Page 1
SARCOMA 180 INHIBITION SCREENING DATA1
C. Chester Stock, Donald A. Clarke, Fredericks. Philipsand Ralph K. Barclay
Division of Experimental ChemotherapySloan-Ketter ing Institute and
Sloan-Kettering Division ofCornell University Medical College
The following method of screening materials for ability to inhibit the
growth of Sarcoma 180 in mice has been employed:
1. Weigh the mice. Swiss females, 18-22 gms., from the Blue Spruce,
Carworth, Harpaul, Millerton Research, and Rockland Farms and from Joseph
E. Stocker have been used. They have been given Purina Laboratory Chow and
water ad lib.
2. Transplant tumor pieces by trocar subcutaneously into the axillary
region. The tumor fragments, approximately 1.5 mm in any dimension, are
cut from non-necrotic portions of the donor tumor and samples of each tumor
cultured for detection of any possible bacterial contamination.
3. Twenty-four hours later start intraperitoneal injections of compounds
in maximum tolerated doses on a repeated basis. In nearly all cases the toxi-
cities of the compounds were determined by either of two methods. The max
imum tolerated doses by intraperitoneal injections repeated daily for five days
have been deter mined or the approximate LD50 for a single dose has been found.
1. The screening program for anti-tumor activity has been supported since 1947by institutional grants from the American Cancer Society. There also hasbeen support in part by a grant-in-aid (CH-22) from the American CancerSociety upon recommendation of the Committee on Growth of the NationalResearch Council.
2. The toxicities of most of the compounds included in this report and manyother compounds were obtained by support in part by a research grant(C-415)from the National Cancer Institute of the National Institutes of Health, U. S.Public Health Service. The data are on file at the Chemical-BiologicalCoordination Center, National Research Council, Washington 25, D. C.
179
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 2
180 CancerResearch Stock et al.
Although exceptions have been encountered, in general, one-fourth to one-third
the single dose LD50 has been found to be a dose satisfactorily approximating
the maximum tolerated on repeated injection. In later studies an arbitrarily se
lected dose of 125 mg/K/day has proven adequately satisfactory as an initial
dose without prior toxicity data. In the tables the doses are reported in mg/K
except for many of the liquids which have been measured by volume and are
listed in cmm/K.
4. Injections are continued twice daily for seven days. In some instances
single injections have been given daily. These include materials prepared fresh
daily or in propylene glycol solution.
5. The test is repeated at the same or a different level depending upon the
result of the first trial. If the first dose has been too toxic, a lower dose is
tried; if the first dose appears to be well tolerated, a higher one may be tried.
For each compound reported herein as negative there are additional supporting
data at lower or higher dose levels or both; however, most of the compounds
have not been tested at dose levels higher than 500 mg/K/day.
Results of testing materials have been evaluated as follows:
No effect, when the average diameter was 3/4 or more
of the average diameter of the control tumors.
+ Slight inhibition, when the average diameter was 1/4 to
3/4 of the average diameter of the control tumors.
+ Marked inhibition, when the diameter was 1/4 or less
of that of the control tumors; actually, the volume of
such a tumor would be 1/64 or less of the control if
tumors may be considered spherical.
Over 13,000 compounds and nearly an equal number of materials of
natural origin have been screened for ability to inhibit Sarcoma 180. Thirteen
compounds have met the requirements for the grading of +. They are:
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 3
Stock et al. Negative Cancer CìimiotlierapyData 181
2,4,6-tris-ethyleneimino-s-triazine
4-aminopteroylglutamic acid
4-amino-N10-methylpteroylglutamic acid
4-aminopteroylaspartic acid (DL)
4-amino-9-methylpteroylglutamic acid
4-aminopteroylthreonine
4-amino-9, 10-dimethylpteroylglutamic acid
4-aminopteroyltriglutamic acid
3-bis(ß-chloroethyl)aminomethyl-4-methoxymethyl
-S-hydroxy-o-methylpyridine dihydrochloride
N, N', N"-triethylenephosphoramide
phosphoric acid, diethylamide diethyleneimide
N-pentamethylene-N1, N"-diethylenephosphoramide
O-diazoacetyl-L-serine
Most of them have already been reported. Annals of the New York
Academy of Sciences 52^ 1360-78 (1950); Cancer Research JJ., 432-36 (1951);
Proc. Soc. Exp. Bioi. Med. 78, 299-305 (1951); Cancer J^ 144-52 (1952);
Naturels, 71 (1954).
Approximately 200 compounds are in the - category. Included are 6-
mercaptopurine, 6-chloropurine, thioguanine, purine, actidione, N-methyl-
formamide, urethane, HN2 and certain other nitrogen mustards, some 2,4-
diaminopyrimidines and some anti-folic acids not as effective as those listed
above. The rest of the - compounds are being studied as possible leads to more
effective, related compounds. All of the othtr compounds wehave tested against
Sarcoma 180 have thus far been negative but many require retesting at higher
dose levels.
In the accompanying tabulated data the solvents have been coded as follows:
UK.. ,.
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 4
182 Camer Research Stock et al.
Solvent Coding
Code No. Solvent
1. saline
2. carboxymethylcellulose (Cellulose gum) high viscosity,
Type 120, Hercules Powder Co., 0.5% in saline
3. gum acacia (gum arabic) 1% or 10% in saline
4. propylene glycol
5. butyl Buccinate
6. peanut oil
It is a pleasure to acknowledge the many sources of the compounds we
have used. All of the cooperating laboratories have been most helpful in at
tempting to provide adequate supplies of compounds many of which would not
otherwise have been available to us. The sources of the compounds have been
designated in the tables as listed below:
C Parke, Davis and Company
D Dr. Max Tishler, Merck and Company
Dl Dr. Karl Folkers, "
D2 Dr. Karl Pfister, " "
D3 Dr. Lewis H. Sarett" "
E Eastman Kodak Company
F Dr. F. E. Ray, Cancer Research Laboratory, University
of Florida
G Southern Research Institute
HI Sterling-Winthrop Research Institute
H Winthrop Stearns, Inc.
la Dr. H. L. Haller, Insecticide Investigations, U. S. Department
of Agriculture, Beltsville, Maryland
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 5
Stock et al. Negative Cancer Chemotherapy Data 183
II Dr. Thomas D. Fontaine, Biologically-Active Compounds
Division, U. S. Department of Agriculture
13 Dr. Monroe E. Wall, Biochemical Division, U. S. Department
of Agriculture
17 Dr. Aaron M. Altschul, Oilseed Division, Southern Regional
Research Laboratory, U. S. Department of Agriculture
J Smith, Kline, and French Laboratories
L Monsanto Chemical Company
M Bound Brook Division of American Cyanamid Company
M2 Dr. R. O. Roblin, American Cyanamid Company
N Lilly Research Laboratories
P Eaton Laboratories, Inc.
Q E.I. duPont de Nemours and Company
S S. B. Penick and Company
W Abbott Research Laboratories
Z William S. Merrell Company
AA B. F. Goodrich Chemical Company
AE National Research Council, Chemical-Biological Coordination Center
AG Lederle Laboratories Division of American Cyanamid Company
AM The Squibb Institute for Medical Research
AN National Aniline Division of Allied Chemical and Dye Corporation
AP Esso Laboratories, Standard Oil Company
AQ Endo Products, Incorporated
AR Commercial Solvents Corporation
AT Dr. William Doering, Hickrill Chemical Research FoundationAW Sloan-Ketter ing Institute personnel or related sources:
AW-1 Dr. Liebe Cavalieri
AW-4 Dr. George Brown
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 6
184 CancerResearch Stock et al.
AW-5 Dr. Ralph Barclay
AW-7 Dr. Earl Balis
AW-13 Dr. Leonlda SantamarÃa
AW-20 Dr. F. DiCarlo
AW-21 Dr. V. Bellavita
AZ Dr. Kenneth M. Campbell, Mead-Johnson and Company
BA Dr. C. K. Cain, McNeil Laboratories
BB Charles Pfizer and Company
BD Dr. Karl Dittmer, Department of Chemistry,
Florida State University
BE Dr. George Hitchings, Wellcome Research Laboratories
BG Socony Vacuum Oil Company, Inc.
BH The Quaker Oats Company
BJ Dr. Ernst A. H. Friedheim
BL Dr. Frederic R. Benson, Remington Rand, Inc.
BP Sharpies Chemicals, Inc.
BX Bristol Laboratories
BY Upjohn Laboratories
CA Dr. N. H. Cromwell, Department of Chemistry,
University of Nebraska
CB Dr. Henry A. Rutter
CC G. D. Bearle and Company
CG Dow Chemical Company
CI General Aniline and Film Corporation
CUI Dr. Donald C. Lewis, Mellon Institute (Carbide and Carbon
Chemicals)
CW Dr. Hoke S. Green, Department of Chemistry,
University of Cincinnati
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 7
Stock et al. Negative Cancer Chemotherapy Data 185
CY Dr. Carl T. Bahner, Department of Chemistry,
Carson-Newman College
DB Virginia-Carolina Chemical Corporation
DI Armour Laboratories
DK Dr. Louis H. Goodson, Midwest Research Institute
DN Dr. W. T. Sumerford, Mead-Johnson and Company
DP Warner-Chilcott Laboratories
DQ Dr. Irving Kaye, Department of Chemistry, Brooklyn College
DU Dr. Jack Nobis, National Distillers Chemical Corporation
DV Dr. C. G. Overberger, Institute of Polymer Research,
Polytechnic Institute of Brooklyn
EA Delta Chemical Works
EC Rohm and Haas Company
EG Dr. Jerry Milionis, Department of Chemistry,
Purdue University
EH N. V. Organon
El Dr. Wilson M. Whaley, Pabst Laboratories
EJ Dr. Marvin D. Armstrong, University of Utah,
College of Medicine
EO Dr. Carl M. Stevens, The State College of Washington
ES Minnesota Mining and Manufacturing Company
EV Linde Air Products
EW Dr. D. S. Tarbell, Department of Chemistry,
University of Rochester
EX Wallace and Tle r nan Products
EZ Dr. Richard H. Wiley, Department of Chemistry,
University of Louisville
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 8
186 Cancer Research Stocketal.
FC Dr. E. R. Weidlein, Jr., Mellon Institute of Industrial Research
Parke, Davis and Company, Fellowships in Medicinal Chemistry at
Mellon Institute:
FC1 Dr. Marcus Morgan
FC2 Dr. Horace DeWald
FC3 Dr. Robert Tipson
FC4 Dr. Alice Renfrew
FE Prof. Dr. F. Bustinza, University of Madrid
FH Dr. Charles F. Geschickter
FK Dr. Patrick J. Hannan, Fungus Control Section Materials
Branch, Engineer Research and Development Laboratories,
Fort Belvoir, Virginia
FM Dr. H. R. Snyder, Department of Chemistry,
University of Illinois
FO The Atlantic Refining Company
FQ Prof. Dr. med. H. Oettel, Badische Anilin and Soda-Fabrik
FR U. S. Industrial Chemicals Company
FU Dr. T. Lloyd Fletcher, School of Medicine,
University of Washington
F W Dr. Ng. Ph. Buu-Hoi, Radium Institute, Paris
GA Dr. Donald Visser, School of Medicine,
University of Southern California
GC Dr. Glenn S. Skinner, Department of Organic Chemistry,
University of Delaware
GD Dr. Ralph L. Shriner, Department of Chemistry,
State University of Iowa
GJ Ethyl Corporation Research Laboratories
GK Dr. E. C. Taylor, University of Illinois
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 9
Stock et al. Negative Cancer Chemotherapy Data 187
GL Antara Chemicals
GM Dr. Henry Gil man, Department of Chemistry,
Iowa State College
GN Dr. G. M. Kosolapoff, Alabama Polytechnic Institute
GO United States Rubber Company
GQ Heyden Chemical Corporation
JI Dr. J. C. Calandra, Northwestern University
JK Dr. D. M. Carney, University of Detroit
JL Prof. E. D. Armstreetz, Lehigh University
JN General Chemical Company
JO W. J. Strange Company
The Sarcoma 180 studies were carried on effectively through the carefulwork at various times since 1947 of the following: in the toxiclty assay program,Alicia Arnold, Rhoda Baskin, Barbara Bond, Marie Borgatta, Carol Cooklin,Margrit Fehlmann, Ann de Blieux Geisler, Beatrice Nissen Greene, CorinneRoss Lacón, Marie McClure, Aileen Mulvey, Ruth Osato and Barbara Wheelock;and in the Sarcoma 180 screening program, Dolores Anderson, Barbara Averill,Marguerite Bagg, Virginia Bailey, Marie Dunn Bartnett, Angela Boryczka,Dorothy Burnham, Françoise Costa, Isabel Lincoln Elmer, Robert Eisner,Barbara Jones Gibson, Jacqueline Grundstein, Janet Hacker, Patricia Hagan,Eleanor Hutcheson, Col innéInnés,Mar gar et Jeter, Helen Karp, Marcia Katzman,Margaret Keeve, Suzanne Knecht, Lorraine Kraus, Joan Leuchten, Edith Lindner,Margaret Lippay, Barbara MacCallum, Lois Montgomery, Annemarie Muller,Mary Helen Nisum, Sheelagh O'Connor, JeanO'Laughlin, Patricia Oley-Dufresne,Angeleine Pagliaro, Joseph Patti, Peggy Pentz, Frances Pepper, Matthew Rudden,Netta Sanow, Lydia Sargent, Elsie Sata, Jean Scoma, Anne Snipes, BarletteSolow, Elizabeth Sprague, Joanna Stein, Arlene Steinberger, Louise Taichert,Anne Tracy, Marie Waite, Robert Wallbrun, Alice Wick, Joan Wiehl, DorothyFong Wong and Joan Cozens Youmans; and for numerous administrative details,Mrs. Sophronia A. Myron.
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 10
188 CancerResearch Stock et al.
ifì O
o -imio o ino — —o
o trt mo o o
O oj mo H—'
M rq
i2* g
H
U
g(J- I
ou
a
U
Iil
$
t aI l I
i
a
I £
a
S
s
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 11
Stock et al. Negative Cancer Chemotherapy Data 189
ú»sa*>S
*X — .£-H-jg §; gsM•E £bu" if ìÌ1!
1§O*f"î m in in m inm0'w o>>o^>o-*
Qm<
§ rt ** mio o m oo ino omomHta P S •*[*«5 (\j —' r\ï~H —' (\j " o o—"U3 Õ3u ili + + i+ ++ iitM359
-^ rg in m rM^£0
M *~ <«t o* co <*>r-Z™aÊ
Bu"3°MaâSa£
~i::J 5 S~£o • •*AOË
SSI«g
ü "n—Û.5 ti U Oà U HMHK ^ Lu [Ü tì -i*i'•O ^WWW^i^iO
<«US§*
o" «r nN<?M-^ INI O M*r*S 1s * 1j -sS~fi
^U B ÖS S3 SB oo? T1 *ö M ^ o Bfx S3 .H p« A Ki «S o ü t» ü oüu
c»MÎi
>. iIli fia i a §•i81 lì i 1 * i
a * il * 1 f 1* e ^x x. 1 saá
.3 »I il 1 S *s «Selig. ia1
i i!- if i ! 1^ 1 lìII î¡iil1 § il Sa £ *« al1
5g 1 3 «S « v S 5«HU •< ivi a VO»HfHÖ-1
^*n^(in»og g -0 «B « <S « 4Do
^*!
i1!i1m
«o
oom —iin-^m^^inmifi-iorgora-<-HOOoo
ino om oo mio o m mio oiinoim—. — OO OO O — —O -H O r¿\ PO PO — ölO1 -f + + 1 11 II +1+ +1+ 1+—
(MiM~*^~HrM<\J~H«.,.,.,s
eeeu
uOOOOOOOOlfl
^iiniMmin^rmiAE
^1j•*
2 ÕSS«- - i.B¿ ¿3SE^H
-Ho"1
°No*o*1 »? *,<«f *: jf «r«es- s~s,Ã%
<-g Z 2 rg o — -Õ2S
rsiBB _ o; ooBm^H ^*ro-<in^-<r4
OUÜOÜÜÜÜUSiliX
V fi'1
! i I 1 i è ÕII II fi f|filIq
E: « •& •*'S. ¿ 7 * -r'S.?s ë s j §•. * Nfe5ii 1 ^ C,g. * - T 2«a"
._ a s « a 355 1 s -o1 -os« s s«ä a ,- l|sl à - à A? a M A- ¿ s^, te I* 2¿ "e- Ë-g e* s là e| Sg •§g-Ñ¡1
|I PI II 11 II It!ÖÖOÖÖOOOOt-ooo^o-tojfo^in
•o ^ so r* r> r- r»r*r-
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 12
190 CancerResearch Stock et al.
Iu
! ïa
lM
m in
Sisal!H
i
-* o110
-<+1"?
7tIII I+ I1 I7 77 71 +
o o
a
I-o
s a 3.n
o.n
3-4;tf
00O
°:*«,i«i»2
sT
^ì>
u
«r im •%
ië
^I
1ay
i5 As t. sufe V
13-3s
2O
iïS
IISi
i!~ H
PO a
?3 2i| Iil *SS I«S. 7su *
(i SE
«I
||
il¿s
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 13
Stock et al. Negative Camer Chemotherapy Data 191
¿ U S \ u
EPI!> H « P R< o a i 8
H
iu
&S
i«
3
ai
MÌÌ
!«ì
Öl O —«l' oo -. o dio
i! § i § S s §
sìs I* o0.8
S
8
S oO wu
<
§io.
§
u
O i iNS*
oh
HCT*U
<o"
S-IM
SBt^u
"Cu
°Sm"1o"
><
i i
s1 i
ai1U?|-feS
-"tÃa|¿
1TE%I2"5-£•s
¿I•s,S5uH•
Ii&s"xfMA4
Ii
i•e
§1IIi
Z u
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 14
192 CancerResearch Stock et al.
e;H
l
I
IM
Ì
u SBissa.i §ss> * z s §< u a i S 1+7 Ai i+ 1(1 +1!5
°-IÜS°i+| + ii+ 11 i +
S § § i
P.5
uH
3-
£~o
sTi/>u
§o.
o
«_o"
a-u
lì
I
ir«a
aäI2
ÃŒsI!8 ial1O Vfs
a"i
l! fi t!Il ¿III4. i A
11
z S
. Ãœp oI
fei i¿,£ 2
il l¿I SÌ
^ - aj ••*M
IIfe»
ShH
I
i
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 15
Stock et al. Negative Cancer Chemotherapy Data 193
III•113
iHO•i-i m ut -H m m mmOS
\ \ "*^ "^N. \ \\A
QH
hjS
*J (M -H (*> ÕNJ -HfMCu
O°H§w
SfrH
-3ÇO7> O O vO O OOQftfi
O "" O ^ O OOQ"N. m m m min1%»
i S2§8
aa1«go0<
5 <y w cy w w o>cyo»Ui
sTXo ; O MOO
*J O U vO • >omU
2 CQ so **^ 2 ioini? £3 üf" «T* I «T J"J*Sa 1 "L a tì- "S-*oA
O^^->^-<in-H'-<rsI2U O O O O OUUg
J.S S S1 5iI
îI ! .ilI 1 1 1 3. IïS1 à i i •tit!
