Ryan Zarychanski BSc, BSc (Med), MD. MSc, FRCP(C ...Rady Faculty of Health Sciences, Max Rady College of Medicine Department of Epidemiology and Community Health Sciences University

Ryan Zarychanski BSc, BSc (Med), MD. MSc, FRCP(C) Associate Professor,

Department of Internal Medicine, Sections of Hematology/Medical Oncology and Critical Care University of Manitoba. Winnipeg, Canada

Hematologist and Clinician Scientist, Cancercare Manitoba. Winnipeg, Canada. Senior Scientist, Research Institute of Oncology and Hematology. Winnipeg, Canada.

Lyonel G Israels, Professor of Hematology, University of Manitoba. ON2051 – 675 McDermot Ave. Winnipeg, Manitoba, Canada. R3E 0V9

Email: [email protected] Tel: 204.787.2993 Fax: 204.786.0196 CITIZENSHIP: Canadian LANGUAGES: English CLINICAL EXPERTISE: Hematology, Critical Care, Epidemiology, CLINICAL RESEARCH Anticoagulants, transfusion, massive transfusion, EXPERTISE: critical care, sepsis, hemolytic anemia METHODOLOGIC RESEARCH Clinical trials, systemic reviews, meta-analysis EXPERTISE: propensity-adjusted analyses EDUCATION Masters of University of Ottawa – Epidemiology and Community Medicine Science (MSc.) Ottawa Hospital Research Institute (Ottawa, Canada) September 2006 – May 2010 Clinician Royal College of Physicians and Surgeons of Canada Investigator University of Ottawa (Ottawa, Canada) Program (CIP) September 2006 – September 2008 Critical Care University of Manitoba, Fellowship July 2004-June 2006 Haematology University of Manitoba/Cancer Care Manitoba Fellowship July 2003-June 2005 Internal University of Manitoba Medicine July 2000 – June 2003 Residency M.D. University of Ottawa - Faculty of Medicine September 1995 - May 2000 B.Sc. Med. University of Manitoba - Faculty of Medicine May 1996 - August 1997 B.Sc. University of Manitoba - Faculty of Science September 1992 - May 1995

mailto:[email protected]

Ryan Zarychanski

PROFESSIONAL COURSES Academic Health University of Manitoba and the Winnipeg Regional Health Sciences Leadership Authority Program Centre for Healthcare Innovation, Winnipeg, Canada October 2013 to March 2014 Acute Critical Events Royal College of Physicians & Surgeons of Canada Simulation (ACES) University of Calgary, Calgary, Alberta Course July 2005 CERTIFICATIONS FRCPC Fellow of the Royal College of Physicians and Surgeons of Canada Internal Medicine, Haematology, Critical Care, & Clinical Investigator

Programme USMLE (1,2 & 3) Completed all three parts of the United States Medical Licensing Exam MCC Medical Council of Canada. Granted December, 2001 ROYAL COLLEGE OF PHYSICIANS AND SURGEONS OF CANADA SPECIALTY CERTIFICATES Clinician Investigator Programme – September 2008 Critical Care – September 2006 Haematology - September 2005 Internal Medicine – June 2004 PROFESSIONAL AFFILIATIONS Canadian Critical Care Trials Group – Member Society of Critical Care Medicine – Member Canadian Intensive Care Foundation – Member American Society of Hematology – Member International Society of Thrombosis and Haemostasis – Member The Society for Clinical Trials – Member Canadian Society of Clinical Investigation – Member Royal College of Physicians and Surgeons of Canada – Fellow College of Physicians and Surgeons of Manitoba – Member in good standing

Ryan Zarychanski

EMPLOYMENT 05/2019 - PRESENT Associate Professor

Rady Faculty of Health Sciences, Max Rady College of Medicine, Department of Internal Medicine, Sections of Hematology/Medical Oncology and Critical Care College of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada

2009 - PRESENT Hematologist and Clinician Scientist CancerCare Manitoba, Department of Medical Oncology & Haematology Winnipeg, Manitoba, Canada AFFILIATIONS 2013 – PRESENT Senior Scientist

Research Institute of Oncology and Hematology CancerCare Manitoba / University of Manitoba, Winnipeg, Canada

2009 - PRESENT Assistant Professor

Rady Faculty of Health Sciences, Max Rady College of Medicine Department of Epidemiology and Community Health Sciences University of Manitoba, Winnipeg, Manitoba, Canada

PREVIOUS POSITIONS 01/2009 – 04/2019 Assistant Professor

Rady Faculty of Health Sciences, Max Rady College of Medicine, Department of Internal Medicine, Sections of Hematology/Medical Oncology and Critical Care University of Manitoba, Winnipeg, Manitoba, Canada

2011 – 2017 Director, Knowledge Synthesis Unit Centre for Health Care Innovation Winnipeg, Manitoba, Canada 2011 – 2017 Medical Director, Therapeutic Apheresis Program Winnipeg Regional Health Authority Winnipeg, Manitoba, Canada 2006-2008 Clinical Research Fellow University of Ottawa, and the Ottawa Hospital Research Institute Clinical Epidemiology Programme

Supervisors: Paul Hébert, Dean Fergusson and Deborah Cook

Ryan Zarychanski

Ottawa, Ontario, Canada 2004-2006 Clinical Fellow – Critical Care Medicine. University of Manitoba 2003-2005 Clinical Fellow – Haematology. University of Manitoba 2000-2003 Medical Resident – Internal Medicine. University of Manitoba

Winnipeg, Manitoba. Canada

Ryan Zarychanski

PEER REVIEW (CCV – RESEARCH FUNDING APPLICATION ASSESSMENT ACTIVITIES) GRANT REVIEW Canadian Institutes of Health Research

• 2019 Chair – RC1 committee (Nov 2019) • 2019 Chair – RC1 committee (May 2019) • 2018 Chair – RC1 committee (Nov 2018 • 2018 Scientific Officer – RC1 committee (March 2018) • 2017 Scientific Officer – RC1 committee (Nov 2017) • 2015 Randomized Controlled Trials (RC1) Committee • 2014 Randomized Controlled Trials (RC1) Committee (May 2014) • 2012 Randomized Controlled Trials (RC1) Committee (May 2012) • 2012 Randomized Controlled Trials (RC1) Committee (Dec 2012) • 2011 Randomized Controlled Trials (RC1) Committee (May 2011) • 2011 Randomized Controlled Trials (RC1) Committee (Dec 2011) • College of Reviewers (2014 – present)

Canadian Critical Care Trials Group

• Internal Grant and Manuscript review (2010-present)

Research Manitoba • 2019 New Investigator Operating Grants • 2017 New Investigator Operating Grants

(CCV – JOURNAL REVIEW ACTIVITIES) MANUSCRIPT New England Journal of Medicine/NEJM (2015) REVIEW The Lancet (2013-Present)

Cochrane Library (2013-Present) Intensive Care Medicine (2013-Present) Cancer Epidemiology (2012-Present)

BMC Pulmonary Medicine (2012-Present) Annals of Internal Medicine (2011-Present)

British Medical Journal (2010-Present) Canadian Medical Association Journal (2009-Present) Critical Care Medicine (2009-Present)

International Journal of Infectious Disease (2009-Present) CHEST (2016 – Present) (CCV – CONFERENCE REVIEW ACTIVITIES) CONFERENCE American Society of Hematology, 2009 ABSTRACTS American Society of Hematology, 2010

• Abstract review coordinator, Antithrombotic agents (CCV – ORGANIZATIONAL REVIEW ACTIVITIES) BSC. MED University of Manitoba, 2011, 2012, 2016 ABSTRACTS

Ryan Zarychanski

SUPERVISION AND MENTORSHIP RESIDENTS, FELLOWS, AND POSTDOCTORAL TRAINEES Neelan Sriranjan Internal Medicine, Resident University of Manitoba (Winnipeg, Canada)

Platelet trajectories in septic shock

2019- Present Co-Primary supervisor

Kelsey Uminski Internal Medicine, Resident University of Manitoba (Winnipeg, Canada)

Concordance of ABG to conventional laboratory hemoglobin values in critical care

2017 – present Primary Supervisor

Chantalle Menard Hematology Fellow University of Manitoba (Winnipeg, Canada)

Evaluation of a comprehensive Massive Transfusion Protocol

2017 – 2019 Primary Supervisor Student Recognitions: First Prize (Oral) – Internal Medicine Resident Research Day (2018) Third Prize (Oral) – CancerCare Research Day (2018)

Brittany Perija Internal Medicine, Resident University of Manitoba (Winnipeg, Canada)

Acquired Hemophilia: A retrospective population based cohort study

2016 – 2018 Primary Supervisor Student Recognitions: First Prize – CancerCare Research Day, 2016 First Prize – Internal Medicine, Research Day, 2017

Murdoch Leeies Emergency Medicine, Resident University of Manitoba (Winnipeg, Canada)

Post-intubation hypotension with ketamine and etomidate in acute traumatic brain injury patients who require ventilation

2014 - 2015

Chantalle Menard Internal Medicine, Resident University of Manitoba (Winnipeg, Canada)

Timing of thrombocytopenia in patients with septic shock (retrospective cohort study)

2014 – 2016 Primary Supervisor Student Recognitions: Second Prize – Internal Medicine Resident Research Day Third Prize – Cancercare Research Day Manuscript PUBLISHED (Critical Care Medicine)

Ryan Zarychanski

Chantalle Menard Internal Medicine, Resident University of Manitoba (Winnipeg, Canada)

Successful management of a patient with hemophila A requiring coronary artery bypass grafting (case report)

2014 – 2015 Primary Supervisor Manuscript PUBLISHED (Journal of Haemophilia)

Brett Houston Internal Medicine, Resident University of Toronto (Toronto, Canada)

HALO (unfractionated heparin to improve outcomes in septic shock) translational analysis

2014 – present Primary Co-Supervisor with Alison Fox-Robichaud

Jennifer Yamamoto Internal Medicine, Resident University of Manitoba (Winnipeg, Canada)

Preoperative therapeutic apheresis for severe medically refractory amiodarone-induced thyrotoxicosis: a case report

2013 Primary Supervisor Manuscript PUBLISHED (Journal of Clinical Apheresis) Student Recognitions: Second Prize – CancerCare Research Day, 2013

Meghan Azad, Post Doctoral Fellow University of Alberta (Edmonton, Alberta)

Probiotic Supplementation During Pregnancy or Infancy for the Prevention of Wheeze and Asthma: A Systematic Review and Meta-Analysis

2013-2014 Primary Supervisor Manuscript PUBLISHED (British Journal of Medicine)

Owen Mooney Critical Care Fellow University of Manitoba (Winnipeg, Canada)

Nucleated red blood cells as an independent predictor of ICU mortality and ICU recidivism

2012-2013 Primary Supervisor Manuscript under preparation Student Recognitions: First Prize – Internal Medicine Resident Research Day

Dr. Emily Rimmer Hematology Fellow University of Manitoba (Winnipeg, Canada)

Clinical outcomes associated with the use activated protein C: A retrospective propensity matched study

2010-2012 Primary Supervisor Abstract accepted to SCCM Manuscript PUBLISHED (Critical Care Medicine)

Dr. Bryce Makar Emergency Medicine Resident, University of Manitoba (Winnipeg, Canada)

Massive Transfusion research Program. (Retrospective cohort study)

2009-2012 Primary Supervisor Abstract accepted to SCCM 1st Manuscript under preparation Student Recognitions: Second Prize – CancerCare Research Day, 2011 Second Prize – CancerCare Research Day, 2012

Dr. James Paul Oncology Fellow

Adverse Events Associated With Bone Marrow Biopsy In a

2010-2011 Primary Supervisor

Ryan Zarychanski

University of Manitoba (Winnipeg, Canada)

Resident Training Program Student Recognitions: First Prize – Internal Medicine Resident Research Day

Dr. Mawash Saeed Internal Medicine Resident University of Manitoba (Winnipeg, Canada)

Classical Hodgkin’s lymphoma presenting with autoimmune dysregulation and systemic inflammation (case report)

2010-2011 Primary Supervisor Manuscript PUBLISHED American Journal of Hematology

Dr. Angela Desautels Internal Medicine Resident University of Manitoba (Winnipeg, Canada)

Acute promyelocytic leukemia (APL) in the absence of peripheral blood abnormalities (case report)

2011 Primary Supervisor Abstract/Poster presented at Resident Research Day, 2011

Dr. Kanwal Kumar, Cardiac Surgery Resident University of Manitoba (Winnipeg, Canada)

The Impact of Twenty-Four Hour In-House Intensivists on a Dedicated Cardiac Surgery Intensive Care Unit

2008-2009 Co-supervisor Manuscript PUBLISHED (Ann Thorac Surg)

Ryan Zarychanski

GRADUATE – (MSC & PHD) TRAINEES Thesis supervision to Graduate Students Sylvain Lother (MSc. Candidate) Critical Care Resident University of Manitoba (Winnipeg, Canada)

