57 (0.84, 2.94)
5.23 (1.61, 17.04)
1.87 (0.37, 9.39)
2.05 (1.49, 2.82)
4.06 (1.69, 9.73)
5.76 (2.59, 12.81)
2.66 (0.97, 7.31)2.10 (0.81, 5.42)
4.01 (1.61, 9.99)
1.95 (0.43, 8.86)
2.52 (1.41, 4.51)
7.79 (0.40, 151.18)
0.84 (0.39, 1.79)
2.21 (0.86, 5.65)
11.20 (0.64, 197.01)
7.52 (1.90, 29.85)
0.72
0.31
1.64
3.00
1.31
0.70
0.22
1.24
2.40
2.55
2.23
2.40
0.22
0.23
2.45
2.32
1.76
0.73
2.03
2.40
1.71
1.65
0.65
0.21
1.801.81
0.52
0.72
0.43
0.99
0.98
1.57
0.20
1.86
0.42
2.61
1.35
0.53
1.89
1.121.20
0.43
0.58
1.06
0.41
1.29
2.59
0.80
2.85
1.36
0.99
0.18
1.78
2.29
2.94
0.99
2.49
1.08
0.64
3.99
1.68
1.89
1.37
0.00
1.50
1.58
0.72
2.68
0.21
2.00
1.52
0.22
0.84
2.56 (2.23, 2.94)
3.11 (0.69, 14.06)
0.65 (0.06, 7.21)
2.19 (0.90, 5.33)
1.58 (0.95, 2.63)
1.99 (0.70, 5.63)
2.63 (0.57, 12.19)
12.30 (0.70, 216.21)
6.89 (2.33, 20.32)
2.50 (1.30, 4.78)
3.31 (1.80, 6.10)
1.96 (0.98, 3.93)
4.27 (2.23, 8.17)
5.83 (0.32, 106.57)
20.60 (1.22, 347.57)
1.11 (0.59, 2.09)
2.85 (1.46, 5.56)
3.43 (1.47, 7.97)
8.20 (1.83, 36.73)
1.55 (0.73, 3.29)
1.52 (0.80, 2.91)
1.48 (0.62, 3.50)
1.03 (0.43, 2.50)
1.20 (0.24, 5.99)
0.96 (0.05, 18.98)
1.21 (0.53, 2.76)1.76 (0.77, 4.02)
2.31 (0.38, 14.24)
4.15 (0.92, 18.78)
7.73 (1.04, 57.63)
5.19 (1.49, 18.10)
2.30 (0.66, 8.06)
2.13 (0.85, 5.33)
3.98 (0.19, 83.06)
7.00 (3.12, 15.69)
9.88 (1.29, 75.93)
2.82 (1.55, 5.12)
1.20 (0.43, 3.33)
2.30 (0.38, 13.94)
2.33 (1.05, 5.18)
2.63 (0.83, 8.35)2.58 (0.85, 7.77)
7.10 (0.93, 54.19)
5.21 (0.94, 29.04)
6.71 (2.03, 22.14)
6.28 (0.78, 50.38)
4.64 (1.62, 13.25)
2.97 (1.63, 5.42)
6.49 (1.57, 26.82)
1.42 (0.83, 2.45)
3.17 (1.15, 8.76)
2.37 (0.68, 8.28)
0.81 (0.03, 19.99)
4.55 (1.97, 10.51)
5.72 (2.91, 11.25)
1.31 (0.78, 2.22)
4.79 (1.37, 16.71)
1.57 (0.84, 2.94)
5.23 (1.61, 17.04)
1.87 (0.37, 9.39)
2.05 (1.49, 2.82)
4.06 (1.69, 9.73)
5.76 (2.59, 12.81)
2.66 (0.97, 7.31)
2.10 (0.81, 5.42)
4.01 (1.61, 9.99)
1.95 (0.43, 8.86)
2.52 (1.41, 4.51)
7.79 (0.40, 151.18)
0.84 (0.39, 1.79)
2.21 (0.86, 5.65)
11.20 (0.64, 197.01)
7.52 (1.90, 29.85)
0.72
0.31
1.64
3.00
1.31
0.70
0.22
1.24
2.40
2.55
2.23
2.40
0.22
0.23
2.45
2.32
1.76
0.73
2.03
2.40
1.71
1.65
0.65
0.21
1.801.81
0.52
0.72
0.43
0.99
0.98
1.57
0.20
1.86
0.42
2.61
1.35
0.53
1.89
1.121.20
0.43
0.58
1.06
0.41
1.29
2.59
0.80
2.85
1.36
0.99
0.18
1.78
2.29
2.94
0.99
2.49
1.08
0.64
3.99
1.68
1.89
1.37
0.00
1.50
1.58
0.72
2.68
0.21
2.00
1.52
0.22
0.84
1.05 5 10 50
Crohn’s disease Weight, %
Odds ratio (95% CI)
(Excluded)
2.56 (2.31, 2.83)
Studies were excluded from meta-analysis if the risk allele/genotype was found neither in cases nor in controls.