! ! ! i HHsaf 1 . T i t S1 ïfïlgI II éâj aililgì
li $1 1 I |!|l(l<r-fMr-sOfMüUu
uI
1MMì
ì§o0m
m\
\ \ \ \ \^+
++ i +1+ 11 i ++lim
*n (*> *n m fi<*»O
O O O O O OO O O O O O0in in in in (^ tn^ico
>o <y^ t-Sè
è è èè<y
& o» o- o» a»<yi
i§oo o o* o* oo>o
tn ^ in in in^oo(*l ivj *-i tn t*ìcfi*£*****£ stf aTa^u
o^1 u"1 o o cTui
i>>>» X ^'NÕ^'ü'^* "^Ü
M M y U B M M MUM8 S S S.S^ö5*J
J J j * T J i i 6Ã-o>Ã- Ã- t? 'ï* t- •* f- P- 5•MS »HI ^- i¿a lÃi.fr»i.t
2 -S -n Jeu Jc¿ ¿S ¿ Ji .CCv a-3 e, z. ac a.,5 a 3 c,—¿A
Jg ¿5 ¿1 J_g J_ g¿1«'S.«5 ¿È- ¿9 «^ ¿'S» ¿'S.
5g £J £J Sa S 'S S § SS0
O O U ü O U
K .
u
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 16
194 CancerResearch Stock et al.
in in
sill! 7 77 7i ++ +i ii +t +-t- ii it i
rq <N|
fO fO Ã*l (*ì «n m m m
§ g § g g §
?É
*
E
y<
cyx
o-<
(y sr or O* W cy-c
cy o>? ?
cy<
a
Ì
'=S u
B ë
O
aT
ë
&
uB
ISU
uB
Ot?
u OS K1¿ >•
2 g
ylic
o. E 'S. h 'S.(;••§,P- •§f- S¿5 «« «S5 S £•>>5 ï
i3 i^ i^u o u
boxylHC1
J %
! IIO. » D. »
J B J 2
B r H B"Sa. SSV O O) «
ffelnemorph
s «fi7ÌCj -C
aff m
&o•sr-
Irl«
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 17
Stock et al. Negative Cancer Chemotherapy Data 195
Was ì
§
o.
; w S
uJu
fe 2o E
J H< %a£2 *°
o, S
0 0o oo inin oiin inin ino oo oo oO 0-f
1o
mi
+m
o+
+o
o+
1in
oi
+
In in
cy
bacyll
IIv aiä'au
HC
&!•a»•§.«
UI i|tu
Oin
Z
ias-v!^ >>
pn°in2L(^oo"1U
Xs
13u£*>iC
O)Q.
Vaffeine-7'-pyrrolidldK
SfMs£—NtT^i»M"^¡|C5a•p-Carboxyin5ÕNrtcTe
1.CB_O-CUa(A0^fiH0u"ordycepino"1sTSS^*U^1nltrophenylpuro.T6
-DiamineiPI(Md¡f>U^i9
">^£•§5•(Dlethylan
phylllne.Hin•^JHNOcTK,ci!do-4-hydroxyp
theophylllneS'a11
ui}^ä<\30r-sfu"1)
theophylllne>»£S•R
Uft°^gBo"oI0ItÃ
Ig>•îlO^jDdiScTS£§iuJ12=
0>¿2olAB)<•*u"1i1rx.thylacetamlde}g^||CÃo.°v*-t>n*oü~u1ikt:•¿:v*
ó•
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 18
196 CancerResearch Stock et al.
IM
Ì Ì
>< u S i0J°. °.l°."îfM
(O ^H~«O+| + 4\ + ^f0 011-*
mi +t ?rg «N-Hoi
+| +*-4O+
+-H
O
+ +o
-.•*••+INÕ
0*•+
+Or«+
lrj—MO"-«IN++1 +1 +
UH O
m m CO fO
r- o o
<y•< u
PQuM
or cr o* O»<
S
T
j
iI
6*
H
£
cfmmfv]*•*u"Îi951E
.,S*-/N-(Methylgluciamlno7theophyl«CIAodoo""1151_g"-(N-Methyl,N-ß-
theophylllneo"mNno"1|I1e-Methyl-8-(N-moitheophyllineX°HintTA
3a1iI&1ìs4)
^T!iHinvi"Ì181Eh-/Q-(5-Methyl-2-
theophylllneS5°Hino"ÃŒi5tjÃ-/a-(4-Methyl-2-theophyllineX°9HIo"1I«
Qrt3&-/a-(3-Methyl-Z-
theophylllne0;2Hin«T1IÎ0)u-(ci-Phenylacetlc
:«o
Xao"è|fei1Eaff
81,1tfj,HotT1IiS0SO"x-
p-D-Rlbofuranos0*Is&r0tTOJi."C-p-D-Ribofuranos
••o. z
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 19
Stock rt al. Negative Cancer Chemotherapy Data 197
I(tU! -Sttogoli
mg/Ktoxic50 mg/Ktoxic25 mg/Ktoxicso
Ingumacacia11
Sil! oiin ifìm e in o i« o ir> Otrt otn oc o o o o o o om o o oim o—«l^ O<M -^ra rg.-« COO
M <M M M NI NI
§ 8 § § 8
s a s u< •< < W U S)
HU W S S« « S m < <
«T
îsf1
3-
"ku
u
a
-81
li
ìt%S «<9
S 5 '
ilg? 29 S N
J•<
I I•a v¿ti
s >.< a
B<
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 20
198 Camer Research Stock et al.
i
n <
tj wa ^ a,sii!•
O tf)| O u-.jinO—
0 — —1 iN~111 1 +1 + 1o
m-HOi
+0
O0
7ino?
7ino?
7OO?
700-4
Om
oO-H
1 1O
Oo
oO00
7oin"V
V00o
o
X
g
ua
U
<Hn o
um
uffl
enCi
f Iin ta
55rf1 »__
O~
msT
zu
zu Õ
3
Q.
§U
I
S
t
=3
l
in
mL !
Es
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 21
Stock et al. Negative Cancer Che/inotherapy Data 199
•*•A. B jr
¿Ì!l 7 ?+ 1O—-« od
1 ll 1Ooà 0 O7 7i 7O
-•7 7
rq IN rg f-J fO
2¿
Un
uu
uuum o
u
a*o
2ed"
S
' O; z
o
5
ofiK
1
E
I
IO
ëI
t
fis
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 22
200 CancerResearch Stock et al.
in in m^ ^ >
< u s h— o o o o
trt in OIO OIO tftlO
O O foliNJ CJIfn O O
fi (*\ fO
un tn§ iin in
§o oo oin in in
UU
Hm o
ouu
nu
i
o-2°
"*
U
oz"
1S
i
s*00u"
XÜS«ti
soJC
- 3È*"*>a
M f:
obarblt
IIA&
o-
|
2
i
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 23
Stock et al. Negative CancerChemotherapy Data 201
s
K%
IH' 'S S •
*li.H
o
3
ra
Ss2
s§P. u
l
§
fM ÕN] ÕNJ
fO rO fO
ooooooo ooo®o o o o o o o oooJQtnmininininin ininin^
«e<
lM
ìoa
fi s ~°."++
1+ 1°.
°.\+1 11 10
0o
ino o"o tnooo
orj•?o
m+
?m
om o—V
5gt,ji§iH
»^
•£U
K2
nTo"
xnTo"
zo
sT6"
ëN
aT
i*
i.|la. E
tiÃŽIti-PIilss
,h*-esD
^•*"2I
eIfe11JH
V»HeVBÎ1if=
^_Q>iIfi*»
J,C^SV
CrC^Hit
¿|«1%oNÛ"v!ÌÌ
ilss SB*
s*
H U
11
*- ¿S ¿2 ¿S ¿|
¿ il || le t|Tw cal rt** «i** td>-
SIs ü
uil-oc
gE
i
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 24
202 CancerResearch Stock etal.
H
i
go ä o233 oe«m e« m
•Is*ìSiali
o o uìm mjtn inio oj<
dla55'-aSM
*O8fc
9O"a"•Eu
<£
oo«o§u0
«Son
Otou222-222222:22g§oooinoooooooooo
ifìOONOoinmooooooniVI in *•< In lìn V^ ^< Ift IO WS In Inins^Ê2.>
Q S S S S SQQ &oa u<M<!<:<:-<
««t
K
irU
s
«s
Z
irU
z^
irU
x**
falìfesff«
|s-RfeOQ.
o
Õ I
S H3Xma
cá° w
i
1
oÃ
gw
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 25
Stock et al. Negative CancerChemotherapy Data 203
lM
a
8t ;
unin+
+in
ini
+tn
m7
Tino+
im
oio miooI
+| 4- +| +in
o+o o+
1m
mi
+o
in+
+
»*l f» fO (*>
o o o o oo o o o oin m m in in
a a•< HmU
Q
Bsu
(_T o*
•È0~
«C zef
o>?
ii1
a8?S m
rj N *äS g S
= ^;
|8
JS
T3 ^3
:§g*
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 26
204 Camer Research Stock et al.
coJaë
îo0u1Mì§uIio0o1iomu1ìo ou1M1tu1I0«
>'a i 11< u s 5 8
in oin o7
fo
ino-o
inm«Min
inÃŽO
+o
o+
+o
ut*+Vo
oioin••amoo+i 1 +o
in00in
oom
+ +
fsl (N rg iM <NJ (M M
w H
98ft m m f»
ti »»«
S|
si
m m m in 888-i in M
OO
»IW U
U 3 U-4
*s~*-oo"1
mo"1 «po'- °maT
Bt
cTB)
cT
5O
°0
o_nTU
zo
o5B~~
ocU
%fM
U
in 3 £
1 l!Ãi i —BÑ 4-il»- ¿S-g|
g a§.1| sllï< < o. a •&
S1"
«S
il8 S
IN
li3 fi
I- iCQa
i
« I
liti
,
g4-
l•?.
¿Su t,od
IIil
•«
lìÃi¿fPIH Ko«
ffII
S S
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 27
Stock et al. Negative Cancer Chemotherapy Data 205
O w* Q
m m« •
> I .,< u 2
Ui4y3u
in in oj o mrg c*i •«*•**i o+ + +1 + +
in o unO <N| O*
i i +
IN) INI 1NÕ rg r\i
oo mo oo o m ino tno mo o*
ÕM IM
m :ino o
ta 0m ro fn M
w K
£§
«i!O 'u
B»
oa
hiJ<Sfe§ugo
uNAMENOS
.SogZ91O
NtrazinicacidmonoaOf*i£|4nBJ°oUoifei5'-Dibromo-2,2'-asif>c*
ttin
OZstt^
MU*1*
*a6-D1tert.butyl-4-(phenylazo)phenolfÃ&"C0aMcT0)S4'-Dichloroazobenz>•*00ff-*Nf\JUT00U155
go12N
T3«=•S«(2'
,5'-Dichlorophendlethyl-2,3-dlmeth]J"o*i°"cosTKo"J£aAl¿'"gì4«/4-(l,8-Dlhydroxy-naphthylazo)-l-naplacid,dlsodiumsalting€*kBnoo""i^1
—o-e2ÈZ'-Dlmethoxy-l,
r-bis(3,3-dimethyltrJ**ioiANtu'0Si6fsyl'-(2,2'-Dlmethoxyasazo)diplperidine-S°I%truì132'-DimethOTy-l,l1-bls-azomorphollnerjo°^
«Czs*zX
Xr*«n
m~*OOi
ëÎ
11!i?IS=3«
-SÌ1"5i-Dimethylamino-2-azo)phenyl^/triphe4-Dlmethylanlline-(coupledwith1,3a-1'"l
NS
£33e£^sToMU*>kgj1C-Dlphenyl-N
,o-c
formazanXSo~00tf"nUS
«1
3115'-(2,2'-Disulfoblpl
dlsallcyllcacid,telingo"00tfKUoÃI¿
!•sIffa75fia-osE
?" «SIpil•B-
us||iin1<^B*r-Uj|¿S">.8
•&k
8H
!mi
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 28
206 CancerResearch Stock et al.
IIQ
*
li
o*oBZ Q
i-'«s\s o < -o
¿III< o a i:.1«07
°oino
oooiin 010o-o|-. «si|7 -m
oimoo— (si oo
oO-HO
OJOOo
-«Im doinioINIod
«ISi
J H
allìp. Ü
1
i* 5
O
<x"ino"1
o"CtfirìcTtota°MtTcffizsT>ouoMKaT9«o"o"msTaToÜ"coo"(^zeì*>AO*M_0°^r2aT<>•ci*QQo"iM2oaTroiT^>aTo»U
a
A .
Si' N
S^L *-•
¿-S9,as
Il "!O.
î
l «*-g
il
s -s
"'S?
s SIli
öM
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 29
Stock et al. Negative CancerChemotherapy Data 207
Ia
Mi»I !
s i£ ìrI I§ §
M
Ì
? Tfȓ-H4-++ 1O
OO —•1 1<n
-*+ io
o•+11 +o
o+rg-H++-*
oo «nr\JOi+O
fÓl-t+11 1
rM -JD fM rg ro rg rg rg ^ rg <M
OJ <*>
a.O
ou
<£>o^1
ff
ff
Oë
17,
o
i*
>,
J.
tiO N
11
11<£
¿IE S-
hli
li I.< oi.
O
!¡iE S
o¿5¿s
1
rtË
I
g
afs
i¡•33
t
a¿•ol
i
S Ssi
II
f
11Si¿=5
">> rt
II
Õ
fi 1§e diSa-S
SI
? ?
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 30
r-.-:,,208 CancerResearch Stock et al.
coMaH30*g
5 > o-o-2Qco.-•
wa \..to -e^o~s2 « «jg ° *> ° ">•"¿
a21i 77 77?<o 2 i SHa
»M fMfMUPCM
QH2 <omg
gKw
-3§75o o o
\ 2 5^o
<co55Ì52a oa,oK
w2g
5 5 5s 5 < 33o»«sO
cocoS 3" 2°sUGmgaT sfsScT o"<jg
-: :- t18f*00>.i
îïW¿h¡IIIevi
iS g "l*II
ï iSa i«¿2? o gSVS si 1
il vîsfM^ ^fi
i„sla1
IIo
oo•3 5 m "5 jrt y)JA^^\. *N. "V. "^ \^^*
o tn tn o ojo oo * m mio ,no+
+ |+ ++ ++ t|+ ++^i
M M (M (M rgIMr-
f> fi ft**><*>'*>¡lA
O O O O O O1*0 O O O O OOinin in in inin3u
u o Q u < w*1st03
coco°* om i" «i"o*
x 5 ¿^ H, z_"„,g"o- a"" a" scf a" a"" a"
o a m 2| * 2—o* ¿T o"1 u~ tT tTuó
„1
f li 4 1Jls
! 1 IH Iu«E «L . BJe3 S " 'S.-* 'S. """i^VBID CIIi i i? si in£
t 11 il li !*ia1 ir V'Sr'S.sgsÃil
ìi! !î!Mi§ v M à i ¿I S'd!fMZ Z* fM 4 fM" 0.0
0in ,n ^H in^+
+ i 11+'fM
- -MfM<*l
co fO rof>§OO
O O0 O OOin vn m minm00èu
tew<h W <Ur
°rj.rvi
ojenenU3w
O OO2 ** z°«**_s 2adpT
", "ÎM *oà 400^^ ^J ^^^o
o o uoë
¿»S^,itsË
5* V« A |KD.i fi 2-îlt1I ? è I1-, II |«:Ì^:
1 f* ¿S'".1Ilg1
I| ÃJHil!S1 fil Iff |I x
:1 ? Ç* ?I3 ?!1i8 m 3-* oo«o.û z. cr E
IM" M •*" 2
i2 o — IM m
I î l l
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 31
Stock et al. Negative Cancer Chemotherapy Data 209
E
îK !
H
O
;lll!*ttSSü!
uu
mOO
O+trt
»n0oin
oo~io
m*+7m
m*+7tn
infOfs|in
o+
+tn
ini o o i inoo-<[*i öd o
+ il* +o
in i mm-¡ölo o
1 II +m
mimooo pJoi+1 +
fegdB2Ä
-9
*ï>w
"3§t>0 O O 0 O
K o o tn o o"^^ »n in »ninÕ!|Õu
<_53E~*fc
SBS¿Ea
uB.
§ U . UUSo **• ¿- ^ u"»OMuggOO
O O 0 0 0OOO O O O —tOmm m in m inr*ÈO
P>o
o oo o oin tni/tHU
Cd U
u
2-N Z Z
u•s
ÃOZ %
sTxO
tT
«Po"
lixz
uttÕ81
u i
2u
||
!l¿.gs s
II¿^
is
1T g
)-p-
fe S
is 3?! îSg Ã
fi
2Ã
i-
C- >.' "a,z •*
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 32
210 CmcerResearch Stock et al.
a 1!!S
4fe
gOt- o o oo
. ^ ~* in -• in in ~< -*mOm o" -*" —" —« o o r*joZ
QM.
•u S ^„•""^ — i u oo oo oo oiifì o in o in o inino;>'S 3 c O*-« fÌO O -< O O* -. -« -HO -HO O—<
o 5 £83^Hfeio
r^«nQ
¡d>.M
^5§>>ooooooooSiomooooooÕÕ
ï*fc2£
8ssguo
^ ^wSo
<-> w S fa o «twwoO«uI£
<M3^
«, "* "« o1" 2* »"•om<izT1 o* _•>•z z"1 z o"zo
o oo Z i« ^ o •*~MrtfM^J-^-HÌSJ^H^S
SS -^SSSSS-*cos a «o 2 2ìa&-i«eoM-if>J —^guuououuuug
filalii¡ filli!'S.£»i!B'Vi5'«I
i 1 x 4 : -TÌllìllfllljii L! 1 l ti 1 itli
I | II If 14 •I-fl ?•¿i |i ig ii i uII i II fi gìal iI1Q.
