Robotic Surgery for Prostate Cancer: A Realistic Approach to Getting Started “The Evolution of a Robotic Surgeon” Douglas S. Scherr, M.D. Clinical Director, Urologic Oncology Weill Medical College of Cornell University
Robotic Surgery for Prostate
Cancer:
A Realistic Approach to
Getting Started “The Evolution of a Robotic Surgeon”
Douglas S. Scherr, M.D.
Clinical Director, Urologic Oncology
Weill Medical College of Cornell University
Is The Disease Important?
PROSTATE CANCERHighest in Incidence and Second in Cause of Death
from Cancer in American Males
Incidence Cause of DeathMelanoma of Skin 5%
Lung & Bronchus 14%
Oral Cavity & Pharynx 3%
Pancreas 2%
Colon & Rectum 11%
Kidney 3%
Prostate 30%
Urinary Bladder 7%
Leukemia 3%
Non-Hodgkin’s Lymphoma 4%
All Sites 637,500All Sites 637,500
189,000 New Cases
3% Esophagus
31% Lung & Bronchus
5% Pancreas
3% Kidney
3% Liver
10% Colon & Rectum
11% Prostate
3% Urinary Bladder
4% Leukemia
5% Non-Hodgkin’s Lymphoma
288,200 All Sites 288,200 All Sites
30,200 Death2002 Estimates
U.S. Incidence and Mortality of
Prostate Cancer
Surveillance, Epidemiology and End Results (SEER) Data
Natural History
• Natural history understood: -To die of prostate cancer or die with prostate cancer? -Conservative Treatment: a.) Gleason 2-4: 4-7% chance of death b.) Gleason 6: 18-30% chance of death c.) Gleason 8-10: 60-80% chance of death**
Frankel et al. Lancet, 361: 1122, March 2003
**Albertsen et al., JAMA, 280: 975, 1998
The Disorder
“Prostate Cancer”
Progression-free probability
by risk group
Low risk
High risk
Intermediate risk
D’Amico et al JAMA 280:969-74, 1998
Swedish randomized trial: Surgery v. Watchful waiting
Surgical excision alters the natural history of prostate cancer,
reducing metastases and cancer-specific mortality by 50% at 8 years.
From: Holmberg L, Bill-Axelson A, Helgesen F, et al. A randomized
trial comparing radical prostatectomy with watchful waiting in early
prostate cancer. N Engl J Med, 2002;347:781-789.
Distant metastases Cancer-specific mortality
WW 27.3%
RP 13.4%
WW 13.6%
RP 7.1%
DEMOGRAPHICS OF AGING
• More and more doctors will be faced with how to treat our aging population
• the older population will burgeon between the years 2010 and 2030 when the "baby boom"
generation reaches age 65.
• This will more than double the 65+ population by the year 2030 compared to 2000 numbers
Source: Administration on Aging (www.aoa.gov)
DEMOGRAPHICS OF AGING
• Over 2.0 million persons celebrated their 65th birthday in 2000 (5,574 per day).
• In the same year, about 1.8 million persons 65 or older died, resulting in an annual net increase of approximately 238,000 (650 per day).
Source: Administration on Aging (www.aoa.gov)
DEMOGRAPHICS OF AGING
Source: Administration on Aging (www.aoa.gov)
• By 2030, there will be over 70 million older persons, more than twice their number in 2000.
• People 65+ were 12.4% of the pop. in 2000 but are expected to grow to be 20% of the pop. by 2030.
Corral DA and Bahnson RR. J Urol. 1994 May;151(5):1326-9
A. Life expectancy by age for all men. At age 70 life expectancy is 11 yrs
B. Ten year survival by patient age. At 70 52% of men will survive 10 years
Life Expectancy and Ten Year Survival
Improved Treatment Strategies
• Endorectal MRI
• Nomograms
• Nerve Grafting
Improved Cancer Detection
Through Imaging Endorectal MRI/Spectroscopy
• Potential improvement over ultrasound
• Biochemical gradients to decipher cancer
from benign
• Remains investigational
• Possible role in high risk patients
Image 8 I 54.44 mm Image 9 I 57.56 mm
H
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H H H
H H H H
H H H
H H
H H
H H H H
H H H H H
* * *
sc vc vc
Treatment Stratifications
• Allow for improvement in patient
understanding
• More objective in guiding treatment
decisions
• Less physician bias
Palm Pilot Nomogram Software
• Includes pretreatment and postoperative
predictions.
• Uses published nomograms in prostate cancer.
Technical Improvements in Surgery
Nerve Grafts
• Cavernosal nerves necessary for post-
operative erectile functions
• In advanced disease, nerves may need to
be resected to obtain a negative margin
• Sural nerve or genitofemoral nerve serve
as sources of nerve grafts in this setting
What’s Next
• Improvements in Surgical Technique have
Stagnated
• Re-birth in Perineal Prostatectomy
Robotic Prostatectomy
Da Vinci Instrumentation
• Stereoscopic design with two 3-chip cameras
• 75% better resolution than any imaging system
da Vinci System: 3-D vision
‘Open’ surgery orientation
• 6 Degrees of freedom
• Surgical hand movements are transposed to the instrument tips
• Ability to scale motion
da Vinci System: Endowrist Technology
History Of Laparoscopic Surgery
• Guillonneau and Vallancien – Montsouris
Technique
“If this laparoscopic procedure is
shown to be equivalent or better, it may
replace open retropubic radical
prostatectomy.”