2019 Co-Primary Supervisor Project Funding Award: Hector Ma Research Award. Department of Internal Medicine, University of Manitoba Funds Awarded $16,000

Brett Houston (PhD Candidate) Hematology Resident University of Manitoba (Winnipeg, Canada)

Evaluation of transfusion rates and transfusion utilization and effectiveness in high-risk non-cardiac surgery

2017 – Present Primary Supervisor Project Funding Award: (2019) HSC Foundation Operating grant Funds Awarded $70,000 Brett Houston, PI. (2018) Manitoba Medical Services Foundation Operating Grant: Funds Awarded: $29,613 Brett Houston, PI. Salary Funding Award: (2018) Samuel McLaughlin/MMSF Research & Education Fellowship Award in Medicine Funds Awarded: $50,780 Research Award: (2018) Hectar Ma Award in Research University of Manitoba Funds Awarded: $16,000 First Prize (Poster)– (2018) Internal Medicine, Resident Research Day

Murdoch Leeies (MSc. Candidate) Critical Care, Resident

Intravenous Immunoglobulin (IVIG) in Septic Shock

2015 – 2019 Primary Supervisor Project Funding Source:

Ryan Zarychanski

University of Manitoba (Winnipeg, Canada)

Samuel McLaughlin Award (2015) (in partnership with the Manitoba Medical Services Foundation) $35,000. Murdoch Leeies, PI (2018) Anesthesia Oversight Committee Operating Grant. Winnipeg Manitoba. Funds awarded: $10,000

Emily Rimmer MD (MSc. Candidate) University of Manitoba (Winnipeg, Manitoba)

Evaluation of white blood cell trajectories in patients with septic shock

2011-Present Primary Supervisor Project Funding Source: Canadian hemophilia society (2011) $75,000 Bayer Hemophilia Award Program (2012) $80,000

Christine Fedorow MD (MSc. Candidate) University of Manitoba (Winnipeg, Manitoba)

Efficacy and safety of fibrinogen concentrates in cardiac surgery

2012-2013 Student withdrew from the graduate program

Project (non thesis) supervision to Graduate Students Daryl Hurrie (PhD Candidate) University of Manitoba (Winnipeg, Manitoba)

Efficacy of iron replacement therapy on fatigue and work capacity in non-anemic adults with iron depletion: a systematic review of randomized controlled trials

2013-2014 Primary Supervisor for this project Manuscript – PUBLISHED (Systematic Reviews( Student Recognitions: First Prize – Health Leisure and Human Performance Research Day, 2014

Jessica Dennis, Ph.D Candidate University of Toronto (Toronto, Canada)

The impact of Provincial helmet legislation on the rate of bicycle related head injuries among children and adults

2011-2013 Primary Supervisor for this project Manuscript – PUBLISHED (British Medical Journal)

Jessica Dennis, Masters Student University of Ottawa (Ottawa, Canada)

The Effects of Provincial Bicycle Helmet Legislation on Helmet Use and Recreational Bicycle Ridership in Canada.

2008- 2010 Primary Supervisor for this project Manuscript PUBLISHED (Injury Prevention)

Ryan Zarychanski

BSC. (MED) SUPERVISION Brett Houston Medical Student, University if Manitoba BSc. Med (Winnipeg, Canada)

Phenotypic and genotypic evaluation of a Manitoba kindred with haemolytic anaemia associated with decreased osmotic fragility. Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis

2010-2012 Role: Primary Supervisor Manuscript PUBLISHED (Red Cells Molecules and Diseases) Manuscript PUBLISHED (Blood) Project Funding Source: • Operating grant from the

Manitoba Medical Services Foundation ($20,000)

• Student Recognitions: • Travel award to American

Society of Hematology (ASH), 2010 ($500)

• ASH Trainee Award ($5000) • ASH abstracts, 2010 and 2011 • Manuscript accepted for

publication • First Prize – CancerCare

Research Day, 2011 • Best Clinical BSc. (Med) project

– University of Manitoba • Best Dissertation with the Most

Significant Merit (BSc. (Med) – University of Manitoba)

• Travel award to the National Student Research Forum (Galveston, TX) 2012

• First Prize – CancerCare Research Day, 2012

• Second Prize – U.S. National Student Research Forum

• Winner – Oral Presentation – Canadian national Medical Student Research Symposium

Ryan Zarychanski

MEDICAL STUDENT SUPERVISION Anna Blankstein (Med II) University of Manitoba (Winnipeg, Canada) Med II research prgm.

Transfusion In Orthopedic Surgery: A Multicentre Retrospective Cohort Study

2019-Present Primary Supervisor

Laurel Grant (Med II) University of Manitoba (Winnipeg, Canada) Med II research prgm.

Association of diary consumption and incident cancer: An overview of reviews

2017 Co-Primary Supervisor

Muzeen Ismath (Med II) University of Manitoba (Winnipeg, Canada) Med II research prgm.

Evaluation of a massive transfusion protocol

2017 Primary Supervisor Project Funding Source: $6000 salary support from the University of Manitoba (Med II summer student research program)

Patrick Boreskie (Med II) University of Manitoba (Winnipeg, Canada) Med II research prgm.

Management of massive transfusion in Cardiac Surgery

2014 Primary Supervisor Manuscript under preparation

Jessica Cudmore (Med IV) University of Manitoba (Winnipeg, Canada)

Methotrexate toxicity in a patient with ulcerative colitis

2010-2011 Primary Supervisor Manuscript PUBLISHED Canadian Family Physician

Allison Stasiuk (Med II) / Pharmacist University of Manitoba (Winnipeg, Manitoba)

Sedation and analgesia usage in severe H1N1 (2009) infection

2009-2010 Primary Supervisor Manuscript PUBLISHED Annals of Pharmacotherapy

UNDERGRADUATE STUDENT SUPERVISION Emily Krupka (Bachelors of Science) University of Manitoba (Winnipeg, Canada)

Tranexamic to reduce red cell transfusion in major non-cardiac surgery

2017 Primary Supervisor Project Funding Source: CCMB Summer Studentship Award ($6000)

Heather Wittick (Bachelors of Science) University of Winnipeg (Winnipeg, Canada)

Regulators of iron overload in patients with hereditary xerocytosis

2012-2013 Primary Supervisor Abstract accepted to American Society of Hematology (ASH), 2013

Ryan Zarychanski

RESEARCH FUNDING HISTORY: FUNDING: REQUESTED/UNDER REVIEW

Ryan Zarychanski

FUNDING: AWARDED May 2019 Integrating clinical data systems to improve the capacity, performance,

and value of Manitoba’s healthcare system PRINCIPAL APPLICANTS: Ryan Zarychanski (Nominated), Paul Komenda, Marshall Pitz, PRINCIPAL KNOWLEDGE USERS: Patients: Kim Mozil, Angela Tessier Clinicians: Piotr Czaykowski, Chris Christodoulou, Claudio Rigatto Decision-Makers: Jeanette Edwards, Deb Malazdrewicz, Brock Wright CO-APPLICANTS: Navdeep Tangri, Kathleen Decker, Dean Ferguson, Lisa Lix, Terry Klassen, James Bolton Alan Katz, Josee Lavoie, Eric Bohm KNOWLEDGE USERS: Decision-Makers: Charles Musuka, Chantale Pambrun, Mauro Verrelli, Matthew Seftel Clinicians: Thomas Mutter, Jason Park, Pamela Skrabek, James Zacharias, Clara Bohm, David Dawe Patients: Mac Horsburgh, Blair Waldvogel, Arlene Desjarlais, Kathryne Grisim, Jan Harris COLLABORATORS : Jim Slater, Perry Poulsen, Tom Ferguson, Eric Jacobsohn, Hema Bagry, Alain Beaudry Sean Armstrong, Pascal Lambert, John Ioculano, Sarah Kirby Funding Source: Canadian Institute of Health Research (CIHR); SPOR iCT Rewarding Success - Phase 3 – Team Grant TOTAL FUNDING: $6,108,118 CIHR Funds Awarded: $2,400,000

Matched Partnership Funding: $2,400,000 - Manitoba Health, Seniors and Active Living (MSHAL) ($1,800,000 in-kind + $600,000 in cash) In kind Partnership contributions: Centre for Healthcare Innovation $425,000; CancerCare Manitoba ($240,000); Manitoba eHealth Services ($219,018); Shared Health ($200,000); University of Manitoba $100,000; Chronic Disease Innovation Centre ($52,000); Bioscience Association Manitoba ($47,500); Research Manitoba ($12,600); Manitoba Renal Program ($12,000); Varian Medical Systems (confidential)

Funding duration: 4 years May 2019 Tranexamic acid use to safely reduce transfusion in major non-cardiac

surgery (TRACTION): A pragmatic, registry-based, pilot randomized controlled trial

Principal applicant: Brett Houston Co-Applicants: Zarychanski R, Mutter T, Jacobsohn E, Buduhan G, Falk J,

Balshaw R Collaborators: Christodoulou C, McPherson J, Muirhead B, Haberman C,

Horsburgh M

Ryan Zarychanski

Funding: Health Sciences Centre Foundation; Operating Grant: Funds Awarded: $70,000 Years: 2

May 2019 Therapeutic Plasma Exchange in Septic Shock (PLEXIS): A pilot

randomized trial Principal applicant: Emily Rimmer Co-Applicants: Zarychanski R, Houston DS, Wilkins J, Balshaw R, Kumar A

Funding: Health Sciences Centre Foundation; Operating Grant: Funds Awarded: $70,000 Years: 2

November 2018 Tranexamic acid to reduce red blood cell transfusion in major non-

cardiac surgery (TRACTION): A pragmatic, registry-based, pilot, randomized controlled trial Nominated Principal Applicant: Ryan Zarychanski Principal Applicants: Dean Fergusson, Rodney Breau, Thomas Mutter, Daniel McIsaac Co-applicants: Abdallah F, Bagry H, Beaule P, Buduhan G, Daya J, Haberman C, Horsburgh M, Houston BL, Jacobsohn R, Jetty P, Kanji S, Lalu M, Martel G, Park J, Taljaard M, Thavorn K, Tinmouth A, Turgeon AF, Wilson K Knowledge Users: Callum J Collaborators: Christodoulou C, Dhalla I, Girling L, McCartney C, McPherson J, Muirhead B, Pambrun C, Funding: Canadian Institute of Health Research (CIHR); SPOR iCT operating grant. Funds Awarded: $100,000 Years: 1

December 2018 Heparin anticoagulation to improve outcomes in septic shock (HALO):

Investigator and Research Coordinator Meeting: Principal Applicant: Ryan Zarychanski Funding: Canadian Institute of Health Research (CIHR); Planning and Dissemination Grant Funds Awarded: $10,000 Years: 1

March 2018 Patient and Public Engagement Award. Related to: Intravenous Immune Globulin in Septic Shock (InVIGIS) to Improve Outcomes in

Patients with Life-Threatening Infection Principal Investigator: Murdoch Leeies (MSc. candidate) Co Applicants: Zarychanski R (Supervisor)

Funding: George and Fay Yee Centre for Healthcare Innovation (Joint funding by: Canadian Institute of Health Research (CIHR), University of Manitoba, Winnipeg Regional Health Authority, and the Government of Manitoba) Funds Awarded: $2,000

Ryan Zarychanski

Years: 1

February 2018 Integrating clinical data systems to improve the capacity,

performance, and value of Manitoba’s healthcare system Principal Applicants/Researchers: Ryan Zarychanski (Nominated), Marshall Pitz, Alan Katz, Josée Lavoie, James Bolton, Lisa Lix, Terry Klassen Principal Knowledge Users: Patients: Donna Forbes, Angela Tessier Clinicians: Piotr Czaykowski, Alex Singer, Jitender Sareen, Thomas Mutter Decision-Makers: Deborah Malazdrewicz, Jeanette Edwards Collaborators: Dan Skwarchuk, Brock Wright, Sri Navaratnam, Frank Krupka Funding: Canadian Institute of Health Research (CIHR); Operating Grant: SPOR iCT Rewarding Success, Idea Brief Funds Awarded: $100,000 Years: 1

January 2018 Intravenous immune globulin in septic shock: A Canadian national

survey Primary investigators: Faisal Siddiqui (nominated), Murdoch Leeies, Ryan Zarychanski Co-applicants: Turgeon AF, Marshall JC, Fowler R, Kumar A, Garland A, Gershengorn H, Charbonney E, Fergusson D, Cowan J, Paunovic B, Embil J, Cameron W, Murthy S Funding: Anesthesia Oversight Committee Operating Grant. Winnipeg Manitoba. Funds awarded: $10,000 Duration: 2 years.