<S Z" Z rii Z" W-i«I_Q
oo <r o — *NI m ^inÌzlì555555o
ooin —* in m m —«^*rgO O "H O POOin
in oio om ino o m oooo-H-Hrgo -^o d*i csd -^o*-^df>j
—i -H rg rg *Mrg"H
-H — -H^^o
o o o o o oo o o o o o om in m inin'S
S S uSS*.
iOÕ0(M rgrg2
Win %» ^si "rgO O O w OO"C
"C \ »O| "Cs¡ü°cT M Q O O O^
m"1
I qj :?iìg a *Zo« «) on—ff
1 SfiIIf! ! l*[;rsâ S &frf|l| ï ! . lm191wii ¿ i f 1 11I!-eS? | 1 | 1 IIil3 3 §"1 5 § "3 s 1 3 S 33 ja m •§ ï. to s 05 a œSw
m M o. w <M«M,«
fâ„¢ OO O* O -HCJ5
Ì*.!Ì!1
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 33
Stock et al. Negative CancerChemotherapy Data 211
'0O>|o
oomo
ommo(Mi
io
m•-iO+
io
of mm-Hdlr-ior
+ +in
oorg+
im
o001o
o+
to
m-4OI
+
sE
M
O
U
efGinX
S1
l
W
dPff
|aifBu
*
aIX
II2 s
I!I?mas
' 3 X•*o* t)
^2•vl8Ou
l
l3ë
SH
la
l
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 34
212 CancerResearch Stock et al.
IL.
iM M
ì
moor-ji
-fin
mioo7f'-rin olooo
o|o TOO^
rȓ+io
m-iO+
iin
mM-«+
+o
in7
VmofM0+
o in-«o
H
UU
sinÜ"
i"
rjU
o" N0fM»T00cT21u1i?^ic7ih«2aTr-UiL«1ii~ö"2sr-Ü"t^m*oo¿T0rjK6800o*
£m ti
u
tS S -:
fi l
l|| ¡
ill t? 4 o M
ÎIÌì
tH
•9-Q
««
sä
au
ig I i
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 35
Stock et al. Negative Cancer Chemotherapy Data 213
9B-iB
•<U
OHOo^ in — in in -«inO' W- ^ o o ^iïï25
Q¿8
"+"+ + ' ' + ? +Ã'1*3:
*M -. rg rg rgrgeld
w 2 2 — 2 221k,M
i90?"> ° ° ° ° o oQ |B «9 o o o o ou\m in m in »nineB$%¡itn
wilA
üz
u^juSEW
MU,Uso<w < < S<s«uou-,
in m m —"m0
O -H ~H 0-HÃŽrg-^
rgo OiN OfMOO Oii l t + + + i ++rg
rg ÕNJ rg rgogfO
2 2222o
o o o ooOO O h- OO•—' ui m mm«
0 ».".u
m H u u H
6c-
H33 "b
u
g gÃŒZ
!»B!
i5 "4*
S 3
HU
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 36
214 CancerResearch Stock et al.
i-i
l 1
o uz a
en;ws ^ Å“
O < Ã)•?: X « S S
in in in »n in m
O OJÃn Oin of oin•
M +in
inO OJO Oin oin mo oo oin i/i i o inrOoto+
i1 + i(
(N4 M rj M <M
S
a ^
<i- ?to w
ȧ- u
~ ugg§8
NU
W<
Uu
Uffl
o.u
KrM
^U
K>
o1«ou1
5IM¿!W«
af
9,
oo.
Iu
NAME
II
ethyl
iII-ifi
iI1Q
ylam
8-DibromothraqulnoneDlbrom
£ •*.*
-Ss
E1
îÃ1»'7
c r
-S
a
i
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 37
Stock et al. Negative Cancer Chemotherapy Data 215
3a<attUJMSoM if!MÌ>,i1
0O0
7inin IooÕ
?'° 7oin°
?m
OJU-!o7
7Õ7 70
iAr-j
-H+
+ID
mOO*+
+0
inj 00-;
pjuru+ i'i +oinrg
oO0o"
rgoo~H
O
rg rg <M n] iM rg rg «M *J rg
8 «Õ 5
9,to'•mO* \o"
taOO
Ó"
s1u,
s
o. „
i! *
i!a3
>,e
1!S
Ì
I
ss
•-<
a
-JD
i
•a
i
¿
I
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 38
216 CancerResearch Stock etal.
•wBsiO O0 0-• (M
+ 1^_:+ t0
O0
Oin
o*j-i
+ io
o?
7O010 010Of»Ì-*lo -*|J-^+1 | +] 4- +tn
o»NI-^+
1O
010"4
OO+
1
f^ fi N ÃM N
§ §
il
H
UOu
u•< H•<
NU
NU
S3*
^ f i60O
°0
it I
I
1
2§U
i
i•
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 39
Stock et al. Negative Cancer Chemotherapy Data 217
«
§o £•
33
il
a; $ linm'r+ "+in
in7
?inin+
7001
+o
in•??in
o7
7oin7
7*+ *+*+ 70 01o o9 ?ï ?0Oo
o
i«
§ § §m m in
I
2
E
ilu
UHU
u
uNU
i
o(M
Oo
»"*
o"
O^»*
S9H
Oti"
tuo"
O^K g O
u
K
£3a g.52
Ä1
If, 1"x-g.5 ">•'S ö» ^
§C"3111!>a1"xHe
2">,C«
0f
1£SII*^—
S>>T;CM0"ÃŽ3
i«111
1aCJn_u
U>•S"ooi>,C10i
-r Z K4.
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 40
218 CancerResearch Stock et al.
tt -S
Ì Ä§ s
s iis
sgO H5= Q
co
S °< 'si!< o 3 .
o in m m mio in o mio oo mo oo 00 oiui Oin otn oin «no-* -+ O O* rvj fNJ O* f\î o'Io -¡ -î o' f»î —" -H" 00 O -î f*J -^ -• -î -« O -H* O*
il NU
NU
§ OaT
cof00a"S
u
°a
X
1
l 0.
"SH
~ aj C_-s ®al^J o-
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 41
Stock etal. NegativeCancerChemotherapyData 219
siil
* z «2•s ™i> * 2 £< o S i
W
u H
i«2; i>
'I
C z£8
inm+
+o
o+0 0m m+
io
mi
tin
o00m
mo inmo+o o+m oi
im
ini
im
oi
io
m00+
II w cgm
Ou i a u
ii_o"
s•*o"
O
sou" s
ocO
i ÃŽo **im O
is- «r
u
i
hyl
'Sanlneamlc<S!.Sg,SiL-AlanylgQ1iXulJi
¿,<db12uRi
_tjiAminocape9.9*X*3S,aJ3"Amlno-4-thlaadlpici1w"oN11coAO•S-oliA§
•9s1¿>osu"Amlno-4,
acldfsloOaj||rt1
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 42
220 CancerResearch Stock et al.
ÃM
ì§
si
S^ M
I
u S S *> -1 »•«î—"iZ£ 0 ++ +1+ ++B«!ûUJUS
(M rgÕSJU>x
Oop ^rtilU
"ö§>> o o o
M Q Q ißin inniI¡Iil§
wD«
ß UWSow < <3
O -«O O OO++ + +1VJ
—t fM —«*>
f<i cor^§o
o oO 00n m-•U<
W H
o o -«Olino —
ou
gMpmiCALFagCOMPOÕ£?n00o"11!i
jatfa5
,-»CV1^
•£ï•Oi"i/*ï"
eoU1äS!0Zo"iusII•bœcyethylauTrvl¿itnUI1LOCX1¿|uilDO€
"Cu"1SaUIuIMo*
o"f*4S5^J
"4»C"biuui1411I
i!jCo"s«sT*o•>!_rtoroacetylp_oZcTC12H12C12NAf0O)1-4-Dlchlori
laraglneH.ft«zsTMcTJL.1III-~"tiQ
rt,uCÃŽ-
rt¿fi0sfo*
U/rosine1SCsTo"~ciI¿*zi"x"inf0110)"methylalaiSz"Mo"msTIS]u'^1Mf"3S
"§•t-
o"Pi>ï,ïaCO.ÕSJfi»CiphenylglycSe*
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 43
Stock et al. Negative Cancer Chemotherapy Data 221
n¡¡a-S
8u
31
v
1
Ilo'SÄ D
GO
liliissi
H
i
mooo+in
O-•
0+mm?
?moO
-i4- 1m
mo«o
inoo+m
oO—'m
ino—'
+ iin
m-H
Om
oi
iin
ini oin0OJ 0 0m
mO-•
+• 1m
oi
i
fe 2°Hm <M «i fi m fi ro »o »o
Ãin in
§ §
q u
ililo
j?<
io
i g i«T
2N i O•ro i i O
2i
uB
I 1a
gss¿i•3a ia jj,
K 13
ii
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 44
222 CancerResearch Stock et al.
o-Ss75
O oin mo ino min oo mio o o o|in o oIM -"f — O ^J — —t r\JO —. —•' OJO
I II II II II I + II
mi o oio
f» ro O «*> f*> ft
i a 8 § §
Q OXu
ou
ti i
ISu
iar-u
JO*
U
Ãœhi
£>j tu
slI
jo
«
o
JQ
Si5
Hi!z a A a
ì
2 i
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 45
Stock et al. Negative Cancer Chemotherapy Data 223
lM
«iìi:>' i U 1 e
< o S ü8o ino* o oiin m
N -ÕÜl/l000*1\Ti
O—
«-H+10
0CNÌ
-:i imiA-H
Mi
iO
ift-•
o110
tfìO-H*
OJIArvi O
olin-i o
§hJ
i16)H
i o i O O i i ieT
fiO
i i
H
l
ÎT Ifï -I! I
i
I
Ivo
I5iI
I
1
SI
1
!Ì 0 —« IN
1 I I
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 46
224 CancerResearch Stock rt <?/.
LO LT> O inod rsj -^ raO+O rq1
iOO1
1-°o -•
+ +rjO+o oo o++
1
o °mzmc*m
OD
<£3" 2-
sf°
(*> WO ^
rsj O*o a"X~ ri° ao-
! « frLÔ S
a ^. i•o T
6 « f
no-ß-ilophe
Q< S
S
nlt
g1"o1Õ1NO¿'S1flè11f"1"cIÌI110
«J2
o5 N¿1Ul*Iß!ti»n
-,i^2"3CNesM-0)31S11Ã iie
"
:i co
5 ? i
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 47
Stock et al. Negative Cancer Chemotherapy Data 225
O W¡=Q
in in
H « ?\S u < •&'* 2 « «!
< u 2 i
inmO«M+
+o
oco—«
+ +0
0—
1CM++o
mr\l
O++O
if>f\Ì*0*•f
1O
in0
O1m
oOrg1 -tm
utO—+
+m
o7
70
0o
-»+m
m7
7m
oooo
mo~+
I¡i
PO PO
in m in in m in m m
K w
IIH
U
Uo" O
Uuu
ÕOa"00
o"Ã*j
Z
msT
isu
ogu
Om
55"J
E*ouJ1"asf
%oU
111
Eisi|izsv«utsg">,sIm
i^Vg
*o'S*Õ1dinitro|'S00i1E1vuBromo-i
mc0JZa•S
oh"c¿_0rai'Sx£«
5EtOT3C
ÕOo»r.=
°lìl
'Sa-~u7s
¿-S°«;Õ!cC§ì~£Bromo-
butyropj»11S*fa2fr'S
aÌ?OA•3?•CEL
¿h?^Bromo-^'Sfco>oVICn%§•>,«-=-oco^oir•DC3OO^3•^5Zfr«WoCl1(-."ni
coBromo-i
«
>, O)8-8
1
I!co
I3
Z ^2 «o o.
•o
I
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 48
226 CancerResearch Stock et al.
o,
M
i2
o o om mm oo oo oo o" o -i -« o o" -Ì -J pg -4
m oo rg —
oo om om oin om m-HO _-. r-g ro O OO r\J O •—<
o oO -ì
fe QÕM fi fi ro m
§000000
m ifl m m m in
Ou
H<
Uu
U<
o
SO
3ü
w52nT•NO«¿Isu
j3SJ£ì
^11r1rgChlorophenyl-draxyphenyl}-¿.Ã^d°•4>%sT00dTi«11
7 =3^«i-Dlacetamlno-
4'-dlnltrodlphm
Vmo"x1utfvKu,K
V,amylpheni'morpholin:-(2,4-Di-tert
nltrobenzoyl_/'<liAiXr*h|tÃ*u•?>g9'-dlnitrobtt•Dlbromo-4,4"dB"_•*OZ,f-aTNUtrobenzeneDlbenzyloxynlinNOmzÃ4Cf«o*u«lonltroethylbDlchloro-a-1-
:oholrf
"rtmo"¡cfc.e>U"RB-nitropropcDlchloro-l-{2
nzene4-J8(M*O^ÃgV-DUDCus•¿N•x*,13°Hl*U1g^3"oSADllodo-4-nltr«0ti¿"*VjaT1inUAS1i•o¿Ì-Dlmethyl-N1-
phenylenediaz
i.z"
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 49
Stock et al.
o£S S
Negative Cancer Chemotherapy Data 227
11wÕJgSoaBSSaì!iaiig
seiisH
iU
mm00i
iin
o00if)
O0
«1o
oj inof>öloin+ 1+ +o
m(N)O+
+m
inON+
im
m7
?inoo
ooini ininrj0 -I<*+i 1 +O
irti oinv
+IT iinoO(M+
i
N f»
8go gZ2
w ?
fi m
a|¡i£8 es
H<
Z•< ^3M0
(45
0W
u
%
O~
0A-O 2
ù°
20
> z«M M
1sif
x5oo
cT
°„cTK
(*i
tT
>•
i
1 S
110
I4>
•2
? »•*.gM 'S
&Lh et? g.»i1 O.
s
&i
AI£s
P£5j•*apj
èo
I
DlnltrophenylnzenethiolsulDlnltro-m-ph
Iìs
4-Dlni
m-nltropl
3 - 3 xQ| Q|•<fï <t 'S
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 50
228 CancerResearch Stock et al.
l !! ! i§ !
o iZ Q
in »ft
0 0d 77 77 ?? ?+? 7-7'r 7+
1.vi0
au
N Pd IM fM
S
ë2
o SZg
<NJ CO
O OO O
in in in o]§ § § §~> m m fì
§3E
2§§1o
H U•< <
U<
CQm
(Ced
0taJig<c3°fMcj"o"|o*
UDOsfO*cTa"100u"<£B-T00tTN0"%u<r»""o<-TÕm"1ocTJ-u~M<Tt-Too*«V5gT.="u"
o00
oo.§
u
u" 1
S
t1
II T
tss
1 'S •§Si
ti
I Ia »a«9 £in "3m"
¿i~>.3C
fi Õ
al i5 ^° £u u
ay
«s
gì il11 ll>•« pï-^Si Ko1
•fîi
iEsg gis*!«i
2-nltro-be
hlorlde
acld IodoI-dl
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 51
Srock et al. Negative Cancer Chemotherapy Data 229
M
ì§
6M
ìg
o o
1 17 ?7 7~+ O<*j "MÕ """? 7-. 0+ +2
2- _:_•_:00~* om
o
+ 7
ni M N m
f*> <*i
e. S
uX
O,o"
o 8 iozm
aT00
U
HNu"
U9
ziliitic1i-rr*.5
'1S ó(cil
ì>••=>aJS1^•g^J«sir-•o* J 7
allSuS >•gfe
u u 4-"mS
m$
9r» i««§i-20)I
Irnr-~ao>
^oId.
i>,ìVifiIAfCJnitrobenzothlazolivO*>,2M«§ifinitro-
1-butanephi
lylester¿1
fi2<4«*ìçrophenyl
Sulfide1
oS33"!ecarbodlthioic
acethylester,tries
'horteacide
>,£•fl
at aliaSAÃ^O*ifìfipphollnyl)
ethyl//.amideo
e5;4)¿1
'>JA0mICo.rphollnyl)
ethyl/o
«a|
•*I'?J2inuSilinyl)
p-nitroacela1^iS1S
us¿•n
in1gg1o.
¿1a>NitroanlliD.X1i915
tlMS
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 52
230 CancerResearch Stock et al.
Ja M
Ìs Sa §£— in
T-* o1 t +o
-.+-Hrg++O
O—t O1 +0
«? 7-H O•~> 0 -« ON—+11 + ! + >N
0+10
— «M -.—++| + +| +
ÃO N
o o00
in un vi S § § iITI tft ir>
§ §
u<
u
o
\o"
o
O)+ MOu *.
x
u
z
«iïu
lH
l S
l
t;
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 53
Stock et al. Negative Cancer Chemotherapy Data 231
1M
•3 «
ì I
5 i§ erg m
M
ìg
m inà >
i/ìO7
7-oinjmm-ÃŽdo+ +1 + +0
0(SJ
Al+
1m
o|ooO-^ rj -J
+• + -f 1o
olo oioo-^oÃd ojo AIo
m7
7O
OjO lA. tf>Od -io" do ^•f1 i 1+ +o
oMrj+
+
(NJ rg AJ rj (%j pg rq fsj t%| IM
f) f»
i §in in
< Wu
O
€X(M
U
i off f
I Bd-
fa
X
Nitro-m-cresol-i1H1Nltro-N,
N'-dlacet|">>1¿.Nitro-
3,4-dlamlncm4Ã>ÃNitrobenzoleacid,lichlorophenylesleÃi."Nitrodlphenylethert1u1Hef
4¿
gfiINltro-4-ethoxytoluÃIS)Nj*
üi,ENltro-2-furaldehydi2-hydroxyethyl)-se:in!\Nltro-2-furfuryllde
dinesulfateinîi(5-Nltro-2-furfuryli
-amlnohydantolnZÃŽ50
03B(5-Nitro-2-furfuryl.mlno-5-methylhydsZI5"^m(5-Nltro-2-furfury¡.mlno-2-oxazolldoniZci1NHrofuroicacidhy<im
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 54
232BnSKh
BOH ood
S Sî^zan^
H S ^„lï
™M 1 1 ° ?7<u e iSHjyB0
0g-B2Iw
-S°Oà §i1B
Ka.
uI
0¡1
«?S»Ou!à a
o*ie ¡**15-fUUUOi
io gu S!u
a-3
^^jZz
ACancer
Researchu
à SA
cri1
^£5§
1I0tn
m «n in —'minmmut(Nl-nO-^OOOi^O-HO
—O OI-M i-4l«4 O O O|— i —1 -\à M«|iH fM ni O|O "ï"J2
2 2 îî 2 S 3 S SS¡u§0000
oooooo o ^ ooooooinin ^^ in in NU in inin•-3U.
*H O < O Q O U Wü»
°^m»O
fsj <*J rq Q fg O-^iviOSSz <*>2x�4PS5Oz*^OTZrjOOl*55«>a!<25--¡zzoC
2 i i 2 î = € €€cjx¿"o"c?o'o*u'uiofili
!'¿ 1 j ij TS-0S
1 ì1 I 1 1 «î!
