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ROAD TO CANCER:
MOLEKULER
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DASAR MOLEKULER
Kerusakan genetik non-letal: Karsinogenesis
Empat kelas gen regulator normal:
1. growth-promoting proto-oncogen (beta katenin),
2. growth-inhibiting tumor suppressor genes (p53), TSG:governor atau guardian
3. genes that regulate programmed cell death (Bcl2),
. gene !ang terlibat dalam reparasi "#$ (%&'
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LES GENETK
!eru"a#an genetik
$% Ke&il 'mutasi pa(a $ titik)insersi)(elesi*
+% ,esar se#inga mene"a"kan peru"a#an
karotpi&
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!ERU,A.AN KAR/OT/!C: TRANSLOK
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DELES
!OOR !ANCREATC CAN
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AM!L0KAS
NEURO,LAST
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ANEU!LOD 1 NOT MULT!LE O0 .A!LOD
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MCRORNA DAN CANCER
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KARSNOGENESS : MULTSTE!!ROCESS
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.ALLMARK O0 CANCER
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!ERAN CDK DAN CDK-N.,TOR DALAM SKLUSSEL
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