December 2017 Integrating clinical data systems to improve the capacity,

performance, and value of Manitoba’s healthcare system Principal Applicants/Researchers: Ryan Zarychanski (Nominated), Marshall Pitz, Alan Katz, Josée Lavoie, James Bolton, Lisa Lix, Terry Klassen Principal Knowledge Users: Patients: Donna Forbes, Angela Tessier Clinicians: Piotr Czaykowski, Alex Singer, Jitender Sareen, Thomas Mutter Decision-Makers: Deborah Malazdrewicz, Jeanette Edwards Collaborators: Dan Skwarchuk, Brock Wright, Sri Navaratnam, Frank Krupka Funding: Canadian Institute of Health Research (CIHR); Operating Grant: SPOR iCT Rewarding Success, Idea Brief Funds Awarded: $2,500 Years: 1

December 2017 Reducing transfusion while preserving Canada’s blood supply:

The use and effectiveness of tranexamic acid in major non-cardiac surgical procedures at high-risk of bleeding Principal Investigator: Brett Houston (PhD candidate) Co Applicants: Zarychanski R (Supervisor), Garland A, Mutter T, Park J

Ryan Zarychanski

Funding: Manitoba Medical Services Foundation (MMSF) Funds Awarded: $29,613 Years: 1

December 2017 Effectiveness of interventions and strategies to reduce emergency

department wait times: A systematic review and meta-analysis Principal Investigator: Maya Jeyaraman Co Applicants: Abou-Setta AM, Rabbani R, Zarychanski R Funding: Manitoba Medical Services Foundation (MMSF) Funds Awarded: $30,000 Years: 1

July 2017 Patient and Public Engagement Award. Related to: A Multicentre,

double blind, randomized, placebo controlled pilot trial to determine whether administration of tranexamic acid (TXA) reduces blood transfusion in patients undergoing major non-cardiac surgery Principal Investigator: Brett Houston (PhD candidate) Co Applicants: Zarychanski R (Supervisor)

Funding: George and Fay Yee Centre for Healthcare Innovation (Joint funding by: Canadian Institute of Health Research (CIHR), University of Manitoba, Winnipeg Regional Health Authority, and the Government of Manitoba) Funds Awarded: $2,000 Years: 1

June 2017 Heparin anticoagulation to improve outcomes in septic shock:

The HALO International Phase II efficacy RCT Principal Investigators: Ryan Zarychanski (Nominated), Dean Fergusson, Anand Kumar Co Applicants: Alejandria M, Yvette Barez, Cook DJ, Turgeon AF, Marshall JC, Fox-Robichaud A, McIntyre LA, Ramsay T, Green R, Leeies M Collaborators: Alavaren H, Buensalido JA, Chua MM, Garland A, Gopalan D, Iyer S, Jurao L, Palo JE, Panaligan M, Podolchuk H, Roxas E, Torno L, Zamora R. Funding: Canadian Institutes of Health Research (CIHR): Project Scheme Funds Awarded: $631,000 Years: 3

June 2017 Heparin anticoagulation to improve outcomes in septic shock:

The HALO International Phase II efficacy RCT Principal Investigators: Ryan Zarychanski Co Applicants: Alejandria M, Kumar A, Houston DS Collaborators: Fergusson DA, Ramsay T, Marshall JC Funding: Cancercare Manitoba Foundation Funds Awarded: $120,000 Years: 2

Ryan Zarychanski

June 2017 REVISE: Re-Evaluating the Inhibition of Stress Erosions in the ICU

Principal Investigator: Gordon Guyatt Co Applicants: Alhazzani W, Alshahrani M, Ball I, Barletta J, Cartin-Ceba R, Charbonney E, Chau L, Cook D, Deane A, Dodek P, Duan E, English S, Finfer S, Freitag A, Goffi A, Golan E, Hall R, Herridge M, Johnson D, Kanji S, Karachi T, Lamontagne F, Lauzier F, Loubani O, Marshall J, Menta S, Muscedere J, Myburgh J, Oeckler R, Ovakin D, Reeve B, Reynolds S, Rochwerg B, Roussos M, Smith O, Surette M, Thabane L, Tsang J, Wiliamson D, Wood G, Xie F, Zarychanski R, D Chong, M Ostermann Funding: Canadian Institutes of Health Research: Project Grant Funds Awarded: $1,935,832 Years: 3

June 2017 Aneurysmal subarachnoid hemorrhage - red blood cell transfusion and outcome: a randomized controlled trial Principal Investigator: Shane English Co Applicants: Acker J, Algird A, Al Thenayan E, Boyd J, Chapman M, Chasse M, D’aragon F, DeCosta L, Dowlatshahi D, Fergusson DA, Griesdale D, Kramer A, Kutsogiannis J, Lauzier F, Lum C, Marshall S, McIntyre L, Pagliarello G, Scales D, Sinclair J, Singh J, Tinmouth A, Turgeon AF, Zarychanski R, Butcher K,

Funding: Canadian Institutes of Health Research: Project Grant Funds Awarded: $1,385,000

Years: 5

June 2017 Critical Care Outcomes in Hematology Malignancy and Stem Cell Transplant Principal Investigators: Laveena Munshi and Sangeeta Mehta Co Applicants: Bagshaw S, Burry L, Cheung M, Daly A, Detsky M, Earl C, Fergusson DA, Green R, Griesdale D, Herridge M, Lapinsky S, Magder S, Minden M, Patel R, Qureshi S, Rochwerg B, Scales D, Schimmer, Wang HT, Zarychanski R.

Funding: Leukemia and Lymphoma Society of Canada Funds Awarded: $199,742

Years: 2 December 2016 Project title: Interventions and Policies Influencing Primary Healthcare

Professionals Managing Chronic Diseases: An Evidence Synthesis Principal Investigators: Bhupendrasinh Chauhan (nominated), Ryan Zarychanski, Jeanette Edwards Co-applicants: Terry Klassen, Kathryn Sibley, Beverley Temple, Alexander Singer, Gayle Halas, Carolyn Shimmin Collaborators: Kristin Anderson, Colleen Metge Knowledge users: Tamara Buchel, Kelsey Kevinsen Partners: Manitoba Health, Seniors and Active Living, Province of Manitoba; College of Pharmacy, University of Manitoba; Saskatoon Health Research

Ryan Zarychanski

Foundation and George and Fay Yee Centre for Healthcare Innovation, The SPOR SUPPORT Unit, Manitoba. Other jurisdictions: Saskatchewan: Thomas Rotter, Donna Goodridge. Newfoundland: Julia Lukewich, Alice Gaudine, Shabnam Asghari

Funding agency: Canadian Institutes of Health Research (CIHR) Total Funds Awarded: $50,468 (CIHR: $25,000 and Partners: $25,468) Duration: 1 year

March 2016 Transfusion in traumatic brain injury (TSiTBI Trial)

Principal Investigators: Alexis F Turgeon, Dean Fergusson, Francois Lauzier Co-investigators: Algird A, Baker A, Ball I, Burns K, Charbonney E, Chassé M, English S, Green R, Griesdale D, Kramer A, Lamontagne F, Laroche V, Moore L, Scales D, Shahin J, St. Onge M, Tinmouth A, Zarychanski R, Zygun D Knowledge users: Clement J, Delage G, Fox-Robichaud A, Hébert P, Oleary S, Riopelle R, Trainee: Lessard Bonaventure P Collaborator: Meade M Funding: Canadian Institute of Health Research (CIHR) Funds Awarded: $1,390,105 Duration: 5 years

March 2016 The Lyonel G. Israels Professorship in Hematology

Principal Investigator: Dr. Ryan Zarychanski Endowed Chair (3,000,000) Funds available: ~$120,000/year for research program support

Years: 5 June 2016 Heparin anticoagulation to improve outcomes in septic shock: The

HALO International Phase II efficacy RCT Principal Investigators: Ryan Zarychanski and Marissa Alejandria Co Investigators: Anand Kumar, Yvette Barez, Dean Fergusson, Deborah Cook, John Marshall, Fox-Robichaud, McIntyre LA, Ramsay T, Turgeon AF Funding: Philippine Council for Health Research & Development (PCHRD) Funds Awarded: $132,000 Years: 3

January 2016 Grant Title: Canadian Traumatic Brain Injury Research Consortium

(CTRC) Principle Investigators: James Hutchison, (co-lead); Alexis F Turgeon (co-Lead); Carolyn A Emery; Isabelle Gagnon; Cheryl Wellington; Richard J Riopelle (Principal Knowledge User) Co Investigators: Archambault P; Baker AJ; Barlow KM; Bayley MT; Beauchamp MH; Chapman MG; Chasse M; Clarke DB; Colantonio A; Cusimano MD; Emeriaud G; English SW; Esser MJ; Fraser DD; Griesdale D; Guerguerian A; Lacroix J; Lauzier F; Marshall SC; McCredie VA; Mcfadyen

Ryan Zarychanski

BJ; Panenka WJ; Ptito A; Reed N; Winston BW; Yeates KO; Zarychanski R; Zemek R; Zygun DA; Fox-Robichaud A (Knowledge User) Collaborators: Babul S; Brubacher J; Cullen N; De Beaumont L; de Guise E; De Matteo C; Gélinas C; Gosselin N; Green Robert; Green Robin; Kramer A; Kutsogiannis J; Lamontagne M; Levine B; Marcoux J; McKerral M; Moore L; Ouellet MC; Rizoli S; Rowe B; Scales D; Schachar R, Schneider K; Sutherland G; Swaine B; Tator CH; Teasell R; Wang YT; Van DonKelaar P; Wheeler A. Funding: Canadian Institute of Health Research (CIHR) Funds Awarded: $1,824,513 Years: 5 (December 1st, 2015 to November 30, 2019)

July 2015 CanVECTOR (Canadian Venous Thromboembolism Clinical Trials and

Outcomes Research) Network Principal Investigators: Marc Rodger & Susan Kahn Co Applicants: Afilalo M; Anderson D; Bates S; Blostein M; Carrier M; Castellucci L; Chagnon I; Chitsike R; Conway E; Crowther M; de Wit K; Demers C; Dolan S; Douketis J; Duffett L; Emed J; Fergusson D; Gandara E; Geerts W; Ginsberg J; Gonsalves C; Grad R; Gross P; Guindon G; Haynes R; Hirsch A; Iorio A; Kassis J; Kearon C; Kovacs MJ; Lang ES; Lazo-Langner A; Le Gal G; Lee AY; Levinson AJ; Levy AR; Liaw PC; Lim W; Linkins L; Louzada MD; McLeod AG; Moodley U; Pai M; Pluye P; Ramsay TO; Ray JG; Roussin A; Routhier N; Schulman S; Selby R; Shivakumar SP; Siegal DM; Smith RE; Solymoss S; Tagalakis V; Takach Lapner S; Thavorn K; Weitz JI; Wells PS; Wu CM; Zarychanski R Funding: Canadian Institute of Health Research (CIHR), Community Development Program Grants Funds Awarded: $1,500,000 Years: 5

July 2015 Tranexamic Acid during Cystectomy Trial (TACT)

Principal Investigators: Rodney H. Breau, Ilias Cagiannos, Franco Momoli. Co Applicants: Bryson G, Cameron C, Fergusson DA, Fradet V, Kanji S, Knoll G, Morash C, Turgeon A, Zarychanski R. Funding: Canadian Institute of Health Research (CIHR) Funds Awarded: $394,050 Years: 3

March 2014 Transfusion of Plasma Prior to Invasive Procedures Pilot Trial

Principal Investigators: Dr. Alan Tinmouth and Dean Fergusson Co Applicants: Zarychanski R, Chasse M, Laroche V, McIntyre L, Turgeon AF

Funding: Canadian Institute of Health Research (CIHR) Funds Awarded: $317,274 Years: 2.5

Ryan Zarychanski

June 2014 Bleeding, transfusion, and the use of anticoagulants in patients with

critical illness: Generating evidence to inform practice change and improve clinical outcomes Principal Investigator: Dr. Ryan Zarychanski Funding: Canadian Institute of Health Research (CIHR) New Investigator Award

Funds Awarded: $300,000 (SALARY AWARD) Years: 5 March 2014 Defining the burden and managing the effects of psychiatric comorbidity

in chronic immunoinflammatory disease Principal Applicant: Dr. Ruth Ann Marrie

Co Applicants: Bernstein CN, Bolton J, Graff L, Walker J, Sareen J, Zarychanski R, Katz A, Blanchard J, Frisk J, Berrigan L, Patten S, Ghaffar, Lix L, Hitchon C

Funding: Canadian Institutes of Health Research (CIHR) Funds Awarded: $2,500,000 Years: 5 February 2014 The George and Fay Yee Centre for Healthcare Innovation Program: Support for People and Patient-Oriented Research and Trials (SUPPORT) Units Principal Applicant: Dr. Terry Klassen

Co Applicants: Zarychanski R, Wittmeier K, Bohm E, Krupka F, Lix L, Abou-setta AM, Mamoud S, Jiang D, Hinrichsen A Collaborators: Martens P, Moses S, Woodgate R, Dean H, Van de Mosselaer G, Anderson-De Coteau M, Weise C, Vielfaure-Mackenzie M, Barnard D

