Ruchi March 2012

Mr&& _mM 2012&& 1

JWmbr dmMH$ MidirMo _m{gH$

Mr_mM 2012, df 31 do,AH$ {Vgam, _y` 10 .

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AH$mV {g Pmbobr _Vo `m `m `VrMr.

"JWmbr' MidirMo "Mr' ho `mgnrR>mg_mZ

_m{gH$ Amho. `mV gd N>Q>m`m {dMmamZm

WmZ Amho. _m `m`mer "JWmbr' {dV

gWm d {VMo {dV gh_V AmhoV Ago Zho.

n`dhma/dJUr nmR>d`mMm nmmJWmbr, _hmnm{bH$m emioMr B_maV, n{hbm_Obm, Q>monrdmbm boZ, S>m. ^ S>H$_H$a amoS>nmo{bg R>m`mg_moa, JQ>amoS>, _w~B 400 007 2389 24 45 \$g : 2387 54 81

JWmbr, B{S>` Z E w`Ho$eZ gmogm`Q>rMr_. \w$bo H$`memim, ~m~aoH$a _mJ, XmXa(n),_w~B 400 028 24306624Email - [email protected]

g.Z.Mnya gm{h` gm{h` g_obZm{Z{_m "Mr'`m {deofmH$m_YyZ

{dX^mVrb KS>m_moS>r nm{h`m. g_obZmMr gmJVm èdr Pmbr. `mbmCXS> {VgmX bm^bm. `mMm dVw{Z> AmT>mdm g_obZmMo EH$ Am`moOH$,mMm ` _XZ YZH$a `m AH$mV KoV AmhoV.

S>m. Cdbm Xidr ` mZr Jobo df^ a AZwdeemmMr Vm|S>AmoiI H$$ZXoUmar boI_mbm {b{hbr. `mMr IwgIwerV Am{U gmonr ebr dmMH${ÀmhoM, `m`m ` m boI_mboZo OoZo{Q>g gw~moY H$$Z gm{JVbo. hr boI_mbmAmVm g_mVrH$S>o Ambr Amho. E{b`m AH$mV boI_mboVrb eodQ>Mm boI{g hmoBb.

16 \o$~wdmar hm XmXmgmho~ \$miHo$ `mMm _{V{XZ. ^mH$a {^S>o `mZr^maVr` {MnQ>g>r`m ` m OZH$m`m dmagmMr ^ oQ> KoD$Z, `m`m H$mQw>{~H$dmQ>MmbrMr AmJir _m{hVr {Xbr Amho.

AmYw{ZH$ _hmam>mMo {Z_mVo èdVamd MhmU `m`m O_eVmXrModf 12 _mM 2012 amoOr gw$ hmoV Amho. gmm{YemH$S>o EH$ S>moim gmH${VH$Agbm nm{hOo Ago ` edVamd hUV. Vo VgoM OJbo. gm{h`-H$bm-gH$VrOnUm`m gWm `mZr {Z_mU Ho$`m. kmZgnZ `pV_dmZm OmUrdnydH$Aem gWmV ` o`mg dm Ho$bo. `mZm dmV`mMr h_r {Xbr. `mVyZ gdmJrU{dH$mg hmoV ho am` XoemV AJoga Pmbo. Jo`m H$mhr dfmV `mg CVaVrH$im bmJbr Amho. OJbamO _mZbo Jobobo {~hma o``m H$mhr dfmV XoemVAJoga hmoBb. Amn`mH$S>o _m XmXm, ~m~m, Am~m, AUm, H$mH$m, nwV`mAer g~moYZo Agbo`m, amOH$s`-gm_m{OH$ jomda ^md AgUm`m`pV_dmZm Hw$R>bo {df` _hdmMo dmQ>VmV, Vo H$m` nmVir JmR>VmV hoAmnU nmhV AmhmoV. EH$_oH$mMo dhaU H$$Z Or ZdgH$Vr OV Amho,

^>mMma `m eXmda Or "H$nm' hmoV Amho Vr nmhVm, `m am`mV amOH$s`-gm_m{OH$ "~XZm_'H$moeM {b{hbm OmD$ eH$Vmo.

èdVamdmMr O_eVmXr gmOar H$aVmZm, `m`m AmR>dUtZmCOmim XoVmZm, `mVyZ ~moY KoD$Z H$Vr H$a`mMo ^mZ R>odbo VaM H$UmH$mR>gwImdob.

- gnmXH$

Mr&& _mM 2012&& 2

Mgy`m Zm JmgUmam amh hmH$`n_wZtMm nw. `m`mM emnmZ `mbmO_VM _ y`gmaI ^ `mdh $n bm^b, Ag{dUwnwamUmV`m H$WoV gm{JVb Amho. VmoMmo$Z A_V nrV AgVmZm {dUyZ `mMm{eaNo>X Ho$bm. Vmoda Oo H$mhr A_VmMo W|~`m`m Vm|S>mV Jobo hmoVo `m_wio `mMYS>mdoJi {ea A_a Pmb. Ag Vo {dH$V,

^`mZH$ _wS>H$, Mgy`mgma`m VoOdrJhJmobmMm Amgwar gyS>~wrZ Kmg KoV.

amhM ho dUZ H$H$amoJmbm VVmoVVbmJy nS>V. H$H$amoJmV {dH$Vr Amho, {dynVmAmho. Vm o _`yMm {V{ZYr Agbm,OrdZmbm JmgyZ Q>mH$V Agbm Var, XwXdmZ`m`m noetZm A_admMm emn Amho.amhgmaImM H$H$amoJhr `m ndrda`mOrdg>rbm nwamVZ H$mimnmgyZ JmgVmoAmho. Mma hOma dfmnydu`m B{Ope`Zn{nag_òhr EH$m ^`m-Wmoa`mH$H$JWrM {M Am{U dUZ Amho. `mhZhrnydu`m H$mimV`m, gw_mao drg H$moQ>r

H$H$-dmS>m. Cdbm Xidr

EH$m ~rOmnmoQ>r

dfmnydu`m S>m`ZmogmamZmhr H$ga`mJmR>r hmo`m. `mMo OZwH$-nwamdo gmnS>boAmhoV.

H$gm hmoVmo hm H$H$amoJ? `m`m noergm_m` noethZ H$em doJ`m AgVmV?