Supplementary Figure 4. Detailed meta-analysis of Leu1007fsincC on the basis of allele frequencies. Crohn’s disease. All studies..
Random effect
Fixed effect
Ahmad T (2002)
Gearry RB (2007)Hugot JP (2001)
Arnot IDR (2004)
Buning C (2005)
Economou M (2007)
Tomer G (2003)Helio T (2003)
Zouiten-Mekki L (2005)
Crawford NPS (2007)
Mascheretti S (2002)
Heresbach D (2004)
Ogura Y (2001)
Cuthbert AP (2002)
Weersma RK (2009)
Vermeire S (2002)
Vind I (2005)
Zaahl MG (2005)
Cavanaugh JA (2003)
Hampe J (2002)
Lakatos PL (2005)
Roussomoustakaki M (2003)
Mendoza JL (2003)
Rodrigo L (2007)
van der Linde K (2007)
Ferreira AC (2005)
Sugimura K (2003)
Murillo L (2002)
Oostenbrug LE (2006)
Protic MB (2007)
Kugathasan S (2005)
Karban A (2005)
Bene J (2006)
Ernst A (2007)
Radlmayr M (2002)
Baptista ML (2008)
Karban A (2004)
Hampe J (2001)
Vermeire S (2004)
Gazouli M (2004)
Karban A (2005)Rigoli L (2008)
Zhou Z (2002)
Magyari L (2009)
Bonen DK (2003)
Diego CD (2006)
Tukel T (2004)
Guo QS (2004)
Kugathasan S (2005)
Ozen SC (2006)
Ferraris A (2006)
Giachino D (2004)
Cukovic-Cavak S (2006)
Annese V (2005)
Nagy Z (2005)
Leung E (2005)
Newman B (2004)
Canto E (2007)
Derakhshan F (2008)
Buhner S (2006)
Cucchiara S (2007)
Cottone M (2006)
Queiroz DM, (2009)
Torkvist L (2006)
Study
Riss L (2007)
Russel RK (2005)
de Ridder L (2007)
Esters N (2004)
Nunez C (2004)
Tukel T (2004)
Ince AT (2008)
Hradsky O (2008)
Vavassori P (2004)
Kugathasan S (2005)
Jess T (2005)
Braat H (2005)
Lappalainen M (2008)
Brant SR (2007)
Bianchi V (2007)
3.84 (3.41, 4.32)
6.50 (3.33, 12.68)
4.17 (1.50, 11.57)6.86 (2.50, 18.83)
3.86 (1.35, 11.03)
5.48 (2.57, 11.67)
7.06 (3.47, 14.37)
5.46 (2.59, 11.49)2.97 (1.42, 6.22)
4.91 (0.25, 95.57)
2.95 (1.13, 7.72)
2.82 (1.75, 4.55)
2.26 (1.03, 4.95)
2.13 (1.31, 3.46)
3.23 (1.72, 6.10)
3.69 (2.73, 4.98)
16.35 (2.24, 119.53)
