School Nurse and Adolescent Obesity: Understanding the disease for effective prevention Manish Singh MD Adjunct Assistant Professor of Surgery UTHSC San Antonio . Texas Medical Director, Advanced Laparoscopic and Bariatric Surgery Doctors Hospital at Renaissance Bariatric and Metabolic Institute Edinburg .Texas
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School Nurse and Adolescent Obesity: Understanding the disease for effective prevention
School Nurse and Adolescent Obesity: Understanding the disease for effective prevention. Manish Singh MD Adjunct Assistant Professor of Surgery UTHSC San Antonio . Texas Medical Director, Advanced Laparoscopic and Bariatric Surgery Doctors Hospital at Renaissance - PowerPoint PPT Presentation
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School Nurse and Adolescent Obesity: Understanding the disease for effective
prevention
Manish Singh MD
Adjunct Assistant Professor of SurgeryUTHSC San Antonio . TexasMedical Director, Advanced Laparoscopic andBariatric SurgeryDoctors Hospital at RenaissanceBariatric and Metabolic Institute Edinburg .Texas
No disclosures
Objectives
1. Understanding obesity as disease.
2. Debunking various myths surrounding obesity
3. Differentiating between prevention and treatment of obesity
4. Understanding Various methods of management of obesity.
Myself
• Born and Medical School in India .
• Surgery Residency at St Agnes Hospital, Baltimore. ( 2004-2010)
• Fellowship in Advanced Laparoscopy and Bariatrics at Cleveland Clinic , Cleveland. (2011)
Obesity is a Disease.
Prevention
vs
Treatment
SURGICAL TREATMENTS FOR OBESITY I Dr. Manish Singh
Obesity is……a disease of excess fat storage with a number of
associated diseases, known as co-morbidities.
It is also…• multi-factorial (many different factors can cause
(*BMI ≥30, or ~ 30 lbs. overweight for 5’ 4” person)
No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30%
INTERESTING FACTS ABOUT OBESITY
• Child-safety seat manufacturers are starting to make bigger models after a recent study showed that over 250,000 U.S. children age 6 and under are too fat to use them.
• Airlines spent $275 million on 350 million additional gallons of fuel in 2000 to compensate for the additional weight of their passengers. Now we know why the peanuts are no longer free!
• Never forget your past: Aborigines and the Pima indians of Arizona developed obesity, type 2 diabetes, and hypertension after transitioning to a Western lifestyle.
• If the entire morbidly obese population of the U.S. lived in one state, it would be the 12th highest-populated state, with more people than Virginia
Obesity is a Disease.
1994National Diabetes Surveillance SystemState-specific Estimates of Diagnosed Diabetes Among AdultsAge-Adjusted Prevalence of Diagnosed Diabetes per 100 Adult Population, by State, United States, 1994
1995National Diabetes Surveillance SystemState-specific Estimates of Diagnosed Diabetes Among AdultsAge-Adjusted Prevalence of Diagnosed Diabetes per 100 Adult Population, by State, United States, 1995
1996National Diabetes Surveillance SystemState-specific Estimates of Diagnosed Diabetes Among AdultsAge-Adjusted Prevalence of Diagnosed Diabetes per 100 Adult Population, by State, United States, 1996
1997National Diabetes Surveillance SystemState-specific Estimates of Diagnosed Diabetes Among AdultsAge-Adjusted Prevalence of Diagnosed Diabetes per 100 Adult Population, by State, United States, 1997
1998National Diabetes Surveillance SystemState-specific Estimates of Diagnosed Diabetes Among AdultsAge-Adjusted Prevalence of Diagnosed Diabetes per 100 Adult Population, by State, United States, 1998
1999National Diabetes Surveillance SystemState-specific Estimates of Diagnosed Diabetes Among AdultsAge-Adjusted Prevalence of Diagnosed Diabetes per 100 Adult Population, by State, United States, 1999
2000National Diabetes Surveillance SystemState-specific Estimates of Diagnosed Diabetes Among AdultsAge-Adjusted Prevalence of Diagnosed Diabetes per 100 Adult Population, by State, United States, 2000
2001National Diabetes Surveillance SystemState-specific Estimates of Diagnosed Diabetes Among AdultsAge-Adjusted Prevalence of Diagnosed Diabetes per 100 Adult Population, by State, United States, 2001
2002National Diabetes Surveillance SystemState-specific Estimates of Diagnosed Diabetes Among AdultsAge-Adjusted Prevalence of Diagnosed Diabetes per 100 Adult Population, by State, United States, 2002
2003National Diabetes Surveillance SystemState-specific Estimates of Diagnosed Diabetes Among AdultsAge-Adjusted Prevalence of Diagnosed Diabetes per 100 Adult Population, by State, United States, 2003
2004National Diabetes Surveillance SystemState-specific Estimates of Diagnosed Diabetes Among AdultsAge-Adjusted Prevalence of Diagnosed Diabetes per 100 Adult Population, by State, United States, 2004
71
Obesity & The Energy Balance Equation
“If we’re getting more obese as a society, it must be the case that our caloric intake exceeds our caloric expenditure.
