Safety and efficacy of the remodelling technique in the treatment of ruptured and unruptured intracranial aneurysms: Analysis in two prospective series (ATENA, CLARITY) L. Pierot, C. Cognard, L. Spelle, J. Moret Reims, Toulouse, Paris - France Symposium Neuroradiologicum, October 4 – 9 2010, Bologna
31
Embed
Safety and efficacy of the remodelling technique in the treatment of ruptured and unruptured intracranial aneurysms: Analysis in two prospective series.
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Safety and efficacy of the remodelling technique in the treatment of ruptured and
unruptured intracranial aneurysms:Analysis in two prospective series
(ATENA, CLARITY)
L. Pierot, C. Cognard, L. Spelle, J. MoretReims, Toulouse, Paris - France
Symposium Neuroradiologicum, October 4 – 9 2010, Bologna
Remodelling?
• Technique initially designed for the treatment of wide neck aneurysms
• What is a wide neck?– > 4mm (Zubillaga, 1994)– Sac / collet < 2? 1.5?
Remodelling: technique
• Balloon placed in front of the aneurysm in the parent vessel
• Inflated during deposition of each coil
• Deflated between each coil• Removed at the end of the
procedure
Remodelling: technique variants
• How to place the balloon?– In the parent vessel, in front of the neck– In the neck– Angle of attack
• Remodelling 2 balloons
Important issues
• Is the remodelling technique associated with a higher risk of complications and morbi-mortality compared to standard coiling?
• Are anatomical results improved by the remodelling technique?
Treatment and SAH morbidity Treatment and SAH mortality
Unruptured aneurysms (ATENA)
Traitement sélectif727 anévrismes
Coiling396 anévrismes74.5%
Remodelling271 anévrismes37,3%
Stenting57 anévrismes7,8%
Trispan: 3 anévrismes (0.4%)
Unruptured aneurysms (ATENA)
Aneurysm location
Unruptured aneurysms (ATENA)
Aneurysm size D-to-N ratio
Unruptured aneurysms (ATENA)
Unruptured aneurysms (ATENA)
Remodelling
Anatomical results
Literature review (Schapiro)
Initial occlusion Occlusion at FU
Ruptured aneurysms (CLARITY)
Initial occlusion Packing
P=0.017
AO= Adequate Occlusion. AR=Aneurysm Remnant.
Unruptured aneurysms (ATENA)
Conclusions
• Safety of the remodelling technique is similar to standart coiling in both ruptured and unruptured aneurysms (ATENA, CLARITY, Literature review).
• The remodelling technique seems to be more efficacious than the standart coiling on anatomical point-of-view.
• The remodelling technique can be widely used in the treatment of ruptured and unruptured aneurysms.
Publications
• Endovascular treatment of Unruptured Intracranial Aneurysms : Comparison of Safety of remodeling technique and standard treatment with coils.L. Pierot, L. Spelle, X. Leclerc, C. Cognard, A. Bonafé, J. Moret Radiology, 2009, 251: 846-855.
• The remodelling technique for endovascular treatment of ruptured intracranial aneurysms is anatomically more efficacious than standard coiling with comparable safety.L. Pierot, C. Cognard, R. Anxionnat, F. Ricolfi, and CLARITY investigatorsRadiology (in press)
Principales séries
• Moret J, Cognard C, Weill A, Castaings L, Rey A. The “remodelling technique” in the treatment of wide neck intracranial aneurysms. Intervent Neuroradiol 1997; 3: 21-35.
• Aletich VA, Debrun GM, Misra M, Charbel F, Ausman JL. The remodelling technique of balloon assisted Guglielmi detachable coil placement in wide-necked aneurysms: experience at the University of Illinois at Chicago. J Neurosurg 2000; 93: 388-396.
Principales séries
• Cottier JP, Pasco A, Gallas S, Gabrillargues J, Cognard C, Drouineau J, Brunereau L, Herbreteau L. Utility of balloon-assisted Guglielmi detachable coiling in the treatment of 49 cerebral aneurysms: a retrospective, multicenter study. AJNR Am J Neuroradiol 2001; 22: 345-351.
• Lefkowitz MA, Gobin YP, Akiba Y, Duckwiler GR, Murayam Y, Guglielmi G, Martin NA, Vinuela F. Balloon-assisted Guglielmi detachable coiling of wide necked aneurysms, II : clinical results. Neurosurgery 1999; 45: 531-537.
• Nelson PK, Levy DI. Ballon-assisted coil embolization of wide-necked aneurysms of the internal carotid artery: medium term angiographic and clinical follow-up in 22 patients. AJNR Am J Neuroradiol 2001; 22: 19-26.
Principales séries
• Layton KF, Cloft HJ, Gray LA, Lewis DA, Kallmes DF. Balloon-assisted coiling of intracranial aneurysms: evaluation of local thrombus formation and symptomatic thromboembolic complications. AJNR Am J Neuroradiol 2007; 28: 1172-1175.
• Sluzewski M, Von Rooij WJ, Beute GN, Nijssen PC. Balloon-assisted coil embolization of intracranial aneurysms: incidence, complications, and angiography results. J Neurosurg 2006; 105: 396-399.