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RSC‐Advances
A novel multicomponent microwave‐assisted synthesis of 5‐aza‐adenines
(Supplementary Information)
Anton V. Dolzhenko,*a,b Svetlana A. Kalinina,c Dmitrii V. Kalininca School of Pharmacy, Monash University Sunway Campus, Jalan Lagoon Selatan, Bandar Sunway, Selangor 46150, Malaysia. Fax: +603 551406207; Tel: +603 55145867; E‐mail: [email protected] School of Pharmacy, Curtin Health Innovation Research Institute, Curtin University, GPO Box U1987 Perth, Western Australia 6845, Australia. E‐mail: [email protected] Perm State Pharmaceutical Academy, 2 Polevaya Street, Perm 614990, Russian Federation
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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N
N
NN
N
NH2
7‐Amino‐1,2,4‐triazolo[1,5‐a][1,3,5]triazine (5a)
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N
N
NN
N
NH2
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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7‐Amino‐2‐phenyl‐1,2,4‐triazolo[1,5‐a][1,3,5]triazine (5b)
N
N
NN
N
NH2
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N
N
NN
N
NH2
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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N
N
NN
N
NH2F
7‐Amino‐2‐(3‐fluorophenyl)‐1,2,4‐triazolo[1,5‐a][1,3,5]triazine (5c)
DMF
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N
N
NN
N
NH2F
DMF
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7‐Amino‐2‐(4‐fluorophenyl)‐1,2,4‐triazolo[1,5‐a][1,3,5]triazine (5d)
DMF
DMF
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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7‐Amino‐2‐(2‐chlorophenyl)‐1,2,4‐triazolo[1,5‐a][1,3,5]triazine (5e)
N
N
NN
N
NH2Cl
DMF
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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N
N
NN
N
NH2Cl
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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7‐Amino‐2‐(3‐chlorophenyl)‐1,2,4‐triazolo[1,5‐a][1,3,5]triazine (5f)
N
N
NN
N
NH2Cl
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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N
N
NN
N
NH2Cl
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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7‐Amino‐2‐(4‐chlorophenyl)‐1,2,4‐triazolo[1,5‐a][1,3,5]triazine (5g)
N
N
NN
N
NH2
Cl
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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N
N
NN
N
NH2
Cl
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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7‐Amino‐2‐(3‐nitrophenyl)‐1,2,4‐triazolo[1,5‐a][1,3,5]triazine (5h)
N
N
NN
N
NH2O2N
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N
N
NN
N
NH2O2N
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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7‐Amino‐2‐(4‐methylphenyl)‐1,2,4‐triazolo[1,5‐a][1,3,5]triazine (5i)
N
N
NN
N
NH2
Me
DMF
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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N
N
NN
N
NH2
Me
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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7‐Amino‐2‐(3‐methoxyphenyl)‐1,2,4‐triazolo[1,5‐a][1,3,5]triazine (5j)
N
N
NN
N
NH2MeO
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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N
N
NN
N
NH2MeO
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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7‐Amino‐2‐(4‐trifluoromethylphenyl)‐1,2,4‐triazolo[1,5‐a][1,3,5]triazine (5k)
N
N
NN
N
NH2
F3C
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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N
N
NN
N
NH2
F3C
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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7‐Amino‐2‐(2‐furyl)‐1,2,4‐triazolo[1,5‐a][1,3,5]triazine (5l)
N
N
NN
N
NH2
O
DMF
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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N
N
NN
N
NH2
O
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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7‐Amino‐2‐(2‐thienyl)‐1,2,4‐triazolo[1,5‐a][1,3,5]triazine (5m)
N
N
NN
N
NH2
S
DMF
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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N
N
NN
N
NH2
S
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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7‐Amino‐2‐(3‐pyridyl)‐1,2,4‐triazolo[1,5‐a][1,3,5]triazine (5n)
N
N
NN
N
NH2
N
DMF
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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N
N
NN
N
NH2
N
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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7‐Amino‐2‐(4‐pyridyl)‐1,2,4‐triazolo[1,5‐a][1,3,5]triazine (5o)
N
N
NN
N
NH2
N
DMF
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013
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N
N
NN
N
NH2
N
Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2013