1i !iii I«i 1IOO O O e ° S* ° ; , M O5¿ £ ¿§¿3^ S^Ãà ** *1 1 z z£lS2 ?fl T si¿
¿X ¿ A3¿.rtA A* ° ¿. ri,Stock
rftfjo
ooMtfl MtMÌ*Ì^T ^H"O*"!rvj
_ â„¢ _' di oOrg
fM MMm
*ì 2«§o
o oo ooUHUH
« -<<î
¿ ¿ 3^ Z ZZf*>
O O O
O O UUulili•sili.-T
*ï*wJf
t ttSii!1I fIi
T> S ?z!" i i f
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 55
Stock Negative Cancer Chemotherapy Data 233
i §in ~o
°Hi«Z Q
cocj u S^ „Elili>3S11< u a £S
u3u
in o in o min min o o°*
co
o 2o'B2 U
a
§ § §m in -e
co Sa
E§o. u
S3
è
& H
¡IS nOU
U«
o1^sTCO0*°"So"
incTm1io1ft*s?1Alo1*,rgKtT r*JÜ*i1ui1uo1sT|wsTmo"
S
*
i §
*
8rj
S
a s£N rt
! if I: I
ii1Sa
2Ã
£«ItM
i
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 56
234 Cmcer Research Stock et al.
uI 1t !o m
tn in
rg NO O0 0** fN]fi o•f•-HO-f 1d do o^ rj^ rjfî OJN N-î «-ïli-îdio
U
o
Ief
i
tar~-
U
O
|X
a-f>
l
Io-terpheny
4-N
:J䡧•
-Nitro-p-t dichloro-5
henon
4)1
J3"o1OtlH5tfM0)13¿èi1
lAlOC1¿¿1au
"éT18g¿ìi.1'S"C1a7¿fit'SS
|->û-i¿I4
fr
l
!Io V
e g5 £
l 8
IA
!>*issEl
nltro
=5
cryl
|H
apt
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 57
Stock et al. Negative CancerChemotherapy Data 235
1i»>Ron ° ° °o5
â„¢* ^ in -H in in~HQ
3 -i o o~ o" o" o"^Z
QGQE>
n •—V M "~" "* 0*1 o —ilrj •*m OO —ioorg<i
5 s ££ ' + ' ' ? + ++ + i+H:
-M ^ fM rg ra roNU09zgìm
« m mm«1O
O O O 0OSS¿> o o ooooo
W P iti in m m in mm5<U
t^ CO-^cowSi§
3;§0m2 e Ed
§WUSS<QOSw0u1h
ooT>o fM mrja
t o o oos€ C C £ $€1l "I t ï 4 ÃÃOU
U O O O0*Q"I
! 1 i IÌ*il
I !ÜáI è g à i g¿Ãáà s*¡**sI 11!5
1 I I1 If ! 1 Õ11
I!!§§in
m 2 in27ïo o -*" ì*ì o*o".
"Î . "Î **Ì°. "î"Õ °.°. "î"î "ΰ.orq^H(M —i o o —i —.1—• o rg Oli^
+ ++ I ++ +1+ ++ilra
^ - N ^ ^*o
o o o o o oo o o o o oom in m "< m m»-H§£0
Uww o <y ta oo8*Cj
.jCO
QQ ** CO CO O O<M (M O M m COfi?>
Ìb ¿^ ^ ^ ZZ33
A ^ 35 53 33Xu
u o o ¿T ouI
¿BE -, gAS.!
1 1 l 1 iI1! I I i liSiii t t i 5Îlii rt o **^ e »*ìHJ J C C l B 1azz i ¿ f fîfiS
's SÌ B« S "f ti 'S s Etj f| f | 9 ¿ -1-f
S R I i i
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 58
236 CancerResearch Stock et al.
S"7
MMì
ioo00(M
msPOH
o oinOM îï o~o~ o' o~ o~o-Z
Q¡aSili!b>*
m B M "" "" ^ "* °° °° °° "*°org•<o 5 i¡8ur\Hfq^r^.0-1
—MSHsiH
M *••M m m itMoH___-_,§S5«Ico
\ o o o o o o oOK o o m o o o o•* —« (M m m minI55
532£
Oo,u8QliEn
u u u u u uo0Müi
?PL«irg rg IM rg rg rg
^ w^S^^^^CvS'^fOOsinin^'"H
p Z rg —. rg fvj rg rgOD X X X X X X
X «n m (M c4oU
O U U O OU">!g
Î1 i* -!gf 1 1 i «*11Sti à i ¡Sx?
8 11 I 1 7 § I1S|| 1 1 ¿5 1ii
41 4 i? al i•HNcvS ^.SÌ-WQ.^**CCtT crt -«£ *^u Jjrt*-rtVUn VV 3al 3J - 3V0)0}?
« B « S «B TE «STaZ
§ "* ™ So
o o oo•\^^'^^.-^"^'^."1^OOOO-'-i'-iO^,
<*> _; _! o o ^rsi O<-i do do^|°1f\ìiNj^rgr«|f*4iM—
«r^i^fO^rgmrOfO„^rt—l-^—
,—t-H^§0000000
o o o o o o oinmminintninin0^«.sUHUHMHUH5T.
COCOo cT<"o'o1ó*ò*'o¿5cO¿¿¿¿^fi
f*J ^* ^ ^D ^3 M i^r^rtlZrnt'l'^-^UBtajoBBWMjf--H
m Mr-tnifitn*UOOUÃœOUUIf
| 1 |¡Ã
Õ^ 1ì*i I • ¿ &îi B 3 J= i o « a
$|jffflliti!
ìì«!jWgïh Ü U "^T _ü¿ASiilliminmirttntnm^
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 59
Stock et al. Negative CancerChemotherapy Data 237
ì ì§in
in ojinol
+'+ +in
o+
io
m7
?mtn7
7moio ojo mmo+o m+
io
in0-Ho
om ojoo77'"* -j;
r* m
(M M
in ift in in§000000 oo
o m o o m o oo«M m in r^ ^ m ^
OH U
8
E
uQ Q
oÕOn
os? zin
f>J
M.
os
I z* cTtfìzo€ff
WZ
to
z¿r^
u
85z*r^
B*
¿Tno
COMPO
NAME
l"ÕÕ
3Sp b
hylanilin
myl-4-(p-dimno)piperazine
Diethylcnobenzal
g0
myl
caiperazinethylrazi
Õ- l'. 7, ^Z
S£3
T*« H
v os •§.—' O
iE
s ¿*
§•Se
? iìl¿'S.l4-¡I"
8
Ì|ög
flozz*
f
Ì"
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 60
238 CancerResearch Stock et al.
SX
O H. <
O W2«
GO; w S^o < •o: f. ai S
•H !K I": o S iH
00
0-??7 7i i0 7_• -
+ i0 7t i0 71II ++ +0
01+7 ?|?
w-3
gg—o
5o
cyo<Q
O in0 co^r
g3
MS
1
E
O0.
sfM
U
>.si* Õ
¡lsÃn i••sa =;
—
ö1finu,-»,•^x1"5.
ii|«^2
SmS. 9¿PS?^n00OrtS§ff^1irt2
u.>.m
,i1-¿51^00afC>]Ulrt2N1
l3n
i'S.1
ssOS
^iBachloro
c:
tÖ-aV00*n
5^
1>0"aÃŽIM
«^ro¿TsS1usIfi|B">.C3€Isl3N£afurtS3fmtE"£|O•*JEiCD1fV)ffi^oShf|"oÄQ,1¿*2m^09(NI*$>ts*MU8o">,fagca.5zz"cor4|K*US1Naphthyltö
giu $ 9 $ $
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 61
Stock et al. Negative CancerChemotherapy Data 239
SSg o
SÃ SS
S S
i i
•iss* iÜ8HÕ1
M
O
oin+
im
o+
im
o+
+O
OjOO+
t ' i +in
o+o o+
tin
m+
+in
o+
7o
oi
+m
ol om+
i im
ino ojini
+' +
M N
O w(*ì ro **> f*> m »o
a
oooo
»TC*
U
ìff
£
•i1AA
S—hX
*5¿i&iim|1 sî=11i•*rsìIi—
10-^fi^Si1I9jPI¿
1
I1
1s1«
£
s
£i.
g5
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 62
240 CancerResearch Stock et al.
O UZ Q
_ ?.'SS1
O O
oà »n ojod|d Ho*
1 11 10717 7~ od oi i1 +0 07 7+ i+ °1
l
il
<\J *M
a•y
u
l
s«'
l
Am
gffr*özaldehyde1"1|D.i1oïliEkffSrgngr-(ffOUi-gIHOts•oi1m(MCcisDUrole
acidIgBVUIMZMUchloroacrldlne-oi1•4tfOt?gK3r-Uuchlorobenzoic
atINIgE
<c1yomZ^^umu1ï(2-dlethylamlnc
.HCl?!§
§li<»i.-0iro[ffODOig3-dlhydro-6-me
1,4-c/pyrldlnef>l0
0CQs
fc<g.1Q*r-|Xu17-dlhydroxypte<c"ÃŒs<l
IM
:i
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 63
Stock et al. Negative CancerChemotherapy Data 241
Hça
2 a
. < o «-g> * z £§<: o a a u
in mi o olir»oi
l'i ii io
ini o o, e mio utin oin mi
iin
oioin7°'7 ?O
Oin inin in
5S
(M PI
l—) W
El Ou
ou
o*a
ou
hJ<U
e~H
o O
S?Z£ tfè"
i
fiC O
1!4!
fäs
£ D.p '
ti
¿I0) lS '•
Saa1S
l< jT
1
£
<
fl
1
l
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 64
242 CancerResearch Stock
I
X
ie
<au S
SSzo
u ™ 5 \ Xr o <; T3 -.* S5 « A £
. < O rt -g> * » £§< o 5 i S
oio in in m o 010 mo ino ino ino oo in o oiin 010 iniin o o-*|rj o' O o' O* -<|O O ^H -H ro do -I -< —'o O O O o' rà lisj O râ -Î O
iJ-o
¡i
1u1OJfOC8
oièag_H*00UuIophenoxy
ethanesu»nosodiumsaltl"o
'S"HiaroO
N1HoMU1zilIIIIli
liIOIcoo"z"Siuuïlophenyl)
benzenei*2,3
WO.¡9aKNh»0ö*èlAminophenjfl)-N-i
iyl)-amino_/ethai-S
ïi^ty,tri
| ÄO7'
aNtfì1M^ai*uv11fiI1111Orv]%tau9•sNnSs
5ophenyl-5-methylcaaMr-
1Nz1OQ
SÃU3H43<M1|l
O.1§1
<Ifì1o1¿Tl-propanol1i***O"ff'
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 65
Stock et al. Negative Cancer Chemotherapy Data 243
l toS
l! ls«M£-56 "SB
g•ïïort in
< o 2 ü
in o in o mio ir,jir Ottn iniin olo in in inlo o in oiin ino oo oo inoo m o o d| ^ o"|o —*—«NI\O olo —<-^ rgl—ìo -* ^|o —*es r«j-H r\io ^-i^4
rg nj IM rg
ou I
as00
»ir,U
acoo
Moo
U
=i/isToo0*
OO
ff
afi¿T
2«"
ir,u"
zhn
ou
*£u
Ua
u
l
a sI II 1
s•< <
IIi I
!Sa
X
laS l
n
I i l
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 66
244 CancerResearch Stock et al.
i * iö
l! i
8M M"a
H
* a «S £•fi 2l f -S
> «* * gm i m 010 o in m o mi m ojO -* o|o -¡ O fvj O O -^ i-tl¡
m o inii mi o m m mio in o mio m inilo o'o
M r4 rsj *J ÕNJ Ì\)
O O O
mS W F*! M f'1< a o S < < m u
n
OH
U•<
UH
3;sTo*CJ
s^
«1o"
J?
CMU
co
o^
XrM
O*
U
Zm
aT00
Ó*
ss^IM
H00ó*
34Q Tu
idine
Dlamin
lfon:
SU0
«55,
4-Diam-s-triaz^0io•S,4-Diamtrlazine-*,j¿^3S
s* sM0—
*E
.2fa*
sTTi£,4-Dlam
.HCloCQ'SS3a•&
ihena
¿
itQ o
|SS
¿«IS
¿£
li Ii r Q>5 ~ò
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 67
Stock et a!. Negative Cancer Chemotherapy Data 245
i
' w S •
K" M*
< O
in j in oo ino ino min ino Ojin in o o o o o in in 010 in in in o•f"+ T + i -f ++ "+ "+T + +
um
O
C'Su
I
p
o
ffin
W
O
Sfi
|*
oa?
oS
«T «T
un
¿
gJD
S
.&b1BT"Ar1u
1inl>îImelamine>>5à AlÕ2
J33Ci
Jli
11-1||rt
CJ2Cso
5hloro-3-cyllsonlcotln!?1
i•5.Ej=i_
..£)UIlamine
moi¡a*s*jUlamine,salesulfonica•d
es§^0)-gS
ai1&ECphosphate5Ei003
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 68
246 CancerResearch Stock et al.
lM
^ ECHO O OOH .„ ... „,„.*?
M rM O O O O O ~t -HCmOH
W i ^ «*11%2i5
§§11 •?'?°'+ ~~ ?e •~'~ °+ ??°NJ8-N«-.«-IBIl«-SeSsoo
:2S>>
gM-8wT^o
o o o o o oocoM 9 o »N o o o o ocg\in-H
tn in in in inirialy
Ãfi'fis
o1u1
Ho
§ s ua.o<wwSwNSw&SM0uoin
m i/» m ~ i/i^ ^ \ ^ ^^vo-i o rg ^Ho(M
(NI >o (\) r>jr^**ì
**>(•> i*) fOi*ì§
§ P i §§rj in —t in*»Nl
w H S Q a w
luHJggauyaiaT(MOfflH*
ftOis!1o*1NKfMO1ffo1»ei*<5"1u1sT00U
^ °¿"s l lu o a
H
1 I ë&. sII 8il i
Tj
S
a
si
I!«ft tl! I
!H
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 69
Stock et al. Negative Cancer Chemotherapy Data 247
!O H
O W2; a
HJU3W
Zes
. Ho "
O ùi
Ì
pggo, op2 U
gg
u
irtiifì
?ìtoÃo mi in in oo'| -^ <NJO O O o o mitn ini o o o
oo o'] — o I rj —' -iun o o in
oo -ÃŽo
un
Oi
H
lU
ës2
H
'C£"¿"is0
Nleneamln,3,5-tria:ramethy
iamlno-1ÕMVIZ^IB"
inu"1iS3I3ims?*oUyme-Triamiifjff€u00Ho"1ö
|§2
Ëhnif3000
Ugg11'S.!IfluoromitTm3"*oul1*".vf»Jz-x^uj"oI>.-Triphend
d"d"ÄHVQNCUuafUSS-f€s1s01^•R|'flsi
o'Cjl5
f
11Äi
5i1v2
ñfiN
0]*•„clnimldg
tn1¡0%Z¿rö*i2ilylamlnoA5a•a?£30O11li§
EO3Ei
flaS?SB5"v"öH10)AGOi5X
o*üIVIiodipheny11S1!N
g|l
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 70
248 CancerResearch Stock et al.
! !| i§U!
X
ÃŒoa
•a U <3£> * z £S«u o H S
omi
iin
oi
+O
0+in ml m ölmin7 7l7 7*1? 7in ojooi
+ itn
oio o+o iniino7
7l? Vo
in i m ino rnl« o
IM er)
B<U
HU
Oo
hB
Uao l
o
o§
us
äs"IM
5^sfo*u
2U*
8
3
UÌ1ÜE
"o
c«oxyanlllbenzotri-p-Carbeth6-dimethyl—12
(ja•-3">>3,iMSSalo
-o¿U1O.2gephaeline.ut•fi11
5«S'S-m-Chloroichlorobenzf^|!o«inillno-(
amIno-1-m-Chloro:
fobenzoyl)^«Oa
jjj11Ci-Chlorobenam1o10o
1IM-Chloro-N-
IdineiftC21Ilta.-Chloro-N-Mni-Cyanoacr)in!+-a53ODfS
oi(ß-Chlorreinecken1EM^
u_«-g>.-iminocitxanthon«¿'Sis
11"iE—'1sO11et~>.1--(3,3-Dlch
qulnollne.',0011§•1,o-Dlchlor0
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 71
Stock et al. Negative Cancer Chemotherapy Data 249
M
Ì
oio ml o~H O O rjI | +1 I
o m
wîlom mO -4
ini m oiool-« cò|<NÌ
uW
ou
Hi
i
1U
I!ilI
s a
1
f
f
Õ
I
I86
f is I
i
Õ«*!••§ii —i
HrgO*
sin
IM
S
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 72
250 CancerResearch Stock et al.
M
ì
1 1oo+r>Jfi+
+Nr4l«-¡o++ +? ?o
o.+ 10
-*-»o+o oT+ +fi
fOo
oltnOrj-H+'+
$Ã
O- H
Ou
!"
H
ÃŽ
* 2-% «r
^H UÃŒU U
g.s
11i
•
1
OftX
A
5"
t-H*
I
8
i
I
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 73
Stock et al. Negative Cancer Chemotherapy Data 251
ft s
î
i§
ino0fMm
o'Stm
om —'mino--in
miut0*j| 0
mi o in m ini m mio o ImOJ "N O; —" Old ^ IN Oloj
I + +' + II +' + +
§ g
Aa upq
M
iuiCOam00*»%5sÎ^tuIIn
-
¡fOu3
äSfurti.rsSodium4.4'-bls/(2--4-morphollnyl-6-sstllbene2,2'-disulf<_S«niÀI1SÌO*umote
's*ofi">»
rtSodium
saltof2-phertrahydro-1.3,5-trlosinSm!mCOu0
C§•M01Sodium
N-sulfomethy-HsinO<ffMAlIis1*<•u1f-ì
.2rfla*>
§*Sulfurlcacld,diesterIminodiethanol,moi
•H2O(MSin3001*\iin|coU4ï-e
—|g"2
Eo
^ß-(4-Tetrahydropyraia-2-thlenyl-a-5-cyc
acetate.HC1Wlg1^sTmUo|Mi2,2,4,6-Tetramethyl
qulnollne*rBin9C?S•-0Iflolii|1^-
—-^^''STetrasodium4,4'-bisethoxy-1-naphthylan*Sfii
1^ÎÛs-triazlnyl
amlno_/
2'-dlsulfonateÕU1"aaihsThlocyanic
acid,dies
ImlnodlphenolxOB(W
ÃOoN^n*
^«ö*2yu1(DO•s2-p-Tolyl
benzlmldazf«S1Mus-Trlazole00£4oo
ou*'"gl
ii|'S£<*+N-/4-(v.TrlazolyI-l
benzoleacidiN£U"oT'S,.§pN,
N'-(2,2,2-Trlchlobis(3-chloroanlline]Q00o
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 74
252 CancerResearch Stock et al.
lT)Oo
moo0
C>tn
in00+
+o
tnNO+
1in
mooi
io
o7
7o
in-•f^o
o7
70
0*+
7tno--.
rgÈ tin
oo-»
t i
SÃ
Wm
i2u"
€ I
oM
o
I
O I
l
lN
£ Et4 Nf-1
K
t-•x,w
ofW
i
3
-p-diphenyl-*-Acetoacetamino
thiazole(M>,83ë
S"ocetodehydrothlot
chloride•<J'S1jj-(N-Allylanilino)KlSlif
°E'S,
3'-(Allyliminodlbis2-thiazolidinfn1
1"*C>•«-Amino-7-hydroj
l,3,3a,7-tetrazNCS-AnisalaminopyrfV]siKn,p'-Anisylideneb
aniline)aoÃs
ethylene
productS
§rmeencdplus3 oxidecondensati<!tropine
sulfate•<
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 75
Stock et al. Negative Cancer Chemotherapy Data 253
!io
¿s
l!§
O H
z oin ut if) tn in
iati5oS*ï oo mo ino mo oinooHi— V fi rgpj OO öl o *i rg o' —i(sarsio
2 h 8 ' ' ' ' ++ +++HEZ2
>finin
o m om oo ininin—
o OO ~*O OO —. C—4g
E EB e e
ini ino o'
¡aoo, o
Rg
Iu
w•<DQ
-rw
<yo
"5
S<M
seZ
•—i—«
U
I §S«4ffcoÕNJ
U
Ua
Õ*° -
«Ä^"rt
¿i
IJ¿I11«1 a
r .
rt
TII
«iff ìli•£Ã2 _: £•S- ï
i g ! ä 5*5 »1f•* co. W U
,!