2.63 (1.10, 6.32)
0.30 (0.04, 2.41)
7.54 (3.48, 16.32)
4.73 (3.26, 6.86)
4.78 (2.48, 9.21)
1.82 (0.30, 11.07)
3.66 (1.78, 7.55)
1.75 (0.49, 6.21)
6.12 (1.81, 20.64)
4.49 (2.18, 9.22)
3.56 (1.87, 6.77)
9.27 (2.74, 31.36)
2.87 (1.71, 4.83)
64.25 (3.92, 1052.26)
2.15 (0.13, 34.64)
5.58 (0.23, 137.89)
5.24 (1.52, 18.07)
5.70 (3.34, 9.74)
9.54 (3.28, 27.77)
4.56 (1.47, 14.08)
3.22 (1.28, 8.08)
4.11 (2.59, 6.54)
6.41 (2.87, 14.31)
3.42 (1.75, 6.69)
3.17 (1.30, 7.73)3.61 (1.46, 8.95)
1.73 (0.82, 3.68)
5.10 (2.18, 11.94)
2.45 (1.53, 3.92)
2.35 (0.96, 5.73)
4.18 (2.09, 8.37)
11.83 (0.72, 194.03)
7.06 (0.43, 115.39)
7.67 (0.37, 161.00)
6.18 (2.08, 18.40)
2.88 (1.27, 6.53)
2.90 (1.30, 6.45)
13.97 (4.35, 44.87)
4.03 (1.40, 11.55)
10.91 (3.30, 36.08)
1.76 (0.95, 3.26)
4.26 (0.53, 34.53)
2.54 (0.35, 18.34)
18.74 (2.53, 138.87)
4.54 (2.23, 9.26)
4.26 (1.82, 9.98)
26.98 (6.62, 109.87)
1.13 (0.35, 3.59)
OR (95% CI)
2.13 (1.15, 3.92)
3.51 (1.00, 12.37)
1.70 (1.02, 2.82)
3.01 (1.55, 5.84)
5.19 (1.49, 18.10)
49.85 (2.29, 1082.74)
1.30 (0.08, 20.99)
4.76 (3.39, 6.69)
10.40 (3.17, 34.13)
6.82 (4.12, 11.29)
1.13 (0.24, 5.23)
2.34 (1.10, 4.98)
3.14 (1.26, 7.78)
2.96 (1.66, 5.30)
5.80 (1.69, 19.89)
1.79
1.021.03
0.97
1.55
1.67
1.581.59
0.15
1.11
2.49
1.47
2.46
1.90
3.31
0.33
1.27
0.30
1.50
2.98
1.83
0.39
1.63
0.72
0.77
1.64
1.87
0.77
2.32
0.17
0.17
0.13
0.75
2.26
0.95
0.87
1.18
2.56
1.43
1.79
1.241.21
1.55
1.32
2.53
1.24
1.72
0.17
0.17
0.15
0.92
1.39
1.44
0.82
0.97
0.79
1.97
0.30
0.33
0.32
1.66
1.32
0.61
0.83
Weight
1.98
0.73
2.38
1.81
0.74
0.14
0.17
3.12
0.80
2.39
0.52
1.55
1.21
2.09
0.75
6.50 (3.33, 12.68)
4.17 (1.50, 11.57)6.86 (2.50, 18.83)
3.86 (1.35, 11.03)
5.48 (2.57, 11.67)
7.06 (3.47, 14.37)
5.46 (2.59, 11.49)2.97 (1.42, 6.22)
4.91 (0.25, 95.57)
2.95 (1.13, 7.72)
2.82 (1.75, 4.55)
2.26 (1.03, 4.95)
2.13 (1.31, 3.46)
3.23 (1.72, 6.10)