Funds Awarded: $29,682,742 Funding partners: Canadian Institutes of Health Research (CIHR) $11,232,049 Manitoba Health $5,000,000

The Winnipeg Regional Health Authority (WRHA) $16,884,582 University of Manitoba $7,798,160 Years: 5 November 2013 Effect of unfractionated heparin on cell free DNA and fibrinolysis in

Septic Shock – HALO translational analysis Principal Applicant: Dr. Ryan Zarychanski Funding: Bayer Funds Awarded: $50,000 Years: 1 June 2013 Mechanisms of inflammation and thrombosis in septic shock: Heparin

anticoagulation to improve outcomes in septic shock: - Translational Analyses

Principal Applicant: Dr. Ryan Zarychanski Co Applicants: Liaw P, Banerji V, Fox-Robichaud A

Ryan Zarychanski

Funding: CancerCare Manitoba Foundation Funds Awarded: $58,000 Years: 2 March 2012 Heparin anticoagulation to improve outcomes in septic shock: The HALO

Pilot Principal Investigators: Dr. Ryan Zarychanski and Dean Fergusson

Co Applicants: Bernstein CN, Carrier M, Cook DJ, Fox-Robichaud A, Hébert PC, Houston DS, Kanji S, Kumar A, Liaw P, Marshall J, McIntyre L, Ramsay T, Tinmouth A, Turgeon AF

Funding: Canadian Institute of Health Research (CIHR) Funds Awarded: $288,152 Years: 2 March 2012 Early determination of long-term prognosis in critically ill patients with

severe traumatic brain injury (TBI-Prognosis multi-centre prospective study)

Principal Investigator: Alexis F Turgeon Co Applicants: Bagshaw S, Bernard F, Burns K, Fergusson D, Green R, Griesdale D, Kutsogiannis J, Lamontagne F, Lauzier F, Martin C, McIntyre L, Meade M, Moore L, Moulin V, Pagliarello G, Reynolds S, Rigamonti A, Savard M, Scales D, Zarychanski R, Zygun D. Funding: Canadian Institute of Health Research (CIHR) Funds Awarded: $1,141,067 Years: 3

March 2012 Tranexamic Acid in Cystectomy Trial (TACT) pilot study Principal Investigators: Rodney H. Breau, Ilias Cagiannos, Franco Momoli. Co Applicants: Bryson G, Kanji S, Morash C, Turgeon A, Zarychanski R. Funding: Canadian Institute of Health Research (CIHR) Funds Awarded: $244,275 Years: 1

March 2011 Heparin anticoagulation to reduce death in septic shock: HADES Pilot Principal Investigators: Ryan Zarychanski and Dean Fergusson

Co Applicants: Bernstein CN, Carrier M, Cook DJ, Fox-Robichaud A, Hébert PC, Houston DS, Kanji S, Kumar A, Marshall J, McIntyre L, Ramsay T, Tinmouth A, Turgeon AF Collaborators: Liaw P

Funding: Canadian Institute of Health Research (CIHR) Funds Awarded: $100,000 Years: 2 years March 2011 Heparin anticoagulation to reduce death in septic shock: HADES Pilot Principal Investigators: Ryan Zarychanski and Dean Fergusson

Ryan Zarychanski

Co Applicants: Bernstein CN, Carrier M, Cook DJ, Fox-Robichaud A, Hébert PC, Houston DS, Kanji S, Kumar A, Marshall J, McIntyre L, Ramsay T, Tinmouth A, Turgeon AF Collaborators: Liaw P

Funding: Manitoba Health Research Council (MHRC) Funds Awarded: $100,000 Years: 2 years June 2011 Screening for occult malignancy in patients with unprovoked venous

thromboembolism: a randomized controlled trial using a comprehensive computed tomography of the abdomen/pelvis (SOME trial) Principal Investigator: Marc Carrier Co-Applicants: Zarychanski R, Coyle D, Ramsay T, Tao H, Lazo-Langner A, Rogder M, Wells P, Le Gal G, Taglakis V,

Funding: Heart and Stroke Foundation of Canada Funds Awarded: $202,590 Years: 3 years December 2010 Phenotypic and genotypic evaluation of a family cohort with haemolytic anaemia

Principal Investigator: Ryan Zarychanski Co-Applicants: Houston BL, Houston DS, Israels S Funding: Manitoba Medical Services Foundation Funds Awarded: $20,000 Years: 1 year July 2010 CIHR Randomized Controlled Trials: Mentoring Award Principal Investigator: Ryan Zarychanski Mentor: Fergusson DA Co-mentors: Bernstein CN, Houston DS, Cook DJ Funding: Canadian Institute of Health Research (CIHR) Funds awarded: $160,000 (SALARY AWARD) Years: 2 years July 2010 Weaning and Variability Evaluation (WAVE) Principal Investigator: Andrew Seely Co-Applicants: Zarychanski R, Fergusson DA, Ferguson N, Lellouche F

Marshal J, Maziak DE, McIntyre LA, Ramsay TO, Rubenfeld G, Scales DC

Funding: Canadian Institutes of Health Research (CIHR), Operating Grant Funds awarded: $544,134 Years: 3 years July 2010 Epidemiology of Thromboembolism in Critical Care (EPITEC) Principal Investigator: Deborah J Cook

Ryan Zarychanski

Co-Applicants: Zarychanski R, Crowther M, Fowler R, Jacka M, Meade M, Turgeon A, Devereaux P, Hall R, Lauzier F, Mehta S, Dodek P, Herridge M, Marshall J, Muscedere J

Funding: Canadian Institutes of Health Research (CIHR), Operating Grant Funds Awarded: $63,899 Duration: 1 year September 2009 Plasma Utilization in Cardiac Surgery (PUCS): A Multicentre

Observational Study Principal Investigator: Dr. Alan Tinmouth Co-Applicants: Zarychanski R, Fergusson DA, Hébert P, Fraser R Shehata N, Webert K Funding: Canadian Institutes of Health Research, Operating Grant Funds awarded: $206,885 Duration: 1 year January 2009 Research Support / New Faculty Start up Funding Funding Source: CancerCare Manitoba

Principal Investigator: Ryan Zarychanski Funding awarded: $225,000 Duration: 3 years July 2006 Canadian Blood Services Research Fellowship Principal Investigator: Ryan Zarychanski Funding Source: Canadian Blood Services Funding Awarded: $142,000 (SALARY AWARD) Duration: 2 years

Ryan Zarychanski

PUBLICATIONS (JOURNAL ARTICLES) **ALL CAPS denotes research supervisor to trainees Accepted or in Press Kashani HH, Lodeewyks C, Kavosh MS, Jeyaraman MM, Neilson C, Okoli G, Rabbani R, Abou-Setta AM, Zarychanski R, Grocott HP. Restrictive versus liberal transfusion strategies in cardiac surgery: a systematic review and meta-analysis with trial sequential analysis. Canadian Journal of Anesthesia. 2019. HOUSTON BL, Uminski K, Mutter T, Rimmer E, Houston DS, Menard CE, Garland A, Ariano R, Tinmouth A, Abou-Setta AM, Rabbani R, Neilson C, Rochwerg B, Turgeon AF, Falk J, Breau R, Fergusson DA, Zarychanski R. Efficacy and safety of tranexamic acid in major non-cardiac surgeries at high risk of transfusion: a systematic review and meta-analysis. Transfusion Medicine Reviews. 2019. HOUSTON BL, Rimmer E, Zarychanski R, Seftel M. Laboratory testing in the evaluation of a monoclonal protein: a practical framework for interpretation. South African Medical Journal. 2019. [Review]. MENARD CM, Seftel M, Ponnampalam A, Zarychanski R (senior author/supervisor). When to transfuse? Red blood cell and platelet transfusion thresholds in clinical practice. South African Medical Journal. 2019. [Review]. Turgeon AF, Zarychanski R, Francoeur CL, Lauzier F. Cardiac Donation after Circulatory Death: The Heart of the Matter. Canadian Journal of Anesthesia. 2019.

Ryan Zarychanski

Submitted/Under Review

Verret M, Lauzier F, Zarychanski R, Savard X, Perron C, Pinard AM, Leblanc G, Cossi MJ, Turgeon AF, on behalf of the Canadian Perioperative Anesthesia Clinical Trials Group (PACT). Perioperative use of Gabapentinoids for the management of postoperative acute pain: A systematic review and meta-analysis. Anesthesia and Analgesia. 2019. MOONEY O, Bell D, Turgeon AF, Kumar A, Rimmer E, Houston DS, Zarychanski R (senior author/supervisor). Nucleated red blood cells as an independent predictor of ICU mortality and ICU recidivism. Intensive Care Medicine. 2017 Oberoi S, Yang J, Woodgate RL, Niraula S, Banerji S, Israels SJ, Altman G, Beattie S, Rabbani R, Askin N, Gupta A, Sung L, Abou-Setta AM, Zarychanski R (senior author/supervisor). Mindfulness based interventions to reduce anxiety in adults and children with cancer: A systematic review and meta-analysis. Critical Reviews in Oncology/Hematology. 2019. Liu S, Skidmore B, Rabbani R, Zarychanski R, Abou-Setta AM, Toleva O. Ischemic post-conditioning for ST-elevation myocardial infarction treated with primary percutaneous coronary intervention: A systematic review and meta-analysis. Canadian Journal of Cardiology. 2019. Akinrolie O, Barclay R, Strachan S, Gupta A, Jasper US, Jumbo SU, Askin N, Rabbani R, Zarychanski R, Abou-Setta AM. Motivational interviewing and physical activity among older adults: A systematic review and meta-analysis. American Journal of Health Promotion. 2019. Fergusson DA, Chassé1 M, Kokolo M, Aaron S, McIntyre L, Hiremath S, Zarychanski R, Turgeon AF, Alvarez G, Beck A, Monsour D, Ducharme R, Grant-Orser A, Kimmelman J, Knoll G. The use of clinically important outcomes in clinical trials assessing effectiveness: a systematic review. Journal for the Society of Clinical Trials. 2017 English SW, Saigle V, McIntyre L, Chassé M, Fergusson DA, Turgeon AF, Lauzier F, Griesdale D, Garland A, Zarychanski R, Algird A, van Walraven C. Multi-centre validation of the Ottawa SAH prediction models using health administrative data. Neurology. 2019

Ryan Zarychanski

Published 138. Matthewson G, Kooner S, Rabbani R, Gottschalk T, Old J, Abou-Setta AM, Zarychanski R, Leiter J, MacDonald P. Does a Delay in Anterior Cruciate Ligament Reconstruction Increase the Incidence of Secondary Pathology in the Knee? A Systematic Review and Meta-Analysis. Clinical Journal of Sport Medicine. 2019; [Epub ahead of print]. DOI: 10.1097/JSM.0000000000000762. PMID: 31743219. 137. Lim S, Hammond S, Park J, Hochman D, Ma M, Rabbani R, Abou-Setta AM, Zarychanski R (senior author/supervisor). Training Interventions to Improve Adenoma Detection Rates During Colonoscopy: A Systematic Review and Meta-Analysis. Surgical Endoscopy. 2019 Oct 8. doi: 10.1007/s00464-019-07153-7. [Epub ahead of print] PubMed PMID: 31595401. 136. Alaifan T, Alenazy A, Xiang Wang D, Fernando S, Spence J, Belley-Cote E, Fox-Robichaud A, Ainsworth C, Karachi T, Kyeremanteng K, Zarychanski R, Whitlock R, Rochwerg B. Tranexamic Acid in Cardiac Surgery: a systematic review and meta-analysis (protocol). BMJ Open. 2019;9(9):e028585. doi:10.1136/bmjopen-2018-028585. PMID: 31530593. 135. Turgeon AF, Dorrance K, Archambault P, Lauzier F, Lamontagne F, Zarychanski R, Fowler R, Moore L, Lacroix J, English S, Boutin A, Muscedere J, Burns KEA, Griesdale D, McIntyre LA, Scales D, Bernard F, Yamada J, Squires JE; Canadian Traumatic Brain Injury Research Consortium and the Canadian Critical Care Trials Group. Factors influencing decisions by critical care physicians to withdraw life-sustaining treatments in critically ill adult patients with severe traumatic brain injury. Canadian Medical Association Journal (CMAJ). 2019 Jun 17;191(24):E652-E663. doi: 10.1503/cmaj.190154. PMID: 31209132 134. Bonaventure PL, Lauzier F, Zarychanski R, Boutin A, Shemilt M, Saxena M, Zolfagari P, Griesdale D, Menon D, Stanworth S, English S, Chassé M, Fergusson DA, Moore L, Kramer A, Robitaille A, Myburgh J, Hutchinson P, Cooper J, Turgeon AF. Red Blood Cell Transfusion in Critically ill Patients with Traumatic Brain Injury: An International Survey of Physicians' Attitudes. Canadian Journal of Anesthesia. 2019. Canadian Journal of Anesthesia. 2019 Apr 22. doi: 10.1007/s12630-019-01369-w. PMID: 31012052 133. Shemilt M, Boutin A, Lauzier F, Zarychanski R, Moore L, McIntyre LA, Nadeau L, Fergusson DA, Mercier E, Archambault P, Lamontagne F, Perron C, Léger C, Turgeon AF. Prognostic value of glial fibrillary acidic protein in patients with moderate and severe traumatic brain injury: a systematic review and meta-analysis. Critical Care Medicine. 2019 Jun;47(6):e522-e529. doi: 10.1097/CCM.0000000000003728. PMID: 30889029 132. Mortaza N, Abou-Setta AM, Zarychanski R, Loewen H, Rabbani R, Glazebrook CM. Upper Limb Tendon/Muscle Vibration in Persons with Chronic Stroke: A Systematic Review and Meta-analysis. European Journal of Physical and Rehabilitation Medicine. 2019 Mar 11. doi: 10.23736/S1973-9087.19.05605-3. [Epub ahead of print]. PMID: 30868835 131. Zawaly K, Rumbolt C, Abou-Setta AM, Neilson C, Rabbani R, Zarychanski R, Singh H. The efficacy of split-dose bowel preparations for polyp detection: a systematic review and meta-analysis.