III
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 76
254 CancerResearch Stock et al.
u:
ì§
o»n*+
?O
iftrvl
00
O1
1O
O O»ndo*|o* o*Oifio" oo o-<
doojmin~
dlJ _:moo
o0ino'
dO inV
7in
oo m~
rvi
coCQ
<:U
W<
W<
Õ^arauÕW,sTuZUSOUi¿4¡f^,a?U5»Ã¿NO*NU16*€un*ug
o
lÅ’
ó"g
u
i
¡gH
iI
ilîlla
il t£3 So o oS l Su ä u 2 ga i
•a
l
Ul
z
8.IΕ*t-
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 77
Stock et al. Negative CancerChettiotherapyData 255
III§
II
O ;z i
09U S.O < 'Z tu O O ir. ir ir ir lAJ in in O O|O in O
~j —' p4f M! OO -,' O O -i Ojo' -« (*ìinim o o m|o o|o tn in O|O o|m o|o-lo'
Xa
is
aM WCOMPOUNDPITMULASOURCECO]gPraiCALSHIPOUNDO0
Ws>•lî-iz
u00Ó"A2-Dlbenzylamlno-2-methyl-
dichloropropane.HC1m'S)„o<MXr^JU"3'S•B">.i
zSB"SH«dl
*x"06*3-amlno-2-(P,
ß-Dlcarbethoxyvlnyl)
1,2,4-trlazoleRUB2fvj5=Xo
rjU'v'Is2-(3,
4-Dlchlorobenzoylmetl1-methyl-p-naphthothlazolooC4UI2u>pylbenzyl-2,4-Dlchloro-N,N-dllsoprc
amineKo0
^U
ff2ui
16,9-DÕchloro-2-methoKyacro
mOir>md"JSC!p-Diethylaminobenzalmalont¿>§
oo.10üU|B,2-(Dlethylamlno)
ethanephof
acld,diethylester(Mm»iZNU">.Dlethylamlnoethyl-a,
a-dlph<
propionate.HCIIn
mm
aiiK)Xc^u*A]">,p-Dlethylamlnoethyl-3-phen
hydroxybenzoate.HCIXft
QSDO
Õm
SB*00cTß-Dlethylamlnoethyl-Q-phen
2-thlenylacetate.HClin
inttX|1¿T!N-^Y-Diethylamino-ß-hydroxphthalimlde.
HCI*a
tnUmg
SJXo\u•e1!Dlethylaminomethanephosph
diethylester^M0
UoiMC?
N%Ã 100
Nutñ
in3,3'-bls
(Dlethylaminometh¡dlallyl4,4'-blphenol.2HC00
mU£intf<M
f\|u1"o4
-p-Diethylaminostyrylquin
methlodidecr
en
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 78
256 CancerResearch Stock et al.
ili7:MW
&ç
1in<t>OH
0og
g o- o- o- o>m"
W2C^tf^ju
oto o in mo o inoi/t^5 a> S 'vil o oo o -« o* -Hoo'<y
g 5 S ' ... +itaa
«MXugsio
u 2 2 2 22iutA
Ã> o o o o inOK o o o o rgQ \ N «ft ininI053
coilo,
u§
0ss
IsuS
v1*f
i s i 1i"5jSB~ i °o"5.o"
o" u~ cT¿Ti
Ii1 ! Ini!î1ìI iÕÕÕ!1
îÎIÎHI**•i A iAsZ ÕNJ" rg fvj (M*„
|BM
3\M
GS
1§>SîSîo-o->ÎÎmo
oo ino mo o m m o m oinOOOO ^H^ O^^ -H|O O -^ fO OO1 ) 1 1 + +' + 1 1 +1u§0000000
o o o o o o cirtroiniftinininirO
ft, fc6u u o o Q :*s
ortJOTCD0
0 K .^CrJ T - rM rg h OO ^Z^Z^(^Z^S2
ff x a i? B* £*"Koo in o^ l^ •*inotTuouootU»
d•i-
1 I 1 A| A! i! 1§" t ; Õ ss i-M 3 II ¡ f ^ If li |I;1
1 1 fi li li fi ;1 1 1 il fi II il"li
ÎI 1 1 ! »i9lf f 9S li rà 9A"—
i O. ^ ^^ —* AL ^m
o m mmo—o o-H+ti ++o
oo omir»HO
<ÃŽ1
JoNIOIM'^ ÕÕ3iaa?=;s>
uuÕ
Af?C|
1!i1I13 o.5?
l—?i»ssIGI3
i 1*9î ti-n¡1£8 ?0[S9 "a à -à 4co. d
>•«,
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 79
Stock ÃÃal. Negative CancerChemotherapy Data 257
iwS\5
§s*z *fcOgHiUfeOHOZiu
~ ™ \ "~£
mm in in o m min inio0*(M* o" 0 0* — 00-.|0¡UUi"-J
'O (M CO-H•C¡Mom
m « m mM§Ss-
s•9"X0 O 0 00Mo o in oom
in r\j oin1II
souEg
«S w ><ou <: n u
:-i°ini o in in Olin o ind[ o' J -.' -.'I -.' -.' o
T 3
mi oo*| o* o o0*1 O*
UtQ
_;
a
I8
N0
tetu
-J%vORr*o"ci
1K3^
C1
61ri1»O1*i
K321
late^i 1i<M3=(M0*fMrOmr-giaBino"1~inao"<?r>J
nq'S,%r«J"-J—
—%
S-in
X
COMPOUND
[EIi»goe2Inophenyl)
3-methyl-)-pentadlenolcacid-(p-Dlmethylam
2(trans),4(clainininllmethylanilineH«oÕVJ1•3,2-Dimethyl-4,isP.
inisoimidazole2'hydroxyethyl),7-Dimethyl-9-(
Isoalloxazlne•£>opinmethyl-4-morphollnyl
ie.2HCl°
B
ziXo*infl-4-morphollnyl)
mide5
iII
T1szo1Cao1
i-(2,6-Dlmethyl--IsobutyramideZvD4-
morpholinylmethyl)-(2,
6-Dimethyl-IsovaleramideZriimethyl
-4-morpholinyl
lide.2HC1M"
rt
Z1z"-JD4-
morpholinylmethyl)
L-form.HCl-(2,
6-Dlmethyl-mandelamide,DZSiE
fi
I§10)•^
TI-(2,6-Dimethyl-i-phenylacetamiZmVÛ">.liil1!^.'
j'rlz£i-
morpholinylmethyl)-(2,
6-Dlmethyl-
-valeramideZ,r-
*oa-phenylisopropyl)4-Dimethyl-6-
(
•quinolineraSTidazlne8-Dioxopyridop)ino*
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 80
258 CancerResearch Stock et al.
O H
O W2 Q
b»H M, W •< o 3 i 8
00O
-Hin
in<MO+
+o
moo+o
m?
?mini
io
ol mir,-H*0*\
+ ' + i0
O+
1m
ojo ojoino -. — o|o* o11+ +m
oO-4O
0+
+
aXu
g£2
U "w
SS*BI
- u
i«
s¡ssW<
là <
Ju
Iu
xo(M
U
<fO
OI
H
U
33
XITI
U
X
2u
"öOff
eÜ"T
3?
.S .g S
i
i1•*isC
0a> 21N1vlenylqulnazolonethiolmethylpseucle
esterofanthr:ilphenyldithlazoll"x
1 «
ffntimino
diacetonltrloxypropyl)bis(|
imine.HCl
S
56
11•?,•£
H—-
l.
s ¿.g 2
gd
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 81
Stock et al. Negative Cancer Chemotherapy Data 259
.O wZ Q
.5
I
O < ^ *z o; "S?
>3£sì«u S i "in o o o ofo oio mi m OjO oim o o oim o o 010 o m ojo m o
*+"+ V i4 'T T"T ++ Ti ii i4
- u
uh
Um
o
i dP
Xf>J
mO«
C%£
uI
CQin
S
i i
W
l
•o
s
•Hg
1*111ÃœS 8
>! >•
25
o
SfO£5*
I
°~èil£
2ESrt
1"".
C2,4,11,13idimethylar<M"'S00V
V•Sg¡1H
£gçBxamethylearomo-v-biS3tiTI
«
||1^ll^¿
l'ni»Srt
g.5Ã
a m|>,iSn"Oy1miIIVClI111EXsiça\SdCJt
¿a^"aL
£Ifi|sgHydroxy-5
:hrollne-3-4aJ."a1|g!¿C11
afiÃ
co
In
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 82
260 CancerResearch Stock et al.
p? M s* r< u 5 h
OOo
oinOO
-i+.10
00
00
O~
o+Oini ITIino
—«loo11 •+•o
o-Hrvj+
+in
OO
—1+• 4-O
ifto
o+OmO
-4+m
Orvj
fNJ-I-iO
OINIO*+O
if)-H
O+
+Ift
OlIf)O
i*Ì|f*J•t-+ +
aa
mm
ma
ma
ma
an
aa
u
ë
S3J"
£•r-u
ofȓ2
O
-ÎÎsîrj
U*
Of»z
oz
ut'S]o1 1
o"fi
A
s?Ift6"
o
Iu
ua
S i
1 »t £t fe
t l3
! îS .SU N"2 rt
ItI
t
»^1I-S .S^T *N
^ rt
Ì!
I53iI
.- 4l•$3U M
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 83
Stock et al. Negative Cancer Chemotherapy Data 261
l'I ^ja S S
o a 5 o i m o o Ojin o o 010 m o Oiin ino -H ~* o
m Oj o mi o~ oÃd -U" ml o oO|-H -."
rìU
(VI (V)
s s s S H<
Uw
0.o
B.Q
"a
S1K
-i-Kl
Ü
e
i1«4
U
o
00
"H
i II i? S Jf*.
g1.SP
I
i 1II 1i:- i1 § •&
IS2
I
B
LIï»1ës|?î ?
¿ai
6-cycHCI
ylt )
olinylhlenyl
Mo
iP¿s¿ItiIIti
m -( 1-
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 84
262 CancerResearch Stock et al.
inoO~H+
iin
m-*o
i im
ojoooölo —i
+ +o
m0-Ho
mrj0*o
ojom0717 7o
inlinoO*IN¡ -^O*+1
+m
oO*O*+»n
oO-H+
+o
m7
?in
m(MOi
+
o o o o oo o o o om m tft tft m
§ §
a>
3a*
n
io.
Ou
6H30N4°4U3S10.o•*
„s
-"2E2
tz"rtSiUt*vOoTu.ï3
11Catro
S-¿*XK•<«aso51tiM
et0USS.il¿
¿2"Mo
fi0
co
mU*i
in11
¡|Cjg~
eoo»f|lirog
s?'S;¿T11I£1*>,CMorphol
1V*ZPiiC?00a"U,>,iIIjf"oÎ!¿22fim£00"ethrtXS
ifMorpholeTEzSiimUC1!Ãi.^P-bis(4-:onamideZ
Mz"in
(*i£0ZN8IH£U11_rtI1CMorphol^¿«omSz00Mü0CJrtC10I1tö
€11¿|z
*"i-
tfi3H46N202(MU1flf1i?MorpholzCO0H20N2O2Ui's3M—"rt
>"H35Morpholii2O*fiimB*o0iCMorphol:iexo
SÉ
1•S_
t*
¡I
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 85
Stock et al. Negative Cancer Chemotherapy Data 263
REMARKS!
¡äo1O Wz a
09: w S \ BB •?«•»z a s £ o iniO l/)i
+o
olm oitninT°l° =1? 7o
mi
io
o+
+ir>
m+
lm
oi
tO
OJOO1
1 1o
mi
+0
0o ini
i
sg
«l
¡ia. o
§«5 ugBs og»u
u uW <
W<
ftQ
0«Q
g6.IVOIHIdWU13H13N502U12HllN02OisT0u"iS?U14HION20uspisTÕcTëN(S1Õi1u16H28N4°2U°NZo6"5S12H17N30.(UÕfnül*>zm
XuZ
<Ts?
3>o^33c7
u(?C¿T
Q§COMPOUNAMEat.n|(J1>0f7«1ortsflidene-5-iSO1CDÕ">,£gImorpholl>i£
•riÕ
10)f***
*3*>»C1
1ÕaI"oNS
lY"x1B,
l•*ester
with
.3HC1S
g32^o
2II1N1SIs_50-s•—•^—'—J2
cd1 u
00 3inmethyl)
2,'S.3
(Plperldiperazines
§•¿¡i1i«1)
iaobiityi^erldylmet_a•Ci11_^e
f_o.|l2•ahfai
57
s
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 86
264 CancerResearch Stock et al.
ÃŒs
•*e ì
g
ooO-H»n
0+
700ro
'S)<iO
07
T0in1
1in
OO
Otn
mo•**
1 +o
m-HO+• io
o—IO+in
int
7inmfMO+
1o
ino—
OJO-I-vi
O. U
I
ao
o.Q
i l i ii i ff
§I
- - 'S i
l
l
•a
l
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 87
Stock et al. Negative Cancer Chemotherapy Data 265
o«sä8
O WZ Q
co
«¡II< u 5 S I
MJ
o in o in ~ ip mio oo oo o m tno o in in in
rrîo -io od old r*îf*i ooin i in mio ini m—[o* INJ|* o|d
»Sigu <3
Sî
z^='
C
I s:u
ÕX
u
om
Z
XinO*
a
l
IS ~*l
t "^•*stÃS«3 gM Srt -0'S -'H Zri -
TZ
s a
Z M
hano
e 3§i
2
I
I 5
2u'u
Hoo5"uHH«ergrt
ï.|UHIHHiÛNH«Ar-J>>O
UN0)rt1
S¿3l1
^S¿*>J
2iäI
ocyani
rs2 SV uü -p
I
nA
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 88
266 CancerResearch Stock et al.
Cd K¿•?1 !•vOO-o
inSuaOH
oo.<; m in m -H -Hm2"
0 > 0- > à à ¡E
Q(Ot¡
w S -„fcO < ^S^
X <^ V o Õ*J ~* r*Ì»*4 —t -~ O O OIO •-»OHJoHW>WK-,
O.
R Kl m 2 « <MmigSXW
•§w\ o in o o ooO»Of*iOO
OO-*in m mosCà i£feil0.
Ui«a
uoÃ.,B
B «9 H M H UuS«U5Ei§*
^^2ills'!
sã•rqNÚ ffl (SI rg PQ
g K K <p M M ^S «n o X <r- >o S
r4 —< 00 r\| IMooWOÜÜÜ¿UUi
iZB ^ •§ |^¿M*
' -^ *O ^« i ^-S2
| f I l ff!ta
1 >•til lis!<1 "T *ïïrfrfï^ï
2 A S i<8ii'8'iS8|,« £ v S o a ' NOe•s
-g. Ili Ì«ltIi-00-b^-Sfr ^
1 l t "ir-" till g
». -g "ri |-g.j8|9«
« «iJr^J€«8<*3-^ m H Û —S
-«SoI" ^ *
S o aSmO £
U r\j inc<o
oA in ^H in in ^^ ininìr^o-^o-o->o-3|O
o in om mm oin oo ooin^|Ors)O —o -j —• OO ——< mr>lrsj1
113
f> Kl nv in inroaIu§§§a§§a§«n
^ in -4 in minS.E«
EdJ U < U U U UUtn0,
«,jn
5 O C? ^ 55 ^n oO «MÌNIOmO^H
O -H <M 00 -HC^K ¿? X EC DO 33rsi S O <M O fM JE
X-HO^iMro^-H^üÜÜUÜUÜUr^l*f
1 ¿ iilá•1 I 1 i*'-'Î! ¿ï '5i•2
H S? PÕ S*xaU
1 ¿ 44 67fl
! 1 t 1 ?41JÕ 1 1 I !1| 1 s | I t 1 iI1?4 ? J a i i$ja r ci- "i - .- 5 ^«Qm
ro-imW — O
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 89
Stock et al. Negative CancerChemotherapy Data 267
fcSOH
o :no S•3?
