© Copyright 2014 Innosight LLC 0 © Copyright 2014 Innosight LLC Designing an Innovative Company Scott D. Anthony March 2014 @ScottDAnthony
© Copyright 2014 Innosight LLC
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© Copyright 2014 Innosight LLC
Designing an Innovative Company
Scott D. Anthony
March 2014
@ScottDAnthony
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Genius is 1 percent
inspiration and 99
percent perspiration
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“Something can be a real failure until it’s not. It’s just an absolute dud
until it’s a hit.
Leadership has to really lean in and not let
things die on the vine. ”
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UK-92480
Pfizer was investigating a drug named “UK-92480″ that they had
discovered by rational drug design. It caused smooth muscle
relaxation through inhibition of the phosphodiesterase
(specifically PDE5), which is responsible for hydrolysis of cyclic
GMP. It was hoped that inhibition of PDE5 would cause smooth
muscle relaxation via the pathway above, and lower blood
pressure in patients. Unfortunately, results were modest.
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An interesting side-effect of the drug was noticed by male patients
however, and the drug was surprisingly popular among the study
participants despite the poor control of blood-pressure.
Pfizer, not being idiots, realized they had hit gold. Finally, a
treatment for erectile dysfunction in pill form had arrived.
Source: The Road to Sildenafil – A history of artificial erections, by Mark Hoofnagle
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“You learn far more from your failures than you do from your
successes – far more from your failures.
What we’re trying to do now is fail a lot faster, fail a lot cheaper,
so we can fail more and get on to the next idea or the next
innovation that may become a commercial success.”
AG Lafley, Procter & Gamble Chairman and CEO
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@ScottDAnthony
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