3.69 (2.73, 4.98)
16.35 (2.24, 119.53)
2.63 (1.10, 6.32)
0.30 (0.04, 2.41)
7.54 (3.48, 16.32)
4.73 (3.26, 6.86)
4.78 (2.48, 9.21)
1.82 (0.30, 11.07)
3.66 (1.78, 7.55)
1.75 (0.49, 6.21)
6.12 (1.81, 20.64)
4.49 (2.18, 9.22)
3.56 (1.87, 6.77)
9.27 (2.74, 31.36)
2.87 (1.71, 4.83)
64.25 (3.92, 1052.26)
2.15 (0.13, 34.64)
5.58 (0.23, 137.89)
5.24 (1.52, 18.07)
5.70 (3.34, 9.74)
9.54 (3.28, 27.77)
4.56 (1.47, 14.08)
3.22 (1.28, 8.08)
4.11 (2.59, 6.54)
6.41 (2.87, 14.31)
3.42 (1.75, 6.69)
3.17 (1.30, 7.73)3.61 (1.46, 8.95)
1.73 (0.82, 3.68)
5.10 (2.18, 11.94)
2.45 (1.53, 3.92)
2.35 (0.96, 5.73)
4.18 (2.09, 8.37)
11.83 (0.72, 194.03)
7.06 (0.43, 115.39)
7.67 (0.37, 161.00)
6.18 (2.08, 18.40)
2.88 (1.27, 6.53)
2.90 (1.30, 6.45)
13.97 (4.35, 44.87)
4.03 (1.40, 11.55)
10.91 (3.30, 36.08)
1.76 (0.95, 3.26)
4.26 (0.53, 34.53)
2.54 (0.35, 18.34)
18.74 (2.53, 138.87)
4.54 (2.23, 9.26)
4.26 (1.82, 9.98)
26.98 (6.62, 109.87)
1.13 (0.35, 3.59)
OR (95% CI)
2.13 (1.15, 3.92)
3.51 (1.00, 12.37)
1.70 (1.02, 2.82)
3.01 (1.55, 5.84)
5.19 (1.49, 18.10)
49.85 (2.29, 1082.74)
1.30 (0.08, 20.99)
4.76 (3.39, 6.69)
10.40 (3.17, 34.13)
6.82 (4.12, 11.29)
1.13 (0.24, 5.23)
2.34 (1.10, 4.98)
3.14 (1.26, 7.78)
2.96 (1.66, 5.30)
5.80 (1.69, 19.89)
1.79
1.021.03
0.97
1.55
1.67
1.581.59
0.15
1.11
2.49
1.47
2.46
1.90
3.31
0.33
1.27
0.30
1.50
2.98
1.83
0.39
1.63
0.72
0.77
1.64
1.87
0.77
2.32
0.17
0.17
0.13
0.75
2.26
0.95
0.87
1.18
2.56
1.43
1.79
1.241.21
1.55
1.32
2.53
1.24
1.72
0.17
0.17
0.15
0.92
1.39
1.44
0.82
0.97
0.79
1.97
0.30
0.33
0.32
1.66
1.32
0.61
0.83
Weight, %
1.98
0.73
2.38
1.81
0.74
0.14
0.17
3.12
0.80
2.39
0.52
1.55
1.21
2.09
0.75
1.05 1 5 10 50
Crohn’s disease
Odds ratio (95% CI)
3.89 (3.58, 4.24)
Supplementary Figure 5. Detailed meta-analysis of Arg702Trp on the basis of allele frequencies. Ulcerative colitis. All studies..