Ogm amh O_OmVM {dH$V hmoVm,`mM_mUo H$H$noet`m KS>UmdirVM{dH$Vr AgVo. Hw$R>`mhr noerMr

KS>Umdi, {VM XZ{XZ H$m_ ho {V`mOZwH$mV Zm|Xbo`m gXoemda Adb~yZAgV. noet`m H$maIm`m~b ~mobVmZmAmnU nm{hb hmoV, H$s Amnbm OZwH$gM`DNAMm ~Zbobm AgVmo. hr DNAMrbm~bMH$ {niXma {eS>r OZwH$mjam`mbmImo eXmZr ~Zbobr AgVo. AmZwd{eH$$n-JwU-AmOma BVH$M Zho, Va Amn`mearamMo gJio XZ{XZ `dhma, ~mbnUrMr{ZH$mon dmT>, d`mV òU, _mVdmgmaIrO~m~Xmar nobU, d`mo_mZm_mUo hmVmahmoU, ` mo` doir Xoh `mJU... ` m gJ`mMdoimnH$ Am{U `m~m~VrVbo nmofUm`m

O_mIMmMo AmS>mIo; ho gma `m nriXma{eS>rboImV Zm|Xbob AgV. ` m boIm~ahHy$_{WZ-gXoe ~Zdbo OmVmV. `m OZwH$-boImH$Sy >Z òUm`m {WZ-gXoemergdgm_m` noetMm A`mhV gwgdmX MmbVAgVmo.

Xa doir noetM {d^mOZ hmoVmZm `mgnyU {eS>rMr h~oh~ H$mnr H$mT>br OmVo.

bmImo eXmMr H$mnr {ZKVmZm Hw$Ro> Zm Hw$Ro>MwH$m m hmoUmaM. Aem MwH$m ~`mM doim{Zndr Ag`m Var H$mhr doim ^bVoAZW CX^dVmV. {dH$V {WZ KS>dbrOmVmV. n[aUm_r, OZwH$ Am{U noer`m`mVbm gdmX {~ZgVmo.

H$H$noet`m DNA_ o` Va AemAZoH$ MwH$m gmR>bo`m AgVmV. `mZr`mMm OZwH$-boI {Ja{_Qy>Z OmVmo. `mVyZnoet`m H$m_H$mOmgmR>r Ag~,AZWH$mar {WZ-gXoe {_iVmV Am{UEH$m noerMm qH$dm Ad`dmMmM Zho, Vag_J earamMm Vmio~X {dH$Qy> eH$Vmo,

Vrg dfmnydun `V H$H$amoJm`m {d{dY H$maUmMo A`mg doJdoJ`m `moJemimV Mmby hmoVo. {dfmUy, XyfU,KmVH$ {H$aU dJao o`H$ Xw> dmrMm H$H$amonUmMm _mJ doJimM Agob Ag emkmZr J{hV Yabob hmoV. nUEH$m OZwH$gM`mVbm DNA Xwg`m noerH|$mV OdU gw_mao Vrg dfmnydu O_b. Am{U `m AZwfJmZo ho H$ibH$s ~hVoH$ H$H$JmR>t_ o` dpamoYH$ OZwH$mMr _wH$Q>Xm~r Pmbobr AgVo. nmg Q>`mhZ A{YH$ H$ga_ o`,p53 `m d{amoYH$mV hm{ZH$maH$ ~Xb Pmbobo AgVmV. dmagm, {dfmUy, XyfU, Ia {H$aU gmao EH$mMH$H$dmQo>d$Z, EH$_oH$mZm hmV XoV MmbVmV.

Mr&& _mM 2012&& 3

gm`m XohmV AamOH$ _mOV.`m MwH$m`m Vhm AZoH$ AgVmV.H$Yr EImX Aja doJiM {b{hb

OmV. Ago "Y'Mo "_m' hmoU hUOoM qH$dmOZwH$nmbQ>.

noer`m {d^mOZm`m doirH$YrH$Yr H$mhr OZwH$eX MwHy$Z nyUnUoJmibo Jobo (deletion), A{YH$Mo KmVbo Jobo(insertion) qH$dm ~Xbbo Jobo (substitu-tion) Va noer`m amoO`m H$m_H$mOmV gm\$doJio gXoe {Xbo OmVmV Am{U AV ` Jm|YiCSy> eH$Vmo. Zoh_r`m ^mfoVbr CXmhaUm`Mr Va "dmKmMr _mder Mmo$Z XyY{nVo'`m OmJr "_mder Mmo$Z XyY {nVo'BVH$M Cab Va Jm|Yi CS>UmaM. "_wbJrAmbr'`m EodOr "_wbJr d`mV Ambr'hQ>b, H$s `m A{YH$`m "d`mV' `meXmZ AW nma ~XbVmo. "KmoS>m YmdVJobm'_Y`m "YmdV'`m OmJr "_$Z' hmeX KmVbm, H$s Va dm`mbm J^raH$bmQ>Ur {_iVo.

"~mBZ KmJarVyZ nmUr ^$Z Zob',Am{U "qe`mZ gwB`m ZoT>mVyZ Xmoam AmodyZKoVbm', `m XmoZ dm`mV JV Pmbr Va`m`m OmJr "~mBZ KmJarVyZ Xmoam AmodyZKoVbm', Am{U "qe`mZ gwB`m ZoT>mVyZnmUr ^$Z Zob' Aer Zdr {ZaWH$ dm `~Zy eH$VmV. AJXr `mM nVrZOZwH$H$moemVb EH$m {R>H$mUM AY aJgyM{ZgQy>Z Xwg`mM {R>H$mU`m, nyUnUodoJ`m a Jgymbm OmD$Z {MH$Q>b(translocation), Va EH$_oH$mer VmodaH$mhrhr g~Y Zgbobo XmoZ doJdoJio OZwH$-VwH$So> `m OmoS>Urnmer EH$_oH$mer gmYboOmVmV. Aem dmQ> MwH$bo`m gmYUrVyZ ZdrHw$MH$m_r qH$dm XwH$_u OZwH$ CX^dyeH$VmV. `wHo${_`m`m EH$m H$mamV,BCR Am{U ABL ho XmoZ doJdoJ`m OZwH$mMo{d{^ VwH$So> AnKmVmZ EH$ OwiyZ ZdKmVH$ OZwH$ ~Zbob AgV. `m`mH$Sy>ZCnOUmam Bcr-Abl hm {dH$V {WZ-gXoenm T>`m aVnoetZm dmT>rM Am{U

nwZnmXZmM H$m_ A{dlmVnUo H$am`bmbmdVmo.

H$mhr OZwH$dm`m_ò (proto-oncogenes = dpOZwH$) noer`m dmT>rMoAmXoe {Xbobo AgVmV. ` m dpOZwH$m_ o`hrAem "Y'-"_m'`m MwH$m hmoVmV, eXJmibo OmVmV qH$dm EImX ^bVM dm`

o`D$Z `m`mV KwgV. _yi AmXoemVbo ho~Xb, dmT>r`m Am{U {d^mOZm`m{H$òbm Q>mM _m$Z, {VMr JVr âYmdH$$ eH$VmV.