• TRUE ?
ORFALSE?
• TRUE ?
FALSE
BMI As a Vital Sign: A Guide to the Treatment of Morbid Obesity l April 22, 2023 l 74
BMI As a Vital Sign: A Guide to the Treatment of Morbid Obesity l April 22, 2023 l 75
BMI As a Vital Sign: A Guide to the Treatment of Morbid Obesity l April 22, 2023 l 76
BMI As a Vital Sign: A Guide to the Treatment of Morbid Obesity l April 22, 2023 l 77
The Leptin Bathtub
80
The Leptin Bathtub
“In this analogy, the amount of water is the same as the amount of adipose tissue in your body. Your body is paying attention to the amount of adipose tissue you have. And that is the defended parameter; that is, when you try to push the amount of water, in this case the amount of body fat, in either direction, the brain is going to fight back by being able to alter how hungry you are and how rapidly you’re burning calories.”
Why diets don’t work ?
82
What is a Set Point ?
“The end result of all this regulatory activity on the part of the body is to defend a particular set point for energy storage, which turns out to effectively be body weight…On the left side is why diets don’t work. And this whole process is determined physiologically. ”
The Myth: Weight can be reliably controlled by voluntarily adjusting energy
balance through diet and exercise.
84
The Myth Of Weight Management
One of the durable misconceptions in the area of weight regulation and obesity is that it results from abnormal or inappropriate behavior…
85
The Myth Of Weight Management
“You have to either engage the body’s regulatory system to make it want to weigh less or you have to fight it. So, this myth comes from the fact that people believe that the best way to do it is to fight it.”
87
The Body’s Defense Of Set Point
“What weight you defend is not a static variable. It’s a variable that can change over time and over circumstance.
The data presented in the above graph is from a study conducted on laboratory rats
Two Questions1.If body weight regulation is so accurate, why is it that we are becoming more obese? In other words, why doesn't this system that makes it so difficult for us to lose weight also defend us from gaining weight in the first place?
2.Why do only some people become obese while others remain lean, even in our relatively obesogenic environment?
• "things in our environment are changing the biological signals that relate to what weight the body sees as appropriate."
The Body’s Defense Of Set Point
90
“Under different dietary conditions, the exact same signal of leptin provides a different response… The point here is things in our environment are changing the biological signals that relate to what weight the body sees as appropriate.”
The data presented in the above graph is from a study conducted on laboratory rats
• Why do only some people become obese while others remain lean, even in our relatively obesogenic environment?
GENETICS
92
Environmental Changes Driving Obesity
“Those four categories of changes in the environment are so profound that they create the perfect storm for re-regulating energy balance, re-regulating set point, and creating obesity.”
93
Evidence for Physiological Mechanisms
94
Surgery Changes Set Point
“What surgery is doing is it’s changing the nature of these physiological curves so that the control of appetite, or energy intake, is blunted in a way. So as you lose body fat you end up with less of a rise in energy intake. And as you lose body fat you see less of a conservation of energy expenditure.”
95
The Leptin Bathtub
96
RYGB vs Dieting
“All of these physiological changes are consistently in the opposite direction after surgery as compared with dieting, and so what that tells you once again is that dieting engenders a counter-regulatory response that pushes you back to your original set point. Surgery, by having the arrows go in the opposite direction, must be changing the physiology.”
The data in the chart above are from multiple studies, presented here in aggregate.
97
Metabolic Impact Of Surgery
Kaplan, LM et al. Bariatric Times. 2012;9(7):12–14.
Obesity is a Disease.
ASMBS DIABETES OVERVIEW
Almost 21 million Americans or 7% of the population have diabetes – another 54 million have pre-diabetes. Studies show a higher body weight and longer duration of obesity significantly increase the risk of developing Type 2 diabetes .
BMI greater than 35 increases the risk for diabetes by 93-fold in women and 42-fold in men.
One out of every 10 health care dollars is spent on diabetes and its complications .
Natural History of Type 2 Diabetes
Risk Factors(Obesity)
Impaired glucose tolerance
Diagnosis
3 years ofDM 2
9 years of DM 2
UncontrolledHyperglicemia
Lifestyle
Monotherapy
Combined
Insulin
Decreased betacell function
50% 10%
HbA1c=<7,7% orFPG= 180mm/dl
HbA1c=8,5% orFPG=>240mm/dl
DiseaseProgression
100%
Impact of Diabetes Mellitus
Diabetes
The leading cause of new cases of end stage renal disease
A 2- to 4-fold increase in cardio-vascular mortality
The leading cause of new cases of blindness in working-aged adults
The leading cause of nontraumatic lower extremity amputations
The Practical Guide, Identification, Evaluation and Treatment of Overweight and Obesity in Adults. NIH Publication #00-4084, Oct, 2000
Surgery
Pharmacotherapy
Lifestyle Modification
Diet Physical Activity
BMI
Obesity Treatment Pyramid
NIH consensus of 1991 concluded:
“Diet alone cannot be considered a reasonable option for permanent weight loss.”