Random effect
Fixed effect
Annese V (2005)Esters N (2004)
Giachino D (2004)
Weersma RK (2009)
Brant SR (2007)
Helio T (2003)
Oostenbrug LE (2006)
Zaahl MG (2005)
Hugot JP (2001)
de Ridder L (2007)
Bianchi V (2007)
Ozen SC (2006)
Ferraris A (2006)
Ince AT (2008)
Cucchiara S (2007)
Karban A (2004)
Crawford NPS (2007)
Braat H (2005)
Russel RK (2005)Economou M (2007)
Arnot IDR (2004)
Jess T (2005)
Cuthbert AP (2002)
Rigoli L (2008)
Ernst A (2007)
Gearry RB (2007)
van der Linde K (2007)
Buning C (2005)
Gazouli M (2004)
Derakhshan F (2008)
Protic MB (2007)
Cavanaugh JA (2003)
Study
1.10 (0.90, 1.34)
0.97 (0.54, 1.77)1.39 (0.75, 2.54)
1.93 (1.02, 3.67)
1.00 (0.77, 1.29)
1.54 (0.75, 3.16)
0.82 (0.23, 2.98)
0.75 (0.40, 1.41)
0.47 (0.06, 3.96)
0.80 (0.31, 2.07)
3.52 (1.42, 8.74)
0.70 (0.27, 1.85)
OR (95% CI)
0.88 (0.22, 3.57)
2.06 (0.74, 5.78)
0.51 (0.13, 1.95)
1.18 (0.64, 2.20)
2.21 (0.55, 8.97)
2.29 (0.63, 8.31)
2.01 (0.97, 4.16)
0.77 (0.27, 2.22)1.26 (0.38, 4.13)
0.46 (0.23, 0.95)
0.11 (0.01, 2.05)
1.04 (0.60, 1.79)
0.91 (0.17, 4.80)
1.16 (0.75, 1.81)
1.51 (0.80, 2.84)
0.78 (0.23, 2.60)
1.19 (0.47, 2.99)
7.52 (1.66, 34.09)
0.25 (0.03, 2.22)
0.09 (0.02, 0.39)
0.13 (0.01, 2.18)
5.085.01
4.77
7.95
4.24
1.95
4.86
0.82
3.04
3.21
2.97
Weight
1.70
2.71
1.81
4.91
1.70
1.94
4.19
2.622.19
4.29
0.45
5.50
1.28
6.36
4.82
2.14
3.14
1.50
0.77
1.59
0.49
0.97 (0.54, 1.77)1.39 (0.75, 2.54)
1.93 (1.02, 3.67)
1.00 (0.77, 1.29)
1.54 (0.75, 3.16)
0.82 (0.23, 2.98)
0.75 (0.40, 1.41)
0.47 (0.06, 3.96)
0.80 (0.31, 2.07)
3.52 (1.42, 8.74)
0.70 (0.27, 1.85)
0.88 (0.22, 3.57)
2.06 (0.74, 5.78)
0.51 (0.13, 1.95)
1.18 (0.64, 2.20)
2.21 (0.55, 8.97)
2.29 (0.63, 8.31)
2.01 (0.97, 4.16)
0.77 (0.27, 2.22)1.26 (0.38, 4.13)
0.46 (0.23, 0.95)
0.11 (0.01, 2.05)
1.04 (0.60, 1.79)
0.91 (0.17, 4.80)
1.16 (0.75, 1.81)
1.51 (0.80, 2.84)
0.78 (0.23, 2.60)
1.19 (0.47, 2.99)
7.52 (1.66, 34.09)
0.25 (0.03, 2.22)
0.09 (0.02, 0.39)
0.13 (0.01, 2.18)
5.085.01
4.77
7.95
4.24
1.95
4.86
0.82
3.04
3.21
2.97
1.70
2.71
1.81
4.91
1.70
1.94
4.19
2.622.19
4.29
0.45
5.50
1.28
6.36
4.82
2.14
3.14
1.50
0.77
1.59
0.49
1.05 1 5 10 50
Ulcerative colitis
Odds ratio (95% CI)
1.06 (0.93, 1.20)
Supplementary Figure 6. Detailed meta-analysis of Gly908Arg on the basis of allele frequencies. Ulcerative colitis. All studies.
Studies were excluded from meta-analysis if the risk allele/genotype was found neither in cases nor in controls.