OZwH$mM EH$ ras Zm_H$ KamU Amho._mUgmZm hmoUm`m H$H$~mYonH$s gw_maon Mdrg Q>o$ ~mYm `m Kam`m`m"H$V~Jmar'_wio hmoVo. noer~mho$Z Ambo`mgXoemZr hr ras-OZwH$ OmJr hmoVmV Am{U`m gXoemZo noerV`m BVa AZoH$ OZwH$mZmgOJ H$aVmV. `m OZwH$mgmR>r Vmo gXoeAmbobm AgVmo Vohr `m_wio OmJ hmoD$Z ` mo`H$m_mbm bmJV. `m ras-OZwH$mV MwH$sMo\o$a\$ma Pmbo, H$s Vr dV Va H$maUm{edm`gVV OmJr amhVmVM, {edm` `m`mH$Sy>Z"OmJmo, Om@@Jmo@@ ao@@'Mm {ZaVa nwH$mamhrhmoV amhVmo. `m_wio AZoH$ dpOZwH$hr{dZmH$maU Mmidbr OmVmV. noetVd{H$moi _mOVmo. Aem ga â Pmbo`mnoetV {dH$V dmT> AZmda hmoVo.

CH$mV, JV m`m_ o` `H$Vm`mnoer doJ`m, _yqnS>m`m doJ`m, _Omnoer`mhZhr doJ`m AgVmV. gJ`m noet_ o`VrM OZwH$ AgVmV. _J Hw$R>`m noerZ Hw$R>bH$m_ H$amd Vo H$g R>aV? H$m_mMr {d^mJUrH$aVmZm _yqnS>m`m noerVbr `H$VmM H$m_H$aUmar OZwH$ JwS>miyZ, `mda IwQ>m R>moHy$ZVr {ZH$m_r Ho$br OmVmV. VerM `H$Vm`mnoerVbr _y V`ma H$aUmar OZwH$ ~mX Ho$bobrAgVmV. OZwH$-MwH$m`m Jm|YimZ H$H$amoJPmbm, H$s noet_Ybm hm o^X^md gnVmo.Vmon `V {~Z~mo^ mQ> H$m_ H$aV Agbobr H$mhrOZwH$ Z> Ho$br OmVmV Va H$mhr Vmoda _wm_{ZH$m_r Ro>dbobr OZwH$ H$~a H$gyZ H$m_mbmbmJVmV. n[aUm_r, `H$VmMr noer

_OmnoerMhr H$m_ H$$ eH$Vo. Hw$R>brhrnoer _Z _mZob Vo Hw$R>bhr H$m_ H$am`bmbmJVo (de differentitaion).

o`H$ aJgym`m Q>moH$mbm CCC-CAA-CCC-CAA- Aer H$m-H$m-Mr nwZVr H$aUmar DNAMr eonQ>rAgVo. DNAMr H$mnr H$aUm`m RNA bm`m eonQ>rM Q>moH$ AmYmambm nH$S>md bmJV.`m_wio `m nH$S>bo`m Q>moH$mMr H$mnr Ho$brOmV Zmhr. n[aUm_r, Xa {d^mOZmZVa`mH$`mnoetV `m eonQ>rMr bm~r H$_r H$_rhmoV OmVo. gw_mao gma {d^mOZmZVa hr eonQ>rBVH$s AmIyS> hmoVo, H$s nwT>`m H$mnrgmR>rAmYma m`bm Vr Anwar nS>Vo. `mZVa `mH$`mnoetM {d^mOZ hmoD$ eH$V Zmhr.`m_wio `m _aVmV. H$H$amoJm`m noetV hreonQ>r _mVr`m eonQ>rgmaIr gVV bm~hmoV amhVo. noetM {d^mOZ AJ{UV doimMmbV amhV. `m A_a hmoVmV.

_mH$So>` nwamUmV aV~rOmMr Jmo>Amho. ` m amjgm`m aVm`m o`H$ W|~mVyZ`m`mgmaImM Zdm dra V`ma hmoB Am{UVem dramMr goZm C^r R>mHo$. `mM_mUo{dH$V OZwH$-KS>U Agbo`m EH$mMH$H$noer`m A{Z~Y nwZnmXZmZ VrMOZwH$-{dH$Vr Agbo`m eoH$S>mo noer hmhm hUVm Cn hmoVmV.

Amn`m earamV`m bmImo noetMJaOoZwgma {d^mOZ MmbyM AgV. `m`mVAem MwH$m hmoVM AgUma. _J gamgòH$mbmM H$H$am oJ H$m hmoV Zmhr?gdgm_m` noet_ò H$H$amoJ CX^dy ZòhUyZ AZoH$ {V~YH$ Cnm` `moOboboAgVmV.

dmY`mMm {dMma H$aVmZm AmnUWRN OZwH$mMr AmoiI H$$Z KoVbrhmoVr. `m gmaIr H$mhr y\$arS>a OZwH$(DNA repair genes) `m MwH$m {Q>nm`bm,`m VnaVoZ IS>mgma`m doMyZ H$mT>m`bmgmM AgVmV.

`m y\$arS>am`m ZOaoVyZ H$mhr MwH$m{ZgQ>VmV. `m MwH$m_wio A{Z~Y dmT>

Mr&& _mM 2012&& 4

g^ dVo. nU noer`m dmT>r`m JVrda bjRo>dUmar H$mhr dpamoYH$ OZwH$ (tumoursuppressor genes) AgVmV. Vr AeramoJQ> dmT> WmondVmV. Oa dmT> AmQ>mo`mV

o`V Zmhr Ag dmQ>b Va hr OZwH$ ({deofVp53 ZmdmM OZwH$) noerbm Am_h`mH$am`bm bmdVmV. noet`m Aemhmam{H$arbm apoptosis hUVmV. noer_$ZM Jobr H$s {V`mVbo OZwH$Xmof \$bmdyeH$V ZmhrV.

WmoS>`mV H$m`, gdgm_m` noer hrEImm Vmbodmam`m dmS>mgmaIr AgVo.{V`m XZ{XZ dmdamVbr gJir H$m_{eVrV nma nS>VmV. amoOMr hmVmImbMrH$m_ H$aUmar H$m_H$ar-OZwH$ AgVmV.`m`m H$m_mV H$mhr {~Zgb, Hw$Ro> gmS>-bdS> (deletion) Pmbr, XodnyOobmCX~mrEodOr {gJmaoQ> (mutation) noQ>dbr,H$Yr MwHy$Z hg ~bm`m XmdUrbm ~mYbrJobr (translocation); Va `m MwH$m VH$mi{ZVaUmar H$ma^mar-OZwH$ (DNA repairgenes) AgVmV. KamXmambm ZOao`m qH$dmeXm`m dMH$mV Ro >dUm`m J{hUr(tumour suppressor OZwH$) AgVmV.`m{edm` H$mhr Xmgr-OZwH$hr (proto-oncogenes) AgVmV. KamVb Xw^`mM\$S>Vmi, Ym`mM H$moR>ma âm`M H$m_`m`mH$So> AgV. `m`m H$m_mZr KamMrââmQ> hmoVo. nU `m g_r KS>dUm`mXmgr-OZwH$mMm (proto-oncogenes) _yid^md MMb AgVmo. Oa {dfmUy`mOZwH$mMr, V~mIyV`m agm`ZmMr, AerHw$R>br ~mhoaMr Xw> gJV bmJbr H$s AemEImm XmgrMm _yiMm CN>Ib d^mdC\$miyZ ` oVmo. nU gJ`m OZwH$gM`m`mH$m_mda S>mo `mV Vob KmbyZ bj Ro>dUmarH$ma^mar-OZwH$ Am{U J{hUrOZwH$ `mCR>di Xmgrbm VH$mi dR>Urda AmUVmV.

o`H$ noer`m OZwH$gM`mV AerAZoH$ ajUH$Vu OZwH$ AgVmV. ~`mMOZwH$-MwH$m O_m hmoD$Z, `m`m g`mZAem AZoH$ ajH$ OZwH$m Mm Am{U

{V~YH$ `moOZmMm nmS>md Ho$bm VaMH$H$amoJ _yi Y$ eH$Vmo.