“Drug therapy for clinically severe obesity has been disappointing.”
Surgical intervention including Roux-en-Y Gastric Bypass is the most appropriate treatments for obesity as defined by: • BMI >40 or
• BMI >35 with co-morbidities
“Never ask a barber if you need a haircut”
Warren Buffet
Evaluation of Obesity Management
• Don’t confuse prevention with treatment
• Must measure effect of intervention
• Evidence based decisions
SURGICAL TREATMENTS FOR OBESITY I Dr. Manish Singh
Adjustable gastric banding is one type of restrictive procedure
• Laparoscopic
• Second most frequently performedbariatric procedure
• Mean excess weight loss at 1 yearof 42%1
• Requires implanted medical device
• Lowest rate of complications
1. Buchwald, H. et al., JAMA. 2004; 292:1724-37.
SURGICAL TREATMENTS FOR OBESITY I Dr. Manish Singh
Vertical sleeve gastrectomy is another restrictive option
1. ASMBS, Position Statement on Sleeve Gastrectomy as a Bariatric Procedure. June 17, 2007.
2. Lee CM, et al. Surg Endosc (2007) 21: 1810–1816
• Laparoscopic
• May be an option for carefullyselected patients, including high-risk or super-super-obese patients1.
• Mean excess weight loss at 1 yearof 59%2
• No implanted medical device
SURGICAL TREATMENTS FOR OBESITY I Dr. Manish Singh
A combination approach is most common
1. Buchwald, H. et al., JAMA. 2004; 292:1724-37.2. Buchwald H. 2004 ASBS Consensus Conference Statement, Bariatric surgery for morbid obesity: Health implications for patients,
health professionals, and third party payers. SOARD 2005;(1):371-8.
Roux-en-Y Gastric Bypass• Laparoscopic
• Most frequently performedbariatric procedure
• Mean excess weight loss at 1 yearof 67%1
• No implanted medical device
• Low rate of complications2
Open Laparoscopic
Surgical Approach
Myths about Bariatric Surgery
1. Bariatric surgery is dangerous
2. Results are variable
3. Patients eventually regain their weight after surgery
4. Bariatric surgery is expensive
5. Patients may loose weight but it does not alter their life-span
#5 Patients may loose weight but surgery does not alter their life-span
Effect on Long-term Mortality Compared to Non-Operated Controls
Study Procedure F/U Mortality Reduction
MacDonald,1997 RYGB 9 yrs 88%
Flum, 2004 RYGB 4.4yrs 33%
Christou, 2004 RYGB 5 yrs 89%
Sjostrom, 2006 VBG/other 14 yrs 31%
Sowemimo, 2007 RYGB 4.4 yrs 50%
Adams, 2006 RYGB 8.4 yrs 53%
O’brien, 2006 LAGB 12 yrs 73%
#6 Only Surgeons Endorse Bariatric Surgery
#6 Only Surgeons Endorse Bariatric Surgery
NIH/NIDDK/NHLBICMS/MedicareInstitute for Clinical Systems ImprovementNorth American Association for the Study of Obesity, NASOAmerican Diabetes Association, ADAAmerican Medical Association, AMAInternational Association for the Study of Obesity, IASOUK National Institute for Health and Clinical Excellence, NICE
These organizations endorse bariatric surgery for the treatment for severe, chronic obesity:
Predictors of Diabetes Resolution
• Medical Therapy only- 12%• Medical Therapy + Bariatric surgery- 37-42%
Natural History of Type 2 Diabetes
Risk Factors(Obesity)
Impaired glucose tolerance
Diagnosis
3 years ofDM 2
9 years of DM 2
UncontrolledHyperglicemia
Lifestyle
Monotherapy
Combined
Insulin
Decreased betacell function
50% 10%
HbA1c=<7,7% orFPG= 180mm/dl
HbA1c=8,5% orFPG=>240mm/dl
DiseaseProgression
100%
Consider surgery•Poor control A1c > 7.5•Burden of treatment is high
Bariatric surgery is the only effective therapy for severe obesity
Metabolic Surgery
Not Just Bariatric Surgery...
Conclusions1. Obesity is a disease.
2. Difference between prevention and treatment of obesity
3. Debunking various myths surrounding obesity- body’s regulatory system has to modified to achieve weight loss.
4. Various methods of management of obesity- depends on the level of obesity