Random effect
Fixed effect
Gearry RB (2007)
Russel RK (2005)
Oostenbrug LE (2006)
Rigoli L (2008)
Braat H (2005)
Cuthbert AP (2002)
Arnot IDR (2004)
Ernst A (2007)
Crawford NPS (2007)
Economou M (2007)
de Ridder L (2007)
Annese V (2005)
Cucchiara S (2007)
Gazouli M (2004)
Helio T (2003)
Esters N (2004)
van der Linde K (2007)
Giachino D (2004)
Weersma RK (2009)
Brant SR (2007)
Buning C (2005)
Derakhshan F (2008)Ozen SC (2006)
Cavanaugh JA (2003)
Ferraris A (2006)Ince AT (2008)
Karban A (2004)
Protic MB (2007)
Hugot JP (2001)Jess T (2005)
Bianchi V (2007)
Zaahl MG (2005)
Study
1.10 (0.87, 1.39)
0.94 (0.34, 2.59)
(Excluded)
0.91 (0.44, 1.86)
1.02 (0.31, 3.40)
0.41 (0.17, 0.97)
3.08 (0.90, 10.49)
7.50 (0.96, 58.85)
0.79 (0.35, 1.80)
1.22 (0.30, 4.96)
0.82 (0.43, 1.59)
0.19 (0.01, 3.10)
0.73 (0.33, 1.58)
1.47 (0.72, 2.99)
4.31 (1.80, 10.33)
(Excluded)
1.77 (0.65, 4.85)
0.58 (0.02, 14.49)
1.95 (0.56, 6.82)
1.00 (0.67, 1.50)
2.00 (0.63, 6.38)
1.30 (0.35, 4.90)
OR (95% CI)
1.51 (0.25, 9.12)0.88 (0.12, 6.32)
0.68 (0.04, 11.84)
0.44 (0.05, 3.95)0.69 (0.06, 7.67)
0.62 (0.13, 3.01)
(Excluded)
0.13 (0.01, 2.69)0.20 (0.01, 4.22)
1.80 (0.36, 8.99)
0.94 (0.04, 23.42)
4.27
0.00
7.24
3.23
5.54
3.13
1.22
5.98
2.48
8.12
0.67
6.47
7.34
5.45
0.00
4.36
0.52
3.02
13.69
3.46
2.74
Weight, %
1.571.33
0.65
1.070.90
1.98
0.00
0.570.57
1.92
0.52
0.94 (0.34, 2.59)
(Excluded)
0.91 (0.44, 1.86)
1.02 (0.31, 3.40)
0.41 (0.17, 0.97)
3.08 (0.90, 10.49)
7.50 (0.96, 58.85)
0.79 (0.35, 1.80)
1.22 (0.30, 4.96)
0.82 (0.43, 1.59)
0.19 (0.01, 3.10)
0.73 (0.33, 1.58)
1.47 (0.72, 2.99)
4.31 (1.80, 10.33)
(Excluded)
1.77 (0.65, 4.85)
0.58 (0.02, 14.49)
1.95 (0.56, 6.82)
1.00 (0.67, 1.50)
2.00 (0.63, 6.38)
1.30 (0.35, 4.90)
1.51 (0.25, 9.12)0.88 (0.12, 6.32)
0.68 (0.04, 11.84)
0.44 (0.05, 3.95)0.69 (0.06, 7.67)
0.62 (0.13, 3.01)
(Excluded)
0.13 (0.01, 2.69)0.20 (0.01, 4.22)
1.80 (0.36, 8.99)
0.94 (0.04, 23.42)
4.27
0.00
7.24
3.23
5.54
3.13
1.22
5.98
2.48
8.12
0.67
6.47
7.34
5.45
0.00
4.36
0.52
3.02
13.69
3.46
2.74
1.571.33
0.65
1.070.90
1.98
0.00
0.570.57
1.92
0.52
1.05 1 5 10 50
Ulcerative colitis
Odds ratio (95% CI)
1.10 (0.91, 1.33)
Supplementary Figure 7. Detailed meta-analysis of Leu1007fsincC on the basis of allele frequencies. Ulcerative colitis. All studies.
Studies were excluded from meta-analysis if the risk allele/genotype was found neither in cases nor in controls.
Random effect
Fixed effect
Ince AT (2008)
Cuthbert AP (2002)
Radlmayr M (2002)
Ernst A (2007)
Bianchi V (2007)Rigoli L (2008)van der Linde K (2007)