_moQ>maJmS>rbm Ogo nm`mMm Am{UhmVmMm Ago XmoZ ~oH$ AgVmV Ver mOZwH$m Mrhr Om oS>r AgVo. `m_wio`m`mnH$s EH$ JahOa Agb Am{U XwgaOZwH$nmbQ>mZ gXmof Pmb VaM Vr Xw$bXw~i hmoVo. _moQ>maJmS>rMm hS>~oH$ ZmXwVPmbobm Agbm Am{U gmYm ~oH$hr ZrQ>bmJV Zgbm VaM AZmdYmZmZ Xm~bobmApgbaoQ>a JmS>r I>mV Kmbm`bm nwaogmAgVmo, `mM_mUo `m bmoH$m V hodpamoYH$ OZwH$mVbo Am{U BVahr ajH$OZwH$mVbo \o$a\$ma AmT>iVmV, `m`mVOZwH$s` H$b H$H$amoJ hmo`mH$So> AgVmo. BVaH$mhr H$maUmZr Xwgam Hw$R>bmhr A{YH$MmOZwH$Xmof CX^ dbm, H$s _J VodT> {Z{_mH$H$amoJ hmo`mgmR>r `mZm nwaV.

noet`m JmS>rMo Xmohr ~oH$ EH$mX_mV {ZH$m_r hm oV ZmhrV. AZoH$OZwH$nmbQ>mZr hiyhiy JOyZ, AmYr EH$,_J H$mhr H$mimZo Xwgam Ago Vo gmdH$meH$m_mVyZ OmVmV. ApgbaoQ>ada Z`mOZwH$-MwH$mMm nm` Xm~bm Om`bm `mZVaAmUIr H$mi bmoQ>Vmo. `m_wio OZwH$-gM`mda amgm`{ZH$, ^m{VH$, O{dH$AmKmV Pm`mnmgyZ H$H$am oJmMm O_~gon`V, H$Yr H$Yr drg-nMdrg dfXoIrb CbQy>Z OmVmV.

d` OgOg dmT>V OmV VgVgmn`mdaUmV`m H$H$O` nXmWm er,{H$aUmer g~Y `m`bm A{YH$ H$mi{_iVmo. noerV A{YH$m{YH$ OZwH$-MwH$mgmR>V OmVmV Am{U eodQ>r H$YrVar AgmMwH$mMm KS>m ^ aVmo. `m_wio nMdrg dfm`mZmVdmnojm nmCUeo d`_mZ Pmbo`mAmOmo~m_ o` AmVS>mMm H$ga hmo`mMre`Vm e^ a nQ>tZr A{YH$ AgVo.

H$Yr H$Yr dMH$ Ro>dUmar OZwH$_wimVM H$_Omoa AgVmV. H$Yr ~mho$Z

oÙmao {dfmUygmaIo qH$dm agm`ZmgmaIo Xw>hVH$ `mZm hV~b H$aVmV. Ag Pmb H$s

_m mS> Xmgr-OZwH$m M MoQ>{H$UtV(oncogenes hUOo H$H$OZwH$) $nmVahmoV. `mM H$mi MoQy>H$ dmS>mMr {eV{~KS>dV. ^ a_gmR> YZYm`, XyYXw^ V ^ abOmV. Zd`m, {dH$V {WZ-ZmoH$amMmgwigwimQ> hmoVmo. _yiMm gw~H$, ZmXVmdmS>m CXdV hmoVmo Am{U `m`m OmJrA{Z~Y, ~o{eV Aer A\$mQ> J{bN>dVr (cancer) \$mo\$mdVo. {V`mV `mMoQ>{H$Ut`m JmoVmd`mMm ~o~X H$ma^maMmbVmo.

Aem mS> Xmgr Am{U Xw~i ajH$-OZwH$ Oa _yi`m OZwH$gM`mVM Agbr,Va `mMm AW H$H$amoJ AmZwd{eH$ AgVmoH$m? EImm _mUgm`m AmBbm, _mderbmqH$dm AmOmo~mZm hm AmOma Agbm Va Vmo`m _mUgmbm hmo`mMm g^ d A{YH$ AgVmoH$m? hmo. H$H$amoJm`m nmM Vo Xhm Q>o$ UmVVmo AmOma AmZwd{eH$ AgVmo.

BRCA1 Am{U BRCA2 hr Ia VaXmoZ d{amoYH$ OZwH$ AmhoV. `mgmo~V VrWmoS> OZwH$-MwH$m doMm`M H$m_XoIrbH$aVmV. H$mhr OZwH$nmbQ> Pm`mZ `mMrhr H$m_ R>n hmoVmV. ho OZwH$nmbQ> dmagmhUyZ {_iVmV Am{U VZm`m Am{UAS>H$moem`m (ovaries) H$H$amoJmH$So> H$bdmT>dVmV. H$mhr `hXr O_mVr ~mH$s`mOJmer amoQ>r-~oQ>r-gnH$ VmoSy>Z, eoH$S>mo dfAmn`m dm`m km{VH$moemV Jwa\$Qy>Zam{h`m. `m`mV ` m Xmohr OZwH$nmbQ>mM,Am{U AWmVM, `m_wio VZm`m Am{UAS>H$moem`m H$H$amoJmM _mU \$ma dmT>bAm{U AOyZhr Vo _moR>M am{hbob Amho.

BVa H$mhr dpamoYH$mVbo (APC,B`mXr) AgoM \o$a\$ma _moR>m AmVS>m`mH$H$amoJmbm O~m~Xma AgVmV. hogwmAmZwd{eH$ AgVmV. _yqnS>, ZonQ>b,AWr dJa|`m H$H$amoJmMr H$mhr OZwH$-XoIrb Aer denanaoZ MmbV òVmV.Am{U H$mhr ajH$-OZwH$mV`m Xmofm_wioVa doJdoJ`m Ad`dm`m H$H$~mYoMr\$mOM earamda Mmb H$$Z o`Vo (Cancer

Mr&& _mM 2012&& 5

associated syndromes).