M
ÃŒg
tn m
;ll»->
010-2
gy§«i
£§0. U
IN O—iO*O
-H+
1+ T0 0O —1+
1T 7omo
omin0
01+in
o~«o+0
O0
y0
07
7m
oi
+
03 IV)
lu
W•< U
t«
I f! t?«r ,5- 1o"Ã1T-«j"*21¿rÃu"¿o1€u£iT00Us00—
ü
af•*
O
!*oi
£o
g |1 II4- 3 S
5d
is&
lseilira dB öS
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 90
268 CancerResearch Stock et al.
-T W S ^g§i!sii»!
tfto00
+o
o0fSI1in
O7
?00r
?oo0 ?oorvj
O+oo*N|^+
+
tnod-:+ iin
o-ÃN+
+o
mioinin-Õ -•o+11 i +o
o*i-*
+ i
§ §
3 MIN
PlO
ao"Sa
U
U«Ã°
l
S,
M
¿
\l— in
tie" -•3* l S Ss -. s.i 5^ •«§••«.u üg
l B. ÄÄJ8 fH !- n
S
Ä5
fi2 >,
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 91
Stock rt al. Negative Cancer Chemotherapy Data 269
§ ¡Q
e.5
OOo
oomi
im
inO-H
+ +in
o+
Tm
in-.o
+ io
m-HO
( 1O
O~->
M+ +O
Ocq
omoorqi
im
m0No
o(M-H+
+m
o-HOm
mO-H+
i
mm
g o raX
o00
sTO1ò~
z
mo"
i
8o
X
IE
— -u
2.=U B
Iu¿
'S,cyanoblphelB
•*A|I€lcyano-a,ß-
snylethaneT*^
5yanoethyl)-phthalene^i
§A•äcyano-4-(ß,3,4-tetrahyS
M"iJa3,-T"cyanohydroÃBm1OJ§0grccyanohydr
«p¡Jfi
0)1
•*-
sI>.4=Hcyano-3-mt
oethyl)-7-m.hydronaphtt-i
u Sen¿v"T
'S*£
-3'Scyano-3-mÃoethyl)-6,7hydronapht!9
H-<o ÄT!1phenylacrylS«O.
fi»
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 92
270 CancerResearch Stock et al.
o3
in in
«5
UJ
o mm oo oi°in
o°iO
lT>|
+O
O¿m oin OO 0o oo m+
itn
in•i
itn
oÃmuni
i | + i
M M M *J (M CJ «M fNJ
eg28"3
j e<*i
£§B. S
gË
» O
2gSi
QU
Q:; w<
Qj
2 "S,tT u1 Mu
sZ
aou
o»No«""
cT
•«
u
K
0er
O«o
z K
O
.O
^z
eiH* A ^§3 "xY60^
z S
¿tsi
|
^- 41"^ * Sl AI
H
1gs
1
43 4> X-«"öSP "B E
II :H 1«Q-s«gz .2
l
l
|s
rt QJx-o& "3
?!ill«
e
c3 0)x-oo ~
»iÎ1il v
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 93
Stock et al. Negative CancerChemotherapy Data 271
MÌÌ
g
o in o
7 7 to ini in oN rj rj _'
I +| + +
in o in-¡ o ~¡
£
£¿
nm u
atr-u
Z
sT inu
o
zco
i O
3 i iB
uU
§•l
lIs
g•s
l
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 94
272 CancerResearch Stock et al.
o u
! i
o 52 Q
00,; u S i, «g O < 1; 'S
5[ga S§uu
ino+
+0
0+
1in
ininin+in oÕ
7mm+
+o
in+
+in
o00o
ini
i0
0iin o+
io
in7
7o
o1
+o
in•??m•*
gsgg'i2
S
E
PiQ OU
5£5aEdOinsTcTg^iMU^i^Ku"0r^o0ss"•C00NoCOUgtntftÃ*Zrr*x"Iflu~0«2¡00U%2¿~0*g2*_,o"Xo-
aU
iu £
S
§i £
t) 1I
-O O"rt
2 2^e<5«
9 Mu*d5*
f5
< a <M o.
O~r
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 95
Stock et al. Negative Cancer Chariotherapy Data 273
dS§SSSS§§*QCO"
w 3s""""^"E!O -<¡'S*3•^SSûStiHo m oo mo ino oo oo oin•^
M * O OO O -H OO ~H ^ —« (N) OO —«O«5S- « ++ ++WH)B
' N "'"*gmI«
QtEjto rt m r- «*i rof>Z
Ssart"
ËU"Oü§7>ooooooo
ÄlfiOOOOOO\ ^^ IM in in in inins"*
<So
„•JB.oes1«s
3a,g o w wu«O§ü§•j
om3Z OT
O I!1*1 O ON o*°EOO
OB •« r-t Si!Hg|«^ ST «- »T "2 *.-.«,,u
u u u o" ucT1
j! iii1-^ S "^4*o
ÕÕ « S a84ls |1iW
o f •2 ¿g 5e<
t« ff t I 1 ^S"!2 sfe: l'as j.SasHDr W M^O O OJ 03i?II 1 S-: t l *;1fS
i -fî Õ 1 4-s sS4 i ¿S B R "R"SII
1 sf 1 1 Õ1|^^g<£< <-3*1m
< ^ -^ fM o «(\j-nOOOfsJOOoo
in in oo oo oo inin inooOi-<OO O^H MO O-* Org OO^H11+
++rqrsj^M^fM-.^iOr'lfnfifirqtomseU§o
o o o o o om Q o o in o o*t ^ in in *vi inins
!s¿S
WWo- u u u u <;<'—
WMIM
O +_ O O m*t2
o o S 2 o 2jl^K K o •* SotTo u°° u u" u° u"o"I
11O.,'.-a
i 'S, 1s1l
¡ ! !l1(H ^ *O MC'S ® i— « 1 L MHl1
1 i Õ 1 f tÃ1If I f l f ?f!a t t- t o g J_ «i
'S Õ5 'à ÕS o T! ¿i"OS*SI"^^lf'ln*C*Bi*B
OS .00rt
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 96
274 CancerResearch Stock et al.
in in in un m
o odO O O O fi' O O O O O »tiM*»lfjl •*
in rg no
~+£UOo
m-*
-•g
gooO
rg o Oo m o oin m m«§m"*§tnS
SssuU§
iESuoossoo o£gvo oe£oom-ȧ
s E
ou oo
OU
u<
ou
ou
O<MtiC)
AsX
O
Bu
mj
u
oo
r^Ho"
•. aT_ ».
u u
S
aa S
'
« "
B -f 1
1 S1 ?
aoI
S vS* i*s |ì !
<
I
!i^
§iJ3«i
»;-g.•"1"T'
li
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 97
Stock et al. Negative Cancer Chemotherapy Data 275
Wet
WS>a < 'S 3»Sälfi
S »2°
HH)O
£b O°H
O u
uS
s
ä^etooP.
o§i
is•gg<!<w g w S M mwo55uH
i« a"
Bu
:
tl
A Ãœi,Q
iUH
IilI-
U II g
1
i 51
ïi^| g<
¿Q
•*
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 98
276 CancerResearch Stock et al.
Mir
o tfiiom—od o
' +1 +0
0-H
O+o
in-H
0+
io
o0~o
inooo
moo+o
mooin
oO<s]i
im
o0^un
tr>o
-»+ +tn
oo•«•
i i
og
u H<
Si
cfaT o
aT
°o
aT00
cT
e,Kr^«"*
ODui"
PicT
aToo"
ì
•i
ii§n
3s"l
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 99
Stock et al. Negative Cancer Chemotherapy Data 211
SM
il
<! o 5 - °°.°.0•?MO+ +? ?o -¡
+ 1O-H+•f
7I7 7<nINI++7 7^ -ilo O
1 1 1 1oo
1o**>
+ 1O(M+
O
H
88il
•<o
EdO
gg
Bo
u«C H
< OOU
H
oisM
mU0o"
¿*<"\JN"v
"Louf
i€M>mr»fi
O*r*—< _H<\Jü
u U0ai*«C0°~o"se**«rcrOo^1r-fiU°N
O"o
maT»^<5
^ÜÜcT
Iìf\-1CO
<-<^HIN]
iiU
U
i
I
i3i">.
rt^3
aèë
I
!
li
Vs ë•i1'S?-L M W
III!s¡Õ*BE S «
I-i.
f
IiB
ÎI«-2
s s
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 100
278 CancerResearch Stock et al.
M
ÃŒo S
S 5
OO+ID oà ino+
1 1 io
oÃino1
+ +o
o0-«m
ojo miomo-|o C), oo
tni ino+
11 i io
oiom+1+ Vo
oitn+
1+
(M M i£
§o otn ir»
2
È
o uu P O
u, uOU
OU
« „- aao X co-H in rg
U U U
5•-o0r afr" o"X•T'-0o"KHu°o«coU
OI
s
"'S
3ä 1
l
Ãi iIJSB
aS
•p-Blphen;
Ea
^.A s
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 101
Stock et al. Negative Cancer Chemotherapy Data 279
gH
M
I l
OOO
rsi+in
or-to
io
o07m
ooom
oi inoo cj —• —"\+ 1 •+•+o
o07Ut
Uto
~*oo—
1 Om
ot°o
m-*o
+ io
o.-tr\i
i 1o
m-^oi
+in
01od -•_:i ili
§ 8
ou Ou- o
u uou § n
n
ob
S SBhmsfo"
no
cT
K
sT
i2»«T
m
** J m•o
U
Mi.
l¿
Sä£
S
¿klA
|1 l
Tg |**> rt O
nd
es §2s s£•§g¿l S
l !
2ä
I
W
lO
i0)
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 102
280 Camer Research Stock et al.
* Q
IM
2
inin7
7oo+
7omo
-ino7
°oo0
Mo
in-i0in
o00o
ooTo
in7
7o
ino-,in
in~*o
i +0
0rg
o+mooo+o
oo~*
ÕM rg in NO
W•< W<
U
u o J
gHu" X
d"1 -oiT
0«i1iB)<J~
H«ou"
oM
U
ou
H
&1It0)
¿
4-benze
SI11x
1
!X
i!Sfm
il n
ï
lo et
tert.Butyl2-methylp
i ès -sI ?Ì3^•sia t
fl
sI-lfhlor
tn
eth
Butyl
ethyl
iM
•sm
oxyto
fa
SK
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 103
Stock et al. Negatine CancerChemotherapy Data 281
>•
H '
M
l
M
l
fe2op
ië
«t
o mmmi
io
ini
i0
0+o m+
?m
m07m
oi
io
mf
?omo
ooo-H
0*oo0
~Hm
o"+°o
m0+m
mio*+7l?
f
P. o
QS3wp2
oO55UuO
UO Oo uo uuWo u
îSiH
2§
f«
t
Vaa-^
"fi, ;'-:
„1
"!*urachloro-sulfide?
5•*'*«"f'>•?
I1 §(Tosi»fom"
"*ITi—•u
u1i•2s
a1
ÃK">.I
11?g":&a
a£iroductfrcliydroaceti•cU1^¡^1|iLNJe
ó3unoo"11O!io*0)i1
.v ' a
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 104
282 CancerResearch Stock et al.
»EO wZ Q
tnÈ! O < "§ o
|§s|< o S - "
Ǥ1*Ss
oo7
7oino
o+ooï
Õinin7
?OOr*j
o+inino
oi i0
0o
rqino+
+o
in-HO+
+in
in-•o
+ io
inooin
oooo
oi
+in
inÃŽO
+
'èsg8ie
ese
COco
w o
i
JEoo
EM
VÛ +.o t.«2 z~o Xa"
o~* 0erarvo"
"1,cT
inO 2-
t: u "-^
I
1 ~NAMECÃlfsD
""g
E>,3E-511
S!•i;halamictXetJ3iIz§
i1iV
3—<o*TaZìnzene
à s
sSM«
ë•s«ri3UCà |
I«
1«ri
0^Χ-°g
E53II
PIVo.iZf
gCVM3£°|i.
|e11t.
KfllU!lh3CJ«S
-&5
- a
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 105
Srock et al. Negative Cancer Chemotherapy Data28m
%°fi
1a!!00in
NÛ£*OH
o oo.^ir> in in -H —i _.m*
S o m o ooco•
6q g \«Eu •<'s'SSSPi *; H o in uìtrt oo o in oim o o oo!^
se ? o roo ora o -H o <vj o o o —i com5 g g ü8 ++++ + + li ++'+W3U
IM rgMUP
OT8gg|1w
;o907> in o o o o ooQA fJ O O O O COOQ\ -H in m m mmgîifti
CJ§wuS|
u o w w u S n«03s3
^ om,. <c«.§oO M Q NU 5ç Og ^ 2 M O <>Jf*1u<
3*" **L Hu s? ^r ss jf°M***' O O f\l "'- (V)pQ;
u u" o" o" u°° o"cT1
,f>5 ' e* uios iÌ 5 9"^o'g '^) o. £'Si
! '5,1 £ I ! 25I
IH i I i!•S-lï &S i-R 1 Sei,| fi ff II ì «SIs
If Ì£Ìi î ?SSüü£ o5,ò*o cj ¿A o
i 1 1 1 1IItÃ
•E-^O f" ^5 o^ o r* ^je«97|V^ fn r*^ 'sf T *TrfS*«0 M? in m ¡n in inu"5Me
10^O
00(M0>faO
O0in^unm^^Hinmoooo^ooooo
oo mo ino mo min omoO^*O-H OO ^f\j ^HfO OO OO >-*
I II + 4- + + 1 1 4+—
• •**• rv]rvji\j^>_f\Ja
sESu
uOOOOOO 10 l/l
000OOoBrJOin ili in IA mii-ìiniW
«0 N W S W< W Q W < <«jl18O
<NCi
IOJ_ÌV) *"ìhu O O O Z u<NiO O^ ^o vo-*o»M
o e, »H m v m U-H« ^r -2 « « w w j*wrg33 m f) oO ^ ooU
L> UOU O O UQ¿f
io3 A*SB
^-S.-
>* --8•oc^-.1 1 « 1UfflisiPI
! I I 118S !è-s * i 1 f?If Iti * I 1 Iio o a'SS-c T? •! •• 5
5 ? ?£3«filiuoocjouoE^mo
r-opo^o— <minin wt « wì 3% m
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 106
284 CancerResearch Stock et al.
IE
I1
M
S
i oinÕ
T ?oino min oi
io
m1
4-o
m•:vo
om mi
+m
oo om mm oo oin m+
i
rg M rj
(A 00 (*> i-o
in N in inm f>
-ou o o
uou
uM
O5tT
OO
m —ig Ü2_JO S3I o
a-cT
O5of1
O
3-i
t oU
Su
§Ic
A3U
s
O TìIIO 5
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 107
Stock et al. Negative Camer Chemotherapy Data 285
5jg s Sso inin o0
01o
m0Cm
moVo
o1m m+
+o
m+
itn
un+
+o
tn+
to
o7
°om+
+m
o+
to
m0
0
. ou u
ou ou o
u ouou
Haz
gu
I
S-o"
l
o
O
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 108
286 CancerResearch Stock et al.
uCQ 'S-Soi
!iS^V!a e ~c^0
«0oinoinvOin&M
$Oj_, o O O O O00
w *"~ ^ ^ ^ ^ — ^^cofc!
WS>.2eo <: ?o•~*-^ —i i mo o o min mio ino min 010min^5 ?* o o -* o'o o -* olo o fH i»ic*ì IMIo* o*o*<U S " ° ' 'l'I •iH3W002"-
2.ht-«~1"2'i>2!3Z
"sSES
ea- s g eeB)T « U uUcoTs o o o m o o o o
O sC in o o et o o ooX— rMininiM^finmiE
OAog2
g S - R SSisgwwu?Süo<OwUiofe
MÕ
2" £ 2~ Õ 1« i"§E
tn U U S vo —O¡ «;*-»{; \ «mS2»ruu u u u uug
*Oc , 3 •***p. 5 » *& Saü»5 « T ">.«">» o.";¿»i
O ^i, L: T; : _^3*
* t | fi |1 I?*i. ti £ja 5r-3 —¿Ã| | | £ II il ÃŽ1fi
I I fi è| li |11S* g o5«°gÃ=2¿"e11
lis §§g! sa g &gSÄS¿ H 3| il lAi 2 i22MJ^1 « u^ T * ï uüUOioiM^^AÒ><cî
•i_iO"^ IM i*i *f in>o >ooZZ
m in in m in in in mW mmtflininininmu
uIliIli§0
^omtnr«iIMoo-
o- o- > ^ >>m
in in in ino oo mm oir>mmoom^H oo ^o --«o —co—i~»-t-1
+ i 1 i i 't22^2222o
m o o o o om t- -H o o oo-H
-H m m mmSsCQ
^3 W DHPHPQ+
WfMo- § < °- S" o ~
G HM 5 H, ^ S SaT SB" s" af aT »j-r4O IM f*> fM KK^-t-H —* —i -* CO00O
U O O U UUg1
„01g'Si
ili» i 1_§§•S 1 ~ «22
1 g Ê ä 1SS1 fr r- IS=8 ö £ 1?SW* M fl H OOi f 5 1 s I1!J. I ! * !!8"Sg- s e §•_&t-t- 'p t- U 1 l" Q.'-o
oeo i0^0*^022£3 ^ Ö'S 2*83UUXÕO a ^rtürtU
4- a à 3 U dà U«.
o « <vj en ^mmm in m m m m
m m m in m m m
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 109
Stock et al. Negative Cancer Chemotherapy Data 287
ë§
it
IIM
•w S \ «
Õ}!S £g Ii u 2 - °
ininï
7mi/t7
7m
mO-Hi
iin
oO-Ho
oOCOo
o0Om
oOfsïO
O-H
<*J+
+o
mP>jO+
+o
ooo0
Oo
omoo
ooo0
-Ho
oo^+
OO
W 3
Cta*COUgigiiO£so
¿CO1mcoa*usT00U3«3
Btcdi1E*1gu
LS*usToe!">>I8a"s•g—
i1gèu0cfrj5ta"oVI«efo8*1uet2
uOÕ"r-0T3¿tjj1ggo
Svmco
UBfr-O11ligi
uias°oO^'ìIM"
|ililo
'S1
sX°hl
s«o*LuIg19rt|iT"Ayob1u¿
O o
»in Hr-
«"
i
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 110
288 CancerResearch Stock et al.
I1
M
ì
>.
l
co
siili!* z B;S ¿>•Ãgn«u 5 - u
Oli« ini l/l
IM -i -H IM O O —•
§ §M w
U•«!
u<
oo
Õ
so
•U
•* o
"o
o"
r
lCJ
lu
i
aiuls •s
R
tl
l! |Us lV3 5
Ä ^S «
Ii
ÃŽl!K
rs(0 U
gfa
;£
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 111
Stock et al. Negative Cancer Chemotherapy Data 289
aU3"U«
« g S|2 TÕ H.Hw
, \3>\PSÕJ g1 ejjfIM
go«-*1--JOIM
un cd^°
H oooz
Q00,J
W S ;>»ftiiff;>
Stì £ O OIM -«O •*-- O-1 IM -H o —i OO5 g 5 £ 8 '' 1 + + l|l ¡l + ++Hufu
O°Hc?W
555kj" ~* O >O O O OOOi? ¡ in o o moQ\ wn N *o --1 «^mSO
<BfeIP0<
oa§H
r)2g
« ^-sggOcq 2 U P»WO
wut<
u1
1 < < ?<SS 2 "C "s"kW
U S ü O Uü'S»
^§S
33»1
ftt0P •» ÕÕ
0 ¿ S BI1*1
1 :S >i^-, 1 1S""
& S l H?Til
! l 1st¿Hi i ?11¡ft¡ 1 ¡ i |1Q•* Q M Ö rg"fNj"g
.00W
m tn m m i/t in ìnO
O O O 0O°°°°°-°-oo
o'o —' — d -^ pnlnj d d r\i —' o*
+ + 11 II 11 1 1 ++IM
IM ~ ^> KlHlro
r*isU§
O 0 0 O O O go o o o oam in m m in in in'-
ü (X[¿j y MWQ W Ed HOfQ*
5f\|
fj-***dT1 <n °°" ^oro
o ^ o o ur<<£if ML M NOQQsO2
•-• IÄ IN ^ ivi (MCS33 ,_,•-' _r-» S EQ W *•
Cr- so H ^ fO o oKtT tiT ei* 0* cT* o oori3
§4.11
¿1! I •i iilililá f«5¡¿ 1 | | « ;-,ïlililÃ
(11^,3 £ f- 3 á §•Sli
f f j ! I ilsmX Q - Q Qü}J»j*invO¡j.ooa-ossssSSs^
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 112
290 CancerResearch Stock et al.
W ¿> uo9
^i Jü^W
Oi >j\a 1 f|goo—
00rt -*IMh.
