SAVE THE DATE CARIM DAY 2016, 2 November · Prof. Antonio Zaza appointed on the Hein Wellens Wisselleerstoel 2016/2017 Professor Antionia Zaza is appointed on the Hein Wellens Wisselleerstoel

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CARIM Newsletter July 2016 View this email in your browser

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CARIM Day 2016Grant Neth ThrombosisFoundation GerryNicolaesCVON grant heartfailure researchersGrant Dutch KidneyFoundation CarinePeutzHigh impact papersMR CLEANAppointment Prof. A.ZazaAward NicolaasSchaperAwards CardiologyresearchersWho's new?!Grant deadlinesCardiovascular GrandRounds MaastrichtSymposia & otherlecturesAcademic events

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SAVE THE DATE ­ CARIM DAY 2016, 2 NovemberCARIM DAY 2016 will take place on Wednesday November 2.

This year’s Robert Reneman Lecture will be given by Professor Stephane Laurent

After last year’s success, the location of the symposium will again be the Minderbroedersberg

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After last year’s success, the location of the symposium will again be the Minderbroedersbergfollowed by a festive evening.More information on the program will be distributed as soon as possible.

Grant NetherlandsThrombosis FoundationGerry NicolaesDuring the last round of grant applications at the NetherlandsThrombosis Foundation ("Trombosestichting Nederland"), theapplication by Dr Gerry Nicolaes and colleagues (Biochemistrydepartment) received a very positive response and was granted.

Funding will be provided for two years to support neededtechnical assistance and benchfee to study molecularmechanisms involved in NETosis and immunothrombosis andprovide a proof­of­concept for novel sepsis therapeutics.

Heart failure researchers receive CVON grantThe CARIM Heart Failure team of Prof.dr. Stephane Heymans recently obtained amillion euro grant of the Dutch Heart Foundation.

His team together with researchers of Amsterdam will look for early markers ofheart failure with preserved ejection fraction.When the heart starts to lose itselasticity, the muscle has trouble relaxing, resulting in higher blood pressure in theheart and lungs. This can lead to shortness of breath and heart failure. Thisparticular type of heart failure, known as HFPEF, is more common in women aged65 and older and people with obesity, high blood pressure, diabetes and/or kidneyfailure. In many patients, this loss of elasticity has progressed for several yearsbefore symptoms occur. At the moment, the disease is untreatable and irreversible.Early detection is therefore important to prevent unnecessary suffering.

This is exactly what UM researchers Anna Papageorgiou and Mathijs Blankesteijnplan to research under the supervision of Professor Heymans and Dr Vanessa vanEmpel. They hope to uncover the early warning signs, such as biomarkers, thatcould indicate a decline in heart health. Preclinical diastolic dysfunction (pDD) is acondition that causes HFPEF in thirty percent of patients. Identifying pDD is animportant objective of the study. The multidisciplinary project group will study thepredictive biomarkers and other patient characteristics that could help detect pDDat an early stage and contribute to the development of tailored treatment.

This project reflects the intense collaboration within the overall Heart Failure teamof CARIM and the department of Cardiology. “The overall Heart Failure team isvery successful, as reflected by the numerous prestigious Dutch and Europeangrants they obtained last 5 years (Prof.L. de Windt, dr. Anna Papageorgiou, dr. B.Schroen, dr. Paola daCosta­Martins, Prof.dr. S. Heymans).”

Click here to read a full article on the Maastricht University website.

Dutch Kidney FoundationInnovation Grant for MassSpectrometry imaging onrenal tissueIn collaboration with the Maastricht Multimodal Molecular

Imaging Institute, Carine Peutz­Kootstra (picture) and Erik

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Imaging Institute, Carine Peutz­Kootstra (picture) and ErikBiessen from the Department of Pathology have been awardedan Innovation grant (100.000 euro) from the Dutch KidneyFoundation for the project “Mass Spectrometry Imaging: anintegrative molecular histology approach to assess severity ofacute and chronic kidney injury”.

There is an urgent need to develop biomarkers for earlydetection of acute and chronic kidney disease in patients, asthese diseases are associated with higher cardiovascularmorbidity and mortality. In previous research, an important rolefor microvascular damage was found already in an early stage ofrenal disease development. Mass Spectrometry Imaging (MSI)can be used to identify metabolites and hitherto unidentifiedcompounds at a high spatial resolution in tissue sections. In thisnew project the research group consisting of Prof. R. Heeren,Prof. S. Olde Damink, Prof. Dr. E.. van Heurn, Prof. E. Biessen,and Dr C Peutz­Kootstra will apply this novel and innovativetechnique on renal tissue. Using this approach their groupultimately aims to unravel the disturbed metabolic and molecularinteractions between microvascular and renal cells in earlystages of kidney disease, by integrating multimodal massspectrometry imaging (MSI) and histopathology on affected renaltissue .