HER2 ho VZ-noet_Yb EH$d{OZwH$. `m`mnmgyZ V`ma hmoUma {WZ`m noetZm Y>nw> hm`Mm, {d^mOZmMmgXoe XoV AgV. Omoda `m OZwH$mMr EH$MOmoS>r noet_ò AgVo Vmoda gJi R>rH$MmbV. nU H$mhr doim Aer XmoZmhZ A{YH$OZwH$ AgVmV. noet`m dmT>rbm â^$ZmogmhZ {_iV, `m JaJ$Z dmT>VmV. _J{d^mOZmZ `mMr g`mhr PnmQ>mZo dmT>VOmVo, Amdm`m~mhoa OmVo. Aer ~obJm_dmT> hUOoM H$H$amoJ.

hr H$H$am oJm`m AmZwd{eH$CX^dmMr H$mhr CXmhaU Pmbr. nUAmZwd{eH$VoZ H$H$amoJmH$So> ZwgVm H$bAgVmo. amoJmMm mXw^ md hmo`mgmR>r `mbm{dfmUy, n`mdaUmVbr {df, KmVH$ {H$aU`mgma`m BVa H$maUmMrhr OmoS> bmJVoM.

{dfmUy, {OdmUy `m`m bmJUr_wio{ZnOUmao H$H$amoJmMo H$mhr H$ma ggJO`hUVm o`Vrb.

_mZdr H$H$am oJmnH$s ~mam-VoamQ>Ho$$ `mYr {dfmUy _wio CX^dVmV.H$H$OZwH$m`m A`mgm`m B{VhmgmV{dfmUyZr \$ma _mobmMr H$m_{Jar ~OmdbrAmho. dpOZwH$mMm Am{U dpamoYH$mMmhremoY bmJbm, Vmo Ca\$mQ>m {dfmUyMm(retroviruses) _mJmodm KoVmZmM.

ho ggJO` H$H$-n[adVZ H$mhr{R>H$mUr ObX hmoV. `m`mV H$H$~rOamodUmar d{OZwH$ {dfmUy`m OZwH$-H$moemVyZ {Xbr OmVmV. ` m Am``m {dfmUy-OZwH$mMr A{^`Vs Pmbr H$s bJoMM `mnoerM H$H$noerV $nmVa hmoV. J^me`m`mVm|S>mMm H$ga (_mZdr Mm_{Iit`m{dfmUy_wio hmoVmo), `H$VmMm H$ga (EH$mH$ma`m H$m{dir`m {dfmUyZr hmoVmo) hrAem ObX H$H$nmbQ>mMr CXmhaU.

{dfmUy noerV {e$Z {VWo H$H$~rOamodVmV ho Vd, W_ H$m|~S>m_Y`mH$ga`m A`mgm_wio gd_m` Pmb. nU_J Ag {Xgb, H$s H$mhr {dfmUyMr OZwH$

H$mhr _mZdr OZwH$mZm OmD$Z {MH$Q>VmVAm{U `mM H$m_ ~X H$aVmV qH$dm _XH$aVmV. _J noet`m H$m_mbm Ya~Y amhVZmhr Am{U hUyZ H$ga hmoVmo. ` mda A{YH$gemoYZ Pmb Am{U noerV`m _yi _mZdrd{OZwH$mda dMH$ Ro>dUmar, p53 qH$dmpRb gmaIr dpamoYH$ OZwH$ emkm`mAmoiIrMr Pmbr.

Ca\$mQ>m {dfmUy `m A`mOZwH$gM`mMr H$mnr _mZdr OZwH$gM`mVKwgVo Am{U {VWo H$m`_M R>mU _mS>Vo. nU_mZdr d{OZwH$mer J>r H$aU {Vbm Xadoir O_VM Ag Zmhr. Ver gYr {VbmOohm {_iVo VohmM `m _mZdr noerVH$H$~mYm gw$ hmoVo. `m_wio ho n[adVZA{YH$ gmdH$me hmoV.

H$YrH$Yr _mZdr d{OZwH$mMr `m{dfmUyer Aer J>r O_Vo, H$s Vo OZwH$ `m{dfmUyMm hmV Y$Z niyZ OmV Am{UXwg`mM H$ma`m noet_ o` nmoMV. {VWo`m`mda dMH$ Ro>dUmar, `m`m _yinoerVbr Img ajH$-OZwH$ ZgVmV. _JH$m`? `m OZwH$mMr MoQ>H$sU ~ZVo, PnmQy>ZH$m_mbm bmJVo, `m Z`m noerMr ~o\$m_dmT> hmoVo Am{U A{V-drZ `m noerMH$H$noerV n[adVZ hmoV.

H$mhr {dfmUyMo ZwgVo {WZ-gXoedpOZwH$mM nmD$b dmH$S> nmS>m`bm H$maUR>aVmV. emkmMr Aerhr AQ>H$i Amho,H$s H$mhr {dfmUy EH$mjar OZwH$-MwH$mMm\$V nm `S>m nmSy>Z XoVmV. _J Vmo {dfmUynoernmgyZ Xya {ZKyZ Jobm VarXoIrb Vr noer~mnS>r VmoM {H$mm {JadV, MwH$mMm KS>mâV amhVo.

{H$ o`H$ {dfmUy `m`m nwZnmXZm-gmR>r H$H$noetdaM Adb~yZ AgVmV. `mnoer _aU, `mZr Am_h`m H$aU `m{dfmUy`m \$m`mM ZgV. hUyZ Or OZwH$noetMr Am_h`m KS>dyZ AmUy eH$VmVAem d{amoYH$ OZwH$m_ò Vo {dfmUy\o$a\$ma KS>dyZ AmUVmV. `mZm Hw$MH$m_rH$$Z Q>mH$VmV. `m{edm` `m {dfmUyOdi

A_admMm _, hUOo viral telomeraseho EPmB_-{WZ AgV. hm _ Vo Amn`mAml`Xm`m noetZm XoVmV. Vmo dmnabm H$snoet`m aJgym`m eonQ>mMr bm~r gVVdmT>VM amhVo. `m_wio `m noer AJ{UVdoim {d^m{OV hmoD$ eH$VmV, A_a hmoVmVAm{U A`mhVnUo {dfmUyZm nmogV amhVmV.

`m noer IamoIaM A_a AgVmV H$m?hoboZ bg ZmdmMr EH$ ~mB hmoVr.