June 2000
Guillonneau and Vallancien, J Urol, 163: 1643, 2000
Eliminates
• Counter-intuitive motion
• Instrument tremor
Provides
• Improved ergonomics
• Hand / eye alignment
Transforms
• 2-D vision to true 3-D
• 4 DOF instruments to 6 DOF (greater endoscopic dexterity)
Enhances Laparoscopy
Disadvantages
• Loss of tactile feedback
• Set-up time
• Surgeon away from OR table
– Conversion
– Communication
• Limitation of instrumentation
• Cost
Robotic Assisted
Laparoscopic Urology
• Nephrectomy
• Partial Nephrectomy
• Prostatectomy
• Adrenalectomy
• Intra-abdominal
orchiectomy
• RPLND/PLND
• Pyeloplasty
• Birch Procedure
• Colposuspension
• Cyst Marsupilization
• Varicocelectomy
Extirpative Reconstructive
• Prostatectomy
• Partial Nephrectomy
• RPLND
• Pyeloplasty
Extirpative Reconstructive
Robotic Assisted
Laparoscopic Urology
Ureteral spatulation
Anastomosis
Ureteral stent
Tewari et al. BJU Int. 92, 205-210, 2003
Functional Outcome: Robotic Prostatectomy vs. Radical
Retropubic Prostatectomy
Continence Erections
Intercourse
Comparison to the Gold Standard
The European Experience
Cathelineau et al. Urol Clin NA, 31: 693-699, 2004
Further Comparison
The Robotic Experience Worldwide
Patient Positioning
8cm 9cm
12mm
12mm
5mm
5mm
Davinci Davjnci
U
Port Placement
Entering the Space of Retzius
• Incise median umbilical ligaments
• Drop bladder
• Expose endopelvic fascia
• Adequate exposure/mobilization facilitates dissection of prostate base/node dissection
Endopelvic Fascia/Dorsal Vein
• Begin lateral to puboprostatic ligament and medial to levator ani
• Critical in facilitating apical dissection
• 80% of prostate cancer comes within 8mm of prostatic apex
• Place DVC stitch distal to prostatic apex
Bladder Neck/Seminal Vesicles
• Biologic significance of + BN margin well documented
• Wide excision necessary
• Send frozen section to confirm absence of any prostatic tissue
• Guide to intraoperative decisions: a.) site specific biopsy labeling b.) DRE c.) endorectal MRI
• Inspect for median lobe
• Compete removal of SV necessary
• Judicious use of electrocautery at SV tip
• Proper dissection of SV sets up posterior plane
Pedicles/Nerve Sparing
• Begin posterior dissection beneath the
posterior layer of Denonviller’s Fascia
• 25% of men with palpable nodule on DRE
will have ECE posteriorly
• Pedicles taken with clips
• Antegrade nerve sparing
Urethral Incision/Apical
Dissection
• Incise DVC distal to prostatic apex
• Place 2nd stitch into DVC if necessary
• Avoid distal urethral dissection – maintain
maximal functional urethral length
Anastamosis
• Running suture with 2.0 monocryl
Video Footage
Results of First 50
• Oncologic: Pos. Margin Rate: 6/50 (12%)
• Continence: -97% of catheters removed at 7 days -3 patients with high JP output -86% of patients with <1 pad at 6 weeks -0% patients with bladder neck contracture
• Potency: Too early to characterize
• Post operative Complications: -one patient required take back for incarcerated hernia -no blood transfusions -mean operative time at 238 minutes -72% of patients discharged < 24 hours
“Robotic assistance offers an open surgeon sophisticated tools to perform complex
laparoscopic surgery. A technologically advanced ergonomic operation is achieved
because of 3-dimensional visualization; wristed instrumentation; intuitive, finger-
controlled movements; and a comfortable seated position for the surgeon”
Urology Gold Journal, 4/03
Robotic Radical Prostatectomy
And The Vattikuti Urology
Institute Technique p.15-20
ff Title
Avg. Operative Time:
160 min.
Avg. Hospital Stay:
1.2 days
Blood Transfusions:
0
Patients
discharged
Within 24 hours:
93%
Avg. Blood Loss:
153 ml.
Positive Margins:
6%
Avg. Catheterization time:
7 days
Continence at 6 mos.:
96%
Potency (men 60 yr) at 6 mos:
82% Had Return of Sexual Function
64% Had Sexual Intercourse
Urology Gold Journal, 4/03
Robotic Radical Prostatectomy
And The Vattikuti Urology
Institute Technique p.15-20
Data Collection:
First 200 patients
da Vinci Benefits:
The Patient
• Shorter hospital stay
• Less post operative pain
• Less risk of infection
• Less blood loss and transfusions
• Less scarring & improved cosmesis
• Faster recovery and return to normal
daily activities
Dave Kinsey, Robotic
Prostatectomy Patient
Is It Any Better?
• Comparable results can be achieved
• Learning curve reasonable
• Long term results await
• Robotic surgery will have a role as long as
prostatectomies exist