ÕoÃ.
!^- in tn in in in in~-<ig
° ° °°03M"
M §>JgÃœ< Ãœo•^55 CtÃ-g ¿ oo mm oo o in Oin oo inini"f B * « ~~ ™° °° °° °° â„¢1 °°aju
-. fM r-oMW§t*
0®HÖ
w "~ "" "" ~ "* " "•z.~-,aB1
Ëu5«w/>o o o o o ooQduin o o o o in o
Q \ in in in inine->
fc<%u<fc2*°:
. ès§
HS
S ^ W W O WOSo<<U O < U <Ãœo
*og&<a
X» o^ »o.mO (NJ iß^-*
S5 2 m >o W- m
rq m 33 PS) >£» -^otT u- u* ü" o"1 o"1u**11g
ss8! !!1
g 1 I1558 i»ï 8 fi "&•!,|
1 1 l f 11s 3 S s i '-alS'S ¿SS fr SartN ^3 N O S"ÎDS
•? § § SE£Ooo ¡a 2 g —aS a- - S z" SS>•£
i" S 3 3 ! S 1§Wi/iintninminin|«100
0O•"^tnu^iftif*^^in^-<fsJO^Hi—
tpJOOOoo
o in ino o in otn oo inoino-^^Hrt oo ^^in ^*fM oo ofNjofM(MM(M(NJ(M
nj(NJrom-^mm
^0OOrsJOOO
00OOflOOOOOin in in in in minm5Õ
WUcyw<<;w-< owcof*l
XU•^OO_rf
J*1 O 35 ÕNJOOf\jZ N N IMrati¿
W ¿¡ W CQ o^PQS»s00 %• s-0 a00 «- M*»X
fM % O O 00(MUUUÃœOO
UUfM8
1^| l«|:
f -S | 1 1| Ii.—ï **^ 5 +* tnrà **R1 f i E 1 H i{^-g g ? S2SE S§C
« O ü O «ÕrO
£ £ O OOÄ5 Ot_o r° O t _rÃ"3^"O Ä"^s
? 1 s a1 ^ I S a9it- T i 3 rg S » l-o£
•*" Q -T IM" d Tf"coo
QV o —i r\i ro ^"ir•^••^"ininminmirtft
in in in in m inif
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 113
Stock Negative Cancer Chemotherapy Data 291
siiliin inold
o. 5Ss
Iè
uo o
üu
iHo"
ao"
CHcT" au*
NO
H5 0B00
^a
»H
H '
!
§iÎö•811k,N-DlbutyKei1Mi6-Dicarb(co2u
£•id'-DichlodXmsi115-Dlchlor
naphthoic(SÌBI•813
5Su*5-Dlchlornaphthoic«i.o2ii4-DlchlorKÎ11i1fn
rMi6-Dlchlor
2-oxlde•*Q)"o1I•86-Dlchlorin0)iI1i(3,4-Dlchrhodanlnei2Unu1ß-Dichlor0*.A)H4-Dichlor<chlorobendi51iip'-Dlchloi
chlorideà E|1»dI5-DlchlonN
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 114
292 CancerResearch Stock et al.
S3ggBSo
S I
! ï§ s
oin7
?OO7
°miftoo+
+in
OO
Oin
oO
O+m
O0
-Ho
m00o
i/i07o
in-i0m
oo'—i
+o
in—0in
o7°o
oioo0-. -i o'
Õ °O. o
2E
I 3-
H
wS
H,«
f
S£t
«8-
£;fOu1i£3is«ichlorothiocyano
ester13^_Mu"oiQ.N3-Dlclnnamide-ip«M•8u«2TIcyandiamlde
ur
resing,*«•^iOS
äs•-•B
uI•O1IUJ5HoMU"oNe1"x^(Dicyclohexylc
acld°00u~fl)I&0)
0}-(3,4-Diethoxybsallcylhydrazid*jB)ir»UÕ,IsClethylammoniurUozr-U1.0•1Ui_*
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 115
Stock et al. Negative Cancer Chemotherapy Data 293
°.ÃöS* o
s •*ho S -
3gH
8gi
0 7-H(*ï1
+Orj UH~«1
111 1OOO OO 0 -i 0t tM OrM oo o0 0
w ?
t§ § § §
asilp.S
u§sAO
C.Q
U< ou
y§p<H
1u
2omm"1
J-
&«
I
Oo*sTmo"1*fB¿UMr«ihrsjB""inu"1^.°COfOM"OA]u—,t9oJr*U1
M1g"CU¡^l4
o" °0
6Õ"
0°
1*«v.
«è
èifl!B*Q
um<MflÃ1loroacet•gU1s3i1ethylmalcSg*>,
1§•eS
atHAH
CLtlv
aS?1
1•jjiDlethylthichloridema5
10~vQ
N/N-(2,2-benzothia*jM1m330glycollca
esterS||S•Mmi5-Dihexy]dienone*in¿a
§«3S"J¿|•ë
<*•J3*4>?1(M
S~Itfî'•xls0)1te¿Ita£
oo S¿3v£)~0)C
U!eiSin-j
liU
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 116
294 CancerResearch Stock et al.
oof
7IftITIO
fìo
inINJOut
inOOin
m*ioo
in-HOm
miooNO O-H+
+1 1m
o-^rqm
oislOo
oi in ini oooo! o >4|cì-•I * il +m
org-^
U U U u u-Q
O"sf
oMx"
Hmu
s !7Sri
1I
IQ
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 117
Stock et al. Negative Cancer Chemotherapy Data 295
H<
oi$
S2ìla01fi•§Ë|§AH•M^5ilO
+jino(MC0MtiSIla
iEU
3
mw S •O •<'
> a S 2 1< u 5 •"u =>o o oo o in o~"' -^ o o o m
o ^ini oo -'
'^'^'M^NrvJisJrJrgogrJ
SS
"i
W
E
o °, oB"
». Kr^o"
-- «
ou
W
î
n•oa
•nS
rô^
87&2O T3Sa-£BSÌ
1
benzaldehyd
•Dimet
4I1S
Dimeth Dimet
X
ï
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 118
296 CancerResearch Stock et al.
H5
-is
*•< o 5 öwJa
Ü
ir. Oin ooin•:?oin0-o
m+
+0
0+
+o
mlmo0-i \--•l|
i i+ i0
.07
?o.-«I-*+
' 1 1
eg•o
O WZ "a
fi 1*1 K» r- m m r- f) fi
W ?O !*S "à § § §in in in in in m m m in
3e§&s§».g
3a
H<
u
Z
«
1—Bupyrldine(p-Dimethylaminostyryl)
methiodidei<s|rMB""00Uj"UU
1flJ-1
SminOXoflfUa_ctlf.N'-Dlmethyl-N,
N'-di-n-fluorobutyryl-p-phenylenZ£sscu1fl1?11is-4-Dimethyl-2,3-dlphenyl7-keto-/2,2,^/bicycloh_"0ÌSnu¿"u&5-Dimethyl-3,4-diphenyl
pentadienonedimerf$mQQ^ri°^rU4^i4-Dlmethyl-3
,5-dithlo-1,
thladiazolldineeg2tTo°P-DimethylglycldamideŒL^L!nT000!NfX
Kl"i>0IMeau,a¿methylmalonlc
acld,bis
phenyl)ester5C0söTorMu0)CIIH16-D
lmethyl-4-myrlstoylici°Z2sT-i-u5-Dlmethylol-v-trlazóleVIMo,SBB"^«UN'-DimethyloxamldeX0z<£•mUj"oN4*iasmmfÕÕm°C*16-Dimethyl-4-(P-phenoxj
morphollneftim^KoU3ejN-Dlmethylphthalamic
aZ
:i
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 119
Stock etal. NegativeCancerChemotherapyData 297
-• ol fi ^+ 11+ +T °7 °T 7î ïO O+ +7 ?0 +
51°ni
IM in
o§ §
J fc5<s fefc *6p o
»I
s
JA
uePIu
•uu
f00
O
ico
Ó"
u
i
"
-in j: *"
ÃŽaI
filE S 3
fill Eas3 Hj-«
e
tS
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 120
298 Camer Research Stock et al.
* =°.0
Siiti<Ss h S
0 0+<M
O+O r«iO —7 °O -H [ O Oo o0 rsj++o"
m+II -t-m
«
Iu
N A4 N ni n] M ft]
g §o "
ulÛ M
E
§ § o o o oO O O O
o. o
I«i(J
EiW
w<
w<
w<
H<
g: , Xft
°2°sR l
u u
v
s00
OS5
2o*su1
K
CtÃû" ìs
*z-M*
Ã
0
•^xla
o§•GO
CO—
Q)&g
IIQ"aoser-"
Sil•§.£
f3phenyl-2,3-ndocarbonyne94-5.
-^ o*|SD
">,£S,Sethyl
cyclSINI
1">,
0) D
fi9
?T^fiiilphenylnltriaXop
benonephenylproplQ00.oa-pyrazolli
acid-Diphenyl-2
inesulfonlc-
g'—'_oi.1,
dlsodluyl
sllanedlo
atlvec
>fÃŽTÃŽ3-eQ1aV*rt>a-itÃ"'-biphenola
a0QiSjfÃSB
f»g
1?CO1
">•a.«c«a20Q100¿'SsQ•capto-4-1a¿i*
1•siGrtI
oQ|Se1
1»?!"*'S-
*ST«(M
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 121
Stock et al. Negative Cancer Chemotherapy Data 299
°5
O U2 Ö
£
l
QJ
§
t>axv< 0 5 ÕJ
olin m io o o olm 010 mio o o m^ ? T •? *? •? r*'9 -^l0* PIN -^ ^ o o Ojo m
O O| O O
mio o.m in o tn o o o«IO r$\Ò O -H —¡—¡ -H O
l
<NJ O Ì\J "N vu %O O fj fsj su
Hb
if
o, o
a
¡io. 5o *u
Xs
o,
à % °0O
ido)
Ú*=o
O* M•«*•U
OI
U9l i
a
2S
2
I
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 122
300 CancerResearch Stock et al.
t>S
M
O H
O w2 Q
*S t<inw
UH3O
inO OO Om oo om oin oo oin oo o0 ino mT
7inino mio
OÃU
iQ co
0O
oEuss
aM$Xa?inJ"itaQfOit*<ocT<nI^¿Tir»to'uff04¿Tim"10"«i¿r—So« "aio"
o" u1Curf<CÕVJtaVm
IMOO1sffiatn
oU
Ü
u<z
dlmet
oxybeoline
-dlmet morpholine
fi fli Io. g ¿
I:
|O
i-
oroacetatIs
4<
i
asogZM
*
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 123
Stock etal. NegativeCancerChemotherapyData 301
1 I1:* * ai
a S oSii 5.n
s>S¿-3•.SOH
o^jnjn^inifljojnjnjngOUM ~*" o o o o o o^îZ
Q•mHwaB5
S „ o c ^J rj —io OO o! O — —i o — o —H" O o O —fu
S ¿8 * + ' '' ++ l+ ' ' ' ' ++H3I»-..«««..,...,(M
Os
s ga* ° a Es01IM g 0Uon
\ O N£> O O O OO O O<mM w *4 O o o o o o*x **^ "^ in in in in ininÜW
Õ/3£
oo.u§MO2
E O M OSöWüWBMWMWÖ1*Ut3
C/3g^j
a? ë0 gPz1 " — toMd^i i O >» O m
u O w Z JO 55 O OfC^S— ^> — ON-cON55^
Sco co W S o o s ~ < DCu'ü'tj'u'o'o'oo'u'R
1 i§lÃÃtÃi*Of « V %1§ 3ÕÕEAÕI*-R! I s.lI 1 1 iiii i I «* f« 1 ^ ', *5.<
i o'-^.p^'ä'r ' S -^a
S ^1 11 {I I | : II!fi
is il lì* Î1 ît¿"*ÌII "i fi 1 | 1 I11icu^
òi m m m mm«
Qf-t i* 31 in --o r- oo a- o —< r^WK O O O O O O ^*,_t•Hr!
ooooaoaoooaoaoaoaoU irtiTiininminmininil
u!iìMf
ìi«00
0,„,«.-, ..,inÕo" o" o >oso
oo mo min oo^("Jjf>iocj ^^o rjrj m —4 ~*l°
i il i + + li'p
« M N ^i-0a
sssss5
3v3in o o ino1ÕM O O*O-H in in*uI-s.BA>)n
>3H M O QWtI
*r
<*^4-
-^,¡1f § « s- s-%«oZ 55 ^ uOy a s jsa~>n tu t~ »Bx-• in o> *t in «
J U 0 0 O0l\
ÄI•o o'cr S'S.•5e"E«
« E » 3•=«s 5 «la«•TIH ci ^ S* OB. H 1 n«,l§0, 3 * rg SC-
3co 2'gJ »o •• 9r3C*™£!
*t 1 ìli!11ì!1 iti ï1>*Brtco IXO«^w-• ">.•%">, '^lo ">•« "£>
i 5*5 «o,§£S 5k H H 3 Huft
^ in so t^oo3
s Ì § ss
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 124
302 CancerResearch Stock et al.
.gsBB
gS3^|* S5 oa » g
>ÃS! t< o 2 i S
Lni ir» OÃm inm inin olin oin inm mm oi
iin
ini
im
mi
iin
oi
i0
0i
io
ini oOiOi
l'i ii
w<
uW
OuU•3
*Ct*lÜ9f2aT*"O>
-iou•^
^^°0a?sä"00
COOJ*M
ofa
ö ^<yo
33 oS—fO -HO-u
u u oa"eÃ0a3sTvOu
ui Õ
•Sa
al">.ll">>t«E S
5
Nms
1!
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 125
Stock et al. Negative CancerChemotherapy Data 303
1ata°.
<2o
wgQ<=•
wS^O ^ ^o2•loia•"t»H •»9> R°3 o S ¿8'NJUaSfc,
O°HsS-¡5-3xgj
£°
1—
t<5iiiie,uS
uggii°§<1ol
¿rs*ogg
1SQu
-<<
*21U3ON¡i
sSS1i
s5iioS.5
oO
00in in in ~H ~< -t inm-H—i O fM O O —'Oo
o in o o ojo »no oo Oin ooinii
+il ii i++++rg
Tf — -, ~,rjrn
22^22^2£gUo
oooooooOOOOOOfMOin
in in in minin.;DEt0z;r^r-d
i*£"S1ŒK¿J
^ -41öO
U O Ü O Ü0t
4IJ1's
2 « S5II
1 f 31-.g1" 1 e?Ili
1 ! .1HfilÕ 1 1 1 t fH?s- t l | | ï i:.m
fOrOfocn^*^1^CO00 00 00 00 00 00 OC!
I"ie15
§fimo
ooO
-H fM O OOo
oo oo oo mo minom+
iliiiiiiifM
in TT -H ^-H^^2222S
BSSu
uOO NÚ O OO0O -* O OOinin in infMmSÌmEd
W H< 0 < UWi
& "R.- f S- g o" z-°oNU
m tn xû ra^Jise in UH »^ nm2
C8 S3 S r-o0O Ó" u" c7¿TLI
1V>•«3Ss1
*fa"
à s=e
i §i 11¿! ! 1 ïîS
¿2 I -t|SJ «-ii îf *îd"33 c —" eC00
CO 00 00 0000inin tn m in in
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 126
304 CancerResearch Stock fi a/.
El
Sit
fioIta*3a
M1
w «^ «oSS? e5 3 s ¿ oi minIM[~H
Oo
mooo
mioooJo 7m
m~* o"+ |o
mO*tjm
o'STin
ofsj^+
+0
O^
momMf*J+
+o
o1mino—
+ +o
o7°m
inlm°°l°
O H
O H
J<
Ou
w< u•<uo"
-Ja
ao.
uXu
sC 9>as1 a1
o cTtao"
I00
Xo"
O
Õ9*
U
WINI
S
8HSS
1ss1jc
f .
". 6
r-
i|Sa
7 a -
»ID
i fa ?•BÎ
-o
aii « «>! -s
i
i
ÃS
1iss
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 127
Stock et al. Negative CancerChemotherapy Data 305
M
le
s
>•3-•*Ì+
lOMi + •+•—iO1
i0rg+~t ro~. O
1 1-Ho
1-*M
+ |(MO
1 +OO+
1oo fi1 +' +
*4 rj rsl
(O M
§ §in irt
s
E
HO <
o.a Ou
«TIM
%ti*ioÓ* m
oU
Iff
«o
€o*
à I %Õ"
t "
«iltÃ
I I
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 128
306 CancerResearch Stock et al.
siW«h,p°.5
« 2°SS
°°(OK
11*3¡>*zr rv* 4)O.«S fi Oin ino°>M •- « g MO 0 -<0°<
o 5 is SHJy
-nl.
