SciBite overview July 2013

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

SciBite

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

Therapeutic Intelligence

I care about asthma. What does the current landscape of (Drugs, Targets, Companies, Trials, Collaborations…) look like?

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

A Bit Like This Actually

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

Where does TI come from?

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

What if the news

came to the

user, and not the

other way round?

A Better Way?

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

What Is SciBite?

Substrate

1000’s ofPatentsLiteratureNewsfeedBlogsClin Dbs.

Constantly

Semantic Concept Tagging

Target, Disease, Drug, Company,MicroRNA,Pathway, Context& More

SciBiteDatabase

Semantically annotated current awareness

SciBite.com

Our website is free to all

Data/APIs

Mine our data

SciBite+

Enhanced analytics and package intelligence reports

What google doesn’t do

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

Free Newsletter Service

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

Anatomy Of The NewsletterColoured bars tell us type of article (news, patent,paper…)

Semantic tags tell us exactly which topics mentioned, regardless of synonyms

Spikes when interesting stuff happening

Never miss a thing, email or RSS updates

Not just “things”, context too.

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

A Closer Look

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

“Faculty Of SciBite”

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

Annotated Abstracts

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

What‟s Hot?

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

WebConnect

http://scibite.com/site/p3/webconnect.html

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

Commercial Products

http://scibite.com/site/p3/products.html

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

Questions You Can Ask

Who‟s publishing on this target, family, protein, micro-RNA?

Who‟s just patented on X/Y/Z? And what for?

Who‟s working on what target-disease combinations ?

Whats hot in breast cancer right now?

Who‟s increasing activity in therapeutic area X right now?

What top news stories, patents, publications and trials might

I have missed?

How does the external landscape for protein family X

compare to my internal data

** New ** : What patented small molecules exist for the

above?

… And any combination thereof

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

API & Data

http://scibite.com/site/p3/prod/scibite_api.html

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

Test It Now!

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

Infographics

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

SciBite Plus (Late-2013)

http://scibite.com/site/p3/prod/scibite_plus.html

Connections plot, relationship to other topics by time and frequency

Target relationship matrix, find new targets by precedence

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

Commercial Landscape Map

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

Termite, SciBite‟s Tagging Engine

Why create our own?

Cost

Configuration

Support

Flexibility/Customisation

Thesauri & Algorithms combined

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

Thesauri, Our Approach

Value of crowd-sourced curation

Tackle issues at the thesaurus level

Public identifiers by default

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

Our Thesauri Products

.. And Now…Cell LineSpeciesInvestigative ProcedurePhenotype

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

Examples Of Added Value

EGFR and “estimated glomerular filtration rate” (eGFR)

Mark “EGFR” as case-sensitive matching only

Mark “EGFR” as ambiguous match only

Add “glomerular filtration” as a match-modifier

Auto-expansion (e.g. CHO cells, CHO cell lines, CHO

transfectants)

Sub-synonyms (e.g. TBI, transient brain ischemia, traumatic

brain injury, TBI Pharmaceuticals and lots more)

Synonym >> Ambig Synonym >> SubSynonym

Dictionary sub-setting (e.g. BIOCHEM is a mixture of lab

chemicals and endogenous molcules)

OnDemand & Batch modes

Support Full Text & Abstracts

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

Indication Thesaurus, Based on MeSH

o Issues with MeSH “raw” for text-miningo Missing numeral versions "Type 1 Diabetes Mellitus", vs.

"Type I Diabetes Mellitus”.

o Basic stemming is not enough. “Breast Neoplasms” vs. “Breast Neoplasm” vs. "Breast Tumor/Cancer/Malignancy/etc”

o International-english variations e.g. “Breast Tumour”; “Hemoglobin H Disease” vs. “Haemoglobin H Disease”; “Celiac disease” vs. "Coeliac”

o Annotation vs. recognition forms e.g. "Chorea, Benign Hereditary" vs. "Benign Hereditary Chorea”

o Greek letter variants: alpha-actin, a-actin, actin-a, actin-α

o Missing major alternative names, e.g. jaundice but no icterus

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

Conclusion & Opportunities

Keeping „current‟ is difficult

Move on from email alerts per source

SciBite is one way of doing it

Natural connection from biomedical news to

chemistry (SciBite+SureChem)

Are there other opportunities to feed in information

streams (e.g. figure legends)

Can we apply SciBite alerting principles to other

domains

Can we evolve text mining technologies to deliver

increasing scientific value

SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456

THANKS