Two high impact papers from the MR CLEANinvestigatorsMR CLEAN was the first randomized study that showed safety and benefit of intra­arterial treatment(IAT) for acute Ischemic stroke. Shortly after the publication of the main results 4 other studies confirmedthe findings of MR CLEAN. All 5 were published in the New England Journal of Medicine. In the last 3months, two high impact papers of the MR CLEAN study group have been published.

In April, the HERMES consortium, a collaborative study group of the 5 IAT studies, presented the resultsof a meta­analysis of individual patient data in the Lancet (IF 44,0). Wim van Zwam (Radiology) andRobert van Oostenbrugge (Neurology), both co­PIs of MR CLEAN, were co­first author resp. co­seniorauthor. In this meta­analysis the high effectiveness of IAT for acute ischemic stroke was confirmed.Efficacy was shown in all predifined subgroups, leading to the main conclusion that IAT is beneficialwhen started <6 hours from onset, independent of age and stroke severity.

In June, the MR CLEAN study group demonstrated in a pre­defined subgroup analysis, published inLancet Neurology (IF 21,8), that early ischemic changes on baseline brain CT do not significantlyinteract with treatment effect of IAT. However, the absolute risk reduction for poor outcome decreasedwith increasing extend of the presence of early ischemic changes on baseline brain CT. As such, themain conclusion of this study was that selection of patients for IAT by grade of early ischemic changeson CT is not warranted.

Goyal M, Menon BK, van Zwam WH, et al. Endovascular thrombectomy after large­vessel ischaemicstroke: a meta­analysis of individual data from five randomized trials. Lancet 2016:387:1723­31

Yoo AJ, Berkhemer OA, Fransen PS, et al. Effect of baseline Alberta Stroke Program Early CT Score onsafety and efficacy of intra­arterial treatment: a subgroup analysis of a randomised phase 3 trial (MRCLEAN). Lancet Neurol. 2016;15:685­94

Prof. Antonio Zaza appointedon the Hein WellensWisselleerstoel 2016/2017Professor Antionia Zaza is appointed on the Hein WellensWisselleerstoel 2016/2017. Professor Antonio Zaza, from theUniversity of Milano­Bicocca in Italy, is a basic scientists with abackground in clinical cardiology, who has devoted the best ofhis professional life to the study of cellular mechanisms ofarrhythmias and their pharmacological modulation. ProfessorZaza is also an academic teacher in cardiac physiology andpathophysiology, with experience at national and internationallevels.

The longstanding scientific interaction between Professor Zazaand members of CARIM, Professor Paul Volders in particular, issupported by a common interest for the ionic mechanismsunderlying ventricular repolarization and contributing to its

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underlying ventricular repolarization and contributing to itsintrinsic stability, or pathological instability. This interaction hasrecently resulted in shared publications. Also shared is theirinterest in the role of myocardial CaZ+ handling abnormalities asa master mechanism of repolarization instability and ectopicimpulse formation, providing a link between arrhythmias andcontractile dysfunction. In this field, the two laboratories haveprovided independent but converging contributions. This justifiesthe expectation that a close interaction between Professor Zazaand Principal Investigators at CARIM, such as that supported bythe Visiting Professorship, may be highly productive.

Prestigious award forNicolaas SchaperNicolaas C. Schaper, MD, PhD (Internal Medicine), has beenselected to receive the American Diabetes Association's 2016Roger Pecoraro Award. This award recognizes a researcher whohas made scientific contributions and demonstrates an untiringcommitment to improving the understanding of the detection,treatment and prevention of diabetic foot complications. Schaperwas recognized with this honor during the Association's 76thScientific Sessions®, that took place from June 10­14, 2016, atthe Ernest N. Morial Convention Center in New Orleans.

"Thank you, Dr. Schaper, for your exemplary leadership andsteadfast work," said Desmond Schatz, MD, President, Medicine& Science for the American Diabetes Association. "Yourexceptional commitment and contributions have raised our levelof understanding of the complex nature and urgency to care fordiabetic foot complications, allowing us to improve the quality oflife for people with diabetes."

With the growing interest in eHealth, Schaper founded the DutchDiabetes Interactive Education Project and serves as editor­in­chief of its website. As the author of more than 170 scientificpublications, his research is mainly focused on lower extremitydisease and mobility in diabetes with topics such as quality oflife, impaired wound healing, peripheral arterial disease,abnormal tissue loading of the foot, the epidemiology of diabeticcomplications and the consequences of sedentary behavior.

Click here for the press release by MUMC+ (in dutch)

Awards for Cardiology researchersTwo CARIM researchers recently won prestigious awards at the world's biggest heart failure conference,Heart Failure 2016, organised by the European Society of Cardiology. Dr Ward Heggermont and DrMark Hazebroek, both researchers and practicing medical doctors, were two of the award recipients atthe four­day conference in Florence, which was attended by well over six thousand participants.

Dr Ward Heggermont won first place in the category 'Basic Research'. He found that a tiny functionalRNA fragment, microRNA­146a, plays an important role in the energy metabolism of the failing heart.One of the characteristics of a failing heart is impaired energy metabolism. The micro­RNA fragment wasfound to suppress a citric acid enzyme (DLST), a discovery that requires further research but may proveuseful in the development of targeted therapy for heart failure in the future.