{Vbm Mm_{Iit`m {dfmUy_wio (HumanPapilloma Virus) J^me`m`m Vm|S>mMmH$ga Pmbm hmoVm. EH$mdZ gmb`m\o$~ wdmarV, hUOo, AmOnmgyZ ~amo~aEH$g>> dfmnydu `mo` dH$-{M{H$gmH$a`mgmR>r `m H$H$-`mYrMm EH$ VwH$S>mS>mQ>amZr H$mnyZ KoVbm. H$ga`m `mnoetZm {dfmUyZr telomeraseMm A_an>m{Xbm hmoVm. hoboZ bg~mB EH$mdZgmbrM, d`m`m EH${Vgm`m dfu dmabr,nU {V`m earamV {Z_mU Pmbo`m `mHeLa noetM `moJemioV `mdoir bmdbob{daOU AOyZhr {OdV Amho. OJâmV`mAZoH$ doJdoJ`m `moJemimZr `m{daOUmMr H$dS>r _mJyZ KoVbr Amho. H$gaAm{U ES>g`m gemoYZmgmR>r, KmVH${H$aUmMo Am{U agm`ZmMo OZwH$mdaMon[aUm_ A`mg`mgmR>r, OZwH$gM`mMmZH$mem V`ma H$a`mgmR>r, EH$ Zm XmoZ,AZoH$ H$ma`m `moJmgmR>r `m {daOUmMmdmna Pmbm Amho. nmo{bAmoMr, H$m{dirMrbg V`ma H$am`bm ` m noetMm Cn`moJ Pmbm.`m AVamimV nmR>d`m Jo`m. Adm`m\$moQ>mV ^mOyZ H$mT>`m Jo`m. `m noetda{b{h`m Jobo`m emoY-{Z~YmMr g`mVrZ dfmnyduM gmR> hOma hm oVr. Xa_{h`mbm `mV VrZeo {Z~YmMr â nS>VoAmho.

H$H$amoJ \$V {dfmUy`mM ggJmZhmoVmo Ag Zmhr. Vmo BVahr OVy_wio hmoD$eH$Vmo.

OR>amV`m AgaM _mUdmT>dUmam Helicobacter pylori ZmdmMm

Mr&& _mM 2012&& 6

OrdmUy OR>am`m noet_ò "Y'Mm "_m'H$a`mgma`m AZoH$ EH$mjar OZwH$-MwH$mKS>dVmo. `m{edm` Vmo OR>anoet_ o` Xmh{Z_mU H$aVmo. Xmh dmT>dUmar {WZ `mOZwH$-MwH$m \$bmdm`bm _XV H$aVmV.`H$VmVbo, _yqnS>mVbo H$mhr OVhr AgoXmh dmT>dyZ OZwH$-MwH$m Mo C{H$aSo >_mOdVmV.

AmZwd{eH$Vm Am{U {dfmUy-OrdmUyMo ggJ ho Va PmboM, {edm` Xmhr{Xem ^$Z amhUmam gy`H$me Am{Un`mdaUmVbr, Xa dmgmdmQo> \w$\w$gmVKwgUmar XyfU hr XoIrb H$H$amoJmbm PwH$V_mn XoVmV.

gy` {H$aU, {deofV `mVbo A{VZrb{H$aU dMo`m noerH|$m_ o` Amnbo hmVIwngVmV. EImm bhmZ _wbmZ ghOHw$VyhbmZ IoiU hmVmimd, _moS>md, VmoS>mdAm{U _J _Zmbm dmQo>b Vg OmoS>md, VgoMho H$memMo hmV noerH|$mV`m DNAMr_moS>-VmoS>-\$moS> H$aVmV Am{U _J `mDNA-{R>H$`m CbQ>m-gwbQ>m H$emhrOwidyZ Ro>dVmV. `m CnX`mnmV AYbm-_Ybm _hdmMm _OHy$a JiVmo, Zdr {ZaWH$qH$dm AJXr AZWH$mar {dYmZ Zm|XbrOmVmV. Aem ZdO{S>V {dYmZmVyZ `mZVa{_iUmao gXoe noet_ò ^bVmM Jm|YiKmbVmV. H$H$amoJmMm XheVdmX _mOVmo.

AUw\$m oQ>mVyZ Cg{OV Pmbobo{H$aU, dH$s` MmM`mgmR>r dmnaboOmUmao j-{H$aU `mMo e{V_mZ ^mboearamV A{YH$ Imobda KwgVmV. aVnoetZmO_ XoUm`m _m`noer hmS>m`m H$So>H$moQ>VQ>~XrV Onbo`m AgVmV. KmVH${H$aUmMo {ddgH$ ^mbo {VWda nmoMyZ `m_m`noet`m DNA_ò hmhmH$ma_mOdVmV. AZoH$ H$maMo aVmMo H$ga~imdVmV. CT scan hr j-{H$aUmZrHo$br OmUmar AmYw{ZH$ VnmgUr {H$ o`H$AMyH$ {ZXmZ H$am`bm Cn`wV Amho,CnH$maH$ Amho, nU Vr VnmgUr H$aVmZmj-{H$aUmMm _moR>m _mUmV _mam hmoVmo.

`mM ^mZ gVV ~miJb Zmhr, Va nwT>rbH$mhr XeH$mVM VoM _mZdr H$H$amoJmM _wIH$maU ~Zy eHo$b!

"ZZ Xh{V nmdH$ Z MZ boX ``mnmo'ho dUZ Ag~ogQ>mg `m I{ZOmbm VVmoVVbmJy nS>V. Vo Og AmJrV OiV Zmhr,nm`mV {ÔV Zmhr VgM Vo {dOoMm dmhXoIrb amoYyZ YaV, dmhZ ZoV Zmhr. OiVZg`m_wio Vo CM Vmn_mZmn`V VmnVAm{U ghO {ZdV Zmhr. `mMo VmR> no~ZVmV VerM `mMr bdMrH$ dhr~ZdVm òVmV. JrH$ ApZhmo`mZr Vo ZOiUmar emdV dmV hUyZ dmnab.ArZ ew hmoD$Z A{YH$M COiUmao`mMo H$nSo > amOo_hmamOm Zr AJmda{_adbo. A`gH$mam Vhr VoM H$nSo >KmVbo H$s _J `m Z Oibo`m H$nS>mVyZnyU XohmMr ajm AbJX H$mTy>Z KoVm o`B.

EH$mo{Ugm`m eVH$mV, Ammo{JH$H$mVrZVa CUVmamoYH$, drOamoYH$ hUyZAg~ogQ>mgMm dmna PnmQ>mZ dmT>bm.H$maIm`mV, H$mèmimV, AmJ~moQ>tVAm{U KamKamVhr `mMr {V>mnZmg_mZmZ Pmbr. EH$moUrgeo nmg VoE|er_Y`m VrZ XeH$mda `mZo A{YgmmJmOdbr. naVw `mM H$mimV `m ~hJwUrnXmWmMr bm~ qeJ _m H$fmZ Q>moMm`bmbmJbr. {_gmoWr{b`mo_m hm \w$\w$gm`mAm{U CXanmoH$ir`m AmdaUmMm H$gaAg~ogQ>mg_wio hmoVmo ho `mM H$mimV {gPmb. hm H$ga gagH$Q> gJ`mZm hmoVZmhr. `mgmR>r _wimV H$H$amoJmH$So> OZwH$s`H$b Agmdm bmJVmo.