https://www.ncbi.nlm.nih.gov/pubmed/?term=PMID%3A+31595401https://www.ncbi.nlm.nih.gov/pubmed/31530593https://www.ncbi.nlm.nih.gov/pubmed/31209132https://www.ncbi.nlm.nih.gov/pubmed/31012052https://www.ncbi.nlm.nih.gov/pubmed/30889029https://www.ncbi.nlm.nih.gov/pubmed/30868835

Ryan Zarychanski

American Journal of Gastroenterology. 2019. Mar 11. doi: 10.14309/ajg.0000000000000155. PMID: 30865011 130. MENARD CE, Kumar A, Houston DS, Turgeon AF, Rimmer E, Houston BL, Doucette S, Zarychanski R (senior author/supervisor). Evolution and impact of thrombocytopenia in septic shock: a retrospective cohort study. Critical Care Medicine. 2019. Apr;47(4):558-565. doi: 10.1097/CCM.0000000000003644. PMID: 30855327 129. Ruel-Laliberté J, Lessard-Bonaventure P, Fergusson D, Lacroix J, Zarychanski R, Lauzier F, Tinmouth A, Hebért PC, Green R, Griesdale D, Fowler R, Kramer A, McIntyre L, Zygun D, Walsh T, Stanworth S, Capellier G, Pili-Floury S, Samain E, Clayton L, Marshall J, Pagliarello J, Sabri E, Neveu X, Léger C, Turgeon AF. Effect of age of transfused red blood cells on neurological outcome following traumatic brain injury (ABLE-tbi Study). Canadian Journal of Anesthesia. 2019. Jun;66(6):696-705. doi: 10.1007/s12630-019-01326-7. Epub 2019 Feb 26. PMID: 30809776 128. Walkty A, Karlowsky J, Zarychanski R, Kadkhoda K, Lagace-Wiens P. Marked elevation of serum ferritin associated with Anaplasma phagocytophilum infection. Journal of the Association of Medical Microbiology. 2019 Jan 4(1):38-41 doi.org/10.3138/jammi.2018-0033 127. Jeyaraman MM, Abou-Setta AM, Grant L, Farshidfar F, Copstein L, Lys J, Gottschalk T, Desautels D, Czaykowski P, Pitz M, Zarychanski R (senior author/supervisor). Dairy product consumption and development of cancer: An overview of reviews. BMJ Open. 2019 Jan 25;9(1):e023625. doi: 10.1136/bmjopen-2018-023625. PMID: 30782711 126. Arabi YM, Al-Hameed F, Burns KEA, Mehta S, Alsolamy SJ, Alshahrani MS, Mandourah Y, Almekhlafi GA, Almaani M, Al Bshabshe A, Finfer S, Arshad Z, Khalid I, Mehta Y, Gaur A, Hawa H, Buscher H, Lababidi H, Al Aithan A, Abdukahil SAI, Jose J, Afesh LY, Al-Dawood A; Saudi Critical Care Trials Group. Adjunctive Intermittent Pneumatic Compression for Venous Thromboprophylaxis. (Collaborator). N Engl J Med. 2019 Apr 4;380(14):1305-1315. doi: 10.1056/NEJMoa1816150. Epub 2019 Feb 18. PMID: 30779530 125. Okoli G, Rabbani R, Kashani HH, Wierzbowski AK, Neilson C, Mansouri B, Zarychanski R, Abou-Setta AM. Vitamin and mineral supplements for migraine prophylaxis: A systematic review and meta-analysis of randomized controlled trials. The Canadian Journal of Neurological Sciences. Mar;46(2):224-233. doi: 10.1017/cjn.2018.394. Epub 2019 Feb 15. PMID: 30764890 124. Abou-Setta AM, Rabbani R, Lix L, Turgeon AF, Houston BL, Fergusson DA, Zarychanski R. Can author bias be detected in meta-analysis? Canadian Journal of Anesthesia. 2019 Mar;66(3):287-292. doi: 10.1007/s12630-018-01268-6. Epub 2019 Feb 6. PMID:30725345 123. Verret M, Lauzier F, Zarychanski R, Savard X, Cossi MJ, Pinard AM, Leblanc G, Turgeon AF. Perioperative use of gabapentinoids for the management of postoperative pain: protocol of a systematic review and meta-analysis. Systematic Reviews. 2019 Jan 16;8(1):24. doi: 10.1186/s13643-018-0906-3. PMID: 30651123 122. Whitehouse CE, Fisk JD, Bernstein CN, Berrigan LI, Bolton JM, Graff LA, Hitchon CA, Marriott JJ, Peschken CA, Sareen J, Walker JR, Stewart SH, Marrie RA; CIHR Team in Defining

https://www.ncbi.nlm.nih.gov/pubmed/30865011https://www.ncbi.nlm.nih.gov/pubmed/30855327https://www.ncbi.nlm.nih.gov/pubmed/30809776https://doi.org/10.3138/jammi.2018-0033https://www.ncbi.nlm.nih.gov/pubmed/30782711https://www.ncbi.nlm.nih.gov/pubmed/30779530https://www.ncbi.nlm.nih.gov/pubmed/30779530https://www.ncbi.nlm.nih.gov/pubmed/30779530https://www.ncbi.nlm.nih.gov/pubmed/30764890https://www.ncbi.nlm.nih.gov/pubmed/30725345https://www.ncbi.nlm.nih.gov/pubmed/30651123

Ryan Zarychanski

the Burden and Managing the Effects of Psychiatric Comorbidity in Chronic Immunoinflammatory Disease. Collaborators: Katz A, Lix LM, Patten SB, Singer A, El-Gabalawy R, Zarychanski R. Comorbid anxiety, depression, and cognition in MS and other immune-mediated disorders. Neurology. 2019 Jan 11. doi: 10.1212/WNL.0000000000006854. [Epub ahead of print]. PMID: 30635487 121. UMINSKI K, Kadkhoda K, Houston BL, Lopez A, McKenzie L, Lindsay R, Walkty A, Embil J, Zarychanski R (senior author/supervisor). Anaplasmosis: an emerging tick-born disease of importance in Canada. ID Cases. 2018 Nov 28;14:e00472. doi: 10.1016/j.idcr.2018.e00472. eCollection 2018. PMID: 30524954 120. Zarychanski R, Turgeon AFT. Re-framing the question: Should hydroxyethyl starch be used in clinical practice? Canadian Journal of Anesthesia. 2018. Nov 7. doi: 10.1007/s12630-018-1246-4. [Epub ahead of print] [Editorial]. PMID: 30406388 119. English SW, McIntyre L, Saigle V, Chassé M, Fergusson D, Turgeon AF, Lauzier F, Griesdale D, Garland A, Zarychanski R, Algird A, van Walraven C. The Ottawa SAH Search Algorithm: Protocol for A Multi-Centre Study to Validate a Novel and Innovative Primary SubArachnoid Hemorrhage Prediction Model using Health Administrative Data (The SAHepi Prediction Study Protocol). BMC Medical Research Methodology. 2018 Sep 15;18(1):94. doi: 10.1186/s12874-018-0553-3. PMID: 30219029 118. LODEWYKS C, Heinrichs J, Grocott H, Karkouti K, Romund G, Arora R, Tangri N, Rabbani R, Abou-Setta AM, Zarychanski R (senior author/supervisor). Point of care viscoelastic hemostatic testing in cardiac surgery: A systematic review and meta-analysis. Canadian Journal of Anesthesia. 2018 Dec;65(12):1333-1347. doi: 10.1007/s12630-018-1217-9. PMID: 30194674 117. Kumar A, Zarychanski R, Pisipati A, Kumar A, Kethireddy S, Bow EJ. Fungicidal versus fungistatic therapy of invasive Candida infection in non-neutropenic adults: a meta-analysis. Mycology. 2018 Jan 9;9(2):116-128. doi: 10.1080/21501203.2017.1421592. PMID: 30123667 116. Kredentser MS, Blouw M, Marten N, Sareen J, Bienvenu OJ, Ryu J, Beatie B, Logsetty S, Graff LA, Eggertson S, Sweatman S, Debroni B, Cianflone N, Arora R, Zarychanski R, Olafson K. Preventing posttraumatic stress in ICU survivors: A single-center pilot randomized controlled trial of ICU diaries and psychoeducation. Critical Care Medicine. 2018 Dec;46(12):1914-1922. doi: 10.1097/CCM.0000000000003367. PMID: 30119073 115. Farooqui MA, Elsayed Y, Jeyaraman MM, Dingwall O, Tagin M, Zarychanski R, Rabbani R, Abou-Setta AM. Pre-symptomatic targeted treatment of patent ductus arteriosus in preterm newborns: A systematic review and meta-analysis. Journal of Neonatal-Perinatal Medicine. 2018 Jul 19. doi: 10.3233/NPM-17130. [Epub ahead of print]. PMID: 30040749 114. English SW, Chassé M, Turgeon AF, Lauzier F, Griesdale D, Garland A, Fergusson DA, Zarychanski R, van Walraven C, Montroy K, Ziegler J, Dupont-Chouinard R, Carignan R, Dhaliwal A, Mallick R, Sinclair J, Boutin A, Pagliarello G, Tinmouth A, McIntyre L. Anemia prevalence and incidence and red blood cell transfusion practices in aneurysmal subarachnoid

https://www.ncbi.nlm.nih.gov/pubmed/30635487https://www.ncbi.nlm.nih.gov/pubmed/30524954https://www.ncbi.nlm.nih.gov/pubmed/30406388https://www.ncbi.nlm.nih.gov/pubmed/30406388https://www.ncbi.nlm.nih.gov/pubmed/30219029https://www.ncbi.nlm.nih.gov/pubmed/30219029https://www.ncbi.nlm.nih.gov/pubmed/30194674https://www.ncbi.nlm.nih.gov/pubmed/30194674https://www.ncbi.nlm.nih.gov/pubmed/30123667https://www.ncbi.nlm.nih.gov/pubmed/30123667https://www.ncbi.nlm.nih.gov/pubmed/30119073https://www.ncbi.nlm.nih.gov/pubmed/30119073https://www.ncbi.nlm.nih.gov/pubmed/?term=30040749https://www.ncbi.nlm.nih.gov/pubmed/?term=30040749