Dr Mark Hazebroek placed second in the European Society of Cardiology's Young Investigator Award.Hazebroek is involved in research on genetic mutations in patients with an enlarged heart, also knownas dilated cardiomyopathy. He compared these patients with a group of patients in an earlier stage ofthe disease and found that genetic mutations could lead to arrhythmias and premature death in bothgroups. These findings have potential consequences for preventative treatment strategies, such as animplanted cardiac defibrillator (ICD).

Who's new?!

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My name is Arantxa Barandiaran and I was born in San Sebastian (Spain)where I completed my medical degree. During my medical studies I had deopportunity to improve my medical training in several international centers. In2008 I had de opportunity to come to the Maastricht, to the department ofcardiology, a turning point in her career. In 2009 I emigrate to the Netherlandsand immediately I started working as a clinitian. In 2010 I started officially withmy cardiology residency in the Maastricht University Medical Center (MUMC+)under the supervision of Prof. H.J.G.M. Crijns and Dr. E.C. Cheriex. During myresidency I noticed that I needed to improve my research abilities to be able tounderstand beter the pathofysiology of the different cardiovascular diseases

and to improve possibilities to treat my patients, in definitief to become a beter clinitian. In april2016 I started my PhD project, under the supervision of B. Schroen and V. van Empelinvestigating the pathophysiology and the possibilities for an earlier diagnosis of HFPEF withCardiac­MRI (metabolism and absolute perfussion), biomarkers and non invasief measurementtechniques of endothelial dysfunction.

My name is Pamir Sawo (no picture) and I am 31 years old. I am originally from Afghanistan andliving in the Netherlands since the age of sixteen. I studied at Faculty of Medicine of MaastrichtUniversity and work now since one month at the department of Biomedical Engineering atMaastricht University. The aim of my research is to develop a new AV graft for patientsundergoing hemodialysis.

Grant deadlinesDOWNLOAD HERE THE SUBSIDY CALENDAR FOR 2016

Science & SciLifeLab Prize for Young Scientists ­ Deadline August 1, 2016 Click here for more information

Dr. E. Dekker Clinical Established Investigator ­ Deadline August 29, 2016 12.00 hours Click here for more information

Dr. E. Dekker Arts vóór aanvang Specialisatie ­ Deadline August 29, 2016 12.00 hours Click here for more information

ERC advanced grant ­ Deadline September 1, 2016 17.00 hoursClick here for more information

Subsidies voor onderzoekssamenwerking met China ­ Deadline Septemer 1, 2016Click here for more information

Investeringen NWO middelgroot ­ Deadline September 1, 2016 14.00 hoursClick here for more information

WUN Research Development Fund ­ Deadline September 13, 2016Click here for more information

Marie Curie Individual Fellowships ­ Deadline September 14, 2016 17.00 hoursClick here for more information

Horizon 2020 COFUND ­ Deadline September 29, 2016Click here for more information

Kootstra Talent Fellowships ­ Deadline October 1, 2016 Click here for more information

July 8 ­ Rudi Vennekens, PhD, KU Leuven, Belgium "The TRP­channel CAN, TRPM4, in cardiac contractility and arrhythmias"

July 15 ­ Stefan Störk, MD, Universitätsklinikum Wurzburg, Germany

"Structures and strategies supporting improved care of heart failure patients in Germany"

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"Structures and strategies supporting improved care of heart failure patients in Germany"

Starts at 7.45 am, Academic hospital Maastricht, Meeting room A3­B3, level 3Breakfast included! Registration not necessary

Click here for an overview of all the CGRM lectures of the second quarter of 2016

Symposia & eventsNetherlands Vascular Biology Meeting ­ October 5 & 6, 2016 Click here for more information. Abstract deadline: September 5 12.00 hours

Pélerin Science Symposium ­ October 5, 2016Click here for more information

4th National eScience Symposium ­ October 13, 2016Click here for more information.

20th Annual Meeting of the European Council for Cardiovascular Research (ECCR) ­ October 14­16,2016Click here for more information. Abstract deadline: July 11, 2016

PhD course 'Systematic Reviewing and Critical Appraisal' ­ October 18, 2016Click here for more information ­ Registration deadline: September 1, 2016

KNAW Agenda

School Council meetings 2016:­ October 18, 12.00­14.00 hours

Academic events

PhD Conferral Ramesh Chennupati, Monday June 20, 2016, 14.00 hoursSupervisors: Prof. J.G.R. De Mey, Prof. W.H. Lamers Co­supervisor: Dr S.E. KöhlerTitle: "Role of arginine metabolism in the production of endothelium­derived relaxing factors;effects of ageing, hyperglycemia and hyperlipidemia"

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PhD Conferral Mark de Vries, Friday July 1, 2016, 14.00 hours Supervisors: Prof. M.J. PostCo­supervisor: Dr D.G.M. MolinTitle: "Cytokines in artheriogenesis from a therapeutic perspective"

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