Oohm Ag~ogQ>m gMo gy_ VVynoerH|$m_ o` KwgVmV Vohm Vo aJgym_ o`Jw VVmV. `m `m \$Q>H$m`m Zr H$mhra Jgym Mo VwH$So > {ZIiVmV, H$mhrOZwH$m_Ybo eX JiVmV, AZoH$ bhmZ-ghmZ OZwH$-MwH$m Jmoim hmoVmV. OaAmYrnmgyZM `m noerMm H$gaH$So> H$bAgob Va ` m MwH$mZr Vr dmr dmT>Vo Am{UH$H$amoJ CX^ dVmo.

~`mM _mUgm`m OrdZmV _mMmn{hbm `mbm Am{U {gJmaoQ>Mm n{hbmPwaH$m ^{d`mV`m H$gaMr ZmXrMR>aVmV.

_nmZm_wio OZwH$m_ o` dm`m`m,eXm`m MwH$m hmoV ZmhrV. OZwH$mjam_ o`{_WmBb, AgoQ>mBb dJao amgm`{ZH$ H$mZo-_mm-dobmQ>m AgVmV. {_WmBbMr _mmOZwH$mbm {MH$Q>br H$s `mM H$m_ Wm~V.AH$mohmob_wio `m Ag`m {_WmBb-_mmH$mTy>Z Q>mH$`m OmVmV. Eadr _wm_hZ R>nRo>dbobr {H$ o`H$ hm{ZH$maH$ OZwH$ CgmhmZH$m_mbm bmJVmV. {edm`, AH$mohmobcytochrome P ` m _wH$mX_-{WZm`m XmXmOZwH$mbm namUr Q>m oMyZ CR>dV Am{UnoerMr dmT>-{d^mOZ H$am`bm ^ mJ nmS>V.`m AVr H$m_m_wio ZH$mo Vo amgm`{ZH$ nXmW~ZVmV Am{U `mMr DNA da nwQ> O_VmV.Aem DNAM {d^mOZ ZrQ> hmoD$ eH$VZmhr. AH$mohmob_wio earamMr H$H$-{V~YH$ eVrhr H$_r Pmbobr AgVo. `mgm`mMm n[anmH$ hUyZ H$ga hmoD$eH$Vmo.

V~mIy`m YwamV Va S>PZmdmarH$H$-OZH$ nXmW AgVmV. noerMr H$H$-{V~YH$ ` moOZm `m`mer Mma hmV H$aVo.nU `m Yw_MH$s_wio Vr doS>mgmaIr H$m_H$am`bm bmJVo. AVr H$m_ Ho$b H$s noerVKmVH$ agm`Z O_VmV, `m `m_wioDNA`m {d^mOZmV AZoH$ MwH$m hmoVmV.Aem MwH$m Oa d{OZwH$m_ò qH$dmd{amoYH$m_ò Pm`m Va noetMr dmT>Am{U {d^mOZ A{Z`{_V hmoD$Z, doSodmH$S>o\$a\$Q>VmV. H$H$amoJmMm {eaH$md hmoVmo. _Am{U V~mIy hr Xmohr `gZ _mUgmbmAgbr Va Vr EH$OwQ>rZ H$H$amoJmM dmJVH$aVmV.

Vrg dfmnydun `V H$H$amoJm`m Aem{d{dY H$maUmMo A`mg doJdoJ`m`moJemimV Mmby hmoVo. {dfmUy, XyfU,KmVH$ {H$aU dJao òH$ Xw> dmrMmH$H$amonUmMm _mJ doJimM Agob Ag

Mr&& _mM 2012&& 7

emkmZr JhrV Yabob hmoV. nU EH$mOZwH$gM`mVbm DNA Xwg`m noerH|$mVOdU gw_mao Vrg dfmnydu O_b. Am{U`m AZwfJmZo ho H$ib, H$s ~hVoH$H$H$JmR>t_ò dpam oYH$ OZwH$m Mr_wH$Q>Xm~r Pmbobr AgVo. nmg Q>`mhZA{YH$ H$ga_ o`, p53 `m d{amoYH$mVhm{ZH$maH$ ~Xb Pmbobo AgVmV. dmagm,{dfmUy, XyfU, Ia {H$aU gmao EH$mMH$H$dmQ o >d$Z, EH$_oH$m Zm hmV XoVMmbVmV. ho g_O`mda ` m doJdoJ`m Xw>gJVtZr {~KS>Umar OZwH$ EH$gmaIrMAg`mMm, "EH$ gmo ~h w`' hm gmjmH$magemoYH$mZm Pmbm. `m gmjmH$mam_wioAZoH$ {R>H$mUr Mmbbo`m, {dIwabo`mgemoYZmV EH$dm`Vm Ambr. `mVyZ{M{H$goMo, CnMmamMo Zdo b`doYr _mJgmnS>bo.

MwH$m Pm`m_wio nmbQ>bo`mOZwH$mMo {ZaWH$ qH$dm AZWH$mar gXoe{dH$V {WZm`m $nmV {Xbo OmVmV. Aer{WZ `m H$H$noetVyZ aVmV, _bmV dJaogmS>VmV. Vr amgm`{ZH$ {M{H$gmZrhS>H$Vm o`VmV. moQo>Q>`m, AmVS>m`m,B`mXr {dd{jV H$H$amoJmM {ZXmZ `mnVrZ H$aVm o`V.

g`m H$H$amoJmda Oo A`mYw{ZH$BbmO Ho$bo OmVmV, `m`mV H$H$noet-_Y`m `m {dH$V {WZmMmM doY KoVbmOmVmo. `m gXoe-{WZmdaMm Zo_H$m CVmam~Zdm`bm _mZdr H$H$JWter BVa m`m`mnoetMm gH$a H$$Z V`ma hmoUmao hybri-doma dmnabo OmVmV. H$mQ>mZ H$mQ>mH$mT>m`Mr hr A{^Zd Ordemr` nVhUm Zm! `moJemioV ~mQ>`mV Omonmg`mOmUm`m m gH$[aV H$H$JWtZm Zdr {WZ~Zdm`M {ejU {Xbob AgV. hr Zdr {WZhUOo {dH$V gXoe-{WZmMr {V-{WZ(monoclonal antibodies) AgVmV. Vr{dH$V H$H$O` gXoe-{WZmZm AmoiIyZ`m`mda nH$S> ~gdVmV Am{U `mMmZm`ZmQ> H$aVmV. `m_wio KmVH$ gXoe

Wm~VmV. noer`m H$m_H$mOmVbm Jm|Yie_Vmo.

Cetuximab, Panitumumab

`mgmaIr {V-{WZ AmVS>m`mH$ga`m d{OZwH$m Mo {WZ-gXoedrH$maUmao {WZ-Mnamer (receptors){ZH$m_r H$$Z AZmda Pmbobr dmT>Wm~dVmV. HER2 ho OZwH$ VZm`mH$H$noetV A{YH$ _mUmV AgV. `m`mOmXm H$m_m_wio noetMr ZH$mo {VVH$s dmT>hmoVo. `mMm gXoe KoUmam {WZ-Mnamer{ZH$mbmV H$mT>m`M H$m_ TrastuzumabqH$dm Herceptin ho {V-{WZ H$aV. AerAZoH$ {V-{WZ g`m doJdoJ`mH$ga`m CnMmamgmR>r dmnabr OmVmV.Aem {V-{WZm`m eonQ>mbm H$H$ZmeH$AmfYmMo na_mUy qH$dm {H$aUmogmar `~mYbr, H$s Vr OmoS>Jmoir A{YH$M ^mdrCnMma gmYVo.