Ryan Zarychanski

hemorrhage – Results of a multi-center cohort study. Critical Care. 2018;Jul 4;22(1):169. doi: 10.1186/s13054-018-2089-7. PMID: 29973245 113. Gerges PRA, Moore L, Léger C, Lauzier F, Shemilt M, Zarychanski R, Scales D, Burns KEA, Bernard F, Zygun D, Neveu X, Turgeon AF; Canadian Critical Care Trials Group. Intensity of care and withdrawal of life-sustaining therapies in severe traumatic brain injury patients: A post-hoc analysis of a multicenter cohort study. Canadian Journal of Anesthesia. 2018; Sep;65(9):996-1003. doi: 10.1007/s12630-018-1171-6. Epub 2018 Jun 14. PMID: 29949093 112. Leblanc G, Boutin A, Shemilt M, Lauzier F, Moore L, Potvin V, Zarychanski R, Archambault P, Lamontagne F, Léger C, Turgeon AF. Incidence and impact of withdrawal of life-sustaining therapies in clinical trials of severe traumatic brain injury: a systematic review of randomized controlled trials. Clinical Trials. 2018 Aug;15(4):398-412. doi: 10.1177/1740774518771233. Epub 2018 Jun 4. PMID: 29865897 111. Breau RH, Lavallée LT, Cnossen S, Witiuk K, Cagiannos I, Momoli F, Bryson G, Kanji S, Morash C, Turgeon A, Zarychanski R, Mallick R, Knoll G, Fergusson DA. Tranexamic Acid versus Placebo to Prevent Blood Transfusion during Radical Cystectomy for Bladder Cancer (TACT): Study Protocol for a Randomized Controlled Trial. Trials. 2018 May 2;19(1):261. doi: 10.1186/s13063-018-2626-3. PMID: 29716640 110. Delara M, Chauhan B, Le ML, Abou-Setta AM, Zarychanski R, tJong GW. Efficacy and safety of pulmonary application of corticosteroids in preterm infants with respiratory distress syndrome: A systematic review and meta-analysis. Archives of Disease in Childhood. 2018 Apr 17. pii: fetalneonatal-2017-314046. doi: 10.1136/archdischild-2017-314046. [Epub ahead of print] PMID: 29666203 109. HOUSTON BL, Hurrie D, Graham J, Perija B, Rimmer E, Abou-Setta AM, Bernstein CN, Houston DS, Zarychanski R. (senior author/supervisor). Efficacy of iron replacement therapy on fatigue and work capacity in non-anemic adults with iron depletion: a systematic review of randomized controlled trials. British Medical Journal Open. 2018 Apr 5;8(4):e019240. doi:10.1136/ bmjopen-2017-019240. PMID: 29626044 108. Singal D, Menard C, Neilson CJ, Brownell M, Hanlon-Dearmnan A, Chudley A, Zarychanski R, Abou-Setta AM. The effectiveness of evidence-based treatments of fetal alcohol spectrum disorders in children and adolescents: A systematic review protocol. BMJ Open. 2018;Mar 9;8(3):e013775. doi: 10.1136/bmjopen-2016-013775. PMID: 29525767 107. Boutin A, Moore L, Green RS, Zarychanski R, Erdogan M, Lauzier F, English S, Fergusson DA, Butler M, McIntyre LA, Chasse M, Lessard-Bonaventure P, Léger C, Desjardins P, Griesdale D, Lacroix J, Turgeon AF. Hemoglobin thresholds and red blood cell transfusion in adult patients with moderate or severe traumatic brain injuries: a retrospective cohort study. Journal of Critical Care. 2018; Jun;45:133-139. doi: 10.1016/j.jcrc.2018.01.023. Epub 2018 Jan 31. PMID: 29459342 106. Jeyaraman MM, Qadar SMZ, Wierzbowski AK, Farshidfar F, Lys J, Dickson G, Grimes K, Parker J, Phillips L, Mitchell J, Leith E, Phillips K, Betty W, Becker L, McCarthy N, Johnson D,

https://www.ncbi.nlm.nih.gov/pubmed/?term=29973245https://www.ncbi.nlm.nih.gov/pubmed/?term=29973245https://www.ncbi.nlm.nih.gov/pubmed/?term=29949093https://www.ncbi.nlm.nih.gov/pubmed/?term=29949093https://www.ncbi.nlm.nih.gov/pubmed/?term=29865897https://www.ncbi.nlm.nih.gov/pubmed/?term=29865897https://www.ncbi.nlm.nih.gov/pubmed/?term=29716640https://www.ncbi.nlm.nih.gov/pubmed/?term=29716640https://www.ncbi.nlm.nih.gov/pubmed/?term=29666203https://www.ncbi.nlm.nih.gov/pubmed/?term=29666203https://www.ncbi.nlm.nih.gov/pubmed/?term=29626044https://www.ncbi.nlm.nih.gov/pubmed/?term=29626044https://www.ncbi.nlm.nih.gov/pubmed/?term=29525767https://www.ncbi.nlm.nih.gov/pubmed/?term=29459342https://www.ncbi.nlm.nih.gov/pubmed/?term=29459342

Ryan Zarychanski

Krupka F, Zarychanski R, Abou-Setta AM. Effective approaches to determining return on investment in healthcare leadership development programs: a systematic scoping review. Leadership in Health Services. 2018 Feb 5;31(1):77-97. doi: 10.1108/LHS-02-2017-0005. Epub 2017 Nov 15. PMID: 29412095 105. Marrie RA, Graff L, Walker J, Fisk JD, Patten SB, Hitchon CA, Lix LM, Bolton JM, Sareen L, Katz A, Berrigan LI, Marriott JJ, Singer A, El-Gabalawy R, Zarychanski R, Bernstein CN. A prospective study of the effects of psychiatric comorbidity in immune-mediated inflammatory disease: rationale, protocol and participation. JMIR Research Protocols. 2018 Jan 17;7(1):e15. doi: 10.2196/resprot.8794. PMID: 29343461 104. Zarychanski R, Houston DS. Assessing Thrombocytopenia in the Intensive Care Unit: The Past, Present, and Future. Hematology Am Soc Hematol Educ Program. 2017. Dec 8;2017(1):660-666. doi: 10.1182/asheducation-2017.1.660. PMID: 29222318 103. Jeyaraman MM, Rabbani R, Copstein L, Sulaiman W, Farshidfar F, Kashani H, Qadar SMZ, Guan Q, Skidmore B, Dias S, Kardami E, Ducas J, Mansour S, Zarychanski R, Abou-Setta AM. Autologous Bone Marrow Stem Cell Therapy in Patients with ST-elevation Myocardial Infarction: A Systematic Review and Meta-analysis. Canadian Journal of Cardiology. 2017. Dec;33(12):1611-1623. doi: 10.1016/j.cjca.2017.10.001. PMID: 29173601 102. Jung J, Pinto R, Zarychanski R, Cook DJ, Jouvet P, Marshall JC, Kumar A, Long J, Rodin R, Fowler R on behalf of the ICU-Flu Investigators and the Canadian Critical Care Trials Group. 2009-2010 H1N1-related critical illness among Aboriginal and non-Aboriginal Canadians. PloS One. 2017;Oct 19;12(10):e0184013. doi: 10.1371/journal.pone.0184013. PMID: 29049285 101. LEEIES M, Flynn E, Turgeon AF, Paunovic B, Loewen H, Rabbani R, Abou-Setta AM, Ferguson N, Zarychanski R (senior author/supervisor). High-flow oxygen via nasal cannulae in patients with acute hypoxemic respiratory failure: A systematic review and meta-analysis. Systematic Reviews. 2017;6:202. DOI 10.1186/s13643-017-0593-5. PMID: 29037221 100. Haghbayan H, Boutin A, Laflamme M, Lauzier F, Shemilt M, Moore L, Zarychanski R, Douville V, Fergusson DA, Turgeon AF. The Prognostic Value of Magnetic Resonance Imaging in Moderate and Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis. Critical Care Medicine. 2017 Dec;45(12):e1280-e1288. doi: 10.1097/CCM.0000000000002731. PMID: 29028764

99. Arnold DM, Lauzier F, Albert M, Williamson D, Li N, Zarychanski R, Doig C, McIntyre L, Freitag A, Crowther M, Saunders L, Clarke F, Cooper J, Qushmaq I, Lopes RD, Heels-Ansdell D, Webert K and Cook DJ, For the PROTECT Investigators, the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group. The Association Between Platelet Transfusions and Bleeding in Critically Ill Patients with Thrombocytopenia. Research and Practice in Thrombosis and Haemostasis. 2017;1:103–111. doi.org/10.1002/rth2.12004. PMID: 30046678 98. BEDNARCZYK JM, Fridfinnson JA, Kumar A, Blanchard L, Rabbani R, Bell D, Funk D, Turgeon AF, Abou-Setta AM, Zarychanski R. Incorporating dynamic assessment of fluid

https://www.ncbi.nlm.nih.gov/pubmed/?term=29412095https://www.ncbi.nlm.nih.gov/pubmed/?term=29412095https://www.ncbi.nlm.nih.gov/pubmed/?term=29343461https://www.ncbi.nlm.nih.gov/pubmed/?term=29343461https://www.ncbi.nlm.nih.gov/pubmed/?term=29222318https://www.ncbi.nlm.nih.gov/pubmed/?term=29222318https://www.ncbi.nlm.nih.gov/pubmed/?term=29173601https://www.ncbi.nlm.nih.gov/pubmed/?term=29173601https://www.ncbi.nlm.nih.gov/pubmed/29049285https://www.ncbi.nlm.nih.gov/pubmed/29049285https://www.ncbi.nlm.nih.gov/pubmed/29037221https://www.ncbi.nlm.nih.gov/pubmed/29037221https://www-ncbi-nlm-nih-gov.uml.idm.oclc.org/pubmed/29028764https://www-ncbi-nlm-nih-gov.uml.idm.oclc.org/pubmed/29028764https://www.ncbi.nlm.nih.gov/pubmed/?term=30046678https://www.ncbi.nlm.nih.gov/pubmed/?term=30046678

Ryan Zarychanski

responsiveness into goal-directed therapy: A systematic review and meta-analysis. Critical Care Medicine. 2017. Sep;45(9):1538-1545. doi: 10.1097/CCM.0000000000002554. PMID: 28817481 97. Azad MB, Abou-Setta AM, Chauhan BF, Pharm M, Rabbani R, Lys J, Copstein L, Mann A, Jeyaraman MM, Derksen AE, Fiander M, MacKay DS, McGavock J, Wicklow B, Zarychanski R (senior author/supervisor). Non-nutritive sweeteners and cardio-metabolic health: A systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. Canadian Medical Association Journal. 2017 Jul 17;189(28):E929-E939. doi: 10.1503/cmaj.161390. PMID: 28716847 96. Azad MB, MacKay DS, Zarychanski R. Response to: The importance of study design in the assessment of non-nutritive sweeteners and cardiometabolic health. Canadian Medical Association Journal. 2017 Nov 20;189(46):E1426. doi: 10.1503/cmaj.733441. PMID: 29158458 95. Wilkinson K, Wei Y, Szwajcer A, Rabbani R, Zarychanski R, Abou-Setta AM, Mahmud SM. Efficacy and safety of high-dose influenza vaccine in elderly adults: A systematic review and meta-analysis. Vaccine. 2017 May 15;35(21):2775-2780. doi: 10.1016/j.vaccine.2017.03.092. PMID: 28431815 94. Turgeon AF, Lauzier F, Zarychanski R, Fergusson DA, Léger C, McIntyre LA, Bernard F, Rigamonti A, Burns K, Griesdale D, Green R, Scales DC, Meade MO, Savard M, Shemilt M, Paquet J, Gariépy JL, Lavoie A, Reddy K, Jichici D, Pagliarello G, Zygun D, Moore L, for the TBI-Prognosis study team and the Canadian Critical Care Trials Group. Prognostication in critically ill patients with severe traumatic brain injury: The TBI-Prognosis multicenter feasibility study. BMJ Open. 2017 Apr 17;7(4):e013779. doi: 10.1136/bmjopen-2016-013779. PMID: 28416497 93. Boutin A, Moore L, Lauzier F, Chasse M, English S, Zarychanski R, Griesdale D, Fergusson DA, Turgeon AF. Transfusion of red blood cells in patients with traumatic brain injuries admitted to Canadian trauma health centers: a multicenter cohort study. BMJ Open. 2017 Mar 29;7(3):e014472. doi: 10.1136/bmjopen-2016-014472. PMID: 28360248 92. Chauhan BF, Jeyaraman MM, Singh Mann A, Lys J, Abou-Setta AM, Zarychanski R, Ducharme FM. Addition of anti-leukotriene agents to inhaled corticosteroids for adults and adolescents with persistent asthma. Cochrane Database of Systematic Reviews 2017: Mar 16;3:CD010347. doi: 10.1002/14651858.CD010347.pub2. PMID: 28301050 91. Guillemette L, Durksen A, Rabbani R, Zarychanski R, Abou-Setta AM, Duhamel TA, McGavock JM, Wicklow B. Intensive gestational glycemic management and childhood obesity: A systematic review and meta-analysis. International Journal of Obesity. 2017. Jul;41(7):999-1004. doi: 10.1038/ijo.2017.65. [Epub ahead of print] doi: 10.1038/ijo.2017.65. PMID: 28286340 90. Chauhan BF, Jeyaraman JM, Man AS, Lys J, Skidmore B, Sibley KM, Abou-Setta AM, Zarychanski R (senior author/supervisor). Behaviour change interventions and policies influencing primary healthcare professionals' practice – An overview of reviews. Implementation Science. 2017 Jan 5;12(1):3. doi: 10.1186/s13012-016-0538-8 PMID: 28057024

https://www.ncbi.nlm.nih.gov/pubmed/28817481https://www.ncbi.nlm.nih.gov/pubmed/28817481https://www.ncbi.nlm.nih.gov/pubmed/28716847https://www.ncbi.nlm.nih.gov/pubmed/28716847https://www.ncbi.nlm.nih.gov/pubmed/?term=29158458https://www.ncbi.nlm.nih.gov/pubmed/?term=29158458https://www.ncbi.nlm.nih.gov/pubmed/28431815https://www.ncbi.nlm.nih.gov/pubmed/28431815https://www.ncbi.nlm.nih.gov/pubmed/28416497https://www.ncbi.nlm.nih.gov/pubmed/28416497https://www.ncbi.nlm.nih.gov/pubmed/28360248https://www.ncbi.nlm.nih.gov/pubmed/?term=28301050https://www.ncbi.nlm.nih.gov/pubmed/?term=28301050https://www.ncbi.nlm.nih.gov/pubmed/?term=28286340https://www.ncbi.nlm.nih.gov/pubmed/?term=28286340https://www.ncbi.nlm.nih.gov/pubmed/28057024https://www.ncbi.nlm.nih.gov/pubmed/28057024