£"? ft mf*>i«*SW
"3ra^> o oo0¿i 0 00X\ m minW
boEW
WB,
U|
UÜ
* °"o
MU3
o*5 | o'o~s
° *S:: i S~*-u
o uuig
3•n
18
IIISS9e-s
S5 g-I• II I1iff.!¿1îiif,•#MÇ
" I*- 00COa
a s sO
O O 0O—
i f\j O OOo
o o o in Ojin o in mo in oo -•-H i%j ^" -H*|^' o o d-4 ^T «Õ
+ + ++ +'+ + ii i 'i8Soo
o o o o oo o o o oo11 in in in inm»
M UW < W O •<•<O
M in r-M M O PO Ö O
!^ 0 Z 0 £ZINGM53
S tS KSO
O U O UUa£
!1vrtB
* •§3'S
S •§ l 2^Issili
1 I f i ?Iii « or •ti PISV ? •§.Ili S.!
! ! fi ffii i i lì!ilKEC 35 K*1^ Ähi i i i -° i -*-•f^J
fi ^ in >oi*-OOCO 00 CO CO CO
CO CO OD CO 00COinm in in in inC)1M§S^o-o-o-o-o-o
m in o in m 0,0 oiinmO-I ^ r\j O 0* rg UH* ol^-^+
+ + + + l ' t ' +1t-H
t-| ^ ^,«O
0 0 O O OO o o rg o Oin in m inmMO-
W U W <¡ UÜ4
21oo §• f I31"i
"» K" à "isao
o u u uu5i
S.JaS
13gS B |
1 =5 tli- & i s| i- i
1 I i fri IÎ1i| i ti ¿1 17 ? 5 "?-s i s34*^ ^ «-i dv-iI
I I 1 I Imo"33
'Saoi0H
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 129
Stock et al. Negative Cancer Chemotherapy Data 307
sS
o m oà m ol m mio o o olin o o OÃo oto mi in o in m m tn inrilo" o"[o" o" o" PJ in o' in rq o
NH
NU
u
X
1aNU3ucd.S1
1S13H16IN02Oîs1•«oifr4-o-Iodobenz(
morphollnetaè00s"Bu1Sucdu1IMaIodomethanessalt,.H2O03iu_Isethionic
aciC6?r-U11aJiD
tÃ"IN-(Isobutyl)-:
Buccinimidein(i*00UOC1*5L.propen;>-,«st(UeN-lBobutylide
ff
!«
3
lli
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 130
308 CancerResearch Stock et al.
B
l?=.«ÕlìB "ä
ja S EMÃŒt
£§ §JS -H .M 1
00
dioOIO in i oo [o* —'Ifsi
7 T
oIQ
nn na nn u uo <<y
OÃQ u
%u"
i Î O °ooK
J?ÃSr
°0
H11
II
til
3
U7«.
l:l1|
l II
11
S3 S3
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 131
Stock et al. NegativeCmcerChemotherapyData 309
M
Ì
(J w SBlii>'S2 I< o 5 i£§ ?
¿3u+ ?OOt 1~+
c*+ 1O
O11o
~*+~4O+
1+ 10Oo o+7 °l° 77 "+- 4J+ i i
m O
O
l
-s?
l
iB^
U
3
l"ñà I2N
I!" .
H
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 132
310 CancerResearch Stock et al.
O HO Wa o
l!
8in
. -> * i £o< u g i S
w
u
oin—0ID
inO0+
im
mo-<
+ io
inoo+o
oÃMft
1 +O
Oo
oinoÃomO~H| ^fli+| + +o
o+
+o
oooo
mr\jrsj+
1o
mioofNJO| 0 0o
inCM0+
1
».2O H
. O«a
oi U
U
lU
2hO) 23r
ro
X
u
oà f
ia13
E•3
il
. „ a— cd
?|
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 133
Stock et al. Negative CancerChemotherapy Data ÃŒli
; w S-o <
mo o inO -H -^ ^
in o
o ~+mi m o od| O ro rsj
Ou Ou
Ou
o ou u
H
I
ÎHoSÇJ«Oïin«-Methoxy-2,
5-crm&¿ï*U0)10.8
•à 1-Methoxy-l.
3,2-INISxO»o^uìsd"-Methoxymethyl-
glutaraldehyded1
Mw*sOU1Ë1">>11W•zXOudfr-o3oi-Methoxy-2-nltroi
benzene"•c?«To*ue1|
1ia
slethoxyoxalacetlca?M*01Us
un
uS•S3'S:-(p-Methoxyphenyló.NtficT§1ïi">!ta
(o-MethoxypheA^J
(Mta(NiU4)f">,H_co,
^..8(p-MethoxyphenAff•&>|oogg
1o1f
iaiça>.1s¿î<?006?
î—O*15«•Methoxy-ß-
(p-m
propiophenonea,ir-sTr*)cT1i•(p-Methoxyphenyl
morphollne•*8"00U*osMethoxysalicyllcin
amU
3
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 134
312 CancerResearch Stock et al.
(X I
O Hi'8OÃ
; w S ^ M'.llîî
H3
|M
i !g
m oo mjtn oio mm o m m,in o o mm o|m o|in m m mjo m|o O|m-<' o'|d o") o —*|«
i ii
(M M
°g9S
f> CO
si
sitn en
§§
E
§ § §m m
S u2l|go
H<
U<
U<
1N
o*<
k
oU
w•<
» . w3 u <
« "oo
rtJ
(^O
OO;r—"
£•g.
tik*
1
«5.&
l
oa
u
5
I
•?TSl-ss
sro
ritl -|SÄ?I 1¿a
mr*o
*s
°o
s?T.ni
U
ï„
I S1
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 135
Stock et al. Negative Cancer Chemotherapy Data 313
ggii
>a°l<oS¿
in mm "M
oin07m
m-Hoi
+m
o?
7mot
°oinO
^I0
0o
om01 oooo Io -H
i im
moo
i +in
ini oojoo—Ui oo+ l'i
gH
»|i 8*g
o "a
aiK O0, U
e w
¡lO t»O
ó1 o1O3*H*
U
ta«ro
Õ00
U
B)m
c7
I iIi
I2i
i
91
a
l lfcf lli a
I I
T! l2l t|| tSÃ-f<i O
fni-"
N .
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 136
314 CancerResearch Stock et al.
fe 33O H
i i
suif•4C Q 9 *P
51s I iin oinin7
?o
o7
7moin inoo7
7inmrg
ointni
+in
in+
iin
in0
O1+in
in+
+in
oï
Tino+o in+
i
£
§ ooOO
S
s-
-UU W
M<
3LJ
un
iCu
*o
8omu
1u
c^a?
gHt^cT
o
Io
u
satln
1 g -•tÃTI
i
Mci Met
E
zot
o o"•g. 'S. of, fi 5
Ss §«2 $Metto
£ulfonlu•
1J1.U1•Methylp
bromideo.uÎii1O|ao.¿1Ifi•s-l11S
o
¿1?!z
S.e•z.
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 137
Stock et al. Negative CancerChemotherapy Data 315
oimM! rjI I
m m o m o in o o o o mo o o 01 o o o 0,0 o m oto o oO o —«<M •-»O olo -HO O'-H rj^H "-»Ira —t r*¡ «ilcn O O otrsj
o ¡in
4|p
§ § § § i § §
§1p.si u
si
oo
6
H•< U U H
I €%m
U
I£
X
f«S1
iïU
o"<N
%Äo
cT
!
2ä|•MethylsuccillXrboxyllc
acid1ii
f.tÃA£1tf
I4•gil
ÃœO*>II3fm)
sallcylamideyl
methyl(4-Morpholln
HC11K.cconol
FSNOS>nyl
chloridei=3m.pht
balene-1,HiiNaphtholcan)a0ÎNaphtholcaniien.NaphtholSs•Naphthol-6,f Isodlumsalti
«(NJetÃ
mide2-NaphthylacK8-dlsulfonicgSNaphthylhydr:
cidiw6,
8-trisulfonìiNaphthylhydrlJl,
1
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 138
316 Cmcer Research Stocketal.
IM*V >i M
! ! i
in o uv in o in mio oim m in o o m-Ho* —*|o o o o!—* d| o do —iIMO inO* O* -
n ojo ojÃna _;( ^ J di i'i ii
§o oo o
m un rq
*
a
Sh
H)M
uu
1 O * Klì» H U
%%ó*
lA
SI•o
i
i
1U
Ã00
U
«_N
1
U
no
H
U
¿pIU
ItiH
1
¿
E
a-Nap
I
&
Bf
-S*3 p gI
2U
lìK¿.
s1
I
as
l
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 139
Stock et al. Negative Camer Chemotherapy Data 317
ii" U
S ««o S O 0)0ino
Y'° 7moiO in+
|un
O+
iirt
oloini
t im
o+
+o
o0-•o
o7
7mmi
+in
olo ölm+
i ' + 1' 1
«lg iî
I-l Ç< 5a Sco tnS Oo. u
SE
«a
§(M
tà ilu
&pó1ft
ui-x.
§, g i Sau£
X
i
.&
h
i
ÃŽÃŽ1 =
11« C
O 3
^
1•e
as
l
i
1 §? !o &.
lii
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 140
318 CancerResearch Stock et al.
Ha
IM
§8
'•**°.S
ig,j u S \C o < "o* 2«a
••<!O *> » SE Õ«u 3 £
83J
IH
Ss. H
g Ua
O Oi Oin+
+ ' + +m
oi
i0
0ivi
0o
o0+o
oif) O+
1m
o+
iin
mi
im
oÃmin+o|o oin
i/i+
+O
m i inm+
+' + i
39y Hs «o. o
5
z u
¡iil0Mu
u«C
_J
U
g I«*lM
U
I O
IBco
cTn
00o"tain
O**2J*
M
lois*u
•§
i
iB
§•S3
D-
CU¿(!)
S Ã
i¿
hydl
!£
!&lo.
^J '
K
¿taa
cu'v. II
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 141
Stock et al. Negatile Cancer Chemotherapy Data 319
! ÎO «0 CID C
sä t
S
O MZ Q
u
iM
gi bp
£
en tn
inO-H
O+o
m"+Vm
inoo+
+o
mOr*ìio
mf-Qoji
+ifi
0O
Oo
oO
OO
iflo
o+omo
o+00+
1o
ino
oomO
PJm
ofVJ~*+
+tfi
0r4
o•f
(X, o
Ì«5 o
S1U
J«
Ot?
W<
H Ou
u
ia
M
¿T
« 05
ÃŒCO
O
°3to'
aM
U
9,I
8,•Cu
°o
idlne
>•
-
Ì°MJ. x
=3-ew 1rg'S
I U
i?!Il
I1.1IÕS*
s sA o
etate
C
14)
~S
loformate
eT,
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 142
320 CancerResearch Stock et al.
fa
*si
S SVj M
Ì f§ s
m o imin—r-l\— Oin
ooom
o7°»n
m0
0in
in7
7inino
oo01inoO—•-M OV +in
oo—»0
0rg
ooinO
0o
oo*eg*omrs]-i
1 1
f^l rq rg (M <M ÕM
«rr-u
mf(M
O*
à a1s H
U
rg
ÃHo~U
r«-U
o
iu
£I
S
O. o)
§1£•
sìa S
AB aCO Oob £f= a fo. IX
1
I
S S s s
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 143
Stock et al. Negative CancerChemotherapy Data 321
&,£5S
> ' K -r
•<o aH
IH
s
f1
OJOdio' o oo' o* o in^i —" oi in
o UlAJ* alo o m o i to mio mi o mie;|_- _,-d - U _-L- oë-ܫ
t l'i l'I l'i III I
u •€
35RHen en
A U
ilO 'u
H<
H< U
•aio*^1>oao
u%H*Al0*<?i00U o ü
M<D
HerU
ff
cS1
'S;
UT
1
IS fA
4.ao u5. o
5 &
ti
Kl3&
1
f"EI
I
aaH
:i
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 144
322 CancerResearch Stock et al.
ftP
> °«i<Sa As
moooin
inoo
i iin
in0O•fr +in
m0-i+
io
in-HO
| +O
OO
-t1o
mi inm„_.|o om
mO-H
+ +in
oooio
in—1 Oio
mC3<MO
O|0Olir,—' o*|o" o'| o"
«
;oz
¡EC Oft U
SÈ
leggs o5 rao
5s
Hnu
aC.
u
"lo*
°mX %
«2o1
ifi-fi-
u
!i137. fe N
- S
«
li3i 3
i
3o.
I
1l•s
a02
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 145
Stock et al. Negative CancerChemotherapy Data 323
«I
a oA U
gU
i
1sM
ì
hi°.|ig
co•W S \ a
&1ÌÌÌ»•lui•<o S £ 8
o mioin0«Jfxi0+
1+ +o
o] oorg —' i%Ìrs]++ + iin
oi
+o
o7
7O
OO
rgin
o~*ro1
+o
oròOo
oo—'1m
oi
io
ojoo0(NI Li(SÌ+1
+ 1in
in00+
i
HU
wî-
iH
Cum
J*Ia?
9,Z IMbe O
r- SS—< oo
as SBM«oU
ogX
o
mM
a<n
U
ou
i
I
IIsi
f1
I
£ì1?8E
1E
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 146
324 CancerResearch Stock et al.
IL:
ëë3ï*oo1
1in
oio tniO01
1tn
oltn o! inoi
'i ' -f +o
mi
im
mi moi
+' +o
m+
io
oi
im
oi
*in
oloi
!
§ §
5?
°.HS?
£tmo•4<?Xc7iÕu€mu<cH1UffauAI9,£u2
0 O»* sf
iIî S
f
IK¿. S
lial3
•
|
|tl
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 147
Stock et al. Negative Cancer Chemotherapy Data 325
£¡SO N
O UZ O
!i
o, u
oÃin mim ml md|o »4lfij o u;
ino°' ">
++
un o mo
KsiO (H
_•w•g
!Ì s\ ">
l
W;
u
t :=*
Ü1
1 1t
IOii
H
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 148
326 CancerResearch Stock fi a/.
§ §
OO~¿
OÕ+ +ir>
ut+
+ir»
oÃom~d J ^
+ i +o
inoo1ift
mOOo
oO~4m
un~*<-j
+ +m
o+
+ifl
O-H"O+o
tnO-Htn
o7
tOOJOt
4r
PiQ
u3
OU
acau
2
s
ffJo S *i
lïl2 •?7
?ÇfîJi v 49«:flN. S =3
taIM
U"
'1 =3
i ëI "11
¿s•auJ.Õ7-1o 5
M
A P
o" <
*icJPOlCshydroxyp
ïcetate4.
arahydro-ethanol,«
Ef-iHUB1ri
ëiÈt'-'SsD
«ïloo•*-•Ã\*N
§4<2cT|-Tetrame•Z
2)-2
2Ez"Bas
i
I
1
U
I
«o
Io •—*
»2 «? g §
¿i¿ si 3 *-< ni
£3 fe|g |
6 f
£•8
I
H
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 149
Stock et al. Negative Cancer Chemotherapy Data 327
uli
.ilili!ìlìï 1 ï Sì¡gS c o o oo
*J £000 inoo« •* in -t -H ininO
H o oo0W 5 §5C^ÃCgiC.ie.Jt.ie.iCÃC.J«!".%Q â„¢ -< O -• O O 0 O 0 0Otj
w S \,C O < •a—Et S ¿iJ!fl2
3 rt -ü oo o m min inooo>3 j, £> g r^O -Io* -10 OO •*fvjHJnin
oin iniin Oin oo inin oitn om inininin-,INI -*f\j ^H-H -^o o^* -io mrj -¡o «-< o-I
•*••*-++ -*-'+ ++ + ++ ++ ii i+ i+u!:rJvu(NJ(vl-'<^r«jrvÃfsjiM_OT|*rgisiUPWëlH
_Q'O 2 2 2 ^ 2 2 2 2 2 m m •- nm*gS>•
Bu$"gEugaSi
§SSS§§§2SS§§p\inmin : mmin':SSQ<lg
gf.in>ZX0PL,u§HÎSg
*SP.WWo woSSS
0 - <<WMW<WWb,<: H WW0Mu
aua<u
Ca00
rvj
O
s?ox°
°o
ai: d"tT **
-^ m NDDUO
8s?
2ö" no
I
£*
I-
II ÕÕil Sag3 gft
Tl> aiÄ* l
m *s T3
•M'a C«'S S•°s •§I| ¿.«o ¿
11 Õ£«2
ütz
lM
Ib5 S—vH
SB=3
¿S 5
II ?«rs «
ioaemi
s
S g ¿5£ig i|oi £ SSs &
¿B O,H
2 a^ « s
H
Ü ?•öS?•
o S "lH N
e>H
S
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 150
328 Cancer Research Stock et al.
slO Uz o
-7.
¿i*!!
K•atix 6SsC m
ino+
io
mooo
o-,ojm
inoo
i iin
moo*i
+o
moo-fo
m00if>
m-<0m
ot^oo
mo* —«ioo1
+m
m-HO*+
+m
m0-H+
+m
mt
T
S
5
u<
W<< <-2 -Ã H< Ou
U<
1•
tÃ1 iuViÃŽiüIE£o^u¿JIj^Ã
ai«0.CS«I-Trichli
[oro-2-m-j.
*oOm1
to'coUO
t.IIrt
^lì7
1ort1
SZ,2-Trie)acetoac«ìtV
»Õ_rp
U1umethylol)"5!Ichlorom
amideriiin000Soo"JS
«ti1ilIchlorom
LorophencT5Îm1U,1CD¡jjè|dt_^sG
tf^0U(AfiÃŽIs"
uHS3
2AS0^5fmuaSN1
^1-Trichlor«*°*1U*s"Ua
_u"33fio
»fiS;|
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 151
Stock et al. Negative Cancer Chemotherapy Data 329
> * z; £§•<U H i g
o in in
O O O O O+ I 1
inort-•
+ io
o-tr*
\ +un
inf^
0++in
in0*0+
io
mOO0
OO
rsiO
0? -foo+"+m
un-HO+
+o
oINO+o
mo-•i
>•£> <M rj rq iM <M rg M
f> co m (*\
s, u
sg
U
COrgHmocodPÌinmcT0Kmtiom"Au°MK•Snt*o*0*¡BCi^0sTo"OfviJ5SXty*r^
^H0 0tf00u^cT«5-vOÕÖDJ
nc*iu
H
i
l3IH
">. ^
0 VN —'e <a
benzo i
!- 8lj?
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 152
330 CancerResearch Stock et al.
ä ^Mu » x«S B»S
1sä<JHg«
à S §S^
S rt Õ3 ° ° Oitfi m IA ino tn i/i ni oom>Ki-aJoO O* OO O O ~ t*t -<O OO OOHJ1
« «
§ 1Õ§
§g-H ini/to
o ooÃ
à iî > ^ i,^inin
om o o oo Oin inoofNJ—l-«fN| ^HO IAO OO «-!•-( -H
OO
o[X
-'S «Q < m
ÃŽi6*
B00o1 IM
U
OI? %
cT
Oz
53o"
.sil'S
2 « ln l!>? J&— &li li- a hH H
Sss
l£
I
aeÊa
S c
os;
os
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 153
Stock et al. Negative Cancer Chemotherapy Data 331
M
ìg
a §
oo
¿l
ÃtÃ
X
o
><-3¿S M
•o
s'S,x
Iës
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Page 154
1955;15:179-331. Cancer Res C. Chester Stock, Donald A. Clarke, Frederick S. Philips, et al. Sarcoma 180 Inhibition Screening Data
Updated version
http://cancerres.aacrjournals.org/content/15/Supplement_2/179.citation
Access the most recent version of this article at:
E-mail alerts related to this article or journal.Sign up to receive free email-alerts
Subscriptions
Reprints and
[email protected] at
To order reprints of this article or to subscribe to the journal, contact the AACR Publications
Permissions
Rightslink site. Click on "Request Permissions" which will take you to the Copyright Clearance Center's (CCC)
.http://cancerres.aacrjournals.org/content/15/Supplement_2/179.citationTo request permission to re-use all or part of this article, use this link
on April 12, 2020. © 1955 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from