{edm` {dH$V OZwH$m Mr qH$dm`m`m {WZ-gXoemMr {V-{WZ West-ern Blotgma`m {M{H$gm-VmV dmn$ZH$H$amoJmM AMyH$ {ZXmZhr H$aVm o`V.

OZwH$b`r CnMmamdaM gemoYZAOyZ m`mo{JH$ AdWoV Amho. H$H$JWrVboOZwH$s` Xmof A`mgyZ Zo_`m `m XmofmdaOZwH$s`M BbmO `moOU ho `m gemoYZmM o`` Amho. nydu ~mXehm`m OZmZIm`mVam`mMr godm H$am`bm VVr`nWr MmH$aRo>dbo OmV. Vo {ddmgy Am{U {ZndrAgV. noet`m AVnwamVbo, hUOoMOZwH$-gM`mVbo Xmof {ZVam`bm AemMH$maMo {ddmgy Am{U {Zndr godH$`moOm`Mm emkmMm ~oV Amho. `mMo AgoZmoH$a hUOo Ca\$mQo> {dfmUy. `m {dfmUyMrnwZnmXZmMr Am{U amoJ Cn H$am`MreVs OZwH$nmbQ>mZ IMr Ho$bobr Agob.{edm` Zo_`m H$H$noer AmoiI`mgmR>rAm{U `m noetV `mo` WmZr nmoM`mgmR>r`mZm Img OZwH$s` {ejU {Xbob Agob.

Aem H$mao H$H$noetV`m ~oVmbdpOZwH$mZm {ZH$m_r H$aUmao oncolytic

(H$H$-{dZmeH$) {dfmUy noetV KwgdVmo`Vrb. OZwH$Xmofm_wio Hw$MH$m_r Pmbo`m

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Mr&& _mM 2012&& 8

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S>m. Cdbm [email protected]

"JoJmoa _|S>ob`m dmQ>m`mVyZ EH$ZdM em, OZwH$em AHw$ab. `mdmQ>m`mMm doby AmVm JJZmdar Jobm Amho.`mMo Yw_mao doJdoJ`m {XemZm \$bmdboAmhoV. _mZdm`m ApVdmMm H$moZmH$monam`mZr `mnbm Amho. ` m dobmMr nmi-_wiVa nma Am{X-Ordmbm OmD$Z {^S>brAmhoV. `m emm`m ~wbXr-J{hamB`m{dVmamV _mZd ZwH$Vm Hw$R>o S>moH$mdVmo Amho.nU Zmdm`m Zg{JH$ M_H$mam`m{X`dmMr MrVr `m`bm, {ZgJ-_mCbr~b _ZmV H$VkVm XmQy>Z ` m`bmkmZmMr VodT>r PbH$hr nwaoer Amho. Jo`mdfâmV AmnU Aem `m ~hAm`m_r,gd`mnr emmMr Vm|S>AmoiI H$$ZKoVbr. E{b`m AH$mV`m boImZo `m_m{bHo$Mm g_mamon hmoBb.'

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_y` 250 n o`gdbVrV 150 n o`

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Mr&& _mM 2012&& 11

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Mr&& _mM 2012&& 12

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drU ~XmnyaH$a9822055799

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AmoiIrMr dmQ>Zrbm g`ZmamÙ

dVwi nwgyZ Q>mH$VmZm...emaXm Zdbo



Mr&& _mM 2012&& 13

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Mr&& _mM 2012&& 14

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Mr&& _mM 2012&& 15

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n|qQ>J_ o` a_bo`m S>m. _mYdr

Mr&& _mM 2012&& 21

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(S>m._mYdr _oh|Xio [email protected])

AObr Hw$bH$Uu3, {dZha AnmQ>_|Q>,O`dY_mZ gmogm`Q>r,

{~~dodmS>r amoS>, nwUo-411037^_UdZr : 9922072158,[email protected]

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Mr&& _mM 2012&& 23

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S>m. _Zmoha OmYdm`mnH$

_amR>r {d^mJ, nwUo {dmnrR>,nwUo - 411 007

^_UdZr 98 22 850 [email protected]

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Mr&& _mM 2012&& 24

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/ColorImageDict > /JPEG2000ColorACSImageDict > /JPEG2000ColorImageDict > /AntiAliasGrayImages false /CropGrayImages true /GrayImageMinResolution 300 /GrayImageMinResolutionPolicy /OK /DownsampleGrayImages true /GrayImageDownsampleType /Bicubic /GrayImageResolution 300 /GrayImageDepth -1 /GrayImageMinDownsampleDepth 2 /GrayImageDownsampleThreshold 1.50000 /EncodeGrayImages true /GrayImageFilter /DCTEncode /AutoFilterGrayImages true /GrayImageAutoFilterStrategy /JPEG /GrayACSImageDict > /GrayImageDict > /JPEG2000GrayACSImageDict > /JPEG2000GrayImageDict > /AntiAliasMonoImages false /CropMonoImages true /MonoImageMinResolution 1200 /MonoImageMinResolutionPolicy /OK /DownsampleMonoImages true /MonoImageDownsampleType /Bicubic /MonoImageResolution 1200 /MonoImageDepth -1 /MonoImageDownsampleThreshold 1.50000 /EncodeMonoImages true /MonoImageFilter /CCITTFaxEncode /MonoImageDict > /AllowPSXObjects false /CheckCompliance [ /None ] /PDFX1aCheck false /PDFX3Check false /PDFXCompliantPDFOnly false /PDFXNoTrimBoxError true /PDFXTrimBoxToMediaBoxOffset [ 0.00000 0.00000 0.00000 0.00000 ] /PDFXSetBleedBoxToMediaBox true /PDFXBleedBoxToTrimBoxOffset [ 0.00000 0.00000 0.00000 0.00000 ] /PDFXOutputIntentProfile () /PDFXOutputConditionIdentifier () /PDFXOutputCondition () /PDFXRegistryName () /PDFXTrapped /False

/Description > /Namespace [ (Adobe) (Common) (1.0) ] /OtherNamespaces [ > /FormElements false /GenerateStructure true /IncludeBookmarks false /IncludeHyperlinks false /IncludeInteractive false /IncludeLayers false /IncludeProfiles true /MultimediaHandling /UseObjectSettings /Namespace [ (Adobe) (CreativeSuite) (2.0) ] /PDFXOutputIntentProfileSelector /NA /PreserveEditing true /UntaggedCMYKHandling /LeaveUntagged /UntaggedRGBHandling /LeaveUntagged /UseDocumentBleed false >> ]>> setdistillerparams> setpagedevice

Ruchi March 2012

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