Ryan Zarychanski

89. Fiest KM, Hitchon CA, Bernstein CN, Peschken CA, Walker JR, Graff LA, Zarychanski R, Abou-Setta AM, Patten SB, Sareen J, Bolton J, Marrie RA; CIHR Team “Defining the Burden and Managing the Effects of Psychiatric Comorbidity in Chronic Immunoinflammatory Disease: Systematic Review and Meta-Analysis of Interventions for Depression and Anxiety in Persons with Rheumatoid Arthritis. Journal of Clinical Rheumatology. 2017; 2017 Dec;23(8):425-434. doi: 10.1097/RHU.0000000000000489. PMID: 28221313 88. Coyle K , Carrier M, Lazo-Langner A, Shivakumar S, Zarychanski R, Tagalakis V, Sollymoss S, Routhier N, Douketis J, Coyle D. Cost effectiveness of the addition of a comprehensive CT scan to the abdomen and pelvis for the detection of cancer after unprovoked venous thromboembolism. Thrombosis Research. 2017; Mar;151:67-71. PMID: 28160670 87. Litster B, Fiest KM, Patten SB, Fisk JD, Walker JR, Graff LA, Bolton JM, Sareen J, Marriott JJ, Berrigan LI, Bernstein CN, Zarychanski R, Singer A, Hitchon CA, Peschken CA, Marrie RA; CIHR Team “Defining the Burden and Managing the Effects of Psychiatric Comorbidity in Chronic Immunoinflammatory Disease”. Screening Tools for Anxiety in People with Multiple Sclerosis: A Systematic Review. International Journal of Multiple Sclerosis Care. 2016 Nov-Dec;18(6):273-281. PMID: 27999521 86. Mercier E, Boutin A, Shemilt M, Lauzier F, Zarychanski R, Fergusson DA, Moore L, McIntyre LA, Archambault P, Légaré F, Rousseau F, Lamontagne F, Nadeau L, Turgeon AF. Predictive value of neuron-specific enolase (NSE) for prognosis in patients with moderate or severe traumatic brain injury: A systematic review and meta-analysis. CMAJ Open. 2016 Jul 22;4(3):E371-E382 PMID: 27975043 85. Ducas RA, Labos C, Allen D, Golian M, Jeyaraman M, Lys J, Mann A, Copstein L, Vokey S, Rabbani R, Zarychanski R, Abou-Setta AM, Menkis A. Association of pre-hospital ECG administration with clinical outcomes in ST-segment myocardial infarction: a systematic review and meta-analysis. Canadian Journal of Cardiology. 2016 Dec;32(12):1531-1541. doi: 10.1016/j.cjca.2016.06.004 PMID: 27707525 84. Green RS, Fergusson DA, Turgeon AF, McIntyre LA, Kovacs GJ, Griesdale DE, Zarychanski R, Butler MB, Kureshi N, Erdogan M. Resuscitation prior to emergency endotracheal intubation: Results of a national survey. Western Journal of Emergency Medicine. 2016. Sep;17(5):542-8. PMID: 27625717 83. Green RS, Fergusson DA, Turgeon AF, McIntyre LA, Kovacs GJ, Griesdale DE, Zarychanski R, Butler MB, Kureshi N, Erdogan M. Device and medication preference of Canadian physicians for endotracheal intubation in critically ill patients. Canadian Journal of Emergency Medicine. 2017 May;19(3):186-197. doi: 10.1017/cem.2016.361 PMID: 27573571 82. Dawe DE, Christiansen D, Swaminath A, Ellis PM, Rothney J, Rabbani R, Abou-Setta AM, Zarychanski R; Mahmud SM. Chemoradiotherapy versus radiotherapy alone in elderly patients with stage III non-small cell lung cancer: a systematic review and metaanalysis. Lung Cancer. 2016 Sept;99:180-185. PMID: 27565937

https://www.ncbi.nlm.nih.gov/pubmed/28221313https://www.ncbi.nlm.nih.gov/pubmed/28221313https://www.ncbi.nlm.nih.gov/pubmed/28160670https://www.ncbi.nlm.nih.gov/pubmed/28160670https://www.ncbi.nlm.nih.gov/pubmed/27999521https://www.ncbi.nlm.nih.gov/pubmed/27999521https://www.ncbi.nlm.nih.gov/pubmed/27975043https://www.ncbi.nlm.nih.gov/pubmed/27975043https://www.ncbi.nlm.nih.gov/pubmed/27707525https://www.ncbi.nlm.nih.gov/pubmed/27707525http://www.ncbi.nlm.nih.gov/pubmed/27625717http://www.ncbi.nlm.nih.gov/pubmed/27573571http://www.ncbi.nlm.nih.gov/pubmed/27565937http://www.ncbi.nlm.nih.gov/pubmed/27565937

Ryan Zarychanski

81. Fiest KM, Bernstein CN, Walker JR, Graff LA, Hitchon CA, Peschken CA, Zarychanski R, Abou-Setta A, Patten SB, Sareen J, Bolton J, Singer A, Marrie RA; CIHR Team “Defining the burden and managing the effects of psychiatric comorbidity in chronic immunoinflammatory disease”. Systematic review of interventions for depression and anxiety in persons with inflammatory bowel disease. BMC Research Notes. 2016 Aug 12;9(1):404. doi: 10.1186/s13104-016-2204-2. PMID: 27514366 80. Gould TJ, Lysov, Z, Swystun LL, Dwivedi DJ, Zarychanski R, Fox-Robichaud AE, Liaw PC on behalf of the Canadian Critical Care Translational Biology Group. Extracellular histones increase tissue factor activity and enhance thrombin generation by human blood monocytes. Shock. 2016. Dec;46(6):655-662. PMID: 27405066 79. McIntyre L, Rowe BH, Walsh TS, Gray A, Arabi Y, Perner A, Gordon A, Marshall J, Cook DJ, Fox-Robichaud A, Bagshaw SM, Green R, Scheitzer I, Turgeon AF, Zarychanski R, English S, Chassé M, Stiell I, Fergusson DA For the Canadian Critical Care Trials Group. Multicountry survey of emergency and critical care medicine physicians' fluid resuscitation practices for adult patients with early septic shock. BMJ Open. 2016. Jul 7;6(7):e010041. PMID: 27388345 78. Delaney JW, Pinto R, Long J, Lamontagne F, Adhikari NK, Kumar A, Marshall JC, Cook DJ, Jouvet P, Ferguson ND, Griesdale D, Burry LD, Burns KE, Hutchison J, Mehta S, Menon K, Fowler RA; Canadian Critical Care Trials Group H1N1 Collaborative. The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness. Crit Care. 2016 Mar 30;20:75. 77. Reid AE, Chauhan BF, Rabbani R, Lys J, Copstein L, Mann A, Abou-Setta AM, Fiander M, MacKay DS, McGavock J, Wicklow B, Zarychanski R, Azad MB. Early exposure to non-nutritive sweeteners and long-term metabolic health: A systematic review. Pediatrics. 2016. March. Mar;137(3):e20153603. doi: 10.1542/peds.2015-3603. PMID: 26917671 76. Ali E, Abdel Wahed M, Alsalami Z, Abouseif H, Gottschalk T, Rabbani R, Zarychanski R, Abou-Setta AM. New Modalities to Deliver Surfactant in Premature Infants: A Systematic Review and Meta-analysis. The Journal of Maternal-Fetal & Neonatal Medicine. 2016 Nov;29(21):3519-24. doi: 10.3109/14767058.2015.1136997 . PMID: 26864884 75. Fiest KM, Walker JR, Bernstein CN, Graff LA, Zarychanski R, Abou-Setta AM, Patten SB, Sareen J, Bolton JM, Marriott JJ, Fisk, JD, Singer A, & Marrie RA for the CIHR Team “Defining the burden and managing the effects of psychiatric comorbidity in chronic immunoinflammatory disease.” Systematic Review and Meta-Analysis of Interventions for Depression and Anxiety in Persons with Multiple Sclerosis. Multiple Sclerosis and Related Disorders. 2016 Jan;5:12-26. PMID: 26856938 74. Ihaddadene R, Corsi DJ, Lazo-Langner A, Shivakumar S, Zarychanski R, Tagalakis V, Solymoss S, Routhier N, Douketis J, Le Gal G, Carrier M. Risk factors predictive of occult cancer detection in patients with unprovoked venous thromboembolism. Blood. 2016. Apr 21;127(16):2035-7. PMID: 26817957

http://www.ncbi.nlm.nih.gov/pubmed/?term=27514366http://www.ncbi.nlm.nih.gov/pubmed/?term=27514366http://www.ncbi.nlm.nih.gov/pubmed/?term=27405066http://www.ncbi.nlm.nih.gov/pubmed/?term=27388345http://www.ncbi.nlm.nih.gov/pubmed/?term=26917671http://www.ncbi.nlm.nih.gov/pubmed/?term=26864884http://www.ncbi.nlm.nih.gov/pubmed/?term=26856938http://www.ncbi.nlm.nih.gov/pubmed/?term=26817957

Ryan Zarychanski

73. Haghbayan H, Boutin A, Laflamme M, Lauzier F, Shemilt M, Moore L, Zarychanski R, Fergusson DA, Turgeon AF. The Prognostic Value of Magnetic Resonance Imaging in Moderate and Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis. Systematic Reviews. 2016 Jan 19;5(1):10. doi: 10.1186/s13643-016-0184-x. PMID: 26791573 72. MENARD CM, Zawadski D, Singal RK, Rimmer E, Houston DS, Zarychanski R (senior author/supervisor). Coronary artery bypass surgery in a patient with Haemophilia A: A case report. Haemophilia. 2016 Jan;22(1):e76-9. PMID: 26635300 71. Boutin A, Chassé M, Shemilt M, Lauzier F, Moore L, Zarychanski R, Griesdale D, Desjardins P, Lacroix J, Fergusson DA, Turgeon AF. Red blood cell transfusion in patients with traumatic brain injury: a systematic review and meta-analysis. Transfusion Medicine Reviews. 2016 Jan;30(1):15-24. PMID: 26409622 70. Magnan S, Zarychanski R, Pilote L, Bernier L, Shemilt M, Vigneault E, Fradet V, Turgeon AF. Intermittent versus continuous androgen deprivation therapy for prostate cancer: A systematic review and meta-analysis. JAMA Oncology. 2015 Dec;1(9):1261-9. doi: 10.1001/jamaoncol.2015.2895. PMID: 26378418 69. HOUSTON BL, Govia R, Abou-Setta AM, Reid GJ, Hadfield M, Menard C, Noyd J, Main S, Zarychanski R (senior author/supervisor). Severe Rh alloimmunization and hemolytic disease of the fetus managed with plasmapheresis, intravenous immunoglobulin and intrauterine transfusion: a case report. Transfusion and Apheresis Science. 2015 Dec;53(3):399-402. doi: 10.1016/j.transci.2015.07.010. PMID:26321100 68. Carrier M, Lazo-Langner A, Shivakumar S, Tagalakis V, Zarychanski R, Solymoss S, Routhier N, Douketis J, Danovitch K, Lee AY, Le Gal G, Wells PS, Corsi D, Ramsay T, Coyle D, Chagnon I, Kassam Z, Tao H and Rodger MA for the SOME Investigators. Screening for occult cancer in unprovoked venous thromboembolism. New England Journal of Medicine/NEJM. 2015;373(8):697-704 PMID:26095467 67. Zarychanski R, Kumar A. What is the best heparin to treat sepsis with? [Author Reply to: The efficacy and safety of heparin in patients with sepsis: A systematic review and meta-analysis. Critical Care Medicine. 2015 June;43(6):e213. PMID:25978177 66. Fowler RA, Abdelmalik P, Wood G, Foster D, Gibney N, Bandrauk N, Turgeon, AF, Lamontagne F, Kumar A, Zarychanski R, Green R, Bagshaw S, Stelfox HT, Foster R, Dodek, P, Shaw SM, Granton, J, Lawless B, Hill A, Rose L, Adhikari NK, Scales DC, Cook DJ, Marshall JC, Martin C, Jouvet P, on behalf of the Canadian ICU Capacity Group and the Canadian Critical Care Trials Group. Critical Care capacity in Canada: results of a national cross-sectional survey. Critical Care. 2015 Apr 1;19(1):133. PMID:25888116 65. Lacroix J, Hébert PC, Fergusson DA, Tinmouth A, Cook DJ, Marshall JC, Clayton L, McIntyre L, Callum J, Turgeon AF, Blajchman MA, Walsh TS, Stanworth SJ, Campbell H, Capellier G, Tiberghien P, Bardiaux L, van de Watering L, van der Meer NJ, Sabri E, Vo D; ABLE Investigators;

http://www.ncbi.nlm.nih.gov/pubmed/?term=26791573http://www.ncbi.nlm.nih.gov/pubmed/?term=26791573http://www.ncbi.nlm.nih.gov/pubmed/?term=26635300http://www.ncbi.nlm.nih.gov/pubmed/?term=26635300http://www.ncbi.nlm.nih.gov/pubmed/?term=26409622http://www.ncbi.nlm.nih.gov/pubmed/?term=PMID%3A+++++26378418http://www.ncbi.nlm.nih.gov/pubmed/?term=26321100http://www.ncbi.nlm.nih.gov/pubmed/?term=26095467http://www.ncbi.nlm.nih.gov/pubmed/?term=25978177http://www.ncbi.nlm.nih.gov/pubmed/25888116

