S-1007 Multistate Research Committee The Science and Engineering for a Biobased Industry and Economy Raw Materials, Byproducts, Agricultural “wastes” Bioprocessing, Bioconversion, Bioreactor design and control, “Biorefineries” Biomaterials Bulk Chemicals, Biofuels Specialty Biochemicals E D U C A T I O N E N V I R O N M E N T E C O N O M I C S
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S-1007 Multistate Research Committee The Science and Engineering for a Biobased Industry and Economy Raw Materials, Byproducts, Agricultural “wastes” Bioprocessing,
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S-1007 Multistate Research CommitteeThe Science and Engineering for a Biobased Industry and Economy
Specific Serum Hybridomas Monoclonal antibodiesMedia Serum Human fibroblasts Interferon
Serum Monkey kidney cells Polio vaccine
1 Murty and Chandra (1997)2 Hortisu et al. (1992)
Byproduct Bioconversions to Products of Increasing Value
IncreasingProductValue
Examples of Research
University Collaborations
Research at Clemson University
• Fungal production of essential fatty acids and SFE fractionation– Walker, Hui, Kuan, Heaton, Cantrell
• Algal production of polar lipids and proposed hydrogen co-production– Drapcho, Brune, Walker
• “Microalgae Platform”– Brune, Benemann
Bioconversion and SFE Process
Microfiltration
SFE
Partially-Refined Product
Bioreactor
i. Raw Material(s)ii. Organism Selectioniii. Metabolic Engineering
Monitor-Control Station
LC and Analysis
(HPLC or GC)Purified Product
Figure 1. Typical bioprocess for bioconversion of raw materials to nutraceutical and specialty biochemicals. Primary separation procedures include ultrafiltration (UF), supercritical fluid
extraction (SFE) and liquid chromatography (LC). Analytical techniques include gas chromatography (GC) and high pressure liquid chromatography (HPLC).
Samples of oil extracted by different extraction methods compared to commercial sample of
refined rice bran oil
Soxhlet extracted sample
(biotreated bran)
Soxhlet extractedsample
(raw bran)
SFE extracted sample
(biotreated bran)
Commercial refined rice ban
oil
Figure 1. Conceptual Process Flow Diagram for Hydrogen Production from Biomass
AFEX Pretreatment
Enzyme Hydrolysis & H2 Production
CO2Absorption
Novel CO2-fixing Microbial Strains
Methane Production
Biomass
H2 + CO2
Novel Membrane Separation
Pure H2
Co-products (Organic acids)
CO2AbsorptionCH4 + CO2
CH4
Steam Reforming Energy
Methane-forming Microbial Cultures
Research at Washington State University
• Manure conversion to sugars:– Analysis of manure components: cellulose, hemicellulose,
lignin, sugar, protein, amino acids, and metal element, – Extensive studies were conducted on pretreatment