Ryan Zarychanski

Canadian Critical Care Trials Group. Age of blood in critically ill adults. New England Journal of Medicine/NEJM. 2015 Apr 9;372(15):1410-8. PMID:25853745 64. RIMMER E, Houston BL, Cook DJ, Turgeon AF, Kumar A, Friesen C, Houston DS, Abou-Setta AM, Zarychanski R (senior author/supervisor). The efficacy and safety of plasmapheresis in sepsis and septic shock: A systematic review and meta-analysis. Critical Care. Dec 20;18(6):699. DOI: 10.1186/s13054-014-0699-2. PMID:25527094 63. Zarychanski R, Abou-Setta AM, Kanji S, Turgeon AF, Kumar A, Houston DS, Rimmer E, Houston BL, McIntyre L, Fox-Robichaud AE, Hébert P, Cook DJ, Fergusson DA. The efficacy and safety of heparin in patients with sepsis: A systematic review and meta-analysis. Critical Care Medicine. 2015 Mar;43(3):511-8. PMID:25493972 62. Lim W, Meade M, Lauzier F, Zarychanski R, Mehta S, Lamontagne F, Dodek P, McIntyre L, Hall R, Heels-Ansdell D, Fowler R, Pai M, Guyatt G, Crowther MA, Warkentin TE, Devereaux PJ, Walter SD, Muscedere J, Herridge M, Turgeon AF, Geerts W, Finfer S, Jacka M, Berwanger O, Ostermann M, Qushmaq I, Friedrich JO, Cook DJ; for the PROphylaxis for ThromboEmbolism in Critical Care Trial Investigators, the Canadian Critical Care Trials Group, and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Failure of Anticoagulant Thromboprophylaxis: Risk Factors in Medical-Surgical Critically Ill Patients. Critical Care Medicine. 2015;43:401-10. PMID:25474533 61. Gershengom HB, Wunsch H, Scales DC, Zarychanski R, Rubenfeld G, Garland A. Relationship between Arterial Catheter Use and Hospital Mortality in Intensive Care Units. JAMA Internal Medicine. 2014;174(11):1746-54. PMID: 25201069 60. Manyanga T, Froese M, Zarychanski R, Abou-Setta AM, Friesen C, Tennenhouse M, Shay BL. Pain management with acupuncture in osteoarthritis: A systematic review and meta-analysis. BMC Complement Altern Med. 2014 Aug 23;14(1):312. PMID: 25151529 59. Boutin A, Chassé M, Shemilt M, Lauzier F, Moore L, Zarychanski R, Lacroix J, Fergusson DA, Desjardins P, Turgeon AF. Red blood cell transfusion in patients with traumatic brain injury: a systematic review protocol. Systematic Reviews. 2014;3(1):66. doi: 10.1186/2046-4053-3-66 PMID: 24943006 58. Enns JE, Yeganeh A, Zarychansk R, Abou-Setta AM, Friesen C, Zahradka R, Taylor CG. The impact of Omega-3 polyunsaturated fatty acid supplementation on the incidence of cardiovascular events and complications in peripheral arterial disease: A systematic review and meta-analysis. BMC Cardiovascular Disorders. 2014 May 31;14:70. doi: 10.1186/1471-2261-14-70 PMID: 24885361 57. Kumar K, Singal R, Manji RA, Zarychanski R, Bell DD, Freed DH, Arora RC on behalf of the Cardiovascular Health Research in Manitoba Investigator Group. The benefits of 24/7 in-house intensivist coverage for prolonged-stay cardiac surgery patients. Journal of Thoracic and Cardiovascular Surgery. 2014;148(1):290-297 PMID: 24703332

http://www.ncbi.nlm.nih.gov/pubmed/?term=25853745http://www.ncbi.nlm.nih.gov/pubmed/?term=25527094http://www.ncbi.nlm.nih.gov/pubmed/25493972http://www.ncbi.nlm.nih.gov/pubmed/25474533http://www.ncbi.nlm.nih.gov/pubmed/25201069http://www.ncbi.nlm.nih.gov/pubmed/?term=25151529http://www.ncbi.nlm.nih.gov/pubmed/24943006http://www.ncbi.nlm.nih.gov/pubmed/24885361http://www.ncbi.nlm.nih.gov/pubmed/24703332

Ryan Zarychanski

56. CUDMORE JA, Seftel MD, Sisler JJ, Zarychanski R (senior author/supervisor). Methotrexate and trimethoprim-sulfamethoxazole: Toxicity from this combination continues to occur. Canadian Family Physician. 2014:60(1):53-6. PMID: 24452563 55. AZAD MB, Coneys JG, Kozyrskyj AL, Field CJ, Ramsey CD, Becker AB, Friesen C, Abou-Setta AM, Zarychanski R (senior author/supervisor). Probiotic Supplementation During Pregnancy or Infancy for the Prevention of Wheeze and Asthma: A Systematic Review and Meta-Analysis. British Medical Journal/BMJ. 2013;347:f6471. PMID: 24304677 54. YAMAMOTO J, Dostmohamed H, Schacter I, Ariano RE, Lewis B, Knoll C, Katz P, Zarychanski R. (senior author/supervisor). Preoperative therapeutic apheresis for severe medically refractory amiodarone-induced thyrotoxicosis: A case report. Journal of Clinical Apheresis. 2014;29(3):168-70. PMID: 24265247 53. Zarychanski R, Dennis J, Singh H. Challenges of population-based colorectal cancer screening and the importance of time-trend analysis when evaluating system change. Cancer Epidemiology. 2013;37:957-958 [Editorial]. PMID: 24210585 52. Bagshaw SM1, Sood MM, Long J, Fowler RA, Adhikari NK; Canadian Critical Care Trials Group H1N1 Collaborative. Acute kidney injury among critically ill patients with pandemic H1N1 influenza A in Canada: cohort study. BMC Nephrol. 2013 Jun 13;14:123. doi: 10.1186/1471-2369-14-123. PMID: 23763900 51. Goldenberg BA, Graff LA, Clara I, Zarychanski R, Walker JR, Carr R, Rogala L, Miller N, Bernstein CN. Is iron deficiency in the absence of anemia associated with fatigue in inflammatory bowel disease? American Journal of Gastroenterology. 2013;108:1392-1397. PMID: 24005345 50. Hallet J, Lauzier F, Mailloux O, Trottier V, Archambault P, Zarychanski R, Turgeon AF. The use of higher Platelet:RBC transfusion ratio in the acute phase of trauma resuscitation: a systematic review. Critical Care Medicine. 2013;41(12):2800-11. PMID: 23982024 49. Lauzier F, Arnold DM, Rabbat C, Heels – Ansdell D, Zarychanski R, Dodek P, Ashley BJ, Albert M, Khwaja K, Ostermann M, Skrobik Y, Fowler R, McIntyre L, Nates JL, Karachi T, Lopes RD, Zytaruk N, Finfer S, Crowther M, Cook D - For the PROTECT Investigators, the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Risk factors and impact of major bleeding in critically ill patients receiving heparin thromboprophylaxis. Intensive Care Medicine. 2013;39:2135-2143. PMID: 23942857

48. Williamson DR, Albert M, Heels-Ansdell D, Arnold DM, Lauzier F, Zarychanski R, Crowther M, Warkentin TE, Dodek P, Cade J, Lesur O, Lim W, Fowler R, Lamontagne F, Langevin S, Freitag A, Muscedere J, Friedrich JO, Geerts W, Burry L, Alhashemi J, Cook DJ. Thrombocytopenia in critically ill patients receiving thromboprophylaxis: frequency, risk factors and outcomes. Chest. 2013;144(4):1207-15. PMID: 23788287 47. RIMMER E, Kumar A, Zarychanski R (senior author/supervisor). Effectiveness of human recombinant activated protein C for severe sepsis and septic shock in adult and pediatric patients: Randomized clinical trial versus nonrandomized study. Critical Care Medicine. 2013;7:e139-40

http://www.ncbi.nlm.nih.gov/pubmed/24452563http://www.ncbi.nlm.nih.gov/pubmed/24304677http://www.ncbi.nlm.nih.gov/pubmed/24265247http://www.ncbi.nlm.nih.gov/pubmed/24210585http://www.ncbi.nlm.nih.gov/pubmed/?term=23763900http://www.ncbi.nlm.nih.gov/pubmed/24005345http://www.ncbi.nlm.nih.gov/pubmed/23982024http://www.ncbi.nlm.nih.gov/pubmed/23942857http://www.ncbi.nlm.nih.gov/pubmed/23788287

Ryan Zarychanski

[Author Reply]. PMID: 23774364 46. Zarychanski R, Turgeon AF, Abou-Setta AM. Meta-analyses of hydroxyethyl starch for volume resuscitation. Journal of the American Medical Association/JAMA. 2013;309:2209 [Author Reply]. PMID: 23736723 45. DENNIS J, Ramsay T, Turgeon AF, Zarychanski R (senior author/supervisor). Helmet Legislation and admissions to hospital for cycling related head injuries in Canadian provinces and territories: interrupted time series analysis. British Medical Journal/BMJ. 2013;346:f2674. PMID: 23674137 44. Mercier E, Boutin A, Lauzier F, Fergusson DA, Simard JF, Zarychanski R, Moore L, McIntyre LA, Archambault P, Lamontagne F, Légaré F, Randell E, Nadeau L, Rousseau F, Turgeon AF. Predictive value of S-100ß protein for prognosis in patients with moderate and severe traumatic brain injury: A systematic review and meta-analysis. British Medical Journal/BMJ. 2013;346:f1757. PMID: 23558282 43. Zarychanski R, Abou-Setta AM, Turgeon AF, Houston BL, McIntyre L, Marshall JC, Fergusson DA. Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis. Journal of the American Medical Association/JAMA. 2013 Feb 20;309(7):678-88. PMID: 23423413 42. Turgeon AF, Lauzier F, Burns KEA, Meade MO, Scales DC, Zarychanski R, Moore L, Zygun DA, McIntyre LA, Kanji S, Hébert PC, Murat V, Pagilarello G, Furgusson DA. Determination of neurological prognosis and clinical decision-making in adult patients with severe traumatic brain injury: A survey of Canadian intensivists, neurosurgeons and neurologists. Critical Care Medicine. 2013;41:1086-93. PMID: 23385104 41. Côte N, Turgeon AF, Lauzier F, Moore L, Scales DC, Bernard F, Zarychanski R, Burns KE, Meade MO, Zygun D, Simard JF, Boutin A, Brochu JG, Fergusson DA. Factors associated with the withdrawal of life-sustaining therapies in patients with severe traumatic brain injury: A multicenter cohort study. Neurocrit Care. 2013;18:154-60. PMID: 23099846 40. RIMMER E, Kumar A, Doucette S, Marshall J, Dial S, Gurka D, Dellinger RP, Sharma S, Penner C, Kramer A, Wood K, Ronald J, Kumar A, Turgeon AF, Houston DS, Zarychanski R (senior author/supervisor), and The Co-operative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group. Activated protein C and septic shock. A propensity matched cohort study. Critical Care Medicine. 2012;40:2974-2981. PMID: 22932397 39. Zhang L, Hiebert B, Zarychanski R, Arora RC, and the Cardiovascular Health Research in Manitoba Investigator Group. Preoperative anemia does not increase the risks of early surgical revascularization following myocardial infarction. Annals of Thoracic Surgery. 2013;95:542-547. PMID: 22939451 38. Zarychanski R, Schulz VP, Houston BL, Maksimova Y, Houston DS, Smith B, Rinehart J, Gallagher PG. Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis. Blood. 2012;120(9):1908-1915. PMID: 22529292

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